Associate Dean for Research and Graduate Programs
Joseph P. and Shirley Shipman Buckley Endowed Professor of Drug Discovery
Professor of Pharmacology
University of Houston College of Pharmacy
4849 Calhoun Road, Room 5027
Houston, TX 77204-5037
Post-Doctorate – Pharmacology, East Carolina University, Greenville, NC
Our research is focused on understanding the cellular and molecular regulation of the Angiotensin hormone and its receptor expression and the physiological and therapeutic role of these molecules (especially AT2 receptor) in improving renal-cardiovascular function, lowering blood pressure and reducing body weight and inflammation. These investigations utilize molecular/biochemical, cellular and physiological/metabolic approaches, including renal function and blood pressure measurements in various obesity animal models.
Angiotension binds to AT1 and AT2 receptors. Compared to the AT2 receptors, the AT1 receptor are expressed in greater density and mediate most of the known actions of Angiotensin II, such as vasoconstriction, anti-natriuresis, and increased blood pressure.
In general, AT2 receptors are suggested to oppose the actions mediated by AT1 receptors. Recently, we found that renal AT2 receptor expression is increased and mediates natriuresis in diabetic and obese rat models. Also, we observed that AT2 receptors may have roles in inflammation, lipid metabolism and insulin sensitivity, which interrelated phenomenon in obesity. Our studies also revealed that AT2R may be more beneficial in females in reducing obesity.
We expect that our molecular and whole-animal studies will indicate a therapeutic target to treat obesity and related health disorders, including hypertension, diabetes and kidney disease.
- UH Award for Excellence in Scholarship and Research (Associate Professor Level), University of Houston, 2010
- Teaching Excellence Award, Rho Chi Society (Beta Omicron Chapter), University of Houston College of Pharmacy, 2009, 2004 and 2002
- Honorable Mention - Teaching Excellence Award, Rho Chi Society (Beta Omicron Chapter), University of Houston College of Pharmacy, 2008
- Faculty Service Excellence Award, University of Houston College of Pharmacy, 2006
- Young Scientist Travel Award, Aventis Pharmaceuticals, Renal and Cardiovascular Symposium at Jackson, MS, 2001
- Junior Scientist Award (Physiology), Association of Scientists of Indian Origin in America, Annual Meeting of Experimental Biology, 1994.
- Young Scientist Travel Award, American Society of Pharmacology and Experimental Therapeutics. "Adenosine Receptor Agonist-Induced Regulation of G-proteins in Coronary Artery," 1992
- Cellular Pharmacology (History of cell signaling: receptor, cAMP, IP3, G proteins)
- Cardiovascular/Renal Pharmacology/Physiology (Renin angiotensin system)
- Advanced Pharmacology (Insulin signaling and resistance, treatment of diabetes)
- Cellular Life Science I (proteins/enzymes, carbohydrate metabolism, cell-cycle and cancer)
Ali, R., Patel, Sanket P., Hussain, T. Angiotensin type 2 receptor activation induces Treg cells and mitigates renal ischemic injury. Eur J. Immnol 2020, (submitted)
Fatima, N, Patel, Sanket P., Hussain, T. Angiotensin AT2 receptor activation produces anti-inflammatory response via IL-10 dependent and independent mechanisms in lipopolysaccharide mice model. Front. Pharmacol. Res. 2020 (submitted)
Patel S, Hussain T. Synergism between Angiotensin AT1 and AT2 Receptors: Role of Angiotensin‐(1‐7) in Modulating AT2R Agonist Response on Nitric Oxide in Kidney Cells. Pharmacol. Res. & Perspect. 2020 (under revision)
Zhang Y, Wang Y-T, Koka S, Zhang Y, Hussain T, Li X. Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells. Front Biosci (Landmark Ed), 25:283-298, 2020 PMID: 31585890
Patel S, Dhande I, Gray EA, Ali Q, Hussain T. Prevention of lipopolysaccharide-induced CD11b+ immune cell infiltration in the kidney: Role of AT2 receptors. Biosci Rep [Internet].39(5), 2019. PMID:31072913
Nag S, Patel S, Mani S, Hussain T. Role of angiotensin type 2 receptor in improving lipid metabolism and preventing adiposity. Mol Cell Biochem 461:195-204, 2019 PMID:
Boini KM, Hussain T, Koka S. Trimethylamine-N-oxide instigates NLRP3 inflammasome activation and endothelial dysfunction. Cell Physiol Biochem 44:152-162, 2017. PMID:29130962
Patel S, Ali Q, Preethi S, Steckelings U, Hussain T. Angiotensin II type 2 receptor and receptor Mas are colocalized and functionally interdependent in obese Zucker rat kidney. Hypertension 70(4):831-838, 2017. PMID:28827476
Ali Q, Dhande I, Samuel P, Hussain T. Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin converting enzyme-2/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury. J Renin Angiotensin Aldosterone Syst. 2016 Aug 5;17(3). pii: 1470320316661871. doi: 10.1177/1470320316661871. Print 2016 Jul. PMID: 27496559.
