Sanghyuk Chung to Use in Drug Screening Development
The University of Houston’s Center for Nuclear Receptors and Cell Signaling received a Hewlett-Packard D300e BioPrinter to advance the fight against COVID-19. The donation includes supply cassettes and training, free of charge.
Sanghyuk Chung, associate professor of biology and biochemistry at UH’s College of Natural Sciences and Mathematics, will use the printer to build an innovative drug screening platform. Chung’s system could identify and develop an anti-viral drug for SARS-CoV-2, the virus that causes COVID-19.
Chung said the cell-based high-throughput screening system will have advantages over the traditional in vitro enzyme systems.
UH is one of four research laboratories, and the only U.S. laboratory, to receive the printer donation from HP.
News Release Issued by HP
HP Inc. (NYSE: HPQ) today announced the deployment of HP D300e BioPrinters, associated supply cassettes, and training, free of charge, to research laboratories in the U.S. and Europe to help accelerate drug and vaccine research to combat COVID-19.
“Each of us has a role to play to combat this pandemic, and HP and the HP Foundation have donated millions of dollars in products and grants to support local communities impacted by COVID-19 worldwide,” said Annette Friskopp, Global Head and General Manager, Specialty Printing Systems, HP Inc. “We are inspired by the research being conducted by laboratories worldwide to better understand this pandemic, and if the HP D300e BioPrinter in the hands of these scientists can help accelerate their drug and vaccine research, it’s our responsibility to step forward and dedicate resources and technology to make it happen.”
How it Works
The BioPrinter with inkjet printing technology enables automated laboratory dispensing to “print” pharmaceutical samples instead of ink. The BioPrinter accurately dispenses or “prints” volumes from picoliters to microliters for fast, reliable dispensing of small molecules and biomolecules. The BioPrinter enables labs to eliminate serial dilution from dose response workflows, miniaturize qPCR reaction volumes, and easily dispense any volume in any well for a broad array of low-volume dispensing applications in drug discovery, genomics, and proteomics research.
Spanish National Research Council (CSIC), the largest and leading public research institution in Spain, will leverage the BioPrinter to investigate how the spike protein of COVID-19 reacts in the population most at risk for infection, including healthcare professionals, security forces, and the elderly. The Madrid-based institution will also contribute to the research of new drugs capable of controlling the interaction of the ACE2 receptor for the protein S of COVID-19, the main gateway for the virus; and map the SARS-COV-2 "peak" protein using different fragments and epitopes of proteins, among others.
Researchers from the Center for Nuclear Receptors and Cell Signaling (CNRCS) at University of Houston are developing anti-viral drugs and prophylactic vaccines for COVID-19. In particular, efforts to develop an innovative drug screening platform for the virus are in progress. This high-throughput screening system can be easily modified for other infectious diseases. The BioPrinter will be used to dispense reagents with high accuracy and will be used to develop a drug development tool for COVID-19 treatment.
Monoclonal Antibody Discovery Laboratory at Fondazione Toscana Life Sciences in Siena, Italy focuses on monoclonal antibody (mAb) discovery against infectious diseases. The lab will use the BioPrinter will accelerate their testing of potency of mAbs against COVID-19, as well as other infectious bacteria and viruses.
The Grenoble Alpes University Hospital (CHUGA), third largest research university in France, released emergency aid to team of scientist and doctors to launch bio-clinical research on COVID-19 immunization. The BioPrinter will be mainly used to automatize the screening of infected individuals' sera for neutralizing antibodies.
COVID-19 Community Response
HP and HP Foundation have committed to donate an estimated $8 million worth of technology and grants to support blended learning and local communities impacted by COVID-19 worldwide. HP and its global network of partners and customers have also produced more than 3.3 million 3D printed parts for face shields, respirators, nasal swabs and other items for distribution to hospitals.