Profile: Richard Bond

Richard Bond
Richard A. Bond, Ph.D.
Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
University of Houston College of Pharmacy
521E Science and Research Building 2
Houston, TX 77204-5037

RABond@uh.edu
713-743-1210 (phone)
713-743-1229 (fax)

Education

B.A. Science, St. Thomas of Villanova, Miami, Fla.
B.S. Pharmacy, University of Houston College of Pharmacy, Houston, Texas
Ph.D. Pharmacology, University of Houston College of Pharmacy, Houston, Texas

Research Interests

  • Pharmacology of receptor theory
  • Characterization and classification of G protein-coupled receptors

Patents

U.S. Patent No. 7,528,175: Method of treating airway diseases with beta-adrenergic inverse agonists. Awarded May 5, 2009.

Awards & Honors

  • Commendation, Medical Futures Innovation Awards, 2011
  • Faculty Excellence Award, University of Houston College of Pharmacy, 2000 and 1995.
  • Established Investigator’s Award, American Heart Association, 1999.
  • Named one of the 100 Most Influential Hispanics by Hispanic Business magazine, 1997.
  • One of University of Houston College of Pharmacy’s 50 Outstanding Alumni celebrating the College's 50th Anniversary, 1997.
  • Teaching Award from Council of Campus Leaders, University of Houston, 1995.

Courses

  • PCOL 6470 Advanced Pharmacology
  • PCOL 7350 Cellular Pharmacology
  • Pharmacology I
  • Skills Laboratory

Peer-reviewed Publications

Nguyen LP, Singh B, Okulate AA, Alfaro VY, Tuvim MJ, Dickey BF, Bond RA. Complementary anti-inflammatory effects of a β-blocker and a corticosteroid in an asthma model. Naunyn Schmiedebergs Arch Pharmacol. 2011 Oct 2. [Epub ahead of print]

Peng H, Bond RA, Knoll BJ. The effects of acute and chronic nadolol treatment on β2AR signaling in HEK293 cells. Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb;383(2):209-16. Epub 2011 Jan 12.

Walker JK, Penn RB, Hanania NA, Dickey BF, Bond RA. New perspectives regarding β(2)-adrenoceptor ligands in the treatment of asthma. Br J Pharmacol. 2011 May;163(1):18-28. doi: 10.1111/j.1476-5381.2010.01178.x. Review.

Hanania NA, Mannava B, Franklin AE, Lipworth BJ, Williamson PA, Garner WJ, Dickey BF, Bond RA. Response to salbutamol in patients with mild asthma treated with nadolol. Eur Respir J. 2010 Oct;36(4):963-5.

Dickey BF, Walker JK, Hanania NA, Bond RA. beta-Adrenoceptor inverse agonists in asthma. Curr Opin Pharmacol. 2010 Jun;10(3):254-9. Review.

Hanania, N.A., Dickey, B.F. and Bond, R.A.: Clinical Implications of the Intrinsic Efficacy of Beta-Adrenoceptor Drugs in Asthma: Full, Partial and Inverse Agonism. Current Opinion in Pulm Med, 16: 1-5, 2010.

Nguyen, L., Lin, R., Omoluabi, O., Hanania, N., Tuvim, M., Knoll, B., Dickey, B.F., Bond, R.A.: βß2-adrenoceptor signaling is required for the development of the asthma phenotype in a murine model. Proc. Nat. Acad. Sci. 101: 4948 – 4953, 2009.

Nguyen, L., Omoluabi, Parra, S., Frieska, J.M, Clement, C., Ammar-Aouchiche, Z., Ho, S.B., Ehre, C., Kessimer, M., Knoll, K.J., Tuvin, M., Dickey, B.F. and Bond, R.A.: Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol. 38: 256-262, 2008.

Hanania, N.A, Singh, S., Eli-Wali, R., Flasner, M., Franklin, A.E., Garner, W.J., Parra, S., Ruoss, S.J., Shardonofsky, F., O’Connor, B.J., Page, C. and Bond, R.A.: The safety and effects of the beta-blocker, nadolol, for the chronic treatment of asthma; an open-label pilot study. Pulmonary Pharmacol. & Ther. 21: 134–141, 2008.

Lin, R., Peng, H., Nguyen, L., Dudekula, N.B., Shardonofsky, F., Knoll, B., Parra, S. and Bond, R.A.: Changes in ß2-adrenoceptors and other signaling proteins produced by chronic administration of ‘ß-blockers’ in a murine asthma model. Pulmonary Pharmacol. & Ther. 21: 115–124, 2008.

