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College of Pharmacy Core Lab

With the UH College of Pharmacy Core Lab, local researchers as well as their students and postdoctoral associates are provided with advanced technologies and equipment to conduct innovative work in the fields of drug discovery, novel target identification and translational research that will yield the next generation of therapeutics to save lives and improve the quality of life for countless patients.

For information on training, scheduling and fees, please contact:

Dakshina M. Jandhyala, Ph.D.
Core Lab Manager
Health 2, Room 6009
713-743-0475
dmjandhyala@uh.edu

The College of Pharmacy Core Lab provides local researchers with equipment and services described below:

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BD FACSMelody Cell Sorter & Flow Cytometer

The FACSMelody Cell Sorter is a three laser Fluorescence Activated Cell Sorter configured for 8 colors as follows:

Laser Filters
488 nm (Blue) 488/15, 527/32, 700/54
561 nm (Yellow-Green) 582/15, 613/18, 697/58, 783/56
640 nm (Red) 660/10, 783/56

The cytometer is capable of 34,000 drops/second. Sorting can be two-way using 1.5, 2.0, and 5.0 ml tubes, or one-way using 6, 24, 48, 96, or 384 well plates or a microscope slide. Collection tubes, plates, or slides can be maintained at specified warm or cool temperatures by use of a coupled water recirculation unit.

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Confocal Microscopy

The core houses a Leica SP8 STED Confocal Microscope with HP Z4 G4 WorkStation. This super resolution platform allows detection of features down to 20 nm. Our core lab also houses an Olympus DSU fluorescent microscope.

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Histology Lab

Our Histology lab is equipped with a Leica CM1850 Cryostat, Leica Microtome, Leica TP1020 Tissue Processor, a Tissue Tek Embedding Station, Varistain 24-4 automated slide stainer, and a slide warmer. 

Leica Cryostat

Leica Cryostat & Microtome

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IVIS XRMS

In vivo imaging platform for rodents and small mammals. Capabilities include X-ray, luminescence, and fluorescence.

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600 MHz NMR

The College of Pharmacy Laboratory Core has a JEOL 600 MHz Spectrometer with broadband Z-gradient high resolution ROYAL NMR liquid probe and runs with Delta V5.3 Software. The system performs high resolution 1D and 2D liquids experiments with and without gradients. Sample automation includes, 24 sample rack for unattended operation, automated probe-tuning, gradient shimming, and variable temperature control. Software includes full non-linear sampling (NUS) and processing, and analysis modules ranging from kinetics and T1/T2 analyses to calculation of self-diffusion coefficients.

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Liquid Chromatography coupled Mass Spectrometry (LCMS)

The core currently houses two Liquid chromatography coupled Sciex 5500 triple quadrupole mass spectrometers and similarly coupled Sciex 3200. Users can be trained to use the instruments or samples can be run by an experience LCMS technician. Users of this core have developed a variety of assays for measuring small molecule drugs and metabolites in a variety of human and animal tissues. The core also provides assay development services.

Sciex 3200

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Vevo 3100 Small Animal Ultrasound

The Vevo 3100 is available with 5 different ultrasound probes for use with organisms ranging in size from zebrafish to rabbits.

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BioRad QX200 Droplet Digital PCR System

We house a new BioRad QX200 Droplet Digital PCR System capable of absolute quantitation of DNA and RNA with Eva-Green or probe based system capability.