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Profile: Jiukuan Hao

jiukuan hao
Jiukuan Hao, Ph.D., M.D. 
Associate Professor of Pharmaceutics

Health 2
University of Houston College of Pharmacy
4849 Calhoun, Room 7003
Houston, TX 77204-5039

713-743-9411
jhao5@uh.edu

Education & Post-graduate Training

  • PhD. in Pharmaceutical Science, Texas Tech University, Lubbock, TX
  • Postdoctoral Fellowship in Neuroscience, Universidad Central Del Caribe, Puerto Rico
  • M.S. in Neurology, China Medical University, China
  • M.D. in Medicine, China Medical University, China

Academic & Research Interests

I have a broad background in medicine, neurology, pharmacology and pharmaceutical science with specific training and expertise in brain drug delivery. My research focuses on elucidating the role of the blood-brain barrier (BBB) in neural injury and neurodegeneration. My research goal is to find new target at the BBB and develop effective approaches by targeting the BBB for treatment of neurodegenerative diseases like Parkinson’s disease, ischemic stroke.

Research Support

Completed Research Support

R15NS088384 (Hao)
04/01/2015-03/31/2018
NIH/NINDS
Title: Targeting the Blood-Brain Barrier in Ischemic Stroke
Goal: To effectively deliver DNA construct into the brain with a goal to protect neuron from injury/death under cerebral ischemia/reperfusion (IR) condition.
Role: PI

R21NS093493 (Hao)
06/01/2015-05/31/2017
NIH/NINDS
Title: Application of Brain-Targeted Anti-inflammatory RNA Nanoparticle for Ischemic Stroke Therapy
Goal: To develop a RNA nanoparticle to target the blood-brain barrier for ischemic stroke therapy in mouse.
Role: PI

Title: “The Multifunctional Cembranoids for Therapy of Parkinson's Disease.”
Role: PI.
Period: 3/1/2012- 2/28/2013.
Agency: the Michael J. Fox Foundation for Parkinson's Research.
Goal: to evaluate therapeutic effect of cembranoids (4R) in Parkinson disease model in rat.

Title: Inhibition of Intercellular Adhesion Molecule-1 in Lung Cancer Cells by Selective SiRNA Nanoparticles.
Role: Co-investigator.
Period: 7/1/2013-06/30/2014.
Agency: Maine Cancer Foundation Pilot Research Grant.
Goal: to evaluate therapeutic effect RNA nanoparticle in lung cancer model in mouse.

Title: “The Role of Hax-1 in Ischemic Stroke”.
Role: PI. Period: 1/1/2012/2013.
Agency: University Research Council Faculty Research Grant Program at University of Cincinnati.
Goal: to investigate the role of Hax-1 in ischemic stroke in mouse.

Title: “Therapy of Stroke With Novel Neuroprotective RNA Nanoparticles”.
Role: PI.
Period: 1/1/2012- 12/31/2013.
Agency: the American Heart Association.
Goal: to develop a RNA nanoparticle to target the blood-brain barrier for ischemic stroke therapy in mouse.

Title: “Targeting Delivery of Anti-NF-kB DNA Nanoparticle to Primary Brain Endothelial Cells.”
Role: PI.
Period: 7/1/2014-6/30/2015.
Agency: the Center for Clinical/ Translational Science and Training at University of Cincinnati: the Just-In-Time grant.
Goal: To develop a novel DNA construct for brain endothelial cells drug delivery.

Awards & Honors

  • Faculty Excellence Award, University of Cincinnati, 2019
  • Research Excellence Award, University of Cincinnati, College of Pharmacy, 2019
  • Research Excellence Award, University of Cincinnati, College of Pharmacy, 2015
  • Research Excellence Award, University of Cincinnati, College of Pharmacy, 2012
  • American Association of Pharmaceutical Scientists scholarship, 2007

Selected Publications

Sakabe M, Fan J, Odaka Y, Liu N, Hassan A, Duan X, Stump P, Byerly L, Donaldson M, Hao J, Fruttiger M, Lu QR, Zheng Y, Lang RA, Xin M. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10918-10923. doi: 10.1073/pnas.1704030114. Epub 2017 Sep 25. PubMed PMID: 28973878; PubMed Central PMCID: PMC5642684.

