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Faculty Profile

Joydip DasJoydip Das

Professor of Medicinal Chemistry
Department of Pharmacological and Pharmaceutical Sciences

University of Houston College of Pharmacy
Health 2, Room 7035
4349 Martin Luther King Boulevard
Houston, TX 77204-5037

Contact: - 713-743-1708 - Fax: 713-743-1884


  • Identifying molecular targets of ethanol at the presynaptic zone
  • Structure/function studies of C1 domain-containing proteins
  • Molecular dynamics simulation studies of peripheral and membrane proteins
  • Ph.D. in Bio-organic Chemistry, Indian Institute of Technology, Bombay, India
  • Postdoctoral: Medical University of South Carolina, Massachusetts Institute of Technology and Massachusetts General Hospital

Google Scholar Profile
  • Y. You Y, S. Katti, B. Yu, T.I. Igumenova, J. Das. Probing the Diacylglycerol Binding Site of Presynaptic Munc13-1, Biochemistry, 60:1286-1298 (2021).
  • J. Das. Repurposing of drugs-the ketamine story, J. Med. Chem. 2020, 63, 13514-13525
  • Y. You and J. Das. Effect of Ethanol on Munc13-1 C1 in Membrane: A Molecular Dynamics Simulation Study, Alcohol Clin Exp Res, 2020, 44, 1344-1355.
  • F. Blanco, A. Czikora, N. Kedei, Y. You, G. Mitchell, S. Pany, A. Ghosh, P. Blumberg, Das J. Munc13 Is a Molecular Target of Bryostatin 1, Biochemistry, 58, 3016-3030 (2019).
  • J. Das, N. Kedei, J. Kelsey, Y. You, S. Pany, G.A. Mitchell, N.E. Lewin and P.M. Blumberg. Critical role of Trp-588 of presynaptic Munc13-1 for ligand binding and membrane translocation, Biochemistry. 57, 732-741, 2018
  • S. Pany, Y. You and J. Das. Curcumin inhibits PKC alpha activity by binding to its C1 domain, Biochemistry, 55, 6327-6336 (2016).
  • G.M. Rahman, S. Shanker, N.E. Lewin, B. V.V. Prasad, P.M. Blumberg and J. Das. Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta (PKCθ), Biochem. J. 451, 33-44 (2013).
  • S. Shanmugasundararaj*, J. Das*, W.S. Sandberg, X. Zhou, D. Wang, R.O. Messing, K.S. Bruzik, T. Stehle and K.W. Miller. Structural and functional characterization of an anesthetic binding site in the second cysteine rich domain of protein kinase C delta, Biophys. J., 103, 2331-2338 (2012).
  • J. Das, S. Pany and A. Majhi. Chemical modifications of resveratrol for improved protein kinase C alpha activity, Bioorg. Med. Chem. 19, 5321-5333 (2011)
  • J. Das, S. Pany, G.M. Rahman and S.J. Slater. PKC epsilon has an alcohol binding site in its second cysteine rich regulatory domain, Biochem. J., 421, 405-413 (2009).
  • J. Das, X. Zhou and K.W. Miller. Identification of an alcohol binding site in the first cysteine-rich domain of Protein Kinase C delta, Protein Sci. 15, 2107-2119 (2006).
  • J. Das, G.H. Addona, W.S. Sandberg, S.S. Husain, T. Stehle and K.W. Miller. Identification of a general anesthetic binding site in the diacylglycerol-binding domain of Protein Kinase C, J. Biol. Chem., 279, 37964-37972(2004).
  • J. Das, M. Kono, J-x. Ma, D.D. Oprian and R.K. Crouch. C9 methyl group of retinal modulates the absorption and transducin activation properties in cone pigments, Biochemistry, 43, 5532-5538(2004).
  • J. Ma, S. Znoiko, K.L. Othersen, J.C. Ryan, J. Das, T. Isayama, M. Kono, D.D. Oprian, D.W. Corson, M.C. Cornwall, D.A. Cameron, F.L. Harosi, C.L. Makino, R.K. Crouch. A visual pigment expressed in both rod and cone photoreceptors, Neuron, 32, 451-461(2001).
  • A.K. Singh, J. Das and N. Majumdar. Novel bacteriorhodopsin analogues based on azo chromophores, J. Am. Chem. Soc., 118, 6185-6191(1996).

Awards & Honors

  • Award for Excellence in Teaching, College of Pharmacy, University of Houston 2012
  • Award for Excellence in Research, College of Pharmacy, University of Houston 2011
  • The Houston Business Journal published, "Briefs: Drug to treat alcoholism is goal of UH research," Oct 04, 2010
  • National Public Radio (Houston) aired the research, "UH Chemist Tracking Alcohol Molecules through the Brain" on September 29, 2010

Editorial Appointments

  • Ad hoc reviewer, NIH study section Neurotoxicology and Alcohol (NAL), 2017
  • Ad hoc reviewer, NIH study section ZAA1JJ (08), 2016
  • Editor-in-Chief, Journal of Addiction and Dependence
  • Editorial board member, International Journal of Biomedical Research and Analysis
  • Editorial board member, Medicinal Chemistry
  • Editorial board member, Journal of Pharmaceutical Technology and Drug Research