CARLOS HUMBERTO PEDEMONTE
Dept. of Pharmacological and Pharmaceutical Sciences
University of Houston,
College of Pharmacy,
4800 Calhoun
Houston, TX 77204-5515
Telephone: 713-743-1228/1211
Fax: 713-743-1229
e-mail: pedemonte@jetson.uh.edu
web-page: http://www.uh.edu/~cpedemon
EDUCATION:
University of Cordoba, Argentina, 1975, BS. (Biochemistry).
University of Rio Cuarto, Argentina, 1982, Ph. D (Biochemistry).
PRESENT POSITION:
Associate Professor, College of Pharmacy, University of Houston 9/98-present
POSITIONS HELD:
Lecturer (Biological Chemistry), University Rio IV, Argentina 1976-82
Instructor (General Chemistry), University Rio IV, Argentina 1978-81
Research Council Post-doctoral fellow, Argentina 1982-83
Post-doctoral fellow, Physiology, University of Pennsylvania 1984-87
Research Assist. Professor, Physiology, University of Pennsylvania 1987-92
Assistant Professor, College of Pharmacy, University of Houston 1992-98
SERVICE AT THE UNIVERSITY OF HOUSTON:
Member of the University of Houston Senate. Member of the Committee on Committees.PUBLICATIONS:
Pedemonte C. H. and Balegno H. F. Isolation of a thermostable modifier of the Ca2+-stimulated ATPase from human red cells. (1981) Biochem. Biophys. Res. Commun. 99, 994-1001.
Pedemonte C. H. and Balegno H. F. Ca2+-stimulated ATPase from rat red cell membranes: studies on the mechanism. (1981) Comp. Biochem. Physiol. 70B, 559-564.
Pedemonte C. H. and Balegno H. F. Inactivation by Ca2+ of Ca2+-stimulated ATPase from rat red cells. (1981) Molec. Cell. Biochem. 40, 105-107.
Pedemonte C. H. and Balegno H. F. Kinetic studies and characteristics of a modifier of Ca2+-stimulated ATPase. (1982) Int. J. Biochem. 14, 429-434.
Pedemonte C. H. and Balegno H. F. Ca2+-stimulated ATPase: Inactivation by Ca2+ and mechanism. (1982) Molec. Cell. Biochem. 47, 31-34.
Pedemonte C. H. and Beauge L. H. Inhibition of Na,K-ATPase by magnesium ions and inorganic phosphate and release of these ligands in the cycles of ATP hydrolysis. (1983) Biochem. Biophys. Acta 748, 245-253.
Beauge L. H., Berberian G., Campos M. and Pedemonte C. H. Substrate role of acetyl phosphate on Na,K-ATPase. In: The Sodium Pump (Glynn I. M. and Ellory C., Eds.) The Company of Biologists Ltd. 321-333, 1985.
Pedemonte C. H. and Beauge L. H. Effects of ATP and monovalent cations on Mg2+-inhibition of Na,K-ATPase. (1986) Arch. Biochem. Biophys. 244, 596-606.
Pedemonte C. H. and Kaplan J. H. Carbodiimide inactivation of Na,K-ATPase. A consequence of internal cross-linking and not carboxyl group modification. (1986) J. Biol. Chem. 261, 3632-3639.
Pedemonte C. H. and Kaplan J. H. Carbodiimide inactivation of Na,K-ATPase, via intramolecular cross-link formation, is due to inhibition of phosphorylation. (1986) J. Biol. Chem. 261, 16660-16665.
Pedemonte C. H. and Kaplan J. H. Interaction of the Na,K-ATPase with H2DIDS. (1988) Progr. Clin. Biol. Res. 268, 327-334.
Pedemonte C. H. and Kaplan J. H. Inhibition and derivatization of the renal Na,K-ATPase by dihydro 4,4'-diisothiocyano stilbene 2,2'-disulfonate (H2DIDS). (1988) Biochemistry 27, 7966-7973.
Pedemonte C. H. Kinetic mechanism of inhibition of the Na-pump and some of its partial reactions by external Na+. (1988) J. Theor. Biol. 134, 165-182.
