Professor of Pharmaceutics
Diana S-L. Chow Endowed Professor of Drug Discovery and Development
University of Houston College of Pharmacy
4849 Calhoun Road, Room 7047
Houston, TX 77204-5037
Postdoctoral Training, Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas
Ph.D. in Pharmaceutics, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan
B.S. in Pharmacy, Shanghai First Medical College, Shanghai, The People's Republic of China
Cancer Prevention Institute of Texas (CPRIT) RP180863, Chemoprevention of Colon Cancer Progression in FAP Children, 2018, PI: Ming Hu. $200,000.
Completed Projects (since 2005)
NIH 2R01GM070737-07A1 National Institute of General Medical Sciences, Disposition of Flavonoids via Glucuronidation, Critical Role of Efflux Transporters, 08/01/2014 – 04/30/2018, PI: Ming Hu. $1,599,687.
1R01NS087149-01 Reducing Memory Dysfunction Following Brain Injury (Pramod K Dash, PI), 02/01/14-1/31/2019, $2,385,895 ($65,094 per year to Hu)
1R56AI106743-01A1 OPTIMIZING IMPDH INHIBITORS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS (Greg Cuny, PI), 9/1/2014-8/31/16, $697,416
NIH R15 Grant Proposal UGT engineering for detoxifying anticancer drug SN-38 (Xiaoqiang Wang, PI), UH Portion $152,758 total cost over 3 years
ZinPro Corp. Transport of Amino Acid Metal Complex in the Caco-2 Cell Culture Model (Ming Hu, PI), 3/1/2013-8/31/2014. $39,518 project direct cost.
NIH R15 AI089671, Clinical Pharmacology of Polymyxin B, 3/1/2010 – 02/28/2013, PI: Vincent Tam (University of Houston), total direct cost per year is $100,000. The direct cost to Ming Hu is $50,000 per year for three years.
NIH 2R01GM070737-0310 National Institute of General Medicine. Disposition of Flavonoids via Metabolic Interplay (competitive renewal). 8/01/09-7/31/13. PI: Ming Hu. The direct cost (all to Hu) is $175,000 ($262,500 total cost) per year for 4 years.
NIH 3R01GM070737-04S1 National Institute of General Medicine. Supplement to Disposition of Flavonoids via Metabolic Interplay. 8/01/09-7/31/13. PI: Ming Hu. The direct cost ($48,000 to Hu) is $90,000 ($135,000 total cost) per year for 3 years.
NIH 1R01AT005522-0110 National Center for Complementary and Alternative Medicine. Chemoprevention of lung cancer with red ginseng extracts. 8/01/09-7/31/13. PI: Ming You (Medical College of Wisconsin), Portion to University of Houston (site PI, Hu), approximately $125,000 per year direct cost (or $187,500 total cost) for four years.
ZinPro Corp. Transport of Amino Acid Metal Complex in the Caco-2 Cell Culture Model 3/1/2011-8/31/2011. PI. M. Hu, $39,518 project direct cost.
NIH 5R21AT004673-02 National Center for Complementary and Alternative Medicine. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects. 8/1/2008-7/31/2011, PI. Nance (Baylor College of Medicine), Ming Hu, co-Investigator (Annual direct cost approximately $26,000 a year for three years).
NIH 5R01AT003203 National Center for Complementary and Alternative Medicine. Chemoprevention of Lung Cancer with Anti-tumor B. 9/30/2007-8/31/2011. PI: Ming You (Medical College of Wisconsin) Ming Hu, co-PI. (Hu’s budget is $125,000 direct cost (or $187,500 total cost) per year, four years.)
ZinPro Corp. Transport of Amino Acid Metal Complex in the Caco-2 Cell Culture Model 10/1/2009-12/31/2010. PI. M. Hu, $26,868 project direct cost.
GCC Pharmacoinformatics Training Grant. Predicting UGT catalyzed metabolism of flavonoids. $31,000 per year for two years, July 1, 2007-June 30, 2009. (M. Hu, Primary Mentor)
Boehringer Ingelheim Pharmaceuticals, Inc. Characterization of BI Compound Absorption Using A Perfused Rat Intestinal Perfusion Model and Caco-2 Cell Culture Model, $100,143 for two awards, November 1, 2007-May 31, 2009, Ming Hu, PI
National Institute of General Medical Sciences (R01GM070737), Disposition of Flavonoids via Recycling. June 1, 2006-May 31, 2008, $298,000, Ming Hu, PI
PDA Foundation. Effects of Pharmaceutical Processing on the Activity and Stability of siRNA. $22,500, January 1, 2007-December 31, 2007, Ming Hu, PI
The Gustavus and Louise Pfeiffer Research Foundation. Biological and Pharmaceutical Considerations in Herbal and Supplemental Product Standardization. $75,000 a year direct cost starting July 1, 2007. Ming Hu, PI
University of Houston, GEAR grant, Improve Bioavailability of Phenolics by Decreasing Metabolism, September 1, 2006-August 31, 2007, $30,000
National Cancer Institute (R01CA087779). Absorption and Metabolism of Isoflavonoids. July 1, 2002-June 30, 2006. $890,051. Ming Hu, PI.
US Pharmacopoeia, Analysis of Red Clover Isoflavone Supplement Products. July 1, 2006-June 30, 2007, $20,000.
US Pharmacopoeia, Red Clover Isoflavones. July 1, 2005-June 30, 2006, $20,000.