Patel S, Ali Q, Hussain T. Angiotensin II type 2-receptor agonist C21 reduces proteinuria and oxidative stress in kidney of high-salt fed obese Zucker rats. Hypertension, 67:906-915, 2016. PMID:25855512
Ali Q, Patel S, Hussain T. Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats. Am. J. Physiol. Renal Physiol 308:F1379-85, 2015. PMID: 25855512
Nag S, Khan MA, Samuel P, Ali Q and Hussain T. Chronic angiotensin AT2R activation prevents high-fat diet-induced adiposity and obesity in female mice independent of estrogen. Metabolism 64:814-25, 2015
Dhande I, Ma W, Hussain T. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertens Res 38:21–29, 2015
Hadi NR, Mohammad BI, Alfatlawi H, Qassam HS, Alhar S, Hussain T. Low dose combination of aspirin and clopidogrel retards the progression of atherosclerosis in hypercholesterolemia rabbits via interfering with inflammatory and oxidative responses. American Journal of BioMedicine 3:32-43, 2015
Hadi Hadi NR, Mohammad BI, Ajeena IM, Mahmood A, Majeed SA, Hussain T. Leukotriene synthesis inhibitors modulate atherosclerosis progression in hypercholestrolemic rabbits. Res J Pharmaceut Biol Chem Sci 6(4):362-370, 2014
Ali Q, Nag S, Wu Y, Hussain T. Estimation of angiotensin peptides in biological samples by LC-MS method. Anal Methods 6:215-222, 2014. PMID:24489613
Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Intl 84:931-939, 2013. PMID:23823602
Dhande I, Ali Q, Hussain T. Proximal tubule angiotensin AT2 receptors mediates an anti-inflammatory response via interleukin-10: Role in renoprotection in obese rats. Hypertension 61:1218-126, 2013, PMID:23547236
Samuel P, Khan MA, Nag S, Inagami T, Hussain T. Angiotensin AT2 receptor contributes towards gender bias in weight gain. PLOS One 8(1):e48425, 2013. PMID:23341867
Samuel P, Ali Q, Sabuhi R, Wu Y, Hussain T. High Na-intake increases renal angiotensin II levels and reduces the expression of ACE2-AT2R-MasR axis in obese Zucker rats. Am J Physiol Renal Physiol 303:F412-419, 2012. PMID:22592638
Ali Q, Hussain T. AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats. Hypertens Res, 167:43-47, 2012. PMID:22297475
Sabuhi R, Ali Q, Asghar M, Al-Zamily NHR, Hussain T. Role of angiotensin II AT2 receptor in inflammation and oxidative stress: Opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol 300:F700-F706, 2011. PMID:21209001
Sabuhi R, Asghar M, Hussain T. NADP(H) oxidase inhibition potentiates AT2 receptor agonist-induced natriuresis. Am J Physiol Renal Physiol 299(4):F815-20, 2010. PMID:20668101
Ali Q, Sabuhi R, Hussain T. Interferon regulatory factor-1 mediates glucose-induced up-regulation of AT2 receptors in proximal tubules. Mol Cell Biochem, 344(1-2):65-71, 2010. PMID:20596758
Sourris KC, Morley AL, Koita A, Samuel P, Coughlan MT, Thomas MT, Bierhaus A, Naworth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. The receptor for advanced glycation end-products (RAGE) exerts renoprotective effects via the AT2 receptor in diabetic nephropathy. Diabetologia 53(11):2442-2451, 2010
Shahid G, Hussain T. GRK2-deficiency reduces insulin activation of ERK1/2 and mitogenesis in mouse liver FL83B cells. The Open Diabetes Journal 2:44-47, 2009
Siddiqui AH, Ali Q, Hussain T. Protective role of angiotensin II AT2 receptor in blood pressure increase in obese Zucker rats. Hypertension, 53:256-261, 2009. PMCID:746398
