Profile; Romi Ghose
Assistant Professor of Pharmaceutics
Texas Medical Center
1441 Moursund Street, Rm 517
Houston, TX 77030
MSc. (Biochemistry) University of Calcutta, India
Ph.D (Biochemistry) University of Notre Dame, IN, USA
Post-doctoral, Baylor College of Medicine, Houston, TX
Regulation of drug metabolism and toxicity.
Drug metabolizing enzymes regulate metabolism of drugs and toxins, and are critical to the survival of mammalian species. Alterations of these enzymes can lead to impaired metabolism of drugs, leading to adverse drug reactions which can have deleterious consequences in terms of human health. Our long-term goal is to increase the efficacy and safety of drugs by characterization of these enzymes at a molecular level. Our current research focuses on investigating the role of inflammation, infectious diseases and obesity on drug metabolizing enzymes and pharmacokinetics and hepatotoxicity of candidate drugs. Biochemical assays, molecular biology techniques and transgenic animal models are utilized in our studies. The knowledge gained from these studies will have significant impact on developing novel strategies to maximize therapeutic efficacy of drugs and reduce incidences of drug-induced liver disease.
- PCEU 6342: Advanced Physical Pharmacy I
- PCOL 7350: Cellular Pharmacology
- PHAR 4331: Pharmaceutics II
- K01 DK076057-02K01. National Institute of Diabetes and Digestive and Kidney Diseases. "Hepatic drug metabolism in inflammation." 2006-2010.
- Small Grants Program. University of Houston. "Regulation of hepatic drug metabolism in obesity." 2008-2010. Romi Ghose, PI
- Pilot/Feasibility Award in GI Research, Texas Gulf Coast Digestive Disease Center. “Endobiotic/Xenobiotic metabolism in inflammation.” 2005-2006. Romi Ghose, PI.
Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of toll-interleukin 1 receptor domain-containing adaptor protein in toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May;39(5):874-81.
Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, McFarlin B, Guo T. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011 Jul 4;89(1-2):57-64.
Adarsh Gandhi, Tao Guo and Romi Ghose. Role of c-jun N-terminal kinase in regulating tumor necrosis factor-alpha mediated increase of acetaminophen and chlorpromazine toxicity in murine hepatocytes. J. Toxicol. Sci. 2010;35(2):163-73..
Tam VH, Ledesma KR, Schilling AN, Lim TP, Yuan Z, Ghose R and Lewis RE. In vivo dynamics of carbapenem-resistant Pseudomonas aeruginose selection following suboptimal dosing Diagnostic Microbiology and Infectious Disease. Diagn Microbiol Infect Dis 2009, 64; 427-433.
Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch. Biochem. Biophys. 2009, 481 (1): 123-30.
Ghose R, White D, Guo T, Vallejo S, Karpen SJ. Regulation of hepatic drug metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of TIR-domain containing adaptor protein (TIRAP). Drug Met. Disp. 2008; 36 (1): 95-101.
Ghose, R., J. Mulder and S. J. Karpen. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPARg agonist, Rosiglitazone. J Hepatol. 2007 46 (1): 115-123.
Zimmerman T.L, Thevananther S, Ghose R, Burns A and S. J. Karpen. Nuclear export of RXR in response to IL-1b-mediated cell signaling: roles for JNK and Ser260. J. Biol. Chem. June 2, 281 (22): 15434-40, 2006.
Ghose, R., Tao Guo and Adarsh Gandhi. Toll-like receptors: novel regulators of hepatic drug metabolism. AASLD, Boston, MA, November 2009.
Ghose, R., Tao Guo and Adarsh Gandhi. Role of Toll-like receptors and the adaptor protein, TIRAP in regulation of gene expression of hepatic drug metabolizing enzymes. AASLD Single Topic Conference, Atlanta, Georgia, September 2009.
Romi Ghose, Tao Guo and Adarsh Gandhi. Role of Toll-like receptor adaptor protein, TIRAP in regulation of gene expression of drug metabolizing enzymes. Division of Drug Metabolism Platform Session. Experimental Biology, ASPET, New Orleans, LA, April 2009.
Adarsh Gandhi, Tao Guo, Gaurav Dhar and Romi Ghose. Role of cytokines in regulating drug-induced hepatotoxicity. Frontiers in Digestive Diseases Symposium, Houston, TX, February 2009.
Adarsh Gandhi, Tao Guo and Romi Ghose. Lipopolysaccharide and cytokine-induced drug hepatotoxicity. AAPS, Atlanta, GA, November 2008.