University of Houston, GEAR grant, Limiting Bioavailability of Food-Borne Carcinogens with Flavonoid Supplementation, September 1, 2005-August 31, 2006, $25,000
- Rho Chi, Pharmacy Honor Society
- Visiting Professor, Jiangsu Academy of Chinese Medicine, 2004-present
- Visiting Professor, Shenyang Pharmaceutical University, 2011-2014
- Visiting Professor, China Medical University, 2011-2013
- Visiting Professor, Shanghai Institute of Pharmaceutical Industries, Shanghai, China, 2003-2006
- Visiting Professor, National University of Singapore, Singapore, 2001
- Visiting Professor, University of Valencia, Valencia, Spain, 2000
Development and validation of ultra-high-performance liquid chromatography-mass spectrometry method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats. Du T, Sun R, Li L, Ebuzoeme C, Bui D, Zheng Z, Yin T, Liang D, Hu M, Gao S. J Sep Sci. 2020 Dec;43(24):4414-4423. doi: 10.1002/jssc.202000835. Epub 2020 Nov 20. PMID: 33119204
Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo. Rong Y, Tu Y, Yin T, Meng Z, Dou G, Hu M. Arch Toxicol. 2020 Nov;94(11):3737-3749. doi: 10.1007/s00204-020-02867-3. Epub 2020 Sep 11. PMID: 32918091
Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose R. Expert Opin Drug Metab Toxicol. 2020 Nov;16(11):1109-1124. doi: 10.1080/17425255.2020.1815705. Epub 2020 Sep 2. PMID: 32841068
Design and Synthesis of a Novel NIR Celecoxib-Based Fluorescent Probe for Cyclooxygenase-2 Targeted Bioimaging in Tumor Cells. Wang X, Wang L, Xie L, Xie Z, Li L, Bui D, Yin T, Gao S, Hu M. Molecules. 2020 Sep 4;25(18):4037. doi: 10.3390/molecules25184037. PMID: 32899627
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD. Eur J Med Chem. 2020 Aug 15;200:112417. doi: 10.1016/j.ejmech.2020.112417. Epub 2020 May 15. PMID: 32505849
Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: Application to a portal vein infusion study. Tu Y, Zhou L, Li L, Wang L, Gao S, Hu M. Anal Biochem. 2020 Jul 15;601:113723. doi: 10.1016/j.ab.2020.113723. Epub 2020 Apr 13. PMID: 32298642
Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma. Bui D, Li L, Yin T, Wang X, Gao S, You M, Singh R, Hu M. J Agric Food Chem. 2020 Jun 17;68(24):6576-6587. doi: 10.1021/acs.jafc.0c01475. Epub 2020 Jun 4. PMID: 32348135
A novel strategy for screening bioavailable quality markers of traditional Chinese medicine by integrating intestinal absorption and network pharmacology: Application to Wu Ji Bai Feng Pill. Duan S, Niu L, Yin T, Li L, Gao S, Yuan D, Hu M. Phytomedicine. 2020 May 16;76:153226. doi: 10.1016/j.phymed.2020.153226. PMID: 32521487
Flavonoids interference in common protein assays: Effect of position and degree of hydroxyl substitution. Singh R, Lu R, Hu M. Anal Biochem. 2020 May 15;597:113644. doi: 10.1016/j.ab.2020.113644. Epub 2020 Feb 24. PMID: 32105737
Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Zhang L, Zhu L, Qu W, Wu F, Hu M, Xie W, Liu Z, Wang C. Biochem Pharmacol. 2020 Feb;172:113753. doi: 10.1016/j.bcp.2019.113753. Epub 2019 Dec 16. PMID: 31837310
Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib. Yun C, Dashwood WM, Li L, Yin T, Ulusan AM, Shatzer K, Gao S, Ruan KH, Hu M. Inflamm Res. 2020 Jan;69(1):131-137. doi: 10.1007/s00011-019-01300-5. Epub 2019 Dec 3. PMID: 31797003
Potential of herb-drug / herb interactions between substrates and inhibitors of UGTs derived from herbal medicines. Liu D, Zhang L, Duan LX, Wu JJ, Hu M, Liu ZQ, Wang CY. Pharmacol Res. 2019 Dec;150:104510. doi: 10.1016/j.phrs.2019.104510. Epub 2019 Oct 31. PMID: 31678209 Review.
Metabolic profiles of Xiao Chai Hu Tang in mouse plasma, bile and urine by the UHPLC-ESI-Q-TOF/MS technique. Du T, Sun R, Du S, Gao S, Hu M, Zhang Y, Chen J, Yang G. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Oct 1;1128:121767. doi: 10.1016/j.jchromb.2019.121767. Epub 2019 Aug 17. PMID: 31627161
Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Sun R, Basu S, Zeng M, Sunsong R, Li L, Ghose R, Wang W, Liu Z, Hu M, Gao S. Curr Cancer Drug Targets. 2019;19(7):551-560. doi: 10.2174/1568009618666181029153255. PMID: 31509102
Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide. Li Y, Song W, Ou X, Luo G, Xie Y, Sun R, Wang Y, Qi X, Hu M, Liu Z, Zhu L. Drug Metab Dispos. 2019 Mar;47(3):203-214. doi: 10.1124/dmd.118.083493. Epub 2019 Jan 2. PMID: 30602435
An update on polyphenol disposition via coupled metabolic pathways. Wang L, Sun R, Zhang Q, Luo Q, Zeng S, Li X, Gong X, Li Y, Lu L, Hu M, Liu Z. Expert Opin Drug Metab Toxicol. 2019 Feb;15(2):151-165. Review. PMID: 30583703
Interplay of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol. Li Y, Lu L, Wang L, Qu W, Liu W, Xie Y, Zheng H, Wang Y, Qi X, Hu M, Zhu L, Liu Z. Mol Pharm. 2018 Dec 3;15(12):5602-5614.
Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy. Wang W, Qin JJ, Voruganti S, Nijampatnam B, Velu SE, Ruan KH, Hu M, Zhou J, Zhang R. Cancer Res. 2018 Oct 1;78(19):5656-5667. PMID: 30217928
Development and validation of a sensitive LC-MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies. He Y, Zhou L, Gao S, Yin T, Tu Y, Rayford R, Wang X, Hu M. J Pharm Biomed Anal. 2018 Jan 30;148:65-72.