Siddiqui AH, Hussain T. Impaired angiotensin II AT1 receptor function and enhanced Na,K-ATPase affinity for sodium in proximal tubule of streptozotocin-treated rats. Clin Exp Hypertens, 29: 435-444, 2007
Shahid G, Hussain T. GRK-2 negatively regulates glycogen synthesis in mouse liver FL83B cells. J Biol Chem 242:20612-20620, 2007
Siddiqui AH, Hussain T. Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats. Am J Physiol 292:H1722-H1727, 2007
Hakam AC, Hussain T. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension 47:1117-1124, 2006
Shah S, and T Hussain. Enhanced angiotensin II-induced stimulation of Na,K-ATPase in the proximal tubules of obese Zucker rats. Clin Exp Hypertens. 28:29-40, 2006
Hakam AC, Hussain T. Renal Angiotensin II AT2 Receptors promote Natriuresis In Streptozotocin-Induced Diabetic Rats. Am J Physiol Renal Physiol. 290:F503-F508, 2006
Hakam AC, Hussain T. Angiotensin II AT2 receptors Inhibit Proximal Tubular Na+,K+-ATPase Activity via a NO/cGMP Dependent Pathway. Am J Physiol Renal Physiol. 290:F1430-F1436, 2006
Banday AA, AH Siddiqui, MM Menezes, T Hussain. Insulin enhances AT1 receptor function in OK cells. Am J Physiol, 288:F1213-F1219, 2005
Hakam, A, T Hussain. Renal angiotensin II type-2 receptors are up-regulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension 45:270-275, 2005
Becker M, DN Umrani, MF Lokhandwala, T Hussain. Increased renal angiotensin II AT1 receptor function in obese Zucker rats. Clin Exp Hypertens 25:35-47, 2003
Banday AA, M Asghar, T Hussain, MF Lokhandwala. Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin. Hypertension 41:1353-1358, 2003
Umrani DN, AA Banday, T Hussain, MF Lokhandwala. Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension 40:880-885, 2002
Narkar VA, T Hussain, MF Lokhandwala. Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney. Am J Physiol Renal Physiol 283:F1290-F295, 2002
Asghar M, T Hussain, MF Lokhandwala. Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol 283:F350-F355, 2002
Lucas-Teixeira VA, T Hussain, P Serrao, P Soares-da-Silva, MF Lokhandwala. Intestinal dopaminergic activity in obese and lean Zucker rats: response to high salt intake. Clin Exp Hypertens 24:383-396, 2002
Fahim M, T Hussain, SJ Mustafa. Role of endothelium in adenosine receptor-mediated vasorelaxation in hypertensive rats. Fundam Clin Pharmacol 15:325-334, 2001
Narkar V, T Hussain, MF Lokhandwala. Role of tyrosine kinase and p44/42 MAPK in D(2)-like receptor-mediated stimulation of Na(+), K(+)-ATPase in kidney. Am J Physiol Renal Physiol 282:F697-F702, 2002
Hussain T, M Becker, S Beheray, MF Lokhandwala. Dopamine fails to inhibit Na,H-exchanger in proximal tubules of obese Zucker rats. Clin Exp Hypertens 23:591-601, 2001
Ricci A, F Amenta, E Bronzetti, L Felici, T Hussain, MF Lokhandwala. Age-related changes of dopamine receptor protein immunoreactivity in the rat mesenteric vascular tree. Mech Ageing Dev 123:537-546, 2002
Vieira-Coelho MA, P Serrao, T Hussain, MF Lokhandwala, P Soares-da-Silva. Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats. Life Sci 69:1957-1968, 2001
Fahim M, T Hussain, SJ Mustafa. Relaxation of rat aorta by adenosine in diabetes with and without hypertension: role of endothelium. Eur J Pharmacol 412:51-59, 2001
Asghar M, V Kansra, T Hussain, MF Lokhandwala. Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J Am Soc Nephrol 12:226-232, 2001
Becker, M., M.F. Lokhandwala, and T. Hussain. Increased AT1 receptor function in proximal tubule of obese Zucker rats. Clin. Exp. Hypertens, 2003; 25:35-47.
