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Faculty Profile

Ming HuMing Hu

Professor of Pharmaceutics
Diana S-L. Chow Endowed Professor of Drug Discovery and Development
Department of Pharmacological and Pharmaceutical Sciences

Office: Health 2
University of Houston College of Pharmacy
4849 Calhoun, Room 7047
Houston, TX 77204-5037

Contact: mhu@uh.edu - Office: 832-842-8320 - Fax: 713-743-1884

Research:

My laboratory study how bioavailability impact safety and efficacy of drugs, micronutrients and endogenous compounds. We utilize a variety of in vitro and in vivo models including microsomes, cells overexpressing enzymes, Caco-2 cells, rat intestinal perfusion, and small animals. We train scientists to work in pharmaceutical and biotech industries and academic labs.

  • Sabbatical Leave at Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland
  • Postdoctoral Training, Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas
  • Ph.D. in Pharmaceutics, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan
  • B.S. in Pharmacy, Shanghai First Medical College, Shanghai, The People's Republic of China

Google Scholar Profile
  • Hepatoenteric Recycling Is A New Disposition Mechanism for Orally Administered Phenolic Drugs and Phytochemicals in Rats, eLife, 2021, 11-05-2020-RA-eLife-58820R3 accepted
  • Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib. Yun C, Dashwood WM, Li L, Yin T, Ulusan AM, Shatzer K, Gao S, Ruan KH, Hu M. Inflamm Res. 69(1):131-137, 2020
  • A novel strategy for screening bioavailable quality markers of traditional Chinese medicine by integrating intestinal absorption and network pharmacology: Application to Wu Ji Bai Feng Pill. Duan S, Niu L, Yin T, Li L, Gao S, Yuan D, Hu M. Phytomedicine. 76:153226, 2020
  • Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. Yun C, Dashwood WM, Kwong LN, Gao S, Yin T, Ling Q, Singh R, Dashwood RH, Hu M*. J Pharm Biomed Anal. 148:42-50, 2018
  • Transport-Glucuronidation Classification System and PBPK Modeling: New Approach to Predict the Impact of Transporters on Disposition of Glucuronides. S Ge, Y Wei, T Yin, B Xu, S Gao, and M Hu*. Mol Pharmaceutics, 14(9):2884-2898, 2017
  • Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Wang M, Yang G, He Y, Xu B, Zeng M, Yin T, Gao S, Hu M*. Mol Nutr Food Res. 60(9):1967-83, 2016
  • Developing an activity and absorption-based quality control platform for Chinese traditional medicine: Application to Zeng-Sheng-Ping (Antitumor B). Yin T, Yang G, Ma Y, Xu B, Hu M, You M, Gao S. J Ethnopharmacol. 172:195-201, 2015
  • Absolute Quantification of UGT1A1 in Various Tissues and Cell Lines Using Isotope-free UPLC-MS/MS Method Determines its Turnover Number and Correlates with its Glucuronidation Activities. Xu B, Gao S, Wu B, Yin Y, Hu M*. J Pharm Biomed Anal. 88, 180-190, 2014
  • Revolving Door Action of BCRP Facilitates or Controls the Efflux of Flavone Glucuronides from UGT1A9-Overexpressing HeLa Cells. Wei Y, Wu B, Jiang W, Yin T, Jia X, Basu S, Yang G, and Hu M*. Mol Pharm, 10(5):1736-50, 2013
  • Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing. Niu T, Smith DL, Yang Z, Gao S, Yin T, Jiang ZH, You M, Gibbs RA, Petrosino JF*, Hu M*. Pharm Res. 30 (3), 836-846, 2013
  • UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Jiang W, Xu B, Wu B, Yu R, Hu M*. Drug Metab Dispos. 40(2):336-45, 2012
  • Absorption and Metabolism of Flavonoids in the Caco-2 Cell Culture Model and a Perfused Rat Intestinal Model. Y. Liu and M. Hu*, Drug Metab Dispos. 30(4):370-7, 2002
  • Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition. J. Chen, H. Lin, M. Hu*, J Pharmacol Expt Therap. 304: 1228-1235, 2003
  • Oral Bioavailability: Basic Principles, Advanced Concepts and Applications (Hu M and Li XL editors, 1st Ed.). July, 2011 Wiley and Son
  • Commentary: Bioavailability of Flavonoids and Polyphenols: Call to Arms, M. Hu*, Mol Pharm. 4(6):803-6, 2007 PMID:18052085

Awards & Honors

  • Rho Chi Pharmacy Honor Society
  • Visiting Professor, University of Valencia, Valencia, Spain, 2000
  • Visiting Professor, National University of Singapore, Singapore, 2001
  • Visiting Professor, Shanghai Institute of Pharmaceutical Industries, Shanghai, China, 2003-2006
  • Visiting Professor, Jiangsu Academy of Chinese Medicine, 2004-2007
  • Visiting Professor, China Medical University, 2011-2013
  • Visiting Professor, Shenyang Pharmaceutical University, 2011-2014