An UPLC-MS/MS method for quantifying tetrandrine and its metabolite berbamine in human blood: Application to a human pharmacokinetic study. Yang G, Zhang C, Hu P, Zhu M, Hu M, Gao S. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Dec 1;1070:92-96. PMID:29100757
Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine. Hu M, Wu B, Liu Z. Mol Pharm. 2017 Sep 5;14(9):2861-2863. PMID: 28870081
Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice. Chen J, Zheng H, Zeng S, Xie C, Li X, Yan T, Gong X, Lu L, Qi X, Wang Y, Hu M, Zhu L, Liu Z. Mol Pharm. 2017 Sep 5;14(9):2967-2976. PMID: 28661152
Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Polyphenolic Acids Impact Safety of Popular Salvianolic Acid A/B-Containing Drugs and Herbal Products. Ma G, Zhang Y, Chen W, Tang Z, Xin X, Yang P, Liu X, Cai W, Hu M. Mol Pharm. 2017 Sep 5;14(9):2952-2966. PMID: 28603997
Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides. Jiang H, Yu J, Zheng H, Chen J, Wu J, Qi X, Wang Y, Wang X, Hu M, Zhu L, Liu Z. Pharm Res. 2017 Jul;34(7):1402-1415. PMID: 28421306
LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine. Xie C, Yan TM, Chen JM, Li XY, Zou J, Zhu LJ, Lu LL, Wang Y, Zhou FY, Liu ZQ, Hu M. Sci Rep. 2017 Jun 20;7(1):3858. PMID: 28634336
High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences. Chen J, Zhu L, Li X, Zheng H, Yan T, Xie C, Zeng S, Yu J, Jiang H, Lu L, Qi X, Wang Y, Hu M, Liu Z. Drug Metab Dispos. 2017 Jun;45(6):624-634. PMID: 28356314
Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Hu Y, Chen M, Wang Z, Lan Y, Tang L, Liu M, Zhao J, Hu M, Zhang L, Ye L. Biomed Chromatogr. 2017 Dec;31(12). PMID: 28557019
Glucuronidation: driving factors and their impact on glucuronide disposition. Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, Liu J, Tu Y, Zhang C, Wei J, Shi J, Zhu L, Liu Z, Wang Y, Gao S, Hu M. Drug Metab Rev. 2017 May;49(2):105-138. PMID: 28266877
Transport-Glucuronidation Classification System and PBPK Modeling: New Approach To Predict the Impact of Transporters on Disposition of Glucuronides. Ge S, Wei Y, Yin T, Xu B, Gao S, Hu M. Mol Pharm. 2017 Sep 5;14(9):2884-2898. PMID: 28221813
Metabolic Disposition of Luteolin Is Mediated by the Interplay of UDP-Glucuronosyltransferases and Catechol-O-Methyltransferases in Rats. Wang L, Chen Q, Zhu L, Li Q, Zeng X, Lu L, Hu M, Wang X, Liu Z. Drug Metab Dispos. 2017 Mar;45(3):306-315. PMID: 28031430
Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data. Ge S, Tu Y, Hu M. Curr Pharmacol Rep. 2016 Dec;2(6):326-338. PMID: 28966903
In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters. Zheng L, Zhu L, Zhao M, Shi J, Li Y, Yu J, Jiang H, Wu J, Tong Y, Liu Y, Hu M, Lu L, Liu Z. AAPS J. 2016 Sep;18(5):1289-99. PMID: 27393480
Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/ß-catenin signaling. Tong Y, Liu Y, Zheng H, Zheng L, Liu W, Wu J, Ou R, Zhang G, Li F, Hu M, Liu Z, Lu L. Oncotarget. 2016 May 24;7(21):31413-28. PMID: 27119499
Determination of 7a-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. Yun C, Yin T, Shatzer K, Burrin DG, Cui L, Tu Y, Hu M. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 1;1025:76-82. doi: 10.1016/j.jchromb.2016.05.005. Epub 2016 May 9. PMID: 27218859
In vitro glucuronidation of methyl gallate and pentagalloyl glucopyranose by liver microsomes. Jiamboonsri P, Pithayanukul P, Bavovada R, Leanpolchareanchai J, Gao S, Hu M. Drug Metab Pharmacokinet. 2016 Aug;31(4):292-303. PMID: 27325020
SGLT-1 Transport and Deglycosylation Inside Intestinal Cells are Key Steps in the Absorption and Disposition of Calycosin-7-O- ß-D-Glucoside in Rats. Shi J, Zheng H, Yu J, Zhu L, Yan T, Wu P, Lu L, Wang Y, Hu M, Liu Z. Drug Metab Dispos. 44(3):283-96, 2016.
Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats. Basu S, Zeng M, Yin T, Gao S, Hu M*. J Chromatogr B Analyt Technol Biomed Life Sci. 1015-1016:34-41, 2016.
Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Wang M, Yang G, He Y, Xu B, Zeng M, Yin T, Gao S, Hu M*. Mol Nutr Food Res. 2016 Sep;60(9):1967-83.
Disposition of Flavonoids via Recycling: Direct Biliary Excretion of Enterically or Extrahepatically Derived Flavonoid Glucuronides. Zeng M, Sun R, Basu S, Ma Y, Ge S, Yin T, Gao S, Zhang J, Hu M*. Mol Nutr Food Res. 2016 May;60(5):1006-19.
Characterization of oxygenated metabolites of ginsenoside Rg1 in plasma and urine of rat. Wang JR, Tong TT, Yau LF, Chen CY, Bai LP, Ma J, Hu M, Liu L, Jiang ZH. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15;1026:75-86.
Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Ge S, Yin T, Xu B, Gao S, Hu, M. Pharm Res. 2016 Mar;33(3):590-602.
Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. Yang G, Gao S, Sun R, Yin T, Hu, M. J Chromatogr B, 2015 Oct 1;1002:13-8.
Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles. Ma Y, Gao S, Hu, M. J Chromatogr B, 1001:202-11, 2015.
Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. Dai P, Luo F, Wang Y, Jiang H, Wang L, Zhang G, Zhu L, Hu, M, Wang X, Lu L, Liu Z. Biopharm Drug Dispos. 2015 Dec;36(9):622-35.
Simultaneous determinations of 17 marker compounds in Xiao-Chai-Hu-Tang by LC-MS/MS: Application to its pharmacokinetic studies in mice. Sun R, Zeng M, Du T, Li L, Yang G, Hu, M, Gao S. J Chromatogr B, 1003:12-21, 2015.
Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4. Liu W, Shi J, Zhu L, Dong L, Luo F, Zhao M, Wang Y, Hu, M, Lu L, Liu Z. Drug Des Devel Ther. 9:5771-83, 2015.
Developing an activity and absorption-based quality control platform for Chinese traditional medicine: Application to Zeng-Sheng-Ping(Antitumor B). Yin T, Yang G, Ma Y, Xu B, Hu, M, You M, Gao S. J Ethnopharmacol. 172:195-201, 2015.
A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. Li Q, Wang L, Dai P, Zeng X, Qi X, Zhu L, Yan T, Wang Y, Lu L, Hu, M, Wang X, Liu Z. J Chromatogr A. 1395:116-28, 2015.
UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes. Zhu L, Lu L, Zeng S, Luo F, Dai P, Wu P, Wang Y, Liu L, Hu, M, Liu Z. Drug Metab Dispos. 43(7):977-83, 2015.
