Funded Projects

Funded Projects

Funded Projects – Abughosh


1. Title: Texas Physicians’ Attitudes and Predicted Pain Management Based on Rescheduling Hydrocodone Combination Products Principal Investigator: Marc Fleming Type of Award: Private Profit Funding Agency: Mallinckrodt Pharmaceuticals Duration: 11/2014-11/2015 Description of Project: This study will predict Texas prescribers’ intention to prescribe hydrocodone combination products in the event these medications are reclassified to Schedule II controlled substances. It is important to understand the implications the rule change will have on patient care as it relates to prescribing patterns.

Funded Projects – Aparasu


1. Title: Anticholinergics and Cognitive Decline in the Elderly with Depression/Dementia Principal Investigator: Rajender Aparasu Type of Award: RO1 Funding Agency: Agency of Healthcare Research & Quality Duration: 09/2012-09/2016 Description of Project: The study will evaluate central adverse effects profile on medications with significant anticholinergic activity in the elderly nursing home residents with depression. The investigation will not only provide strong evidence base for central adverse effects for anticholinergics but also strengthen support for the Anticholinergic Drug Scale as a quality of care measure in long term care.

2. Title: Impact of Atypical Antipsychotic Use on Health Care Utilization in the Elderly Principal Investigator: Rajender Aparasu Type of Award: RO3 Funding Agency: Agency of Healthcare Research & Quality Duration: 04/2009-09/2011 Description of Project: With increasing evidence of efficacy and safety concerns of atypical agents, there is a need to evaluate atypical antipsychotic use in the elderly. Little is known about the cumulative health care impact of atypical agents due to their safety and efficacy profile. An evaluation of health care utilization in the elderly will be valuable to health care providers and policy makers so that atypical antipsychotic use and expenditures can be optimized in this population.

3. Title: The Impact of the FDA Antidepressant Black Box Warning on Psychiatric Practice Principal Investigator: Hua Chen Type of Award: RO3 Funding Agency: Agency of Healthcare Research & Quality Duration: 03/2007-09/2009 Description of Project: The study will examine the policy impact of the Food and Drug Administration (FDA) antidepressant black box warning on the utilizations of psychotropic medications and psychiatric services among children and adolescents.

Funded Projects-Chen


1. Title: Anticholinergics and Cognitive Decline in the Elderly with Depression/Dementia Principal Investigator: Rajender Aparasu Type of Award: RO1 Funding Agency: Agency of Healthcare Research & Quality Duration: 09/2012-09/2016 Description of Project: The study will evaluate central adverse effects profile on medications with significant anticholinergic activity in the elderly nursing home residents with depression. The investigation will not only provide strong evidence base for central adverse effects for anticholinergics but also strengthen support for the Anticholinergic Drug Scale as a quality of care measure in long term care.

2. Title: The Definition, Utilization and Development of Long Term Psychotropic Polypharmacy in Children and Adolescents Principal Investigator: Hua Chen Type of Award: Private Non-Profit Funding Agency: PhRMA Foundation Duration: 01/2010-12/2011 Description of Project: The study is a retrospective analysis of 3 years (2003-2005) Medicaid claims data from 4 states in the continental US. The purpose is to validate the definition of long term psychotropic polypharmacy and assess the extent of this practice in children and adolescents.

3. Title: The Impact of the FDA Antidepressant Black Box Warning on Psychiatric Practice Principal Investigator: Hua Chen Type of Award: RO3 Funding Agency: Agency of Healthcare Research & Quality Duration: 03/2007-10/2009 Description of Project: The study will examine the policy impact of the Food and Drug Administration (FDA) antidepressant black box warning on the utilizations of psychotropic medications and psychiatric services among children and adolescents.

4. Title: The Impact of the FDA Antidepressant Black Box Warning on the Utilization of Psychotherapy, Psychotropic Medications, and Antidepressant Follow-up Care Among Children and Adolescents Principal Investigator: Hua Chen Type of Award: Private Non-Profit Funding Agency: American Association of Colleges of Pharmacy Duration: 12/2006-12/2007 Description of Project: The purpose of this study is to investigate the impact of the FDA antidepressant black box warning on psychiatric practice.