Pedemonte C. H. Interaction of external Na+ with the Na-ATPase. A by-product inhibition? (1988) Progr. Clin. Biol. Res. 268, 545-552.
Pedemonte C. H. and Kaplan J. H. Chemical modification of the sodium-pump protein as an approach to the elucidation of the function-structure relationship (1989) Am. J. Physiol. 258 (Cell Physiol. 27): C1-C23.
Pedemonte C. H., Sachs G. and Kaplan J. H. An intrinsic membrane glycoprotein with cytosolic oriented N-linked sugars. (1990) Proc. Natl. Acad. Sci. USA. 87, 9789-9793.
Pedemonte C. H. and Kaplan J. H. The Na-pump alpha-subunit has N-linked glycans facing the cytosol. (1991) Soc. Gen. Physiol. Ser. 46, 309-312.
Pedemonte C. H. and Kaplan J. H. A monosaccharide is bound to the Na-pump alpha-subunit. (1992) Biochemistry 31, 10465-10470.
Pedemonte C. H., Kirley T. L., Treuheit M. J., and Kaplan J. H. Inactivation of the Na, K-ATPase by modification of Lys-501 with 4-acetamido-4'-isothiocyanato stilbene-2,2'-disulfonic acid (SITS) (1992) FEBS Lett. 314, 97-100.
Pedemonte C. H. Structure-function relationship of membrane ion pumps. (1993) Drug News and Persp. 6, 498-507.
Pedemonte C. H. Inhibition of Na-pump expression by impairment of protein glycosylation is independent of the reduced sodium entry into the cell (1995) J. Membrane Biol. 147, 223-231.
Pedemonte C. H., Pressley T. A., Lokhandwala M. F. and Cinelli A. R. Regulation of Na,K-ATPase transport activity by protein kinase C (1997) Journal Membrane Biology 155, 219-227.
Pedemonte C. H., Pressley T. A., Cinelli A. R. and Lokhandwala M. F. Stimulation of protein kinase C rapidly reduces intracellular Na+ concentration via activation of the Na+-pump in OK cells (1997) Molecular Pharmacology 52, 88-97.
Chibalin A. V., Pedemonte C. H., Katz A. I., Feraille E., Berggren P-O. and Bertorello A. M. Phosphorylation of the catalytic alpha-subunit constitutes a triggering signal for Na,K-ATPase endocytosis. (1998) J. Biol. Chem. 273, 8814-8819.
Chibalin A. V., Ogimoto G., Pedemonte C. H., Pressley, T. A., Katz A. I., Feraille E., Berggren P-O and Bertorello A. M. Dopamine-induced endocytosis of Na,K-ATPase is inititated by phosphorylation of Ser-18 in the rat alpha-subunit and is responsible for the decreased activity in epithelial cells. (1999) J. Biol. Chem. 274, 1920-1927.
Ferraile E., Carranza M. L., Gonin S., Beguin P., Rouselot M., Pedemonte C. H. Cavezasio J., Geering K., Martin P-Y., and Favre H. Insulin-induced stimulation of Na,K-ATPase activity in proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10.(1999) Mol. Biol. Cell 10, 2847-2859.
Efendiev R., Bertorello A. M. and Pedemonte C. H. PKC-b and PKC-z mediate opposing effects on proximal tubule Na,K-ATPase activity. (1999) FEBS Let. 456, 45-48.
Ogimoto G., Yudowski G. A., Barker C. J., Kohler M., Katz A. I., Feraille E., Pedemonte C. H., Berggren P-O. and Bertorello A. M. G-protein-coupled receptors regulate Na,K-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin. (2000) Proc. Natl. Acad. Sciences (USA) 97, 3242-3247. This paper was communicated by Nobel Prize Winner Jens C. Skou
Yudowski G. A., Efendiev R.,Pedemonte C. H., Katz A. I., Berggren P-O. and Bertorello A. M. Phosphoinositide-3 kinase binds to a proline-rich motif in the Na,K-ATPase alpha-subunit and regulates its trafficking. (2000) Proc. Natl. Acad. Sci. (USA) 97, 6556-6561.