Determination of pharmacokinetics of chrysin and its conjugates in wild-type FVB and Bcrp1 knockout mice using a validated LC-MS/MS method. Ge S, Gao S, Yin T, Hu, M. J Agric Food Chem. 63(11):2902-10, 2015
Triple recycling processes impact systemic and local bioavailability of orally administered flavonoids. Dai P, Zhu L, Luo F, Lu L, Li Q, Wang L, Wang Y, Wang X, Hu, M, Liu Z. AAPS J. 17(3):723-36, 2015
Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method. Yan T, Gao S, Peng X, Shi J, Xie C, Li Q, Lu L, Wang Y, Zhou F, Liu Z, Hu, M. Pharm Res. 32(3):1141-57, 2015.
Characterization of oxygenated metabolites of ginsenoside Rb1 in plasma and urine of rat. Wang JR, Yau LF, Tong TT, Feng QT, Bai LP, Ma J, Hu, M, Liu L, Jiang ZH. J Agric Food Chem. 63(10):2689-700, 2015.
A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. Li Q, Wang L, Dai P, Zeng X, Qi X, Zhu L, Yan T, Wang Y, Lu L, Hu, M, Wang X, Liu Z. J Chromatogr A. 1395:116-28, 2015
The influences of aconitine, an active/toxic alkaloid from aconitum, on the oral pharmacokinetics of CYP3A probe drug buspirone in rats. Zhu L, Lu L, Guo E, Wu J, Wang Y, Hu, M, Liu Z. Drug Metab Lett. 8(2):135-44, 2014
Uptake of polymyxin B into renal cells. Abdelraouf K, Chang KT, Yin T, Hu, M, Tam VH. Antimicrob Agents Chemother. 58(7):4200-2, 2014.
Amino acid facilitates absorption of copper in the Caco-2 cell culture model. S Gao, T Yin, B Xu, Y Ma, Hu, M, Life Sci. 109(1):50-6, 2014.
Comparison of nephrotoxicity rates associated with colistimethate versus polymyxin B therapy: in vitro assessment and a multicenter cohort study. K Phe, Y Lee, PM McDaneld, N Prasad, T Yin, D A Figueroa, W L Musick, J M Cottreau, Hu, M, V H Tam, Antimicrobial Agents and Chemotherapy AAC 02476-13, 2014
In Vitro Assessment and Multicenter Cohort Study of Comparative Nephrotoxicity Rates Associated with Colistimethate versus Polymyxin B Therapy. K Phe, Y Lee, PM McDaneld, N Prasad, T Yin, D A Figueroa, W L Musick, J M Cottreau, Hu, M, V H Tam, Antimicrobial Agents and Chemotherapy 58 (5), 2740-2746, 2014
Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells. Wang JR, Yau LF, Zhang R, Xia Y, Ma J, Ho HM, Hu P, Hu, M, Liu L, Jiang ZH. J Agric Food Chem. 62(12):2558-73, 2014.
Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Antimicrob Agents Chemother. 2014 58(3):1603-14.
Breast Cancer Resistance Protein-Mediated Efflux of Luteolin Glucuronides in HeLa Cells Overexpressing UDP-Glucuronosyltransferase 1A9. Tang L, Li Y, Chen WY, Zeng S, Dong LN, Peng XJ, Jiang W, Hu, M, Liu ZQ. Pharm Res. 31 (4), 847-860, 2014
Absolute Quantification of UGT1A1 in Various Tissues and Cell Lines Using Isotope-free UPLC-MS/MS Method Determines its Turnover Number and Correlates with its Glucuronidation Activities. Xu B, Gao S, Wu B, Yin Y, Hu, M. J Pharm Biomed Anal. 88, 180-190, 2014
In vitro pharmacodynamics of AZD5206 against Staphylococcus aureus. Tam VH, Chang KT, Yang Z, Newman J, Hu, M. Antimicrob Agents Chemother. 57(2):1062-4, 2013.
A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. He J, Gao S, Hu, M, Chow DS, Tam VH. J Antimicrob Chemother. 68(5):1104-10, 2013.
The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone. Zhu L, Yang X, Zhou J, Tang L, Xia B, Hu, M, Zhou F, Liu Z. Food Chem Toxicol. 2013 Jan;51:396-403
The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Ye L, Yang X, Yang Z, Gao S, Yin T, Liu W, Wang F, Hu, M, Liu Z. Toxicol Lett. 2013 Feb 4;216(2-3):86-99
Mutual Regioselective Inhibition of Human UGT1A1-Mediated Glucuronidation of Four Flavonoids. Ma G, Wu B, Gao S, Yang Z, Ma Y, and Hu, M. Mol Pharm, 10, 2891-903, 2013
Revolving Door Action of BCRP Facilitates or Controls the Efflux of Flavone Glucuronides from UGT1A9-Overexpressing HeLa Cells. Wei Y, Wu B, Jiang W, Yin T, Jia X, Basu S, Yang G, and Hu, M. Mol Pharm, 10(5):1736-50, 2013
Chemopreventive effect of a mixture of Chinese herbs (antitumor B) on chemically induced oral carcinogenesis. Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu, M, Lubet RA, and You M. Mol. Carcinogenesis., 52(1):49-56, 2013 PMID: 22086836
Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing. Niu T, Smith DL, Yang Z, Gao S, Yin T, Jiang ZH, You M, Gibbs RA, Petrosino JF, Hu, M. Pharm Res. 30 (3), 836-846, 2013. PMID:23254888
Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. Liu W, Feng Q, Li Y, Ye L, Hu, M, Liu Z. Toxicol Appl Pharmacol. 265(3):316-24, 2012 PMID: 22982073.
Ginsenoside Rb1 Directly Scavenges Hydroxyl Radical and Hypochlorous Acid. Lü JM, Weakley S, Yang Z, Hu, M, Yao Q, Chen C. Curr Pharm Des. 18(38):6339-47, 2012 PMID: 22974003.
