Controlling Microparticle Structure and Composition to Modulate Drug Release Kinetics
Tuesday, March 1, 2022
12:00 pm - 1:00 pm
About the Event
This seminar will describe the development of a microfabricated particle platform that releases drug in a discrete pulse after a lag period that can be tuned from hours to months by altering the composition of the particles’ biodegradable shell. These microparticles are largely payload-agnostic, enabling their use across a variety of applications. In particular, the McHugh Lab is employing this technology as a potential replacement for daily drug dosing to improve patient adherence and as a single-injection vaccination system that improves both vaccine efficacy and patient access in low-resource settings.
About the Speaker
Kevin McHugh’s primary research interest is in the development of biomaterial microdevices for drug delivery and tissue engineering. His laboratory combines cutting edge manufacturing techniques (e.g. multi-photon 3D printing) at the nano- and microscale with favorable material properties to facilitate device behavior. By using polymers’ well-understood structure-function relationships, McHugh aims to rationally design constructs that demonstrate predictable behavior and can be customized for a variety of applications. New research in the McHugh Lab, which is supported by a $2 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT), aims to apply the controlled-release technology he has developed for vaccines to cancer immunotherapy for the treatment of hepatocellular carcinoma.