Hu J, Al-Waili D, Hassan A, Fan GC, Xin M, Hao J. Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex. Neuroscience. 2016 Aug 4;329:30-42. doi: 10.1016/j.neuroscience.2016.04.033. Epub 2016 Apr 27.

Martins AH, Hu J, Xu Z, Mu C, Alvarez P, Ford BD, El Sayed K, Eterovic VA, Ferchmin PA, Hao J. Neuroprotective Activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in Rodent Models of Brain Ischemia. Neuroscience. 2015 Apr 16;291:250-9. doi: 10.1016/j.neuroscience.2015.02.001. Epub 2015 Feb 10.

Hu J, Xiao F, Hao X, Bai S, Hao J. Inhibition of monocyte adhesion to brain-derived endothelial cells by dual functional RNA chimeras. Molecular Therapy — Nucleic Acids, 2014 Nov 4;3:e209. doi: 10.1038/mtna.2014.60.

Martins AH, Hu J, Xu Z, Mu C, Alvarez P, Ford BD, El Sayed K, Eterovic VA, Ferchmin PA, Hao J. Neuroprotective Activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in Rodent Models of Brain Ischemia. Neuroscience. 2015 Apr 16;291:250-9. doi: 10.1016/j.neuroscience.2015.02.001. Epub 2015 Feb 10.

Jing Hu, P. A. Ferchmin, Ann M. Hemmerle, Kim B. Seroogy, Vesna A. Eterovic, Jiukuan Hao, 4R-Cembranoid Improves the Outcome of 6-Hydroxydopamine Induced Parkinson’s Disease Model in Rat. Neurodegeneration in Frontiers in Neuroscience (under revision).

Hu J, Xiao F, Hao X, Bai S, Hao J. Inhibition of monocyte adhesion to brain-derived endothelial cells by dual functional RNA chimeras. Molecular Therapy — Nucleic Acids, 2014 Nov 4;3:e209. doi: 10.1038/mtna.2014.60.

Mu C, Dave N, Hu J, Desai P, Pauletti G, Bai S, Hao J. Solubilization of Flurbiprofen into Aptamer-modified PEG-PLA Micelles for Targeted Delivery to Brain-derived Endothelial Cells in vitro. J Microencapsul. 2013;30(7):701-8. doi: 10.3109/02652048.2013.778907. Epub 2013 Mar 21.

Hao J, Bickel U. Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion, J Pharm Pharm Sci. Sep.16 (4) 541 - 550, 2013.

Hu J, Mu C, Hao J. Cerebral ischemia reduces expression of Hs1-associated protein X-1 (Hax-1) in mouse brain. Neurosci Lett. 2013 Feb 8;534:338-43. doi: 10.1016/j.neulet.2012.12.009. Epub 2012 Dec 20.

Hao J, Mdzinarishvili A, Abbruscato TJ, Klein J, Geldenhuys WJ, Van der Schyf CJ, Bickel U. Neuroprotective effects of NGP1-01 after transient brain ischemia in mice. Brain Res. 2008 Feb 27;1196:113-20. doi: 10.1016/j.brainres.2007.11.075. Epub 2008 Jan 29.

Ferchmin PA, Hao J, Perez D, Penzo M, Maldonado HM, Gonzalez MT, Rodriguez AD, de Vellis J. Tobacco cembranoids protect the function of acute hippocampal slices against NMDA by a mechanism mediated by alpha4beta2 nicotinic receptors. J Neurosci Res. 2005 Dec 1;82(5):631-41.