Human and Animal Experiments Links
Building Trust for Engagement of Minorities in Human Subjects Research: Is the Glass Half Full, Half Empty, or the Wrong Size?Link recommended by Sonia Jiwani
In 1974, in the aftermath of Tuskegee, Congress passed the National Research Act (Pub. L. No. 93-348), creating the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research as well as US federal regulations providing, for the first time, formal oversight of research with human participants. The Belmont Report, perhaps the most enduring legacy of the Commission, outlined three ethical principles to guide human research, and imposed new requirements for independent institutional review board assessment to ensure that research was consistent with these principles, reasonable with regard to risks and benefits, had appropriate informed consent procedures, and involved vulnerable groups only with justification and appropriate safeguards. Read more ...
Link recommended by Shyam Panthi
From the Nuremberg Code onward, the core mission of human subjects research ethics has been to protect study participants from infringements motivated by a zeal for medical progress. However, with individuals, clinicians, and policymakers increasingly dependent on scientific information for decision-making and with vast social resources invested in developing and utilizing the fruits of research, actors have powerful incentives to coopt research for narrow ends. Contemplated revisions to human subjects research ethics policies in the United States and existing policy in Canada and the United Kingdom fail to capture harms that, although they may not threaten participants, nonetheless undermine the social value of research. This is illustrated by postmarketing (phase IV) research. As a corrective, research ethics should focus on safeguarding the integrity of research as a critical component of an evidence-driven, health information economy. Read more ...
he Presidential Commission for the Study of Bioethical Issues today issued its report concerning federally-sponsored research involving human volunteers, concluding that current rules and regulations provide adequate safeguards to mitigate risk. In its report, “Moral Science: Protecting Participants in Human Subjects Research," the Commission also recommended 14 changes to current practices to better protect research subjects, and called on the federal government to improve its tracking of research programs supported with taxpayer dollars. Read more ...
Physicians, either in their role as investigators or as decision-makers involved in the deliberations related to the funding or the review of research, hold an ethical obligation to ensure the protection of research participants. When the research is to be conducted in countries with differing cultural traditions, health care systems, and ethical standards, and in particular in countries with developing economies and with limited health care resources, US physicians should respect the following guidelines: Read more ...
Link recommended by Olga Datskova
FILMED MAY 2012 • POSTED JAN 2013 • TEDxGoodenoughCollege
It’s an all too common story: after participating in an HIV clinical trial, a woman in sub-Saharan Africa is left without the resources to buy a bus ticket to her health clinic, let alone to afford life-saving antiretrovirals. Boghuma Kabisen Titanji asks an important question: how can researchers looking for a cure make sure they’re not taking advantage of those most affected by the pandemic?
Boghuma Kabisen Titanji set out to research HIV drug resistant viruses. In the process, Titanji met a woman who changed the way she thinks about research subjects. Read more ...
Published: October 17, 2013
Link recommended by Nathan Parker
Dr. Perry Hudson, 96, in South Pasadena, Fla. As part of a study he led in Manhattan, biopsies were taken on the prostates of alcoholic men, and testicles were removed in some cases.
A medical researcher from Columbia University, Dr. Perry Hudson, made the skid row alcoholics in Lower Manhattan an offer: If they agreed to surgical biopsies of their prostates, they would get a clean bed and three square meals for a few days, plus free medical care and treatment if they had prostate cancer. Read more ...
Until the early 1970S, R. J. Reynolds, Dow Chemical, the US Army, major pharmaceutical companies, and other sponsors conducted a wide variety of research on prisoners - a captive, vulnerable, and easily accessible population. During that time, approximately 90% of all pharmaceutical research was conducted on prisoners, who also were subjected to biochemical research ranging from testing diet drinks and simple detergents to studies involving dioxin and chemical warfare agents. Read more ...
Link recommended by Maleeya Coleman
Henrietta Lacks' cells were essential in developing the polio vaccine and were used in scientific landmarks such as cloning, gene mapping and in vitro fertilization. (Courtesy of the Lacks family)
Medical researchers use laboratory-grown human cells to learn the intricacies of how cells work and test theories about the causes and treatment of diseases. The cell lines they need are “immortal”—they can grow indefinitely, be frozen for decades, divided into different batches and shared among scientists. Read more ...