5. Title: Outcomes of Angiogenesis Receptor Blocker Use for Heart Failure in the Elderly Principal Investigator: Michael Johnson Type of Award: RO3 Funding Agency: Agency of Healthcare Research & Quality Duration: 08/2008-01/2011 Description of Project: The purpose of this project is to examine the outcomes of treatment with angiotensin receptor blockers in a national cohort of elderly patients with CHF.

6. Title: Impact of Atypical Antipsychotic Use on Health Care Utilization in the Elderly Principal Investigator: Rajender Aparasu Type of Award: RO3 Funding Agency: Agency of Healthcare Research & Quality Duration: 04/2009-09/2011 Description of Project: With increasing evidence of efficacy and safety concerns of atypical agents, there is a need to evaluate atypical antipsychotic use in the elderly. Little is known about the cumulative health care impact of atypical agents due to their safety and efficacy profile. An evaluation of health care utilization in the elderly will be valuable to health care providers and policy makers so that atypical antipsychotic use and expenditures can be optimized in this population.

7. Title: Clinical Outcomes Associated with Pre-emptive Cytomegalovirus Therapy in Allogeneic Hematopoietic Stem-cell Transplantation Recipients Principal Investigator: Kevin Garey Type of Award: Private Profit Funding Agency: Agency of Healthcare Research & Quality Duration: 04/2014-07/2015 Description of Project: The purpose of this project is to assess overall and pharmacotherapy-related outcomes associated with CMV infection in HSCT patients.

Funded Projects-Essien


1. Title: Videotape-based HIV Prevention Intervention Principal Investigator: Ekere James Essien Type of Award: RO1 Funding Agency: National Institute of Mental Health Duration: 09/03/2003-08/31/2007 Description of Project: This study is designed to test whether or not social cognitive theory principles applied to HIV prevention can be delivered effectively by videotapes and community based organization personnel with minimal training in skills building techniques in Houston, Texas.

2. Title: The Nigerian Uniformed Services AIDS Project Principal Investigator: Ekere James Essien Type of Award: RO1 Funding Agency: National Institute of Mental Health Duration: 03/24/2005-02/28/2009 Description of Project: The goal of this project is to develop and test the efficacy of an Information-Motivation-Behavioral (IMB) Skills model based HIV prevention intervention among men and women in the Nigerian Uniformed Services.

Funded Projects-Fleming


1. Title: The Emergency Department Pain Registry: Impact Evaluation of the 2012 American College of Opioid Prescribing Guidelines Principal Investigator: Todd Knox Type of Award: State Funding Agency: UT MD Anderson Cancer Center via Pfizer Duration: 10/2013-11/2014 Description of Project: The purpose of this study is to compare the effectiveness of ACEP’s opioid guideline dissemination to an enhanced strategy that includes patient informed feedback and chart review of physicians.

2. Title: Texas Physicians’ Attitudes and Predicted Pain Management Based on Rescheduling Hydrocodone Combination Products Principal Investigator: Marc Fleming Type of Award: Private Profit Funding Agency: Mallinckrodt Pharmaceuticals Duration: 11/2014-11/2015 Description of Project: This study will predict Texas prescribers’ intention to prescribe hydrocodone combination products in the event these medications are reclassified to Schedule II controlled substances. It is important to understand the implications the rule change will have on patient care as it relates to prescribing patterns.

Funded Projects-Johnson


1. Title: A Clinical Risk Index for Primary Clostridium Difficile Infection Principal Investigator: Kevin Garey Type of Award: State Funding Agency: Texas Department of State Health Services Duration: 07/2014-08/2014 Description of Project: The overall objective of this project is to identify a high-risk population for primary CDI in order to initiate future preventative strategies.

2. Title: Anticholinergics and Cognitive Decline in the Elderly with Depression/Dementia Principal Investigator: Rajender Aparasu Type of Award: RO1Funding Agency: Agency of Healthcare Research & Quality Duration: 09/2012-09/2016 Description of Project: The study will evaluate central adverse effects profile on medications with significant anticholinergic activity in the elderly nursing home residents with depression. The investigation will not only provide strong evidence base for central adverse effects for anticholinergics but also strengthen support for the Anticholinergic Drug Scale as a quality of care measure in long term care.