Efendiev R., Bertorello A. M., Pressley T. A. and Pedemonte C. H. Molecular mechanism responsible for hormonal regulation of renal Na-pump. (2000) Exc. Medica Int. Cong. Series. 1207, 501-506.Efendiev R., Bertorello A. M., Pressley T. A., Rousselot M. Feraille E. and Pedemonte C. H. Simultaneous phosphorylation of Ser11/Ser18 in the alpha-subunit promotes the recruitment of Na,K-ATPase molecules to the plasma membrane. (2000) Biochemistry 39, 9884-9892.
Allen J. C., Abramowitz J., Pedemonte C. H. and Jemelka S. Functional expression of Na pump a1T in two mammalian expression systems. (2000) Exc. Medica Int. Cong. Series. 1207, 501-506.
Salgado-Commissariat D., Zandomeni R. and Pedemonte C. H. (2001) Cytoplasmic Segment Interactions in the alpha-1 subunit of the rat Na,K-ATPase. Clin. Exper. Hypertension 23, 479-488.
Pedemonte C. H. and Bertorello A. M. (2001) Short-term regulation of the proximal tubule Na,K-ATPase: Increased/decreased Na,K-ATPase activity mediated by protein kinase C isoforms. J. Bioenerg. Biomemb. 33, 441-449.
Narkar V. A., Hussain T., Pedemonte C. H. and Lokhandwala M. F. (2001) Dopamine D2 receptor activation causes mitogenesis via p44/42 MAPK in Opposum kidney cells. J. Am. Soc. Nephrol. 12,1844-1852.
Efendiev R., Bertorello A.M., Zandomeni R., Cinelli A.R., and Pedemonte C. H. (2002) Agonist-dependent regulation of renal Na,K-ATPase activity is modulated by intracellular sodium concentration. J. Biol. Chem. 277: 11489-11496.Stefania Cotta DonÈ, Ingo B. Leibiger, Riad Efendiev, Adrian I. Katz, Barbara Leibiger, Per-Olof Berggren, Carlos H. Pedemonte, and Alejandro M. Bertorello (2002) Tyrosine-537 within the Na,K-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis. J. Biol. Chem. 277,17108-17111
Efendiev R., Yudowski G. A., Zwiller J., Leibiger B., Katz A. I., Berggren P. O., Pedemonte C. H.,Leibiger I. B., Bertorello A. M.(2002) Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na,K-ATPase endocytosis. J. Biol. Chem. 277, 44108-44114.
Budu C. E., Efendiev R. , Cinelli A. M. , Bertorello A. M. and Pedemonte C. H. (2002) Hormonal-dependent recruitment of Na,K-ATPase to the plasmalemma is mediated by PKC-beta and modulated by intracelular sodium concentration. Brit J. Pharmac. 137, 1380-1386.
Bertorello A. M. , Komarova Y., Smith K. , Leibiger I. B., Efendiev R., Pedemonte C. H., Borisy G. and Sznajder J. I. (2003) Analysis of Na + ,K + -ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells. Mol. Biol. Cell 14, 1149-57
Dada L. A., Chandel N. S. , Ridge K. M., Pedemonte C. H., Bertorello A. M. and Sznajder J. I. (2003) Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC. J. Clin. Invest. 111, 1057-64.
Efendiev R., Budu C. E., Cinelli A. M., Bertorello A. M. and Pedemonte C. H. (2003) Intracellular Na+ regulates dopamine- and angiotensin II-receptors availability at the plasma membrane, and their cellular responses in renal epithelia. J. Biol. Chem. 278: 28719 - 28726.
SCIENTIFIC MEETING COMMUNICATIONS:ï Pedemonte C. H. and Balegno H. Activation of (Ca2+ + Mg2+)-ATPase in rat erythrocyte membranes. (1979). XV National Meeting of the Argentine Society of Biochemical Research (SAIB). Mendoza, Argentina.
ï Pedemonte C. H., Domenech C. and Balegno H. Biphasic activation of Mg2+-ATPase by ATP and Mg2+ (1979) PAABS Meeting. Vina del Mar. Chile.