Link recommended by Maleeya Coleman
The healthy baby is part of a large research project outside the nation's capital that is decoding the DNA of hundreds of infants. New parents in a few other cities soon can start signing up for smaller studies to explore what's called genome sequencing - fully mapping someone's genes to look for health risks - should become a part of newborn care.
It's full of ethical challenges. Read more ...
Flawed Ethics in HPV Vaccine Trials in India
4. Vaccine trial's ethics criticized
A stuttering experiment performed on twenty-two orphan children in Davenport, Iowa in 1939.Link recommended by Madhumitha Mahadevan
“By the time I left to go home — just like every time from then on — I would recall nothing of my tests or the different doctors. I would only remember whatever explanations Dr. Robert G. Heath (of Tulane Medical School) gave me for the odd bruises, needle marks, burns on my head and fingers and even the genital soreness. I had no reason to believe otherwise. Already they had begun to control my mind!”
Claudia S. Mullen, March 15, 1995
Testimony to the Advisory Committee on Human Radiation Experiments
Link recommended by David Fullerton
Dr. Ram Yogev, director of the pediatric HIV/AIDS program at Children's Memorial Hospital in Chicago, examines a former foster child who is now adopted, on April 8 in Chicago.
Government-funded researchers tested AIDS drugs on hundreds of foster children over the past two decades, often without providing them a basic protection afforded in federal law and required by some states, an Associated Press review has found.
The research funded by the National Institutes of Health spanned the country. It was most widespread in the 1990s as foster care agencies sought treatments for their HIV-infected children that weren’t yet available in the marketplace. Read more ...
Click the link to visit the interactive website.
Chimp Haven in Keithville, La., serves as the national chimpanzee sanctuary.
By JAMES GORMAN
Published: June 11, 2013
Adding the animals to the list of endangered species would pose a new obstacle to their use in invasive biomedical research. Read more ...
The Harvard primate research center is shutting down after a very troublesome year. Photo credit: nytimes.com
The Harvard primate research center where four monkeys died because of animal care problems will be largely shut down by 2015, Harvard Medical School announced Tuesday afternoon. The university cited a tough economic climate for biomedical research funding and shifting long-term strategic plans.
The announcement stunned outside researchers, because it comes a year and a half after Harvard began investing significant time and resources into the New England Primate Research Center in Southborough, to correct animal care and oversight problems that had resulted in the deaths of four monkeys between June 2010 and Feb. 2012.
The US Department of Agriculture investigated the center and cited Harvard for violations of animal welfare rules, an embarrassing black eye that caused consternation across the university. But medical school leaders said the decision to close the primate center was unrelated to its previous problems. Read more ...
11 March 2013 | The search for alternatives to animal testing goes on
The ban applies to all new cosmetics and their ingredients sold in the EU, regardless of where in the world testing on animals was carried out.
The 27 EU countries have had a ban on such tests in place since 2009. But the EU Commission is now asking the EU's trading partners to do the same.
Animal rights lobbyists said EU officials had "listened to the people".
The anti-vivisection group BUAV and the European Coalition to End Animal Experiments (ECEAE) said they had spent more than 20 years campaigning on the issue and had enlisted celebrities including Sir Paul McCartney, Morrissey and Sienna Miller to their cause. They congratulated the EU Commission for putting the ban into effect. Read more ...
21 Feb 2013 | 19:13 GMT | Posted by Brendan Maher
US government officials have passed two more checkpoints on the long, winding road towards a policy for dealing with risky research. That journey was forced into overdrive at the end of 2011, when a government body recommended against publishing two studies showing how a deadly form of avian influenza H5N1 could be made to pass between mammals.
Today, the US National Institutes of Health (NIH) announced a final framework for vetting specific types of experiments before funding them. The US Office of Science and Technology Policy (OSTP) also published a long-awaited draft policy for how scientists and institutions should monitor and report on a wide range of research that malevolent forces could manipulate to do harm. This type of research, called dual-use research of concern (DURC), is fundable if the potential benefits are deemed significant and the risks deemed manageable. Read more ...
