The UH Libraries are made up of the M.D. Anderson Library (main library) and four smaller branch libraries with specialized collections in Architecture and Art, Music, Optometry. The O'Quinn Law Library in the UH Law Center and the Library and Hospitality Archives in the Massad Family Library Research Center and Hospitality Industry Archives at the Conrad N. Hilton College of Hotel & Restaurant Management are other specialized libraries on campus. They are administered separately from the UH Libraries.

The M.D. Anderson Library's collections include rare and archival materials, information published by U.S. and Texas government agencies, and high-use, course-related materials.

The UH Libraries provide a pleasant and well-appointed environment to accommodate users' learning and technological needs.  Quiet study areas and group study rooms are available to all users in the M.D. Anderson Library.  Study areas are also available in Architecture & Art Library, Music Library, Optometry Library, and Pharmacy Library.  The UH Libraries are well equipped for users' technological needs. The Academic Research Center located in the M.D. Anderson Library offers more than 200 desktop computers. Students can check out laptops and take advantage of the University's wireless network. Users can send documents to the numerous printers on the first floor and make use of the photocopiers in the Library's copy room. Adaptive technologies are available for users with certain disabilities.