Romi Ghose, Tao Guo, Nadia Haque and Adarsh Gandhi. Role of Toll-like receptor 2 signaling pathway in regulating the gene expression of hepatic drug metabolizing enzymes. Gordon Research Conference on Drug Metabolism, Holderness School, NH, July 2008.
Romi Ghose and Tao Guo. Lipoteichoic acid modulates hepatic drug metabolizing enzyme gene expression by activating the Toll-like receptor 2 signaling pathway. Experimental Biology, ASPET, San Diego, CA, April 2008.
V.H. Tam, K.R. Ledesma, A.N. Schilling, K.T. Chang, T.P. Lim, R. Ghose, R.E. Lewis. In-vivo selection of carbapenem-resistant Pseudomonas aeruginosa following sub-optimal dosing. European Society of Clinical Microbiology and Infectious Diseases. Barcelona, Spain, April 2008.
Ghose, R., White, D. A., Guo, T., Vallejo, J., and S. J. Karpen. Role of the Toll-like receptor signal transduction pathway in regulation of drug metabolizing enzymes in inflammation. GTCbio Annual Conference on Protein Kinases in Drug Discovery, Boston, MA, 2007.
Ghose, R., White, D. A., Guo, T., Vallejo, J., and S. J. Karpen. Regulation of drug metabolizing enzymes in inflammation: Role of the Toll-like receptor 4 signaling pathway. Experimental Biology, ASPET, Washington, D.C., 2007.
Sun H, Ghose R, Karpen S.J. and Thevananther, S. Hepatocyte proliferative response to partial hepatectomy is markedly impaired in TIRAP Knockout mice. Hepatology, Vol 46, No. 4, Suppl. 1, 531A, 2007.
Ghose, R., Doerre, D. A., Vallejo, J., and S. J. Karpen. TLR4, but not the TLR adaptor protein, TIRAP, is required for LPS-mediated suppression of drug metabolizing enzyme (DME) gene expression. Hepatology, (Suppl.), 44, 2006.
Kosters, A., Gulati, A., Thevananther, S., Mulder, J., Von Furstenberg, R., Zimmerman, T. L., Ghose, R., and S. J. Karpen. Dietary curcumin prevents downregulation of hepatic transporter gene expression by LPS. Hepatology, (Suppl.), 42, 570A, 2005.
Ghose, R., J. Mulder, Von Furstenberg, R., and S. J. Karpen. Rosiglitazone attenuates LPSmediated suppression of RXR-alpha-regulated hepatic genes. Hepatology, (Suppl.), 42, 568A, 2005.
Zimmerman T. L., Ghose, R., Thevananther, S., Kosters, A., Von Furstenberg, R., and S. J. Karpen. IL-1 beta induced ubiquitination and proteasomal degradation of Retinoid X Receptor alpha in HepG2 cells. Hepatology, (Suppl.), 42, 567A, 2005.
Ghose, R., and Tao Guo. Role of Toll-like receptor adaptor protein, TIRAP in regulation of gene expression of drug metabolizing enzymes. Division of Drug Metabolism Platform Session. Experimental Biology, ASPET, New Orleans, LA, April 2009.
Ghose, R., T. Guo, A. Gandhi, S. J. Karpen and D. White. Role of Toll-like receptors on hepatocytes in regulating the gene expression of drug metabolizing enzymes. Parallel Session on Drug and Alcohol Toxicity: The 59th Annual meeting of the American Association of Liver Diseases, San Francisco, CA, 2008.
Ghose, R. Liver toxicity consideration in drug discovery and development. ACS Southwest Regional Meeting Symposium, 2006.
Toll-like receptor mediated regulation of hepatic drug metabolism. Institute of Biosciences and Technology, Texas A&M University, Houston, TX, December 2009.
Hepatic Drug metabolism in Inflammation. College of Pharmacy, University of Texas at Austin, Austin, TX, September 2009.
Inflammation and Hepatic Drug Metabolism. Dr. B.C. Guha Centre for Genetic Engineering and Biotechnology, University of Calcutta, Kolkata, India, January 2008.
Inflammation and Hepatic Drug Metabolism. Genitourinary Oncology Program Seminar Series. The Methodist Hospital. August 2007.
Molecular mechanism of regulation of drug metabolism and toxicity. New Investigator Symposium, Houston, TX, May 2007.
Mechanisms underlying altered endobiotic/xenobiotic metabolism in inflamed liver. Feigin Center Symposium, Baylor College of Medicine, Houston, TX, January 2005.
- American Association for the Study of Liver Diseases
- American Society for Pharmacology and Experimental Therapeutics
- Manuscript Reviewer (ad hoc): Journal of Hepatology, Hepatology, European Journal of Pharmacology, British Journal of Pharmacology, Life Sciences