ï Pedemonte C. H. and Balegno H. Effect of an endogenous activator on the Mg2+-ATPase activity of rat erythrocyte membranes (1980). XVI National Meeting of the Argentine Society of Biochemical Research (SAIB). Mendoza, Argentina.
ï Pedemonte C. H. and Balegno H. Effect of a thermostable modifier on the phosphorylation and dephosphorylation of the Ca2+-pump of human erythrocytes (1981) XVII National Meeting of the Argentine Society of Biochemical Research (SAIB). Cordoba, Argentina.
ï Pedemonte C. H. and Beauge L. Inhibition of the Na,K-ATPase by Mg2+ and Pi. (1982) XVIII National Meeting of the Argentine Society of Biochemical Research (SAIB). Cordoba, Argentina.
ï Pedemonte C. H. and Beauge L. Different modalities of ATP hydrolysis by the Na,K-ATPase characterized from Mg2+ inhibition (1983) XIX National Meeting of the Argentine Society of Biochemical Research (SAIB). Cordoba, Argentina.
ï Beauge L. H., Berberian G., Campos M. and Pedemonte C. H. Substrate role of acetyl phosphate on Na,K-ATPase. (1984) 4th International Conference on the Na,K-ATPase. Cambridge, England.
ï Pedemonte C. H. and Beauge L. Alternative pathways for ATP hydrolysis carried out by the Na,K-ATPase. (1984) 8th International Biophysics Congress. Bristol, United Kingdom.
ï Pedemonte C. H. and Beauge L. Mechanism of ATP hydrolysis by Na,K-ATPase from Mg2+ inhibition patterns (1984) Biophys. J. 45, 322. 28th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H. and Kaplan J. H. Carbodiimides inhibit Na,K-ATPase by forming intramolecular cross-links. (1985) Biophys. J. 47, 342. 29th Annual meeting of the Biophysical Society.
ï Pedemonte C. H. and Kaplan J. H. Inhibition of the Na,K-ATPase by H2DIDS (1986) Biophys. J. 49, 35a. 30th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H. and Kaplan J. H. Mechanism of inactivation of renal Na,K-ATPase by H2DIDS. (1987) Biophys. J. 51, 348a. 31th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H. and Kaplan J. H. Interaction of the Na,K-ATPase with H2DIDS. (1988). 5th International Conference on Na,K-ATPase. Aarhus, Denmark.
ï Pedemonte C. H. and Kaplan J. H. Modification of arginine residues in the Na,K-ATPase (1988) Biophys. J. 53, 222a. 32th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H. Interaction of external Na+ with the Na-ATPase. A by-product inhibition? (1988). 5th International Conference on Na,K-ATPase. Aarhus, Denmark.
ï Pedemonte C. H., Hall K., Sachs G. and Kaplan J. H. Glycosylation state of the Na-pump alpha-subunit. (1990) Biophys. J. 57, 355a. 34th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H. and Kaplan J. H. The Na-pump alpha-subunit has N-linked glycans facing the cytosol (1990) 44th Annual Symposium of the Society of General Physiologists. 6th International Conference on Na,K-ATPase. Woods Hole, Massachusetts.
ï Bucholtz S., Pedemonte C. H. and Kaplan J. H. Anomalous gel electrophoresis resolution of a membrane protein (1991) Physiological Society of Philadelphia. Philadelphia, Pennsylvania.
ï Pedemonte C. H. and Kaplan J. H. A molecule of N-acetyl glucosamine is N-linked to the alpha-subunit of the Na-pump. (1991) Biophys. J. 59, 122a. 35th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H., Kaplan J. H., Truheit M. J., and Kirley T. L. Inactivation and labeling of the Na,K-ATPase by SITS and H2DIDS. (1992) Biophys. J. 61, A121. 36th Annual Meeting of the Biophysical Society.
ï Pedemonte C. H. Reduced Na-pump activity produced by inhibition of protein glycosylation (1994) Biophys. J. 66, A117. 38th Annual Meeting of the Biophysical Society. New Orleans, Louisiana.
ï Pedemonte C. H. The Na-pump: Regulation and involvement in cardiovascular diseases (1995) Gulf Coast Hypertension Club Vascular Biology Meeting. Galveston, Texas.
