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Profile: Lei Wu

Lei Wu
Lei Wu, Ph.D.
Research Assistant Professor


Health 2
University of Houston College of Pharmacy
4849 Calhoun Road, Room 7052
Houston, TX 77204-5037

Office: 281-615-1539
Fax: 713-795-8305
lwu7@uh.edu

Education

Ph.D. Pharmaceutics, University of Houston College of Pharmacy, Houston, TX

Bachelor of Pharmacy, China Pharmaceutical University, Nanjing, China

Licensed Pharmacist (China)

Certified Assistant Engineer (China)

Research Interests

Biopharmaceutical analysis, preclinical pharmacokinetics study in animal models, and pharmacokinetics/pharmacodynamics (PK/PD) modeling

Research Skills

  • Population PK modeling using NONMEN, Phoenix NLME
  • PK/PD modeling using ADAPT and Matlab
  • Drug analysis using ABI 3200,5500 QTRAP HPLC/MS/MS, HPLC and GC
  • DNA extraction using Maxwell 16® instrument
  • Protein analysis using Luminex 200 instrument
  • Plasmid and genomic DNA preparation and manipulation
  • Protein preparation and electrophoresis
  • PCR

Research Funding

NASA Johnson Center ($50,840), October 2015 – September 2016
Project: Development of predictive degradation models and determination of bioequivalence of pharmaceutical preparations contained in the medical kits on board the International Space Station [Support of NSBRI First Award Fellowship as Postdoctoral Associate]

CPRIT, ($514,623), September 2018 – August 2023
Project: GCC Center for Comprehensive PK/PD and Formulation (CCPF) Co-I under PI of Dr. Chow, Subaward from Texas Southern University for PK/PD modeling and correlation and simulation

Awards & Honors

  • PPS Research Symposium, 2nd Prize for podium presentation, 2018
  • First Award Fellowship from the National Space Biomedical Research Institute (NSBRI), 2015
  • Student/Trainee Awards, American College of Clinical Pharmacology, 2012, 2014, and 2015

Publications and Patents

Publications

 

Daping Zhang, Lei Wu, Diana S.-L. Chow, Vincent H. Tam, Danielle R. Rios, Quantitative determination of dopamine in human plasma by a highly sensitive LC-MS/MS assay: Application in preterm neonates, Journal of Pharmaceutical and Biomedical Analysis, 117: 227-231, 2016.

Wu L, Boyd JL, Daniels V, Wang Z, Chow DS, Putcha L. Dose escalation pharmacokinetics of intranasal scopolamine gel formulation. J Clin Pharmacol. 55(2): 195-203, 2015.

Weeks PA, Teng Y, Wu L, Sun M, Yang Z, Chow DS. Chemical and physical compatibility of an intravenous solution of epinephrine with calcium chloride. Int J Pharm Compd. 2014 MarApr;18(2):152-8.

Cui Z, Chow DS, Wu L, Lazar DA, Rodrigo R, Olutoye OO, Olutoye OA. High performance liquid chromatography-tandem mass spectrometric assay of dexmedetomidine in plasma, urine and amniotic fluid samples for pregnant ewe model. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 961: 13- 19.

John J, John M, Wu L, Hsiao C, Abobo CV, Liang D.Effects of etravirine on the pharmacokinetics and pharmacodynamics of warfarin in rats. Br J Pharmacol. 2013 Apr; 168(8):1851-8. doi: 10.1111/bph.12082.

Yin J, Lu K, Lin J, Wu L, Hildebrandt MA, Chang DW, Meyer L, Wu X, Liang D. Genetic variants in TGF-β pathway are associated with ovarian cancer risk. PLoS One. 2011; 6(9):e25559.

Cyril Abobo, Lei Wu, Mathew Kizhakkekara, Jyothy John, Dong Liang. LC-MS/MS determination of etravirine in rat plasma and its application in pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Nov 15; 878(30):3181-6.

Patents

Itraconazole Formulations, US patent published # WO/2012/039768.

Presentations

Lei Wu*, Pavan Chityala*, Romi Ghose and Diana S-L Chow. Development of a Best-fit Pharmacokinetic Model of Irinotecan and Its Active Metabolite, SN-38 in Mice with and without Inflammation. To be resented in 32nd Annual Meeting of AAPS, Washington, DC, November 4-7, 2018.

Ashley Nguyen, Lei Wu, Angela Teng, Mahua Sarkar, Elizabeth Toups, Robert G Grossman and Diana S-L Chow. Progressive model for population pharmacokinetics of riluzole therapy in patients with acute spinal cord injury. To be presented in NeuroTrauma 2018, the 3rd Joint Symposium of the International and National Neurotrauma Societies and AANS/CNS Section on Neurotrauma and Critical Care, Toronto, Ontario, Canada, August 11-16, 2018.

Pavan Kumar Chityala, Lei Wu, Guncha Taneja, Diana S-L Chow, Ming Hu, Song Gao, Romi Ghose. A pharmacokinetic study of irinotecan (CPT-11) during inflammation in mice. Presented in Annual Meeting of Experimental Biology, San Diego, CA, April 21-25, 2018.

