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Profile: Romi Ghose

Romi Ghose
Romi Ghose, Ph.D.
Associate Professor of Pharmaceutics
Department of Pharmacological and Pharmaceutical Sciences
Physical Address: Science and Research Building 2, 3455 Cullen Blvd., Room 145, Houston, TX 77204
Mailing Address: Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX 77204-5037
Phone: 832-842-8343
Fax: 832-842-8305
rghose@uh.edu

Education

BSc. Honors (Chemistry), University of Calcutta, India
MSc. (Biochemistry), University of Calcutta, India
Ph.D. (Biochemistry), University of Notre Dame, Notre Dame, IN
Post-doctoral, Baylor College of Medicine, Houston, TX

Research Interests

The primary research interest of our group is to investigate the regulation of drug metabolism and toxicity. The overall goal is to understand how drugs become less effective or more toxic in patients undergoing treatment for diseases such as infections, diabetes, cardiovascular diseases, cancer and liver disorders. The knowledge gained from these studies will have significant impact on developing novel strategies to reduce adverse effects of drugs and help us develop individualized approaches to treat patients.

Specific projects involve:

  • Hepatic drug metabolism and transport
  • Cytochrome P450 enzymes
  • Nuclear receptors
  • Pharmacokinetics/Pharmacodynamics
  • Toxicokinetcs/Toxicodynamics
  • Drug-drug interactions
  • Drug-induced liver injury

Courses

Ph.D. Courses

  • Advanced Pharmaceutics I, PCEU 6342
  • Cellular Pharmacology I, PCOL 7350
  • Regulatory Affairs, PCEU 6346
  • Laboratory Methods for Pharmaceutical Research, PCEU 7351

Pharm.D. Courses

  • Pharmaceutics I, PHAR 4330
  • Pharmaceutics II, PHAR 4331
  • Pharmacokinetics, PHAR 5332

Research Grants

Active/Completed
  • National Institutes of Health: K01, R21
  • Northarvest Bean Growers Association
  • Inflammation Research Foundation/Zone Labs
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • University of Houston: Small Grants Program; GEAR Grant
  • Pilot/Feasibility Award in GI Research. Texas Gulf Coast Digestive Diseases Center

Selected Publications

Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BS. Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opin Drug Metab Toxicol. 2017 Sep;13(9):901-923. doi: 10.1080/17425255.2017.1360277. Epub 2017 Aug 17. Review. PMID: 28766962

Mallick P, Taneja G, Moorthy B, Ghose R. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun;13(6):605-616. doi: 10.1080/17425255.2017.1292251. Epub 2017 Feb 22. Review. PMID: 28537216

Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun;41:75-82. doi: 10.1016/j.tiv.2017.02.019. Epub 2017 Feb 27. PMID: 28242239

Ghose R, Mallick P, Taneja G, Chu C, Moorthy B. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016;1395:55-68. doi: 10.1007/978-1-4939-3347-1_4. PMID: 26910068

Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon β in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan;44(1):61-7. doi: 10.1124/dmd.115.066761. Epub 2015 Oct 15. PMID: 26470915

Mallick P, Shah P, Gandhi A and Ghose R. Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38. Life Sci. 2015; Oct; 139: 132-138.

Pranav Shah, Tao Guo, David D Moore and Romi Ghose. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug metabolizing enzymes and transporters. Drug Met. Disp. 2014 Jan; 42 (1): 172-81.

Gandhi A, Guo T,Moorthy B and Ghose R. Chlorpromazine-induced hepatotoxicity in inflammationis mediated by TIRAP-dependent signaling pathway in mice. Toxicol Appl Pharmacol. 2013 Feb 1; 266 (3): 430-8.

Fahy BN, Guo T and Ghose R. Impact of Hepatic Malignancy on CYP3A4 Gene Expression. Journal of Surgical Research. 2012; Dec 178 (2): 768-72.

Gandhi A, Moorthy B and Ghose R. Drug Disposition in Pathophysiological Conditions. Current Drug metabolism. (Review) 2012 Nov; 13(9): 1327-44.

Gandhi A, Shah P, Guo T, Moorthy B, Chow S-L. D, Hu M & Ghose R. Altered pharmacokinetics and pharmacodynamicsof the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins.British Journal of Pharmacology. 2012; Aug 166 (7) : 2167-87.

Ghose R, Omoluabi O, Gandhi A, Shah P,Strohacker K, Carpenter KC, McFarlin B, Guo T. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011; Jul 4;89 (1-2):57-64.

Ghose R, Guo T, Vallejo S, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug metabolizing enzymes. Drug Met. Disp. 2011; 39 (5): 874-81.

Adarsh Gandhi, Tao Guo and Romi Ghose. Role of c-jun N-terminal kinase in regulating tumor necrosis factor-alpha mediated increase of acetaminophen and chlorpromazine toxicity in murine hepatocytes. J. Toxicol. Sci. 2010, 35; 163-73.

Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch. Biochem. Biophys. 2009, 481 (1): 123-30.

Ghose R, White D, Guo T, Vallejo S, Karpen SJ. Regulation of hepatic drug metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of TIR-domain containing adaptor protein (TIRAP). Drug Met. Disp. 36 (1): 95-101; 2008.

Ghose, R., J. Mulder and S. J. Karpen. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPARϒ agonist, Rosiglitazone. J Hepatol. 2007 46 (1): 115-123.

Book Chapters

Gandhi A and Ghose R. Altered Drug Metabolism and Transport in Pathophysiological Conditions. 2012; Drug Metabolism. InTech - Open Access Publisher, ISBN 979-953-307-295-0.

Romi Ghose, Pankajini Mallick, Guncha Taneja, Chun Chu and Bhagavatula Moorthy. In vitro approaches to study regulation of hepatic cytochrome P450 (CYP) 3A expression by paclitaxel and rifampicin. 2015 Methods in Molecular Biology (In press).

Memberships

  • American Association for the Study of Liver Diseases
  • American Society for Pharmacology and Experimental Therapeutics
  • International Society for the Study of Xenobiotics
  • Society of Toxicology

Editorial Appointments

  • Member of the Editorial Board: Chemico-Biological Interactions
  • Member of the Editorial Board: Journal of Clinical Trials
  • Member of the Editorial Board: Journal of Molecular Pharmaceutics and Organic Process Research