ï Pedemonte C. H., Pressley T. A. and Lokhandwala M. F. Amino acids located in the amino terminal end of the rat Na-pump alpha-subunit are essential for the stimulation by protein kinase C. (1996) 40th Annual Meeting of the Biophysical Society. Baltimore, Maryland.
ï Pedemonte C. H. Hormonal regulation of the Na-pump (1996) Poster presented as part of the participation in the 1996 FASEB Summer Research Conference "Transport ATPases". Copper Mountain, Colorado.
ï Pedemonte, C.H., Cinelli, A.R., and Pressley, T.A. The molecular mechanism by which the Na,K-ATPase may regulate kidney Na+ reabsorption (1996) 8th International Conference on the Na,K-ATPase. Buenos Aires, Argentina.
ï Riggs P. K., Pedemonte C. H. and Yang T. C. Radiation exposure decreases electrical resistance across cell membranes in cultured epithelial cells (1997) 8th Annual Investigator's Workshop in Space Radiation Research, Brookhaven National Labs., NY.
ï Riggs P. K., Pedemonte C. H. and Yang T. C. Radiation exposure impairs tight junction formation and maintenance in cultured epithelial cells (1997) Annual Meeting of the Radiation Research Society, Providence, RI.
ï Efendiev R., Pressley T. A., Bertorello A. M. and Pedemonte C. H. Amino acids involved in PKC mediated stimulation of Na-pump activity in renal cells. (1997) Annual Meeting of the American Society for Cell Biology. San Francisco, CA.
ï Chibalin A. V., Pedemonte C. H., Katz A. I., Owada S., Ogimoto G., Feraille E. and Bertorello A. M. Na,K-ATPase alpha-subunits internalized in response to dopamine are dephosphorylated in late endosomes. (1997) 30th Annual Meeting American Society of Nephrology, San Antonio, TX.
ï Chibalin A. V., Pedemonte C. H., Katz A. I., Feraille E. and Bertorello A. M. Dopamine-dependent endocytosis of Na,K-ATPase is triggered by PKC-mediated phosphorylation of the catalytic alpha-subunit. (1997) 30th Annual Meeting American Society of Nephrology, San Antonio, TX.
ï Efendiev R., Pressley T. A., Bertorello A. M. and Pedemonte C. H. Relevance of the alpha-subunit Ser-11 and Ser-18 for phorbol ester regulation of kidney epithelial Na-pump. (1998) 42nd Annual Meeting of the Biophysical Society. Biophys. J. 74, A196.
ï Efendiev R., Bertorello A. M., Pressley T. A. and Pedemonte C. H. Stimulation of PKC produces both activation and inhibition of Na-pump activity in renal epithelial cells. (1998) Annual Meeting of the American Society for Biochemistry and Molecular Biology, Washington, DC.
ï Ogimoto G., Chibalin A. V., Pedemonte C. H., Pressley T. A., Katz A. I., Feraille E. and Bertorello A. M. Dopamine-induced endocytosis of rat renal Na,K-ATPase is initiated by phosphorylation of ser-18 in the alpha-subunit and is responsible for the decreased activity. (1998) 31th Annual Meeting American Society of Nephrology, Philadelphia, PA.
ï Yudowski G. A., Ogimoto G., Katz A. I., Feraille E., Pedemonte C. H. and Bertorello A. M. Dopamine-induced endocytosis of rat renal Na,K-ATPase is initiated by phosphorylation of ser-18 in the alpha-subunit and is responsible for the decreased activity. (1998) 31th Annual Meeting American Society of Nephrology, Philadelphia, PA.
ï Jones J. A., Riggs P. K.,Stanford M., Au W., Scucs S., Smith S., Nillen J., Sams C., Penkala J., and Pedemonte C. H. Reduction in space radiation-induced bioeffects with a chemoprevention strategy.(1998) Proceedings of the Aerospace Medical Association. 69th Annual Scientific Meeting, Seattle WA. Abstract 323, page 107. This presentation received a first place award from the Space Medicine Branch of the Aerospace Medical Association.