A Novel Local Recycling Mechanism That Enhances Enteric Bioavailability of Flavonoids and Prolongs Their Residence Time in the Gut. Xia B, Zhou Q, Zheng Z, Ye L, Hu, M, Liu Z. Mol Pharm, 9(11):3246-58, 2012 PMID:23033922
Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Singh R, Swick MC, Ledesma KR, Yang Z, Hu, M, Zechiedrich L, Tam VH. Antimicrob Agents Chemother. 2012 Apr;56(4):1680-5. PMID: 22232279
Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein. Yang Z, Zhu W, Gao S, Yin T, Jiang W, and Hu, M. Drug Metab Dispos. 40:1883-1893, 2012
Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female Sprague-Dawley rats. Kulkarni KH, Yang Z, Niu T, Hu, M. J Agric Food Chem. 2012 Aug 15;60(32):7949-56 PMID: 22757747
Pharmacokinetics and Renal Disposition of Polymyxin B in an Animal Model. Abdelraouf K, He J, Ledesma KR, Hu, M, Tam VH. Antimicrob Agents Chemother 56(11):5724-7, 2012 PMID:22908162
A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2). Wu B, Jiang W, Yin T, Gao S, Hu, M. Pharm Res. 29(11):3199-208, 2012 Jul 3. PMID:22752253
Characterization of Polymyxin B-induced Nephrotoxicity: Implications for Dosing Regimen Design. Abdelraouf K, Braggs KH, Yin T, Truong LD, Hu M, Tam VH. Antimicrob Agents Chemother. 2012 Sep;56(9):4625-9 doi: 10.1128/AAC.00280-12. Epub 2012 Jun 11. PMID: 22687519
Chemopreventive effect of a mixture of Chinese herbs (antitumor B) on chemically induced oral carcinogenesis. Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, and You M. Mol. Carcinogenesis., 2011 Nov 15. doi: 10.1002/mc.20877. ePub Nov 2011 PMID: 22086836
Inhibition of p-glycoprotein leads to improved oral bioavailability of compound k, an anticancer metabolite of red ginseng extract produced by gut microflora. Yang Z, Wang JR, Niu T, Gao S, Yin T, You M, Jiang ZH, and Hu M. Drug Metab Dispos 40:1538-1544, 2012. PMID: 22584255
CYP3A-dependent Drug Metabolism is Reduced in Bacterial Inflammation in Mice. Gandhi, A, Guo T, Shah P, Moorthy B, Chow D, Hu M, and Ghose, R. Br J. Pharmacol. 2012 Aug;166(7):2176-87. doi: 10.1111/j.1476-5381.2012.01933.x. ePub Feb 2012 PMID: 22394353
Systematic Studies of Sulfation and Glucuronidation of 12 Flavonoids in the Mouse Liver S9 Fraction Reveals both Unique and Shared Positional Preferences. Tang L, Yang CH, Zhou J, Xia BJ, Hu M, Liu ZQ J. Agric. Food Chem. 2012 Mar 28;60(12):3223-33. Epub 2012 Mar 15. Epub 2012 Mar 15. PMID: 22352802
SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies. Meng SN, Wu BJ, Singh R, Yin T, Morrow JK, Zhang S, and Hu M. Mol. Pharm. 2012 Apr 2;9(4):862-73. Epub 2012 Mar 16. PMID: 22352375
Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches. Wu BJ, Singh R, Yin T, Morrow JK, Zhang S, and Hu M. Pharm Res. 2012 Jun;29(6):1544-61. PMID: 22302521
Development and validation of a highly sensitive ULPC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetic study of aconitine, mesaconitine, and hypaconitine. Ye L, Gao S, Liu W, Yang Z, Hu M and Liu, ZQ. Xenobiotica 2012 Jun;42(6):518-25. doi: 10.3109/00498254.2011.641608. Epub 2011 Dec 22. PMID:22188409
Systematic Studies of Sulfation and Glucuronidation of 12 Flavonoids in the Mouse Liver S9 Fraction Reveals both Unique and Shared Positional Preferences. Tang L, Yang CH, Zhou J, Xia BJ, Hu M, Liu ZQ J. Agric. Food Chem. 2012 Mar 28;60(12):3223-33. doi: 10.1021/jf201987k. Epub 2012 Mar 15.
UGT1A9-overexpressing HeLa Cells Is a Appropriate Tool to Delineate the Kinetic Interplay between BCRP and UGT and to Rapidly Identify the Glucuronide Substrates of BCRP. Jiang W, Xu B, Wu B, Yu R, Hu M, Drug Metab. Disp., 2012 Feb;40(2):336-45. doi: 10.1124/dmd.111.041467. Epub 2011 Nov 9.
UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Jiang W, Xu B, Wu B, Yu R, Hu M, Drug Metab. Disp., 40(2):336-45, 2012. Epub 2011 Nov 9. PMID: 22071170
Evaluation of 3,3’,4’-trihydroxyflavone and 3,6,4’-trihydroxyflavone (4’-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1. Wu B, Zhang SX, Hu M. Mol. Pharm.2011 Dec 5;8(6):2379-89. Epub 2011 Oct 21. PMID: 21985641
Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. Ye L, Tao W, Tang L, Liu W, Yang Z, Zhou J, Zheng Z, Cai Z, Hu M, Liu, Z, J. Pharm. Sci. 2011 Nov;100(11):5007-17. doi: 10.1002/jps.22693. Epub 2011 Jun 30. PMID: 21721007
Enhancement of oral bioavailability of ginsenoside 20(s)-Rh2 through improved understanding of its absorption and efflux mechanisms. Yang Z, Gao S, Wang J, Yin T, Teng Y, Wu B, You M, Jiang ZH, and Hu M. Drug Metab. Disp., 39:1866-72, 2011. PMID: 21757611
In-vitro potency of various polymyxin B components. Tam VH, Cao H, Ledesma KR, Hu M. Antimicrob Agents Chemother. 2011 Sep;55(9):4490-1. Epub 2011 Jun 27. PMID: 21709096
Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms. Wu B, Xu B, Hu M. Pharm Res. 2011 Aug;28(8):1905-18. Epub 2011 Apr 7. PMID: 21472492
Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison. Yang CH, Tang L, Lv C, Ye L, Xia BJ, Hu M, Liu ZQ. J Pharm Pharmacol. 2011 Jul; 63 (7) :967-70.
Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: Application to pharmacokinetic and disposition studies. Gao S, Yang Z, Yin T, You M, Hu M. J Pharm Biomed Anal. 55(2):288-93, 2011.
Uridine Diphosphate Glucuronosyltransferase Isoform-Dependent Regiospecificity of Glucuronidation of Flavonoids. Singh R, Wu B, Tang L, Hu M., J. Agric. Food Chem., 59(13):7452-64, 2011
3D-QSAR Studies on UGT1A9-mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-based CoMFA Model. B. Wu, J. Morrow, R. Singh, S. Zhang, and M. Hu. J Pharmacol Exp Ther. 336(2):403-13, 2011.
Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Chen Y, Wang J, Jia X, Tan X, Hu M. Molecules. 16(2):1336-48, 2011.
Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide. Liu W, Zheng Z, Liu X, Gao S, Ye L, Yang Z, Hu M, Liu Z. J Pharm Biomed Anal. 2011 Apr 5;54(5):1157-62.
Disposition of Flavonoids Impacts their Efficacy and Safety. Yong MA, Zeng M, Sun R, Hu, M. Curr Drug Metab. 15(9):841-64, 2014.
Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobiotics. W Liu, K Kulkarni, Hu, M, Expert opinion on drug metabolism & toxicology, 9 (12), 1555-1569, 2013
Microbiota Structures, Human Health and Cancer Chemoprevention. Niu T, Hu M Progress in Chemistry, 25, 1602-1613, 2013
Oral Bioavailability Challenges of Natural Products Used in Cancer Chemoprevention, Gao S, Basu S, Yang G, Deb A, Hu, M. Progress in Chemistry, 25, 1554-1575, 2013
Quantitative prediction of glucuronidation in humans using the in vitro- in vivo extrapolation approach. Wu B, Dong D, Hu, M, Zhang S. Curr Top Med Chem. 2013;13(11):1343-52.
Bioavailability Challenges Associated with Development of Saponins as Therapeutic and Chemopreventive Agents. Gao S, Basu S, Yang Z, Deb A, Hu, M. Curr Drug Targets. 2012
Oral Bioavailability: Basic Principles, Advanced Concepts and Applications (Hu M and Li XL editors, 1st Ed.). July, 2011
Book Chapters & Reviews (since 2004)
Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways. Jiang, W and Hu, M. RSC Adv., 2012, 2, 7948-7963
Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME. Yang Z, Kulkarni K, Zhu W, Hu M. Anticancer Agents Med Chem. 2012 May 2. PMID: 22583407
Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes. Dong D, Ako R, Hu M, Wu B. Xenobiotica. 2012 Mar 2 PMID: 22385482
Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Dong D, Wu B, Chow D, Hu M. Drug Metab Rev. 2012 Jan 18 PMID:22251142
Caco-2 Cell Culture Model for Oral Drug Absorption. K Kulkarni and M Hu , in “Oral Bioavailability: Basic Principles, Advanced Concepts and Applications (Hu M and Li XL editors, 1st Ed.). July, 2011
Amino Acid Drug Transporters. Z. Liu and M. Hu, in “Oral Bioavailability: Basic Principles, Advanced Concepts and Applications (Hu M and Li XL editors, 1st Ed.). July, 2011
Drug Metabolism in Gastrointestinal Track. R. Singh and M. Hu, in “Oral Bioavailability: Basic Principles, Advanced Concepts and Applications (Hu M and Li XL editors, 1st Ed.). July, 2011
Barriers to Oral Bioavailability: An Overview. M. Hu and X. Li, in “Oral Bioavailability: Basic Principles, Advanced Concepts and Applications (Hu M and Li XL editors, 1st Ed.). July, 2011
Regioselective Sulfation and Glucuronidation of Phenolics: Insights into the Structural Basis of Conjugation. Wu B, Basu D, Meng S, Wang X, Zhang S, Hu M. Curr Drug Metab. 12(9):900-16, 2011 PMID: 21933112
First-pass metabolism via UDP-glucuronosyltransferases: a barrier to oral bioavailability of phenolics. B. Wu, K. Kulkarnia, S. Zhang, M. Hu, J. Pharm. Sci., 100(9):3655-81, 2011 PMID: 21484808
Bioavailability Challenges Associated with Development of Anti-Cancer Phenolics. S. Gao, M. Hu, Mini Rev Med Chem. 10 (6): 550-567, 2010
Oral Absorption Basics: Pathways, Physicochemical and Biological Factors, and Methods of Study. Z. Liu, S. W.J. Wang, and M. Hu in “Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice” (Y. Qiu, Y. Chen, G. G.Z. Zhang, L. Liu, W. Porter Eds.), Academic Press, 2008
Commentary: Bioavailability of Flavonoids and Polyphenols: Call to Arms, M. Hu, Mol Pharm. 4(6):803-6, 2007
Natural Polyphenol Disposition via Coupled Metabolic Pathways. Z. Liu, M. Hu, Expert Opinion in Drug Metabolism, 3, 389-406, 2007
Coupling of Conjugating Enzymes and Efflux Transporters: Impact on Bioavailability and Drug Interaction, E.J. Jeong, X. Liu, X. Jia. J. Chen, M. Hu. Curr. Drug Metab., 6, 455-468, 2005
In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism. E. J. Jeong, Y. Liu, H. Lin, M. Hu, in “Optimization in Drug Discovery: In Vitro Methods” (Z. Yan and GW Caldwell eds.) Humana Press, pp.69-76, 2004
The Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism. M. Hu, J. Lin, H. Lin, J. Chen, in “Optimization in Drug Discovery: In Vitro Methods” (Z. Yan and GW Caldwell eds.) Humana Press, pp.19-35, 2004
Taking Advantages of First-Pass Metabolism for Designing Colon-Bioavailable Drugs. Fudan University, School of Pharmacy Shanghai, China (2016)
Dysregulation of CYPs In Human Liver Cancer: Possible Biological and Therapeutic Implications, Jiaotong University, College of Medicine, Shanghai, China (2016)
Use of Mechanistic Approaches to Search for Chinese Medicinal Herbal Formula that Reduce Irinotecan-Induced Late Onset Diarrhea. World Federation of Chinese Medicine Societies 10th Annual Research Meeting. Xi’an, China (2015)
Translational Medicine and Its Application at Hubei University of Medicine. Hubei, China(2014)
Membrane Transporters for Drugs. Guangzhou University of Chinese Medicine. International Institute for Translational Chinese Medicine. Guangzhou, China (2014)
Prediction of Flavonoid Glucuronidation: Promises, Progresses and Problems. World Federation of Chinese Medicine Societies 9th Annual Research Meeting. Guangzhou, China (2014)
Prediction of Glucuronidation: Progresses and Challenges, Lanzhou General Hospital, Lanzhou, Gansu, China (2014)
Understanding Oral Bioavailability Challenges. China Eastern Normal University, School of Biological Sciences, Shanghai, China (2014)
Prediction of Glucuronidation: Progresses, Promises and Problems, School of Pharmacy, Fudan University, Shanghai, China (2014)
