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Faculty Profile

Yi DuYi Du

Research Assistant Professor
Department of Pharmacological and Pharmaceutical Sciences

University of Houston College of Pharmacy
Health 2, Room 5006
4349 Martin Luther King Boulevard
Houston, TX 77204-5037



My research focuses on understanding molecular mechanisms of cancer development and drug resistance by investigating the signaling and tumor micro-environment to develop mechanism driven therapeutic strategies.

  • Ph.D., The Graduate School of Biomedical Science, The Department of Molecular and Cellular Oncology, MD Anderson Cancer Center, University of Texas Health Science Center at Houston, Houston, TX
  • B.S., Department of Biology, Sichuan University, China


  • Dong Q*, Du Y*, Li H, Liu C, Chen MK, Zhao X, Chu YY, Qiu Y, Wei Y, Qin L, Yamaguchi H, and Hung MC, EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma. Cancer Research. 2019 Feb 15; 79(4): 819-829. PMID: 30573522.*Co-first authors
  • An J*, Du Y*, Fan X, Wang Y, Ivan C, Zhang XG, Sood AK, An Z, Zhang N. EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis. Oncogene. 2019 Mar; 38(12): 2123-2134. PMID: 30455428, *Co-first authors
  • Du Y, Yamaguchi H, Hsu JL and Hung MC, PARP inhibitors as precision medicine for cancer treatment. National Science Review. 2017 April 4; 4: 576592
  • Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR 4th, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nature Medicine. 2016 Feb; 22(2): 194-201. PMID: 26779812
  • Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MC. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 2014 Feb 6; 33(6): 756-70. PMID: 23376851
  • Du Y, Hsu JL, Wang YN, and Hung MC. Nuclear functions of receptor tyrosine kinases, Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease. Edited by Wheeler DL and Yarden Y. Springer Science, New York, pp 77-109, Date: 30 October 2014.

Awards & Honors

  • 2016 - Outstanding Research Publication Awards, University of Texas, MD Anderson Cancer Center
  • 2016 - The Harold C. and Mary L. Daily Endowment Fund Fellowship award, University of Texas, MD Anderson Cancer Center