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Facile Preparation of 4-Substituted Quinazolines (UH Clear Lake)

The Innovation

A facile one-step method for the preparation of 4-substituted quinazolines is disclosed in this report, in which 2-aminophenyl ketones are converted easily into appropriate quinazolines with substituents at 4-position, in a fashion of one-pot synthesis.  This clean reaction can be easily worked up to afford materials with important applications in both medicinal/pharmaceutical and dye/colorant industries.

Competitive Edge

The clean reaction can be easily worked up to manufacture materials with important applications in both medicinal/pharmaceutical and dye/colorant industries.

Targeted Market

Reagent manufacturers, pharmaceutical, and dye manufacturers.