Statsyuk Research Group
Welcome
We are a group of chemical biologists studying protein ubiquitination and protein phosphorylation signaling pathways, and misregulation of these processes in diseases.
Our highly interdisciplinary research group combines techniques of synthetic organic chemistry, biochemistry, cell biology, and protein synthesis.
News
Summer 2016
We will present our recent results on using the UbFluor probe in HTS and FBDD screens to discover inhibitors of HECT E3 ligases at the 14th Annual Discovery on Target Conference in Boston from September 20-21, 2016. Visit the conference website at http://www.discoveryontarget.com/ubiquitin-proteasome/
Spring 2016
Our publication "A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases" has been recognized as a Highly Read Article of 2014 by the Journal of Medicinal Chemistry. Congratulations Stefan and Ziyang!
Sandipan Roy Chowdhury joins Statsyuk Research Group as a postdoctoral fellow.Welcome Sandipan!
Our manuscript "UbFluor: A Mechanism-Based Probe for HECT E3 Ligases" has been accepted for publication in Chemical Science. Congratulations David, Sungjin, Galyah, and Sara!
David Krist successfully defended his thesis "Development of Chemical Tools to Study HECT Ubiquitin Ligases ". Congratulations Dr. Krist!
Winter 2016
Our manuscript "Covalent Tethering of Fragments For Covalent Probe Discovery" has been accepted for publication in MedChemComm. Congratulations Stefan!
Heeseon An successfully defended her thesis "Investigating Ubiquitin-like Protein Activating Enzymes Using Chemical Approaches". Congratulations Dr. An! We wish you much success in the Wade Harper Lab!
Join Us
Applicants for graduate studies must apply to the UHCOP Pharmacology, Pharmacology/Medicinal Chemistry and Pharmaceutics program. Applications for postdoctoral research positions should be sent by e-mail directly to:
Asst. Professor Alexander Statsyukavstatsyuk@uh.edu