Bond, R.A., Spina, D., Parra, S. and Clive, C.P. (2007). Getting to the heart of asthma; can ‘beta-blockers’ be used to treat asthma? Pharmacol & Ther.. 115: 360-374, 2007.

Parra, S. and Bond, R.A.: Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant? Current Opinions Pharmacol., 7: 146-150, 2007.

Bond, R.A.: A proposal for a national program reporting beneficial drug responses, analogous to the existing program to detect adverse drug responses. Med. Hypoth. 66: 10-13, 2006.

Bond, R.A. and IJzjerman, A.P.: Recent developments in constitutive receptor activity and inverse agonism and their potential for drug discovery. Trends Pharmacol. Sci., 2: 92 – 96, 2006.

Dudekula, N., Arora, V., Callaerts-Vegh, Zs. and Bond, R.A.: The temporal hormesis of drug therapies. Dose-Response 3: 414-424, 2005.

Invited Publications

Bond RA, Giles H. For the love of paradox: from neurobiology to pharmacology. Behav Pharmacol. 2011 Sep;22(5-6):385-9.

Bond RA, Spina D. Special issue of BJP on respiratory pharmacology. Br J Pharmacol. 2011 May;163(1):1-3. doi: 10.1111/j.1476-5381.2011.01239.x.

Michel MC, Harding SE, Bond RA. Are there functional β₃-adrenoceptors in the human heart? Br J Pharmacol. 2011 Feb;162(4):817-22. doi: 10.1111/j.1476-5381.2010.01005.x. Review.

Charlton SJ, Bond RA. BJP issue on drug discovery. Br J Pharmacol. 2010 Nov;161(6):1201-2. doi: 10.1111/j.1476-5381.2010.01028.x.

McGrath JC, Bond RA. Sir James Black (1924-2010). Br J Pharmacol. 2010 Jul;160 Suppl 1:S2.

Bond, R.A., Omoluabi, O. And Nugyen, L.: Beta-blockers and beta-agonists in asthma – unraveling a paradox. Resp. Drug Delivery 1: 15 – 24, 2009.

Bond, R. A., Parra, S., Hills, R. A., Bylund, D. B., Bouvier, M., Clarke, D. E., Eikenberg, D. C., Hieble, J. P., Koblika, B. K., Langer, S. Z., Lefkowitz, R. J., Minneman, K. P., Ruffolo, R. R. and Strosberg, A. D.: Adrenoceptors - beta(3), IUPHAR Receptor database. (doi: 10.1786/304416402524). Also, middle author on remaining 8 adrenoceptor classifications. 2005.

Book Chapters

Bond, R.A. and Lefkowitz, R.J.: Historical background and introduction. G protein-coupled receptors as drug targets: Analysis of activation and constitutive activity. Ed. T. Weiland and R. Seifert. Wiley-VCH. 2006.

Bond, R.A., Evans, K.J. and Callaerts-Vegh, Zs.: From inverse agonism to paradoxical pharmacology. Ed. A.P. Ijzerman. Inverse Agonism.  Elsevier Science. 10: 27-37, 2003

Bond, R.A., Milligan, G. and Bouvier, M.:  Inverse Agonism. For Handbook of Experimental Pharmacology, Volume:  "The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems", Ed. T. Kenakin and J. Angus, 2001.

Abstracts

Hui Peng, Brian Knoll, Richard A. Bond. Novel effects of nadolol on desensitization and heterologous sensitization systems. IUPHAR (2006), Beijing, China.

Rui Lin, Sergio Parra, Vikas Arora, Becky Chan, Joanna Frieske, Brian Knoll, Richard A. Bond. Potential mechanisms of the beneficial effect of chronic nadolol treatment in a murine model of asthma. IUPHAR (2006), Beijing, China.

Sergio Parra, Carlos Rodriguez, Rui Lin, Zoma Omoluabi, Joanna Frieske, Felix Shardonofsky, Brian Knoll, Richard A. Bond. Muscarinic M2 receptors modulate airway responses to methacholine in a murine model of asthma. IUPHAR (2006), Beijing, China.

Invited Lectures

New GPCR and cAMP (or are they cAMP?) paradigms: pathophysiological and therapeutic relevance. BPS focused symposium “Novel cAMP signaling paradigms: New insights into the development and progression of chronic inflammatory disease. London, UK, 2011.