3. Title: Outcomes of Angiogenesis Receptor Blocker Use for Heart Failure in the Elderly Principal Investigator: Michael Johnson Type of Award: RO3 Funding Agency: Agency of Healthcare Research & Quality Duration: 08/2008-01/2011 Description of Project: The purpose of this project is to examine the outcomes of treatment with angiotensin receptor blockers in a national cohort of elderly patients with CHF.

Funded Project-Sansgiry


1. Title: Texas Physicians’ Attitudes and Predicted Pain Management Based on Rescheduling Hydrocodone Combination Products Principal Investigator: Marc Fleming Type of Award: Private Profit Funding Agency: Mallinckrodt Pharmaceuticals Duration: 11/2014-11/2015 Description of Project: This study will predict Texas prescribers’ intention to prescribe hydrocodone combination products in the event these medications are reclassified to Schedule II controlled substances. It is important to understand the implications the rule change will have on patient care as it relates to prescribing patterns.

2. Title: Inpatient Pharmacist Productivity – A Comparison of Computer Physician Order Entry (CPOE) versus a Paper-Based System Principal Investigator: Sujit Sansgiry Type of Award: Foundation Funding Agency: Texas Society of Health-System Pharmacists Foundation Duration: 01/2013-01/2014 Description of Project: The objective of this study, namely comparing the number of orders processed and the time associated with processing these orders in a CPOE versus non-CPOE system. The goal is to evaluate the impact of CPOE on pharmacist’s productivity which is crucial for pharmacy management in estimating the future allocation of pharmacist’s resources.

3. Title: Development of Documentation Processes for Quality of Life Outcomes Measures for Patients in Niche Markets Principal Investigator: Sujit SansgiryType of Award: Private Profit Funding Agency: Statscript Duration: 08/2012-12/2013 Description of Project: The project aims to develop systems and tools for collecting data that would measure health-related quality of life in the patient population that receives services at Statscript.

4. Title: Impact of Complementary and Alternative Medication Use on Antiretroviral Plasma Concentrations and Adherence Principal Investigator: Rosa Yeh Type of Award: Foundation Funding Agency: American Society of Health-System Pharmacists Foundation Duration: 10/2006-09/2008 Description of Project: This research project seeks to investigate the impact of CAM use in HIV-infected patients who are taking ARVs.

5. Title: The Role of Collaborative Team Approach to Managing Patients with Diabetes to Improve Economic and Health Outcomes Principal Investigator: Sujit Sansgiry Type of Award: State Funding Agency: Texas Pharmacy Association Duration: 08/2010-08/2013 Description of Project: This is a retrospective study that will assess the role of pharmacists based on educational intervention on clinical economic and humanistic outcomes associated with diabetic patients.

6. Title: A Randomized Controlled Study to Identify Workflow Factors Principal Investigator: Sujit Sansgiry Type of Award: Private Non-Profit Funding Agency: St. Luke’s Episcopal Hospital Duration: 03/2011-03/2013 Description of Project: The study will compare time devoted to medication administration in an intensive care unit with and without bedside bar code technology. Data collected previously will be analyzed to test the research objective.

Funded Projects-Yeh


1. Title: Impact of Complementary and Alternative Medication Use on Antiretroviral Plasma Concentrations and Adherence Principal Investigator: Rosa Yeh Type of Award: Foundation Funding Agency: American Society of Health-System Pharmacists Foundation Duration: 10/2006-09/2008 Description of Project: This research project seeks to investigate the impact of CAM use in HIV-infected patients who are taking ARVs.

2. Title: Phase I Study of EGCG in HIV-1 Infected Individuals Principal Investigator: Rosa Yeh Type of Award: University Funding Agency: Baylor College of Medicine Duration: 02/2010-07/2014 Description of Project: To evaluate the safety, tolerability, and pharmacokinetic characteristics of EGCG taken as monotherapy for 14 days in HIV-1 infected participants.

3. Title: Retrospective Evaluation of Lopinavir/Ritonavir Single Agent Therapy in a Real-Clinic Setting Principal Investigator: Rosa Yeh Type of Award: Private Profit Funding Agency: Abbott Laboratories Duration: 01/2008-01/2011 Description of Project: To describe demographics, use, efficacy, and safety of lopinavir/ritonavir single agent therapy (SAT) at a single-site.