ï Jones J. A., Riggs P. K.,Stanford M., Au W., Scucs S., Smith S., Clarke M., Pedemonte C. H., Feeback D., George K. and Yang T. Mammalian cells treated with chemoprevention agents show alterations in bioeffects from space radiation. (1998) American Institute for Aeronautics and Astronautics Technical Symposium, Houston, TX.
ï Allen J., Abramowitz J., Pedemonte C. H., Odebunmi T. , Jemelka S. Functional expression of Na-pump alpha-1T in two mammalian cell lines. (1999) FASEB Annual Meeting.
ï Efendiev R., Bertorello A. M., Pressley T. A. and Pedemonte C. H. Molecular mechanism responsible for hormonal regulation of renal Na-pump. (1999) 43rd Annual Meeting of the Biophysical Society. Baltimore, MA. Biophys. J.
ï Narkar V., Hussain T., Pedemonte C. H. and Lokhandwala M. Dopamine activates p42/44 MAP kinase and promotes mitogenesis in opossum kidney cells. (1999) Experimental Biology Meeting.
ï Pedemonte C. H. Molecular mechanism responsible for hormonal regulation of renal Na-pump. (1999) IX international conference on the Na,K-ATPase and related ATPases. Sapporo, Japan.
ï Allen J., Abramowitz J., Pedemonte C. H., Odebunmi T. , Jemelka S. Functional expression of Na-pump alpha-1T in two mammalian cell lines. (1999) IX international conference on the Na,K-ATPase and related ATPases. Sapporo, Japan.ï Efendiev R., Bertorello A. M., Pressley T. A. and Pedemonte C. H. Stimulation of Na,K-ATPase is mediated by recruitment of transport molecules to the plasma membrane. (1999) 32th Annual Meeting American Society of Nephrology, Miami.
ï Narkar V., Hussain T., Pedemonte C. H. and Lokhandwala M. Dopamine D2-like receptor stimulation causes activation of p44/42 MAP kinase and promotes mitogenesis in opossum kidney cells. (1999) 32th Annual Meeting American Society of Nephrology, Miami.
ï Efendiev R., Bertorello A. M. and Pedemonte C. H.Dopamine inhibition and PMA activation of proximal tubule Na,K-ATPase activity are mediated by PKC-z and PKC-b. (1999) 32th Annual Meeting American Society of Nephrology, Miami.
ï Ogimoto G., Yudowski G. A., Katz A. I.,Feraille E., Pedemonte C. H. and Bertorello A. M. Na,K-ATPase activity and endocytosis are regulated by AP-2 binding to the alpha-subunit and clathrin recruitment. (1999) 32th Annual Meeting American Society of Nephrology, Miami.
ï Yudowski G. A., Pedemonte C. H., Efendiev R., Katz A. I. and Bertorello A. M.Phosphatidylinositol-3'kinase p85 alpha-subunit binds to a proline-rich motif in the Na,K-ATPase alpha-subunit and regulates its endocytosis. (1999) 32th Annual Meeting American Society of Nephrology, Miami.
ï Efendiev R., Bertorello A. M. and Pedemonte C. H. Dopamine inhibition and PMA activation of proximal tubule Na,K-ATPase involve different PKC isoforms. (1999) Meeting of the Amercian Society of Cell Biology. Washington.
ï Salgado-Commissariat D. and Pedemonte C. H. Cytoplasmic segment interactions in the alpha 1 subunit of the rat Na,K-ATPase. (2000) 44rd Annual Meeting of the Biophysical Society. Baltimore, MA. Biophys. J. 78, 51A
ï Efendiev R., Bertorello A. M. and Pedemonte C. H.The level of intracellular sodium determines whether PMA stimulates or inhibits Na,K-ATPase activity in renal epithelial cells. (2000) A0146, 33th Annual Meeting American Society of Nephrology, Toronto, Canada.
ï Mendez «. F., Leibiger B., Efendiev R., Pedemonte C.H., Katz A. I., Leibiger I. B., and Bertorello A. M. PKC-z phosphorylates the Na,K-ATPase alpha-subunit and associates with Clathrin vesicles during subunit endocytosis in response to dopamine. (2000) A0286, 33th Annual Meeting American Society of Nephrology, Toronto, Canada.