Narkar, V., T. Hussain, C. Pedemonte, and M.F. Lokhandwala. Dopamine D2 receptor activation causes mitogenesis by increasing phosphorylation of p44/42 MAPK in oppusum kidney cells. J. Am. Soc. Nephrol.,. 12:1844-1852, 2001
Asghar M., T. Hussain, M.F. Lokhandwala. Activation of dopamine D1-like receptor causes phosphorylation of α1-subunit of Na,K-ATPase in rat renal proximal tubules. Eur. J. Pharmacol. 411:61-66, 2001.
Asghar, M., V. Kansra, T. Hussain, and M.F. Lokhandwala. Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J. Am. Soc. Nephrol., 12:226-232, 2001.
Lokhandwala M.F., T. Hussain. Defective renal dopamined1-like receptor signal transduction in obese hypertensive rats. Acta Physiol. Scand. 168:251-255, 2000
Beheray, S., T. Hussain, and M.F. Lokhandwala. Dopamine inhibits Na,H-exchanger via D1-like receptor-mediated stimulation of protein kinase A in renal proximal tubules. Clin. Exp. Hypertens 22:635-644, 2000
Beheray, S., V. Kansra, T. Hussain, and M.F. Lokhandwala. Diminished natriuretic response to dopamine in old rat is due to an impaired D1-like receptor-signaling pathway. Kidney Intl 58:712-720, 2000
Hussain, T., S. Beheray, and M.F. Lokhnadwala. Defective dopamine receptor function in proximal tubules of obese Zucker rats. Hypertension 34:1091-1096, 1999.
Vieira-Coelho, M.A., T. Hussain, V. Kansra, M.P Serrao, J.T. Guimaraes, M. Pestana, P. Soares-da-Silva, and M.F. Lokhandwala. Aging, high salt intake and renal dopaminergic activity in Fischer 344 rats. Hypertension 34:666-672, 1999.
Hussain, T., V. Kansra, and M.F. Lokhandwala. Renal dopamine receptor signaling mechanisms in spontaneously hypertensive and Fischer 344 old rats. Clin. Exp. Hypertens 21:25-36, 1999.
Hussain, T., R. Abdul-Wahab, D. Kodak, and M.F. Lokhandwala. Bromocriptine regulates angiotensin II response on sodium pump in proximal tubules. Hypertension 32:1054-1059, 1998.
Hogan, Y.H., G. Florent, T. Hussain, K.A. Alkhadi. Cyclic AMP antagonizes adenosine-induced inhibition of ganglionic transmission. Brain Res. 787:242-247, 1998.
Bharatula, M., T. Hussain, and M.F. Lokhandwala. Angiotensin II AT1 receptor/ signaling mechanisms in the biphasic effect of the peptide on proximal tubular Na,K-ATPase. Clin. Exp. Hypertens 20:465-48, 1998
Kansra, V., T. Hussain, and M.F. Lokhandwala. Alterations in DA1 receptor and G-proteins in renal proximal tubules of old rats. Am. J. Physiol. 273:F53-F59, 1997.
Hussain, T. and M.F. Lokhandwala. Renal dopamine-1 receptor coupling with Gs and Gq/11proteins in spontaneously hypertensive rats. Am. J. Physiol. 272:F339-F346, 1997.
Hussain, T., R. Abdul-Wahab and M.F. Lokhandwala. Bromocriptine stimulates Na,K-ATPase in renal proximal tubules via cAMP pathway. Eur. J. Pharmacol. 321:259-263, 1997
Hussain, T. and M.F. Lokhandwala. Dopamine-1 receptor G-protein coupling and the involvement of phospholipase A2 in dopamine-1 receptor mediated cellular signaling mechanisms in the proximal tubules of SHR. Clin. Exp. Hypertension 19: 131-140, 1997.
Hussain,T. and M.F. Lokhandwala. Altered arachadonic acid metabolism contributes to the failure of dopamine to inhibit Na,K-ATPase in kidney of spontaneously hypertensive rats. Clin Exp Hypertension, 18: 963-974, 1996
Abebe, W., T. Hussain, and S.J. Mustafa. Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery. Am. J. Physiol. 269: H1672-H1678,1995.
