My research has focused around the phenomenon of “skeletal muscle damage”, both in determining how skeletal muscle membrane structure influences this phenomenon as well as a mechanism for why certain pharmaceutical drugs (statins) trigger symptoms commonly associated with skeletal muscle damage. I have also developed an interest in various clinical measures of athletic injury assessment and care as well as the reliability of those measures.
Recent Publications and Research Activity
Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshil AD, Knoblauch M, et al. A Chemical Chaperone Alleviates ER Stress and Improves Muscle Function in Mice with an RyR1 Mutation. Nature Communications. March 2017. 8:14659
Babcock LW, Knoblauch M, Clarke, MSF. The role of myostatin and activing receptor IIB in the regulation of unloading-induced myofiber type-specific skeletal muscle atrophy. Journal of Applied Physiology 2015: 119(6): 633-642.
Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, et al. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skeletal Muscle. 2015; 5:4
Pedrotti S, Guidice J, Dagnino-Acosta A, Knoblauch M, et al. The RNA-binding protein Rbfox1 regulates splicing required for adult skeletal muscle function. Human Molecular Genetics. 2015: 24(8): 2360-74.
Chang Seok Lee, Dimitra K. Georgiou, Adan Dagnino-Acosta, Jianjun Xu, Iskander I Ismailov, Mark Knoblauch, et al. Ligands for FKBP12 Increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem 2014. 289(37): 25556-70
Knoblauch, MA; Dagnino-Acosta, A; Hamilton, S. Mice with an RyR1 mutation (Y524S) Undergo a Hypermetabolic Response to Simvastatin. Skeletal Muscle, 2013. 3:22
Knoblauch, MA; O’Connor, DP; Clarke, MSF. Obese mice incur greater myofiber membrane disruption in response to mechanical load compared to lean mice. Obesity (Silver Spring). 2013 Jan;21(1):135-43
O’Connor, DP; Knoblauch, MA. Electrocardiogram testing during athletic preparticipation physical examinations. Journal of Athletic Training. 2010. 45(3):265-72
Knoblauch, MA; O’Connor, DP; Clarke, MSF. Capillary and Venous Samples of Total Creatine Kinase Are Similar After Eccentric Exercise. Journal of Strength and Conditioning Research. 2010. 24(12):3471-3475.
Sharma SV, Bush JA, Lorino AJ, Knoblauch M, Abuamer D, Blog G, Bertman D. Diet and Cardiovascular Risk In University Marching Band, Dance Team and Cheer Squad Members: A Cross-Sectional Study. J Int Soc Sports Nutr. 2008 Apr 18;5:9.
A.A. in Sports Medicine at Hutchinson Community College, 1994
B.A. in Exercise Science (Emphasis:Athletic Training) at Wichita State University, 1996
M.S. in Kinesiology (Emphasis: Exercise Science) at University of Nevada, Las Vegas, 1998
Ph.D. in Kinesiology (Emphasis: Exercise Science) at University of Houston, 2011
Post-doc in Molecular Physiology and Biophysics at Baylor College of Medicine, 2013