Scientific Research: Topics, Development and Design (A Conversation with Future Scientists). Hubei University of Chinese Medicine. Shiyan, Hubei, China (2014)
Prediction of Glucuronidation: Promises, Progresses and Problems, School of Pharmacy, Sun-Yat Sen University, School of Pharmacy, Guangzhou, China (2014)
Understanding Oral Bioavailability Challenges Associated With Poorly Soluble Compounds That Are Also Effluxed or Metabolized, AAPS Chicagoland Pharmaceutical Discussion Group, North Chicago, IL (2013)
Prediction of Glucuronidation Progresses, Promises and Problems, Fudan University, School of Pharmacy, Shanghai, China (2013)
Oral Bioavailability Barriers to Chemopreventive Agents. Xiangshan Scientific Meeting, Chinese Academy of Sciences, Beijing, China (2013)
Exploring the Interactions between Microbiome and Ginseng. Jinan University, College of Pharmacy, Guangzhou, China (2013)
Marching Toward Prediction of Glucuronidation of Phenolics In Vivo Bristol-Myers Squibb, Princeton, New Jersey (2013)
Disposition of Phenolics via Glucuronidation: Progresses and Challenges. Sun Yan-Sen University College of Pharmacy, Guangzhou, China (2013)
Dual Roles of BCRP in Disposition of Flavonoids and Chemopreventive Phenolics. Mechanism Based Natural Product Development Conference. Vancouver, British Columbia, Canada (2012)
Development of Wudang-Based Herbal Drugs for Lung Cancer Prevention and Treatment. Hubei University of Medicine, Shiyan, Hubei, China (2012)
Ginsenosides and Gut Microbiome: Mutually Beneficial Interactions? Peking University Centennial Lecture Series, Beijing, China (2012)
Manipulating Intestinal Microbiome for Bioavailability Improvement. Macau University of Science and Technology, Macau, China (2012)
Marching Toward Prediction of Glucuronidation of Phenolics In Vivo. University of Michigan, College of Pharmacy, Ann Arbor, Michigan, USA (2012)
Prediction of Glucuronidation Promises, Progresses and Problems. China Pharmaceutical University, Nanjing, China (2012)
Manipulating Intestinal Microbiome By Chinese Medicinal Herbs. Jiangsu Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, China (2012)
Computational Modeling of UGT for Better Prediction of Its Functionality and Structure. Controlled Release Society, China Section, Shanghai, China (2011)
Computational Modeling of UGT for Better Prediction of Its Functionality and Structure. China Medical University, Shenyang, China (2011)
In Search of Herbal-Based Chemopreventive Agents. Hainan Haikou Hospital, Haikou, Hainan, China (2011)
Computational Modeling of UGT for Better Prediction of Its Functionality and Structure. Shenyang Pharmaceutical University, Shenyang, China (2011)
Permeability and Transport of Sorafenib, Sunitinib, Pazopanib and Axitinib in Caco-2 Cells: Implication for Combination Therapies. Yu He, Taijun Yin and Ming Hu, 2015 American Association of Pharmaceutical Scientists Annual Meeting. Orlando, FL. (2015)
Nano-formulation approach alters pharmacokinetics of genistein; Manas Gupte, Ming Hu, 2015 American Association of Pharmaceutical Scientists Annual Meeting. Orlando, FL. (2015)
The Role of Breast Cancer Resistance Protein (BCRP) in Disposition of Phenolics via Glucuronidation. Shufan Ge, Song Gao, Taijun Yin and Ming Hu, 2015 American Association of Pharmaceutical Scientists Annual Meeting. Orlando, FL (2015)
Curcumin Affects Phase II Disposition of Resveratrol through Inhibiting Efflux Transporters MRP2 and BCRP. Shufan Ge, Song Gao, Taijun Yin, and Ming Hu, 2015 American Association of Pharmaceutical Scientists Annual Meeting. Orlando, FL. (2015)
Locally Bioavailable COX-2 Inhibitors for Colon Cancer Prevention. Yong Ma, Song Gao, and Ming Hu, A Tribute to Ronald T. Borchardt – Teacher, Mentor, Scientist, Colleague, Leader and Friend. Lawrence, KS. (2015)
Perfusion with Celecoxib Decelerates the Rates of PGE2 Production in 2,4,6-Trinitrobenzenesulfonic Acid (TNBS)-treated Rat Colon. Yong Ma, Song Gao, and Ming Hu, The Texas Medical Center Digestive Diseases Center 6th Annual Frontiers in Digestive Diseases Symposium, Houston, TX. (2015)
Nanoformulation Approach to Improve CNS Delivery of Genistein and Its Subsequent Quantification in the Brain Tissue. Manas Gupte and Ming Hu. American Association of Pharmaceutical Scientists Annual Meeting, San Diego, CA. (2014)
Determination of Pharmacokinetics of Chrysin and Its Conjugates in FVB Wild-Type and Bcrp1 Knockout Mice Using a Validated LC-MS/MS Method. Shufan Ge, Song Gao, Taijun Yin, and Ming Hu. American Association of Pharmaceutical Scientists Annual Meeting, San Diego, CA. (2014)
Development of a Modified Intestinal Perfusion Model for the Determination of Relative Contribution of Intestine vs Liver in the Disposition of Genistein. Min Zeng, Sumit Basu, Taijun Yin, and Ming Hu. American Association of Pharmaceutical Scientists Annual Meeting, San Diego, CA. (2014)
Pharmacokinetics Study of Celecoxib and Its Metabolites in Rat Blood by LC-MS/MS: Neglected Drug Distribution in the Blood Cells. Yong Ma, Song Gao, and Ming Hu. American Association of Pharmaceutical Scientists Annual Meeting, San Diego, CA. (2014)
Transporter mediated disposition of intravenous infused CPT-11 in rats by three major metabolic organs: liver, kidney and intestine. Sumit Basu, Min Zeng, Taijun Yin and Ming Hu. AAPS Annual Meeting and Exposition, San Diego, CA. (2014)
In Vitro Characterization of Tyrosine Kinase Inhibitors Interactions with Efflux and Uptake Transporters. Yu He and Ming Hu. AAPS Annual Meeting and Exposition, San Diego, CA. (2014)
In Vitro Intestinal Absorption of Three Phenolic Principles in Thai Mango Seed Kernel Extract Across the Caco-2 Cell Monolayer. Pimsumon Jianboonsri, Pimolpan Pithayanukul, and Ming Hu. AAPS Annual Meeting and Exposition, San Antonio, TX. (2013)