ï Yudowski G. A., Efendiev R., Pedemonte C. H., Katz A. I., Zwiller J., and Bertorello A. M. Dephosphorylation of dynamin by PP2A is critical for Na,K-ATPase endocytosis in response to dopamine receptor signals. (2000) A0296, 33th Annual Meeting American Society of Nephrology, Toronto, Canada.
ï Narkar V. A., Hussain T., Pedemonte C. H. and Lokhandwala M. F. Evidence for expression of dopamine D2 and D4 receptors in opossum kidney cells and the role of D2 receptors in mitogenesis. (2000) A2342, 33th Annual Meeting American Society of Nephrology, Toronto, Canada.
ï Efendiev R., Bertorello A. M. and Pedemonte C. H.Intracellular sodium level modulates the effects of phorbol ester and dopamine on Na,K-ATPase activity. (2000) Meeting of the Amercian Society of Cell Biology.
Bertorello A. M., Pedemonte C. H., Vena R., Katz A. I., and Sznajder J. I. Regulation of dynamin II phosphorylation by G protein-coupled receptor signals is essential for Na,K-ATPase traffic to the plasma membrane. (2001) 903.2, A1156. Experimental Biology 2001. Orlando, Florida.
Pedemonte C. H., Efendiev R., Cinelli A. and Bertorello A. Intracellular sodium modulates the regulation of proximal tubule Na,K-ATPase by dopamine and phorbol esters. (2001) 27th Meeting of the Federation of European Biochemical Societies. Lisboa, Portugal.
Krmar R.T, Efendiev R., Torielli L., Pedemonte C.H., Katz A.I., Bianchi G., Bertorello A.M. Impaired endocytosis of renal Na,K-ATPase in Milan hypertensive rats is associated with a mutation in the adducin molecule. (2001) 34th Annual Meeting American Society of Nephrology San Francisco. California.
Efendiev R., Bertorello A. M.,Cinelli A. R. and Pedemonte C. H. A sodium-response mechanism modulates the dopamine inhibition of renal Na,K-ATPase activity. (2001) 34th Annual Meeting American Society of Nephrology San Francisco. California.
Bertorello A.M., Budu C.E., Efendiev R., and Pedemonte C.H. Serotonin produces the recruitment of Na+,K+-ATPase molecules to the plasma membrane via PKC- b• p h o s p h o r y l a t i o n o f b o t h S e r - 1 1 a n d S e r - 1 8 i n t h e a•- s u b u n i t . 1 0 t h I n t e r n a t i o n a l C o n f e r e n c e o n N a , K - A T P a s e , E l s i n o r e , D e n m a r k , 2 0 0 2 . < / P > < P > B e r t o r e l l o A M , K o m a r o v a Y , E f e n d i e v R , P e d e m o n t e C H , L e i b i g e r I B , B o r i s y G , S z n a j d e r J I . R e a l - t i m e a n a l y s i s o f N a K -ATPase traffic to the plasma membrane in response to G protein-coupled receptor signals. Experimental Biology, New Orleans, LA, 2002, FASEB J., 16, A466.
Budu C., Efendiev R., Cinelli A., Bertorello A.M., Pedemonte C.H. The concentration of intracellular sodium modulates the serotonin-dependent recruitment of Na+,K+-ATPase to the plasmalemma of OK cells. 6th Annual meeting of American Society of Nephrology, Philadelphia, PA, 2002.
Bertorello A., Cotta-Done S., Leibiger I., Efendiev R., Leibiger B., Katz A. and Pedemonte C. H. Tyrosine-537 within the Na,K-ATPase a-subunit is essential for AP-2 binding and clathrin-dependent endocytosis in response to G protein-coupled receptor signals. Meeting of the European Life Science Organization. 2002 France.
Efendiev R., Rafael T. Krmar, Adrian I. Katz, Bertorello A.M., Pedemonte C.H. A 14-3-3 protein translates the Na,K-ATPase alpha-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis. 7th Annual meeting of American Society of Nephrology, San Diego, CA, 2003.
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