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Faculty Profile

Jiukuan HaoJiukuan Hao

Associate Professor of Pharmaceutics
Department of Pharmacological and Pharmaceutical Sciences

University of Houston College of Pharmacy
Health 2, Room 7003
4349 Martin Luther King Boulevard
Houston, TX 77204-5039

Contact: - 713-743-9411


My research focuses on understanding mechanisms of neural injury and developing new therapeutic approach for neuronal-degenerative diseases such as ischemic stroke, Parkinson disease, Alzheimer's disease, vascular dementia; investigating the role of microglia in neuroinflammation, and the roles of endothelial hippo signaling pathway and TDP43 in neuronal-degenerative diseases; and developing novel delivery system targeting the blood-brain barrier for macromolecule brain delivery.

  • PhD. in Pharmaceutical Science, Texas Tech University, Lubbock, TX
  • Postdoctoral Fellowship in Neuroscience, Universidad Central Del Caribe, Puerto Rico
  • M.S. in Neurology, China Medical University, China
  • M.D. in Medicine, China Medical University, China

Ongoing Research

  • R01NS105787 (Hao), 10/01/2018-09/30/2023, NIH/NINDS, Targeting the Hippo signaling at the Blood-brain barrier for therapy of ischemic stroke, Goal: To elucidate the role of YAP/TAZ in regulating the BBB function, and evaluate protective effect of YAP/TAZ on brain ECs and the BBB against ischemia/reperfusion injury, and to develop a novel approach, YAP/TAZ-exosome, for treatment of ischemic stroke. Role: PI

Completed Research Support

  • R15NS088384 (Hao), 04/01/2015-03/31/2018, NIH/NINDS, Targeting the Blood-Brain Barrier in Ischemic Stroke Goal: To effectively deliver DNA construct into the brain with a goal to protect neuron from injury/death under cerebral ischemia/reperfusion (IR) condition. Role: PI
  • R21NS093493 (Hao), 06/01/2015-05/31/201, NIH/NINDS, Application of Brain-Targeted Anti-inflammatory RNA Nanoparticle for Ischemic Stroke Therapy Goal: to develop a RNA nanoparticle to target the blood-brain barrier for ischemic stroke therapy in mouse. Role: PI
  • The Michael J. Fox Foundation for Parkinson's Research: THE MULTIFUNCTIONAL CEMBRANOIDS FOR THERAPY OF PARKINSON'S DISEASE. (P.I.: Hao J) Role: Principal investigator 3/1/2012- 2/28/2013 The goal of this project is to evaluate therapeutic effect of β-cembrane, a compound from tobacco, and its underlying mechanisms in the treatment of PD.
  • Maine Cancer Foundation Pilot Research Grant (P.I.: Hao J): Inhibition of Intercellular Adhesion Molecule-1 in Lung Cancer Cells by Selective SiRNA Nanoparticles. Role: Co-investigator. 7/1/2013-06/30/2014 The goal of this project is to develop a dual functional RNA nanoparticle targeting Intercellular Adhesion Molecule-1 for Lung Cancer therapy.
  • American Heart Association: THERAPY OF STROKE WITH NOVEL NEUROPROTECTIVE RNA NANOPARTICLES Role: Principal investigator 1/1/2012-12/31/2013. The goal of this project is to develop a dual functional RNA nanoparticle targeting Intercellular Adhesion Molecule-1 for ischemic stroke therapy.
  • University Research Council Faculty Research Grant Program at University of Cincinnati: The Role of Hax-1 in Ischemic Stroke. Role: Principal investigator 1/1/2012-12/31/2012
  • The Center for Clinical/ Translational Science and Training at University of Cincinnati: the Just-In-Time grant: Targeting delivery of anti-NF-kB DNA nanoparticle to primary brain endothelial cells. Role: Principal investigator 7/1/2014- 6/30/2015


  • 2007 - American Association of Pharmaceutical Scientists scholarship
  • 2012 - Research Excellence Award, University of Cincinnati, College of Pharmacy
  • 2015 - Research Excellence Award, University of Cincinnati, College of Pharmacy