Hussain, T., J. Linden and S.J. Mustafa. 125I-APE binding to adenosine receptor in coronary artery: Photoaffinity labelling with 125I-azidoAPE. J. Pharmacol. Exper. Ther. 276: 284-288, 1995
Hussain, T. and S.J. Mustafa. Binding of A1 adenosine receptor ligand 3H-8-cyclopentyl-1,3-dipropylxanthine in coronary artery smooth muscle. Cir. Res. 77: 194-198, 1995
Hasan, A., T. Hussain, S.J. Mustafa and P.C. Srivastava. 2-subsitituted thioadenine nucleoside and nucleotie analogues- synthesis and receptor subtype binding affinities. Bioconj. Chem. 5(4):364-369,1994
Hussain, T. and S.J. Mustafa. Regulation of adenosine receptor function in rat aorta. J. Cardivas. Pharmacol. 24: 95-99,1994.
Hussain, T. and S.J. Mustafa. Regulation of G-proteins coupled to adenosine receptor in coronary artery. Am. J. Physiol. 266: H1273-1279, 1994.
Hussain, T. and S.J. Mustafa. An in vitro pharmacological model in coronary smooth muscle. J. Pharmcol. Toxicol. Methods, 30: 111-115,1993.
Hussain, T. and S.J. Mustafa. Regulation of adenosine receptor system in coronary artery: functional studies and cAMP. Am. J. Physiol. (264, Heart Circ. Physiol. 33): H441-H447,1993.
Hussain, T. and S.J. Mustafa. Effects of adenosine analogues on ADP-ribosylation of Gs-proteins in coronary artery. Am. J. Physiol. 262: H875-H879, 1992.
Sabouni, M.H., T. Hussain, D.J. Cushing and S.J. Mustafa. G-proteins subserve relaxations mediated by adenosine receptors in human coronary artery. J. Cardiovas. Pharmacol. 18:696-702, 1991.
Shukla, G. S., T. Hussain, R.S. Srivastava and S.V. Chandra. Glutathione peroxidase and catalase in liver, kidney, testis and brain regions of rats following cadmium exposure and subsequent withdrawal. Ind. Hlth., 27:59-69,1989.
Shukla, G.S., T. Hussain, R.S. Srivastava and S.V. Chandra. Diagnostic significance of erythrocyte antioxidative enzymes in cadmium toxicity. Biochem. Arch.4:429-436, 1988.
Shukla, G.S., T. Hussain, and S.V. Chandra. Protein malnourishment alters organ distribution of 54manganese in rat. Biochem. Arch. 4:151-157, 1988.
Shukla, G.S., T. Hussain, and S.V. Chandra. Protective effects of vitamin E on cadmium-induced alterations in lipofuscin and superoxide dismutase in rat brain regions. Pharmacol Toxicol 63:305-306, 1988.
Shukla, G.S., T. Hussain, and S.V. Chandra. Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: In vivo and in vitro studies in growing rats. Life Sciences 41:2215-2221, 1987.
Hussain, T., G.S. Shukla and S.V. Chandra. Effects of cadmium on superoxide dismutase and lipid peroxidation in liver and kidney of growing rats: In vivo and in vitro studies. Pharmacol. Toxicol. 60:355-358, 1987.
Hussain, T., S.K. Bansal, S.K. and S.V. Chandra Effects of interaction of metal ions on the activity of K+-p-nitrophenyl phosphatase in rat brain sub cellular fractions. J. Environ. Biol. 8:51-61, 1987.
Hussain, T., M.M. Ali and S.V. Chandra. The combined effect of Pb2+ and Mn2+ on monoamine uptake and Na+,K+-ATPase in striatal synaptosomes subjected to lipid peroxidation. J.Appl. Toxicol.7 (4):277-280, 1987.
Agarwal, A.K., T. Hussain, P.K. Seth and S.V. Chandra. Effect of co-exposure of lead and manganese on neurotransmitter uptake and binding in subcellular fractions of rat brain. Biochem. Arch. 2:279-285, 1986.
Saxena, D.K., T. Hussain, B. Lal, B. and S.V. Chandra. Lead induced testicular dysfunction in weaned rats. Ind. Health. 24:105-109, 1986.
