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College of Pharmacy Faculty
Department of Pharmacological and Pharmaceutical Sciences


Riad Efendi (Efendiev), Ph.D.

Research Assistant Professor

560 Science and Research Building 2
Houston, TX 77204-5037
713-743-1228


refendiev@uh.edu

Education
Ph.D. in Biochemistry, 1997, Moscow Institute of Physics & Technology, Moscow, Russia. Dissertation: Topographical study of Na,K-ATPase via method of surface-specific iodination

M.S. in Molecular Biology, 1992, Moscow Institute of Physics & Technology, Moscow, Russia. Thesis: Lactoperoxidase iodination in the study of the Na,K-ATPase transmembrane design

B.S. in Applied Mathematics and Physics, 1990, Moscow Institute of Physics & Technology, Moscow, Russia

Academic/Research Interests:
Cardiovascular Physiology
Signal transduction
GPCR biology
Bioimaging

Professional service or affiliations:
American Heart Association, 2006 – current
Society of General Physiologists, 2005 – current
American Society of Nephrology, 2002 – current
American Society for Cell Biology, 1999 – 2000

Selected Publications:
Efendiev, R., Das, K., Cinelli, A.R., Bertorello, A.M., and Pedemonte, C.H. Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner, accepted to Brit. J. Pharmacol., 2007

Efendiev, R., Das, K., Cinelli, A.R., Leibiger, I.B., Bertorello, A.M., and Pedemonte, C.H. FRET analysis reveals critical changes within the Na,K-ATPase a1 subunit N-terminus during GPCR-dependent endocytosis, FEBS Lett., 2006, 580, 5067-5070

Efendiev, R., Pedemonte, C.H. Contrary to the rat-type, the human-type Na,K-ATPase is phosphorylated at the same amino acid by hormones that produce opposite effects on the enzyme activity. J. Am. Soc. Nephrol., 2006, 17, 31-38.
Full Text PDF Link: http://jasn.asnjournals.org/cgi/reprint/17/1/31

Efendiev, R., Chen, Z., Katz, A.I., Pedemonte, C.H., and Bertorello, A.M. A 14-3-3 protein translates the Na,K-ATPase alpha-subunit phosphorylation signal into binding and activation of phosphoinositide 3-kinase during endocytosis. J. Biol. Chem., 2005, 280, 16272-16277
Full Text PDF Link: http://www.jbc.org/cgi/reprint/280/16/16272

Efendiev, R., Krmar, R.T., Leibiger I.B., Ogimoto, G., Zwiller, J., Tripodi, G., Katz, A., Bianchi, G., Pedemonte, C.H., and Bertorello, A.M. Hypertension-linked mutation in the adducin alpha-subunit affects AP2-mu2 phosphorylation and impairs Na,K-ATPase endocytosis. Circ. Res, 2004, 95, 1100-1108
Full Text PDF Link: http://circres.ahajournals.org/cgi/reprint/95/11/1100

Efendiev, R., Budu, C.E., Cinelli, A.R., Bertorello, A.M., and Pedemonte, C.H. Intracellular Na+ regulates dopamine- and angiotensin II- receptors availability at the plasma membrane and their cellular responses in renal epithelia. J. Biol. Chem., 2003, 278, 28719–28726
Full Text PDF Link: http://www.jbc.org/cgi/reprint/278/31/28719

Efendiev, R., Yudowski, G.A., Mendez, C.F., Zwiller, J., Cotta Done, S., Leibiger, B., Katz, A., Berggren, P.-O., Pedemonte, C.H., Leibiger I.B., and Bertorello, A.M. Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na,K-ATPase endocytosis. J. Biol. Chem., 2002, 277, 44108-44114
Full Text PDF Link: http://www.jbc.org/cgi/reprint/277/46/44108

Efendiev, R., Bertorello, A.M., Zandomeni, R., Cinelli, A.R., and Pedemonte, C.H. Agonist-dependent regulation of renal Na,K-ATPase activity is modulated by intracellular sodium concentration. J. Biol. Chem., 2002, 277, 11489-11496
Full Text PDF Link: http://www.jbc.org/cgi/reprint/277/13/11489

For a Full List of Publications, Click Here

 
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