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Profile: Yefei Wen

Yefei Wen, DVM, Ph.D.
Research Assistant Professor of Pharmacology

Health 2
University of Houston College of Pharmacy
4849 Calhoun, Room 5008
Houston, TX 77204-5039

Education & Post-graduate Training

DVM in Animal Husbandry and Veterinary Medicine, Northwest University for Nationalities, Lanzhou, Gansu, China

M. Agr. in Clinical Veterinary, Northwest A&F University, Yangling, Shaanxi, China

Ph.D. in Cell Biology, Academy of Military Medical Sciences, Beijing, China

Postdoctoral training at the Baylor College of Medicine, Houston, TX

Post-doctoral training at the University of Texas Health Science Center, Houston, TX

Postdoctoral training at Purdue University, West Lafayette, IN

Research Interests

Mechanisms of skeletal muscular regeneration; Regulation of skeletal muscle atrophy and hypertrophy; Diabetes and nutrients metabolism in skeletal muscle; Muscle stem cells and tissue engineering; Gametogenesis, embryogenesis, and fetal development.

Selected Publications

Shiyang Song*, Yefei Wen* (equal contribution), Hui Tong, Emanuele Loro, Ying Wooi Wan, Yingyun Gong, Jidong Liu, Tejvir S. Khurana, Zhandong Liu, Maoping Chu, and Zheng Sun (2019). The HDAC3 Enzymatic Activity Regulates Skeletal Muscle Fuel Metabolism. Journal of Molecular Cell Biology 11:133-143

Lianghao Lu*, Yefei Wen* (equal contribution), Yuan Yao, Fengju Chen, Guohui Wang, Fangrui Wu, Jingyu Wu, Padmini Narayanan, Michele Redell, Qianxing Mo and Yongcheng Song (2018). Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21)). Theranostics. 8:2189-2201.

Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Yefei Wen, Xin Gong, Qingyun Liu and Yi-Ping L (2017). Tumor Induces Muscle Wasting in Mice through Releasing Extracellular Hsp70 and Hsp90. Nature Communications 8:589

Pengpeng Bi, Feng Yue, Yusuke Sato, Sara Wirbisky, Weiyi Liu, Tizhong Shan, Yefei Wen, Daoguo Zhou, Jennifer Freeman, Shihuan Kuang (2016). Stage-specific Effects of Notch Activation during Skeletal Myogenesis. eLife 5, e17355.

Chunhui Jiang, Yefei Wen, Kazuki Kuroda, Kevin Hannon, Michael A. Rudnicki, Shihuan Kuang (2014). Notch Signaling Deficiency Underlies Age-dependent Depletion of Satellite Cells in Muscular Dystrophy. Disease Models & Mechanisms 7: 997-1004.

Yi-ping Li, Airu Niu, Yefei Wen (2014) Regulation of Myogenic Activation of p38 MAPK by TACE-mediated TNF-alpha Release. Frontiers in Cell and Developmental Biology 2:21. doi: 10.3389/fcell.2014.00021.

Airu Niu, Yefei Wen, Huijie Liu, Mei Zhan, Bingwen Jin, Yi-ping Li (2013). Src Mediates the Mechanical Activation of Myogenesis by Activating TNFα-converting Enzyme. Journal of Cell Science. 126: 4349-57.

Yefei Wen, Pengpeng Bi, Weiyi Liu, Atsushi Asakura, Charles Keller, Shihuan Kuang (2012). Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-renewal of Skeletal Muscle Satellite Cells. Molecular and Cellular Biology 32: 2300-2311.

Weiyi Liu, Yefei Wen, Pengpeng Bi, Xinsheng Lai, Shihuan Kuang (2012). Hypoxia Promotes Primary Myoblast Self-renewal and Enhances Myoblast Transplantation. Development 139: 2857-2865.

Sarah Nicklas, Anthony Otto, Xiaoli Wu, Pamela Miller, Sandra Stelzer, Yefei Wen, Shihuan Kuang, Klaus Wrogemann, Ketan Patel, Ding Hao, Jens Schwamborn (2012). TRIM32 Regulates Skeletal Muscle Stem Cell Differentiation and is Necessary for Normal Adult Muscle Regeneration. PLoS One. 7:e30445.

Dongjiao Zhao, Amber Pond, Bruce Watkins, Dave Gerrard, Yefei Wen, Shihuan Kuang and Kevin Hannon (2010). Peripheral Endocannabinoids Regulate Skeletal Muscle Development and Maintenance. European Journal Translational Myology 1: 167-179.


"How Does Notch Play in Division of Muscle Satellite Cells," poster presentation at Annual Scientific Retreat of Center for Cancer Research, Purdue University, September 16, 2010, West Lafayette, IN.

"Notch Regulation in Stem Cell Fate and Development in Skeletal Muscle, poster presented at Neuromuscular Therapeutic Strategies: Overcoming the Barriers from Microscope to Marketplace, March 13-16, 2011, Las Vegas, NV.

"Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells," Department of Biological Science, University of Notre Dame, Sept. 2, 2011, South Bend, IN.

"Muscular satellite cells and muscle regeneration," School of Biology, Dezhou University, May 7, 2012, Dezhou, Shandong, China.