Murthy, R.C., T. Hussain, and S.V. Chandra. Effects of lead and cadmium on monoamine uptake and Na+, K+-ATPase in striatal synaptosomes subjected to lipid peroxidation. J. Environ. Biol. 7:67-73, 1986.
Hussain, T., M.M. Ali and S.V. Chandra. Effects of cadmium on lipids, lipid peroxidation and metal distribution in rat brain regions. Ind. Health. 23:199-205, 1985.
Chandra, S.V., K. Kalia, K. and T. Hussain. Biogenic amines and some metals in brain of cadmium exposed diabetic rats. J. Appl. toxicol. 5:378-381, 1985.
Bansal, S.K., T. Hussain, R.C. Murthy and S.V. Chandra. The effects of substrate and potassium on the inhibitory kinetics of MnCl2 on the enzyme K+-p-nitrophenyl phosphatase in rat brain. J. Appl. Toxicol. 5:35-39, 1985.
Bansal, S.K., T. Hussain, R.S. Srivastava, and S.V. Chandra. The distribution and characterization of HC03--dependent SCN--inhibited anion transporting ATPase in different sub-cellular fractions of mouse jejunum. J. Environ. Biol. 5:213-216, 1984.
Chandra, S.V., R.C. Murthy, T. Hussain and S.K. Bansal. Effect of interaction of heavy metals on Na+,K+-ATPase and the uptake of 3H-DA and 3H-NA in rat brain synaptosomes. Acta Pharmacol. Toxicol. 54:210-213, 1984.
Patel SN, Narayan P, Goldberg ID, Naaz F, Hussain T, Ali Q (2017) Kidney appreciates stable blood pressure. American Journal of Hypertension, 31:532-533, 2018. PMID: 29272328 https://doi.org/10.1093/ajh/hpx212
Patel SN, Hussain T. Role of AT2R (Angiotensin type 2 receptor) in maintaining sodium-potassium balance. Hypertension 71:563-565, 2018
Patel SN, Hussain T. Dimerization of AT2 and Mas receptors in control of blood pressure. Curr. Hypertens. Reports 20:41, 2018
Ali Q, Hussain T. AT2 receptor: its role in obesity related hypertension. Intl J Pharmacol Toxicol 1: 15-19, 2012
Asghar M, Tayebati SK, Lokhandwala MF, Hussain T. Potential dopamine-1 receptor stimulation in hypertension management. Curr Hypertens Rep 13:294-302, 2011
Hussain T, Lokhandwala MF. Renal dopamine receptors and hypertension. Exp Biol Med 228:134-142, 2003
Hussain, T. and M.F. Lokhandwala. Renal dopamine receptor function in hypertension. Hypertension, 32:187-197, 1998.
Dhande I, Hussain T. The protective role of angiotensin II type 2 (AT2) receptor in renal disease: Molecular mechanisms and indications for AT2 agonist therapy: The protective arm of renin angiotensin system (RAS) Ed Unger, Thomas, Elsevier 2014
Mustafa, S.J., R. Marala, W. Abebe, N. Jeanssone, H. Olanrewaju, T. Hussain. Coronary adenosine receptor: subtypes, localization and function. In: Adenosine and Adenine Nucleotides, eds. L. Belardinelli and A. Pelleg; pp 229-239, 1994.
Hussain T, Patel SN, Ali Q. Angiotensin II type 2-receptor agonist C21 reduces proteinuria and oxidative stress in kidney of high-salt fed obese Zucker rats. Q. Journal of Hypertension,33(e-Supplement 1):e229, pp.11.17, 2015.
Ali Q, Patel SN, Hussain T. Angiotensin AT2 Receptor Agonist Prevents Salt-Sensitive Hypertension in Obese Zucker Rats. The FASEB J, 2015.
Ali Q, Nag S, Hussain T. AT2 receptor activation prevents high sodium-induced increase in blood pressure and insulin resistance in obese rats. Annual Meeting of the Council on High Blood Pressure Research, 2013.
Dhande I, Hussain T. Angiotensin AT2 Receptor Exerts an Anti-inflammatory response in Lipopolysaccharide-activated THP-1 Macrophages. Annual Meeting of the Council on High Blood Pressure Research, 2013.
Dhande I, Ali Q, Nag S, Khan A, Hussain T. Protective role of the Angiotensin AT2 Receptor in obesity-induced renal inflammation. FASEB J, 2012.