Determination of Dinoprostone (PGE2) Concentrations in Human Blood by Liquid-Liquid Extraction and UPLC-MS/MS Quantification. Yong Ma and Ming Hu. AAPS Annual Meeting and Exposition, San Antonio, TX. (2013)
Purification and Characterization of a Ginsenoside Hydrolyzing Bacterial ß-glucosidase from A/J Mouse Feces. Tao Niu and Ming Hu. AAPS Annual Meeting and Exposition, San Antonio, TX. (2013)
Inactivation of Active Toxic Metabolite of Anticancer Drug Irinotecan by Plant UGT Enzyme Expressed E. coli: An In Vitro and In Vivo Study. Sumit Basu and Ming Hu. AAPS Annual Meeting and Exposition, San Antonio, TX. (2013)
Determination of (-)-epigallocatechin-3-gallate in human urine by a sensitive and robust SPE-UPLC-MS/MS method and its application to the anti-HIV-1 studies of (-)-epigallocatechin-3-gallate in human. Tao Niu, Baojian Wu, Rosa Yeh and Ming Hu, AAPS Annual Meeting and Exposition, Chicago, IL. (2012)
An UPLC-MS Fingerprint Method to Characterize the Prunella Vulgaris. Song Gao, Taijun Yin, and Ming Hu. AAPS Annual Meeting and Exposition, Chicago, IL. (2012)
Drug Detoxifying Bacteria: A New Strategy to Reduce Anticancer Drug Toxicity. Sumit Basu and Ming Hu. AAPS Annual Meeting and Exposition, Chicago, IL. (2012)
Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) 1A1 in human tissues and various human cell lines using LC-MS/MS. Beibei Xu, Song Gao, Baojian Wu, Taijun Yin and Ming Hu. AAPS annual meeting and exposition, Chicago IL. (2012)
Effects of Breast Cancer Resistance Protein (BCRP) on the Disposition of Wogonin in Caco-2 cells, Engineered HeLa cells and FVB mice. Wen Jiang and Ming Hu. AAPS Annual Meeting and Exposition, Washington D.C. (2011)
Role of UGT1A and Mrp2 on pharmacokinetics and disposition of genistein in rats following oral administration. Kaustubh Kulkarni, Zhen yang, Tao Niu, Song Gao and Ming Hu. AAPS Annual Meeting and Exposition, New Orleans, LA. (2011)
Characterization of Stepwise Metabolism of Ginsenosides Rb1 in Mouse Intestinal Microbiota. Tao Niu, Song Gao, Zhen Yang, Ming Hu. AAPS Annual Meeting and Exposition, Washington DC. (2011)
Comparison of Resokaempferol metabolism by selected Human UGTs and relevant Plant UGTs. Sumit Basu, Baojian Wu, Ming Hu. AAPS Annual Meeting and Exposition, Washington D.C. (2011)
Evaluation of 3,3’,4’-trihydroxyflavone and 3,6,4’-trihydroxyflavone (4‘-O-glucuronidation) as the in vitro functional marker for hepatic UGT1A1. Baojian Wu, Shuxing Zhang, Ming Hu. AAPS Annual Meeting and Exposition, Washington DC. (2011)
Role of p-glycoprotein in the efflux of ginsenosides in Caco-2 cells and MDR1 knockout mice. Zhen Yang, Song Gao, Taijin Yin, Jingrong Wang, Zhihong Jiang, Ming Hu. AAPS Annual Meeting and Exposition, Washington, D.C. (2011)
- Editorial Board Member, Molecular Pharmaceutics
- Editorial Board Member, Pharmaceutical Research
- Editorial Board Member, Journal of Clinical Pharmacology
- Editorial Board Member, Current Drug Targets
- Editorial Board Member, Journal of Alternative and Complementary Medicine
- Editorial Board Member, Drug Metabolism Letters
- Editorial Board Member, Chinese Journal of Pharmaceutical Sciences
- Editorial Board Member, Asia Journal of Pharmaceutical Sciences
- Journal Reviewer (ad hoc): American Chemical Society Book Series, Biopharmaceutics and Drug Metabolism, British Journal of Nutrition, British Journal of Pharmacology, Carcinogenesis, Comparative Biochemistry and Physiology, Current Drugs Ltd, Current Drug Metabolism, Drug Metabolism and Disposition, European Journal of Pharmaceutical Sciences, Gastroenterology, Biochemical Pharmacology, International Journal of Pharmaceutics, Journal of Agricultural and Food Chemistry, Journal of Biochemical and Molecular Toxicology, Journal of Chromatogram B, Journal of Controlled Release, Journal of Natural Products, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmaceutical Sciences, Journal of Pharmacology and Experimental Therapeutics, Life Science, Molecular Nutrition and Food Research, Molecular Pharmaceutics, Molecular Pharmacology, Pharmaceutical Research, PLOS One
- American Society of Pharmacology and Experimental Therapeutics
- American Association of Pharmaceutical Scientists
- American Chemical Society
- National Center for Complementary and Alternative Medicine, Mechanistic Research on CAM Natural Products (RFA AT11-001) (2011, 2013)
- National Institutes of Health, Translational Clinical Small Business SBIR/STTR, Cancer Drug Development and Therapeutics (CDDT) (2012)
- National Center for Complementary and Alternative Medicine, Botanical Research Center (2009, 2010)
- National Science Foundation of China, Reviewer, Key Projects in Pharmacology and Pharmaceutics (2005, 2006)
- National Science Foundation of China, Council Member, Pharmacology and Pharmaceutics (2005, 2006)
- National Institute of Ageing. P01 Grant Review, University of Illinois at Champaign-Urbana (2004)
- National Cancer Institute, Small Grant Program in Cancer Prevention (2003)
- National Cancer Institute, NCI FLAIR program (PA-01-091) (2003)
- National Institutes of Health, Chemo/Dietary Prevention Study Section (ad hoc 2003-2005) (Permanent 2005-2008)
- National Institutes of Health, Metabolic Pathology Study Section (ad hoc member 2003)
- National Cancer Institute: Special Emphasis Panel (RFA-CA-03-003) Molecular Targets for Nutrients in Prostate Cancer Prevention (Nov. 2002)
- National Science Foundation (May 2002)
- U.S. Civilian Research and Development Foundation (2001)
- American Institute of Biological Sciences (1992, 1994)