Think the impossible: beta-blockers for treating asthma. Pro and Con debate at EAACI, Istanbul, Turkey, 2011

Taking a lesson from heart failure.  Can 'ß-blockers be used in the treatment of asthma? University of Texas Medical School – Houston.  Biochemistry and Molecular Biology Seminar Series, 2011.

Beta-blockers and beta-agonists in asthma: unraveling a paradox. McMaster University Honours Biology & Pharmacology Program "3rd Annual Biology & Pharmacology Lectureship" 2010.

Getting to the heart of asthma – can beta-blockers be used as chronic asthma therapy? Systems Biology of Human Disease Conference, Boston, MA, USA, 2009.

Beta-blockers and beta-agonists in asthma: unraveling a paradox. Respiratory Drug Delivery (RDD), Lisbon, Portugal, 2009.

Paradoxical pharmacology; Can beta-blockers be used to treat asthma? William Harvey Research Institute Seminar Series, London, UK, 2008.

Debate: Beta-2 adrenoceptor agonists and corticosteroids are all we need for asthma. Presenting the ‘Against’ position. 5th James Black Conference – Cutting EdgeConcepts in Lung Pharmacology, Crieff Hydro, Perthshire, Scotland, 2007.

Special ‘Hot Topic’ Session: Further explanation of the worldwide increase in morbidity and mortality from asthma. European Respiratory Society Conference, Stockholm, Sweden, 2007.

Use of beta-blockers in chronic heart failure and asthma bronchiale. German Congress of Anaethesiology, Hamburg, Germany, 2007.

‘Paradoxical Pharmacology’; A way forward in asthma therapy? University of Amsterdam (AMC) Department of Experimental & Clinical Experimental Anesthesiology. Amsterdam, The Netherlands, 2007.

Getting to the heart of asthma; can beta-blockers be used to treat asthma? Special Symposium of the British Pharmacological Society’s 75th Anniversary Celebration, Oxford, UK, 2006.

Paradoxical Pharmacology. 6th Melbourne International GPCR Forum, Melbourne, Australia, 2006.

Getting to the heart of asthma; can beta-blockers be used to treat asthma? Australia’s Medicines Research Conference, Melbourne, Australia, 2006.

Beta-blockers as possible asthma therapy. Kansas City, MO, USA, 2006.

Inverse Agonists as signaling enhancers. CHI-organized GPCR Symposium, La Jolla, CA, USA, 2006.

Getting to the heart of asthma; can beta-blockers be used to treat asthma? GlaxoSmithKline, RTP, NC, USA, 2006

Articles Written By Others About Our Research

Lipworth, B.J. and Williamson, P.A.: Think the impossible: beta-blockers for treating asthma. Clinical Science, 118: 115–120, 2010.

Ray, L.B.: Inverse Agonist to the Rescue. Sci. Signal. (formerly Science STKE) 2: ec76, 2009.

Penn, R.B.: Agonizing over agonism: Should asthmatics turn their ß-receptors on or off? Proc. Nat. Acad. Sci. 106: 2095-2096. 2009.

Lipworth, B.J. and Williamson, P.A.: ß-blockers for asthma: a double-edged sword? The Lancet 3: 104-105, 2009.

Chupp, G.L: Say what, beta-blockers for asthma? Am J Respir Cell Mol Biol. 38: 249-250, 2008.

Abbott, A.: Beta-blocker goes on trial as asthma therapy. Nature. 432: 7, 2004.

Ellis, C.: Timing is everything. Nature Reviews – Drug Discovery. 3: 387, 2004.

Martindale, D.: What doesn’t kill you. New Scientist. p.38-41Oct. 25, 2003.

Black J.W. and Shankley N.P.: Drug receptors. Inverse agonists exposed. Nature. 374: 214-5, 1995.

Memberships

  • American Association for the Advancement of Science
  • American Society for Pharmacology and Experimental Therapeutics
  • British Pharmacological Society
  • New York Academy of Sciences
  • IUPHAR Adrenoceptor Classification Committee
  • American Association of Colleges of Pharmacy

Editorial Appointments

  • Senior Editor, British Journal of Pharmacology
    • Co-Editor for "A Special Issue Celebrating the Life and Work of James Whyte Black", Br. J. Pharmacol. Vol. 160, Supplement 1, 2010.
    • Co-Editor for Special Issue on Respiratory Pharmacology. Br. J. Pharmacol. 2011.
  • Naunyn-Schmiedeberg’s Archives of Pharmacology
  • Journal of Receptors and Signal Transduction