Nag S, Khan MA, Hussain T. Activation of angiotensin type 2 receptor rescues high-fat diet-induced adipocyte size in young male mice. FASEB J, 2012.
Ali Q, Hussain T. Activation of AT2 receptors reduces renal AT1 receptor and enhances ACE2 activity in obese Zucker rats. FASEB J, 2012.
Samuel P, Khan MA, Nag S, Patki G, Lau Y-S, Inagami T, Hussain T. Angiotensin AT2 receptor contributes towards gender bias in weight gain. Presented in High Blood Pressure Research 2011 at Orlando, Fla., September 20-24, pp 8.
Ali Q, Hussain T. Non-peptide Agonist C21 Promotes Natriuresis in Obese rats via Proximal Tubule AT2 Receptor Linked to NO/cGMP Pathway. Presented in High Blood Pressure Research 2011 at Orlando, September 20-24, pp 194.
Ali Q, Samuel P, Sabuhi R, Hussain T. Chronic Treatment with CGP42112A decreases Blood Pressure and lowers Renin Expression in Obese Zucker Rats. American Society Hypertension, 2010.
Samuel P, Ali Q, Sabuhi R and Hussain T. Differential changes in RAS genes and blood pressure by high Na-intake in lean and obese Zucker rats. American Society Hypertension, 2010.
Ali Q and Hussain T. Role of AT2 receptor in long-term blood pressure control in obese Zucker rats. FASEB J, 2009.
Ali Q and Hussain T. Long-term treatment with ATII subtype 2 receptor agonist CGP42112A increases urinary sodium excretion and lowers blood pressure in obese Zucker rats. (April 2009) The Journal of Clinical Hypertension, Supplement A, Volume 11, Issue 4.
Sabuhi R, Siddiqui A and Hussain T. Cross-talk between NAD(P)H oxidase and AT1 receptors in the proximal tubules of obese Zucker rats. FASEB J ,2009.
Hussain T and Suddiqui A.H. Angiotensin II AT1 and AT2 receptors are differentially dysfunctional to regulate Na-K-ATPase (NKA) Activity in the Proximal Tubules of Spontaneously Hypertensive (SHR) rats. FASEB J 22:lb167, 2008.
Hussain T and Siddiqui, A.H. Phospholipase C and NADPH Oxidase Contribute to the Enhanced AT1 receptor mediated Na-K-ATPase Stimulation in the Proximal tubules of Obese Zucker rats. JASN 18:152A, 2007.
Siddiqui, A.H. and Hussain T. Chronic treatment with Angiotensin II type 2 receptor Antagonist Increases Blood Pressure in Obese Zucker Rats. (Presented at the 61st Annual Meeting of Council for High Blood Pressure Research, Westin La Paloma - Tucson, AZ, Sep 26-29, 2007.
Siddiqui, A.H. and Hussain T. Enhanced Na-K-ATPase (NKA) Affinity for Sodium and Reduced AT1 Receptor Function on NKA Activity in the Proximal Tubule of Streptozotocin-Induced Diabetic Rats. FASEB J, 2007.
Hussain T, Fouladi N. Angiotensin II AT2 receptor agonist produces natriuresis in spontaneously hypertensive rats. Hypertension 48:e102, 2006.
Siddiqui A, Hussain T. Na,K-ATPase exhibits higher affinity for sodium and insensitivity to Angiotensin II receptors action in proximal tubule of streptozotocin-induced diabetic rat. Hypertension 48:e101, 2006.
Shahid G, Hussain T. GRK2 differentially regulates insulin-induced glycogen synthesis and mitogenesis. Acta Pharmacologica Sinica Suppl 1:302, 2006.
Hakam A, Hussain T. Role of angiotensin II AT2 receptors in sodium metabolism in obese Zucker rats. Acta Pharmacologica Sinica Suppl 1:414, 2006.
- Member, American Physiological Society
- Member, American Society of Pharmacology and Experimental Therapeutics
- Member, American Society of Nephrology
- Member, American Heart Association
- Member, American Association of Colleges of Pharmacy
- Member, Rho Chi Society
- Associate Editor, Clinical and Experimental Hypertension (2008 – present)
- Editorial Advisory Board Member, The Open Nitric Oxide Journal (2008 – present)
- Editorial Board Member, Clinical and Experimental Hypertension (2002 – 2007)