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Faculty Profile

Riyasat AliRiyasat Ali

Research Assistant Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences

University of Houston College of Pharmacy
Health 2, Room 5007
4349 Martin Luther King Boulevard
Houston, TX 77204-5037



Currently, I am working on chronic and acute kidney diseases in animal models. My work explores immune cell infiltration in the kidney in response to ischemia/reperfusion (IR) injury in SD rats. Also, I am working to understand the mechanism(s) of immune cell infiltration and develop therapeutics. Moreover, I am exploring the renoprotective roles of AT2 receptor and its correlation with immune cell infiltration in chronic and acute kidney diseases. My recent work has shown that AT2R activation (by C21, a synthetic AT2R agonist) reduces the kidney infiltrating immune cells, thereby limiting post-IR kidney injury, and enhancing the tissue repair. Moreover, I have identified a potential role of T regulatory cells (Tregs) and AT2R-mediated Treg modulation in mitigating post-ischemia renal injury, and accelerating repair.

  • Ph.D. (Biochemistry/Immunology), All India Institute of Medical Sciences, New Delhi, India
  • Postgraduate Diploma (Bioinformatics), Jamia Millia Islamia (Central University), New Delhi, India
  • M.Sc. (Biotechnology), Jamia Millia Islamia (Central University), New Delhi, India
  • B.Sc. (Zoology, Botany, Chemistry), Meerut University, Meerut, UP, India

Google Scholar Profile
Web of Science Profile

Research and Review Articles

  • Ali R, Patel SN, Hussain T. Angiotensin type 2 receptor activation limits kidney injury during early phase and induces Treg cells during late phase of renal ischemia. American Journal of Physiology-Renal Physiology. 2021 Mar 15; doi:10.1152/ajprenal.00507.2020.
  • Schloss J, Ali R, Babad J, Guerrero-Ros I, Pongsachai J, Keler T, DiLorenzo TP. Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes. Immunohorizons 2019; Jun 26;3(6):236-253.
  • Schloss J, Ali R, Racine JJ, Chapman HD, Serreze DV, DiLorenzo TP: HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. The Journal of immunology 2018; 200 (10), 3353-3363.
  • Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP: Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease. Immunology 2016, 148(4):339-351.
  • Patel SN, Fatima N, Ali R, Hussain T: Emerging role of angiotensin AT2 receptor in anti- inflammation: an update. Curr Pharm Des. 2020; Jan 14. 26 (4), 492-500.

Selected Abstracts

  • "AT2 Receptor Activation Induces Treg Cells and Mitigates Renal Ischemic Injury," (R2046) Experimental Biology 2021, April 27-30, 2021
  • "Angiotensin AT2 Receptor Activation during Ischemic Injury Protects against High Salt-Induced Hypertension and Proteinuria in the Long-term: Role of IL-17A Cells." R Ali, S Patel, T Hussain. The FASEB Journal 36. Experimental Biology 2022, April 2-5, 2021
  • "Protective Role of Angiotensin II type 2 receptor (AT2R) in High Salt Diet-Induced Low Molecular Weight Proteinuria and Loss of Megalin in the Kidney." K Kulkarni, S Patel, R Ali, T Hussain. The FASEB Journal 36. Experimental Biology 2022, April 2- 5, 2021
  • "Development of a Humanized Mouse Model for Type 1 Diabetes Using Lentiviral Vector Based Gene Transfer Strategy (PP-09)," presented at the 42nd Annual New England Immunology Conference, Woods Hole, Massachusetts, USA, October 15-16, 2016
  • "Humoral and mucosal immune response to immunodominant peptides of YscF antigen of Yersinia pestis: An Immunoprophylactic approach to plague infection (PP- 049-23)," presented at the 14th International Congress of Immunology Kobe Japan, August 22-27, 2010. International Journal of Immunology, Volume 22, Issue Suppl_1_Pt_3, August 2010, Pages iii47–iii51,

Book Chapters

  • Book Title "Advances in Protein Chemistry," Chapter title "New peptide based therapeutic approaches." Riyasat Ali, Richa Rani, Sudhir Kumar (OMICS eBooks group).
  • Santwana Bhatnagar, Raza Ali Naqvi, Riyasat Ali, and D. N. Rao. 2014. "Preparation of Peptide Microspheres Using Tumor Antigen- Derived Peptides." Michael J.P. Lawman and Patricia D. Lawman (eds.), Cancer Vaccines: Methods and Protocols, Methods in Molecular Biology, vol. 1139, DOI 10.1007/978-1-4939-0345-0_34.
  • Riyasat Ali and D.N. Rao (2012). "Recent Advancement in the Development of Vaccines Against Y. pestis – A Potential Agent of Bioterrorism." Bioterrorism, Dr. Stephen Morse (Ed.), ISBN: 978-953-51-0205-2, InTech.

Awards & Honors

  • Dennis Shields Postdoctoral Award, Albert Einstein College of Medicine, New York, 2016
  • Foreign travels bursary, International Union of Immunology Societies, (IUIS), 2010
  • Council for Scientific and Industrial Research, Junior Research Fellow (CSIR-JRF)
  • Indian Council for Medical Research, Junior Research Fellow (ICMR-JRF)

Achievements and Involvement

  • Secretary, Einstein Postdoc Association, 2017-2018
  • Einstein College Senate Member (for Postdocs), 2017-2018
  • The Indian Immunology Society, India
  • The Society of Young Scientists AIIMS, New Delhi, India
  • The National Postdoctoral Association
  • Council for Scientific and Industrial Research, Senior Research Fellow (CSIR-SRF)
  • International editor: Journal of Nobel Medical College