Lei Wu, Diana S-L. Chow, Development and validation of a UPLC-MS/MS method for determination of loratadine in tablets stored on board the International Space Station. Presented in 31st Annual Meeting of AAPS, San Diego, CA, November 12-16, 2017.

Lorita Agu, Lei Wu, Anna Carmela P. Sagcal-Gironella, Diana S-L. Chow. Compartmental pharmacokinetic model analysis for mycophenolic acid and its glucuronide metabolite in patients with childhood-onset systemic Lupus Erythematosus. Presented in the 46th Annual Meeting of ACCP, San Diego, CA, September 17-19, 2017.

Lei Wu, Diana S-L Chow and Vernie Daniels. Development and validation of an UPLC-MS/MS method for simultaneous determination of ibuprofen and promethazine in tablets stored on board the International Space Station. Presented in 30th Annual Meeting of AAPS, Denver, CO, November 13- 17, 2016.

Lei Wu, Diana S-L. Chow, Vincent Tam, Lakshmi Putcha. Validation of a best-fit pharmacokinetic model for scopolamine disposition after intranasal administration. Presented in 29th Annual Meeting of AAPS, Orlando, FL, October 25-29, 2015.

Cheng-Hui Hsiao, Olutoyin Olutoye, David Lazar, Lei Wu, Dong Liang and Diana S-L. Chow. Fat percentage as important covariate on propofol pharmacokinetics in pediatric obese population. Presented in the 44th Annual Meeting of ACCP, San Francisco, CA, September 27-29, 2015. [Cheng-Hui Hsiao: Winner of ACCP President’s Student Abstract Award].

Lei, Wu, Diana S-L. Chow, Lakshmi Putcha. The utility of population approach of bioequivalence analysis for intranasal scopolamine in simulated microgravity study. Presented in the 44th Annual Meeting of ACCP, San Francisco, CA, September 27-29, 2015. [Lei Wu: Winner of ACCP President’s Student Abstract Award].

Lei, Wu, Vincent Tam, Diana S-L. Chow, Lakshmi Putcha. A population pharmacokinetic model for disposition in plasma, saliva and urine of scopolamine after intranasal administration to healthy human subjects. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Cheng-Hui Hsiao, Zhiyi Cui, Lei Wu, Olutoyin A. Olutoye, Dong Liang, and Diana S-L. Chow. Fat percentage as important covariate on propofol pharmacokinetics in obese Zucker rat model. Presented in 28th Annual Meeting of AAPS, San Diego, CA, November 2-6, 2014.

Lei Wu, Vincent Tam, Diana S-L. Chow, Lakshmi Putcha. Pharmacokinetic modeling of intranasal scopolamine in plasma saliva and urine. Presented in the 43rd Annual Meeting of ACCP, Atlanta, GA, September 14-16, 2014 [Lei Wu: Winner of ACCP President’s Student Abstract Award].

Lei Wu, Diana S-L. Chow, and L Putcha. Population pharmacokinetics of intranasal scopolamine. Presented in 27th Annual Meeting of AAPS, San Diego, TX, November 10-14, 2013.

Lei Wu, Diana S-L. Chow, and L Putcha. Impact of gender on pharmacokinetics of intranasal scopolamine. Presented in the 42nd Annual Meeting of ACCP, Bethesda, MD, September 22-24, 2013.

L Wu, VR Daniels, CJ Crady, D. S-L. Chow and L. Putcha. Dose-escalating clinical pharmacokinetics of scopolamine in plasma, saliva and urine from intranasal gel formulation. Presented in 26th Annual Meeting of AAPS, Chicago, IL, October 14-18, 2012.

Zhiyi Cui, Lei Wu, Olutoyin A. Olutoye, Diana S-L. Chow, Determination of dexmedetomidine in maternal - fetal unit of pregnant ewes using high performance liquid chromatography - tandem mass spectrometric detection. Presented in 26th Annual Meeting of AAPS, Chicago, IL, October 14-18, 2012.

L Wu, VR Daniels, CJ Crady, D. S-L.Chow and L. Putcha. Pharmacokinetics of intranasal scopolamine gel formulation – A dose escalation clinical trial. Presented in the 41st Annual Meeting of ACCP, San Diego, CA, September 23-25, Clinical Pharmacology in Drug Development, 1: 204, 2012 [L Wu: Winner of ACCP President’s Student Abstract Award].

Lei Wu, V. R. Daniels, C. J. Crady, Diana S-L. Chow and Lakshmi Putcha. Pharmacokinetics of intranasal scopolamine gel formulation during antiorthostatic bedrest - a microgravity analog. Presented in 25th Annual Meeting of AAPS, Washington, DC, October 23-27, 2011.

Memberships

  • Member, American College of Clinical Pharmacology, 2012 – Present
  • Member, American Association of Pharmaceutical Scientist, 2009 – Present
  • Member, Chinese Association of Pharmaceutical Scientists, 2004 – Present