Link recommended by Hawley Kunz
Government officials are revising the 1991 Common Rule regulations that govern most human research in the United States. They have already received public comments on a 2011 Advance Notice of Proposed Rulemaking (ANPRM) (1). The public will have another chance to comment when officials publish specific proposals. The revision effort's overall goal is to remove unwarranted regulatory impediments to research while strengthening essential human subject protections. I offer three ideas for additions to the oversight system, each tied to one of the 1979 Belmont Report's (2) three ethical principles governing human research.
Although prepared by a U.S. advisory group, the Belmont Report expresses values embodied in historic documents like the Nuremberg Code, international statements like the Helsinki Declaration, and domestic oversight systems in countries around the world. The report emphasizes three ethical concepts (see the table). Although these concepts underlie many Common Rule provisions, insights gained since 1991 and unaddressed problems in the current oversight system point to new measures that could enhance the rule's ethical legitimacy. Read more ...
Published: May 12, 1997
Link recommended by Bismah Motawala
It has been 25 years since the nation learned that more than 400 black men infected with syphilis went untreated for decades in a federally financed experiment in this rural Southern town laced with sandy roads and pine forests.
These men, who are expected to receive a Presidential apology on Friday in Washington, have been the subject of countless academic studies, news articles and books, as well as a play and a made-for-television movie. Read more ...
An Institute of Medicine committee has released a report recommending stringent limits on the use of chimpanzees in biomedical and behavioral lab work performed at the National Institutes of Health. The report comes amid Congressional pressure to make sure such research is completed humanely.
The IOM’s recommendations focus on the scientific need for chimpanzees as research subjects, but they also took ethical issues into consideration. According to the IOM, chimpanzees' genetic closeness to humans and their similar biological and behavioral characteristics not only make these mammals a valuable species for certain types of research but these animals also demand “greater justification for conducting research with them,” the committee said. Read more ...
October 1, 2010 6:08 p.m. EDT
The Public Health Service took photographs during the Tuskegee syphilis study, but no captions remain. This is one of them.
(CNN) -- The Tuskegee syphilis experiment of the 20th century is often cited as the most famous example of unethical medical research. Now, evidence has emerged that it overlapped with a shorter study, also sponsored by U.S. government health agencies, in which human subjects were unknowingly being harmed by participating in an experiment.
Research from Wellesley College professor Susan Reverby has uncovered evidence of an experiment in Guatemala that infected people with sexually transmitted diseases in an effort to explore treatments. Read more ...
by Hayley Kappes / The Daily News
Posted on September 12, 2010 at 1:34 PM
Updated Sunday, Sep 12 at 1:37 PM
JOHNSON SPACE CENTER — April Evans wrestled for weeks whether to quit her dream job working for NASA’s operations with the International Space Station.
She concluded in March there was no other option but to resign after learning the space agency proposed a $1.75 million experiment to irradiate 18 squirrel monkeys to determine astronauts’ ability to withstand high levels of continuous radiation in deep space. Read more ...
(NaturalNews) Four prominent doctors at Kaplan Hospital in Rehovot and the Hartzfeld Geriatric Hospital in Gedera -- both located in Israel -- were arrested this week on suspicion of using elderly patients as the subjects of hundreds of illegal experiments.
The four doctors are suspected of wrongful death through negligence, abuse of helpless victims, aggravated assault, fraud, violation of a statutory obligation and interference in an investigation. Read more ...
Human medical experimentation in the United States: The shocking true history of modern medicine and psychiatry (1965-2005)Monday, March 06, 2006 by: Dani Veracity
The CIA continues a limited number of MKULTRA plans by beginning Project MKSEARCH to develop and test ways of using biological, chemical and radioactive materials in intelligence operations, and also to develop and test drugs that are able to produce predictable changes in human behavior and physiology (Goliszek).
Dr. Henry Beecher writes, "The well-being, the health, even the actual or potential life of all human beings, born or unborn, depend upon the continuing experimentation in man. Proceed it must; proceed it will. 'The proper study of mankind is man,'" in his "exposé" on human medical experimentation Research and the Individual ("Human Experimentation: Before the Nazi Era and After"). Read more ...