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Faculty Profile

Riyasat AliRiyasat Ali

Research Assistant Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences

Office: 
University of Houston College of Pharmacy
Health 2, Room 5007
4349 Martin Luther King Boulevard
Houston, TX 77204-5037

Contact: rali31@central.uh.edu

Research:

Currently, I am working on chronic and acute kidney diseases in animal models. My work explores immune cell infiltration in the kidney in response to ischemia/reperfusion (IR) injury in SD rats. Also, I am working to understand the mechanism(s) of immune cell infiltration and develop therapeutics. Moreover, I am exploring the renoprotective roles of AT2 receptor and its correlation with immune cell infiltration in chronic and acute kidney diseases. My recent work has shown that AT2R activation (by C21, a synthetic AT2R agonist) reduces the kidney infiltrating immune cells, thereby limiting post-IR kidney injury, and enhancing the tissue repair. Moreover, I have identified a potential role of T regulatory cells (Tregs) and AT2R-mediated Treg modulation in mitigating post-ischemia renal injury, and accelerating repair.

  • Ph.D. (Biochemistry/Immunology), All India Institute of Medical Sciences, New Delhi, India
  • Postgraduate Diploma (Bioinformatics), Jamia Millia Islamia (Central University), New Delhi, India
  • M.Sc. (Biotechnology), Jamia Millia Islamia (Central University), New Delhi, India
  • B.Sc. (Zoology, Botany, Chemistry), Meerut University, Meerut, UP, India

ORCID ID
Google Scholar Profile
Publons Profile

Research and Review Articles

  • Ali R, Patel SN, Hussain T. Angiotensin type 2 receptor activation limits kidney injury during early phase and induces Treg cells during late phase of renal ischemia. American Journal of Physiology-Renal Physiology. 2021 Mar 15; doi:10.1152/ajprenal.00507.2020.
  • Schloss J, Ali R, Babad J, Guerrero-Ros I, Pongsachai J, Keler T, DiLorenzo TP. Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes. Immunohorizons 2019; Jun 26;3(6):236-253.
  • Schloss J, Ali R, Racine JJ, Chapman HD, Serreze DV, DiLorenzo TP: HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression. The Journal of immunology 2018; 200 (10), 3353-3363.
  • Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP: Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease. Immunology 2016, 148(4):339-351.
  • Patel SN, Fatima N, Ali R, Hussain T: Emerging role of angiotensin AT2 receptor in anti- inflammation: an update. Curr Pharm Des. 2020; Jan 14. 26 (4), 492-500.

Selected Abstracts

  • "AT2 Receptor Activation Induces Treg Cells and Mitigates Renal Ischemic Injury," (R2046) Experimental Biology 2021, April 27-30, 2021
  • "Angiotensin AT2 Receptor Activation during Ischemic Injury Protects against High Salt-Induced Hypertension and Proteinuria in the Long-term: Role of IL-17A Cells." R Ali, S Patel, T Hussain. The FASEB Journal 36. Experimental Biology 2022, April 2-5, 2021
  • "Protective Role of Angiotensin II type 2 receptor (AT2R) in High Salt Diet-Induced Low Molecular Weight Proteinuria and Loss of Megalin in the Kidney." K Kulkarni, S Patel, R Ali, T Hussain. The FASEB Journal 36. Experimental Biology 2022, April 2- 5, 2021
  • "Development of a Humanized Mouse Model for Type 1 Diabetes Using Lentiviral Vector Based Gene Transfer Strategy (PP-09)," presented at the 42nd Annual New England Immunology Conference, Woods Hole, Massachusetts, USA, October 15-16, 2016
  • "Humoral and mucosal immune response to immunodominant peptides of YscF antigen of Yersinia pestis: An Immunoprophylactic approach to plague infection (PP- 049-23)," presented at the 14th International Congress of Immunology Kobe Japan, August 22-27, 2010. International Journal of Immunology, Volume 22, Issue Suppl_1_Pt_3, August 2010, Pages iii47–iii51, https://doi.org/10.1093/intimm/dxq229

Book Chapters

  • Book Title "Advances in Protein Chemistry," Chapter title "New peptide based therapeutic approaches." Riyasat Ali, Richa Rani, Sudhir Kumar (OMICS eBooks group).
  • Santwana Bhatnagar, Raza Ali Naqvi, Riyasat Ali, and D. N. Rao. 2014. "Preparation of Peptide Microspheres Using Tumor Antigen- Derived Peptides." Michael J.P. Lawman and Patricia D. Lawman (eds.), Cancer Vaccines: Methods and Protocols, Methods in Molecular Biology, vol. 1139, DOI 10.1007/978-1-4939-0345-0_34.
  • Riyasat Ali and D.N. Rao (2012). "Recent Advancement in the Development of Vaccines Against Y. pestis – A Potential Agent of Bioterrorism." Bioterrorism, Dr. Stephen Morse (Ed.), ISBN: 978-953-51-0205-2, InTech.

Awards & Honors

  • Dennis Shields Postdoctoral Award, Albert Einstein College of Medicine, New York, 2016
  • Foreign travels bursary, International Union of Immunology Societies, (IUIS), 2010
  • Council for Scientific and Industrial Research, Junior Research Fellow (CSIR-JRF)
  • Indian Council for Medical Research, Junior Research Fellow (ICMR-JRF)

Achievements and Involvement

  • Secretary, Einstein Postdoc Association, 2017-2018
  • Einstein College Senate Member (for Postdocs), 2017-2018
  • The Indian Immunology Society, India
  • The Society of Young Scientists AIIMS, New Delhi, India
  • The National Postdoctoral Association
  • Council for Scientific and Industrial Research, Senior Research Fellow (CSIR-SRF)
  • International editor: Journal of Nobel Medical College