Skip to main content

Profile: Randall Prince

Randall Prince
Randall A. Prince, Pharm.D., Ph.D., FCCP, FCP, FIDSA 
Professor
Adjunct Professor of Medicine, UT-MD Anderson Cancer Center, Department of Medical Specialties, Section of Infectious Diseases
Department of Pharmacy Practice and Translational Research
University of Houston College of Pharmacy
Health and Biomedical Sciences Building 2, Room 4043
4849 Calhoun
College of Pharmacy
Houston, TX 77204-5000
832-842-8389
832-842-8383 (Fax)
RPrince@uh.edu

Education

B.S., Philadelphia College of Pharmacy & Sciences
Pharm.D., Philadelphia College of Pharmacy & Sciences

Research Interests

  • Infectious Diseases
  • Pharmacokinetics

Patents

“Anti-infective Endotracheal Tube,” Rabih O. Dariouche and Randall A. Prince, Patent No. 7,452,345 (awarded November 18, 2008).

Awards & Honors

  • Distinguished Service Award, Society of Infectious Diseases Pharmacists, 2011
  • Fellow, American College of Clinical Pharmacology, 2008
  • Fellow, Infectious Diseases Society of America, 2008
  • UH College of Pharmacy Faculty Achievement Award, 1999
  • Outstanding Service Award, Society of Infectious Diseases Pharmacists, 1997
  • Fellow, American College of Clinical Pharmacy, 1994

Courses

  • Infectious Diseases Pharmacotherapy
  • Infectious Diseases Clerkship
  • Advanced Therapeutics I and II

Selected Journal Articles (since 2009)

Rolston KV, Wang W, Nesher L, Smith JR, Rybak MJ, Prince RA. Time-kill determination of the bactericidal activity of telavancin and vancomycin against clinical methicillin-resistant Staphylococcus aureus isolates from cancer patients. Diagn Microbiol Infect Dis. 2017 Apr;87(4):338-342. doi: 10.1016/j.diagmicrobio.2016.12.010. PMID: 28109549

Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, Jones AL, Shelburne SA, Prince RA, Bhatti MM, Rolston KV, Jones RN, Castanheira M, Chemaly RF. High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center. Clin Infect Dis. 2016 Oct 1;63(7):954-8. doi: 10.1093/cid/ciw398. PMID: 27313265

Rolston KV, Wang W, Nesher L, Shelburne SA, Prince RA. In vitro activity of dalbavancin and five comparator agents against common and uncommon Gram-positive organisms isolated from cancer patients. J Antibiot (Tokyo). 2016 May;69(5):381-7. doi: 10.1038/ja.2015.120. Epub 2015 Dec 2. PMID:26626876

Kassamali Z, Prince RA, Danziger LH, Rotschafer JC, Rhomberg PR, Jones RN. Microbiological Assessment of Polymyxin B Components Tested Alone and in Combination. Antimicrob Agents Chemother. 2015 Dec;59(12):7823-5. doi: 10.1128/AAC.01021-15. Epub 2015 Sep 21. PMID: 26392511

Rolston K 6th, Wang W, Nesher L, Coyle E, Shelburne S, Prince RA. In vitro activity of telavancin compared with vancomycin and linezolid against Gram-positive organisms isolated from cancer patients. J Antibiot (Tokyo). 2014 Jul;67(7):505-9. doi: 10.1038/ja.2014.30. Epub 2014 May 14. PMID: 24824818

Kassamali Z, Rotschafer JC, Jones RN, Prince RA, Danziger LH. Polymyxins: Wisdom Does Not Always Come With Age. Clin Infect Dis. 2013 Sep;57(6):877-83. doi: 10.1093/cid/cit367. Epub 2013 Jul 11. Review. PMID: 23728146

Rolston KV, Kapadia M, Tarrand J, Coyle E, Prince RA. Spectrum of gram-positive bacteraemia and in vitro activities of daptomycin, linezolid and vancomycin against organisms isolated from cancer patients. Int J Antimicrob Agents. 2013 Jun;41(6):516-20. doi: 10.1016/j.ijantimicag.2013.01.014. Epub 2013 Mar 6. PMID: 23481658

Lewis RE, Albert NP, Liao G, Wang W, Prince RA, Kontoyiannis DP. High-dose induction liposomal amphotericin B followed by de-escalation is effective in experimental Aspergillus terreus pneumonia. J Antimicrob Chemother. 2013 May;68(5):1148-51. doi: 10.1093/jac/dks521. Epub 2013 Jan 24.

Chaftari AM, Hachem RY, Ramos E, Kassis C, Campo M, Jiang Y, Prince RA, Wang W, Raad II. Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation. Transplantation. 2012 Aug 15;94(3):302-8.

Lewis RE, Liao G, Wang W, Prince RA, Kontoyiannis DP. Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection. Virulence. 2011 Jul-Aug;2(4):348-55.

Lewis RE, Liao G, Hou J, Prince RA, Kontoyiannis DP. Comparative in vivo dose-dependent activity of caspofungin and anidulafungin against echinocandin-susceptible and -resistant Aspergillus fumigatus. J Antimicrob Chemother. 2011 Jun;66(6):1324-31.

Mihu CN, Rhomberg PR, Jones RN, Coyle E, Prince RA, Rolston KV. Escherichia coli resistance to quinolones at a comprehensive cancer center. Diagn Microbiol Infect Dis. 2010 Jul;67(3):266-9.

Yuan Z, Ledesma KR, Singh R, Hou J, Prince RA, Tam VH. Quantitative assessment of combination antimicrobial therapy against multidrug-resistant bacteria in a murine pneumonia model. J Infect Dis. 2010 Mar 15;201(6):889-97.

Lewis RE, Albert ND, Liao G, Hou J, Prince RA, Kontoyiannis DP. Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of pulmonary mucormycosis. Antimicrob Agents Chemother. 2010 Mar;54(3):1298-304.

Stein GE, El-Mortada M, Smith C, Dybas L, Prince R, Havlichek D. Fungicidal activity of anidulafungin in serum from patients does not correlate to its susceptible breakpoint against Candida spp. J Antimicrob Chemother. 2010 Feb; 65 (2):374-6.

Singh R, Ledesma KR, Chang KT, Hou JG, Prince RA, Tam VH. Pharmacodynamics of moxifloxacin against a high inoculum of Escherichia coli in an in vitro infection model. J Antimicrob Chemother. 2009 Sep;64(3):556-62.

Book Chapters

Coyle E and Prince RA. Urinary tract Infections and Prostatitis. DiPiro j (ed). Pharmacotherapy: A Pathophysiologic Approach, 10th ed, in press.

Coyle E and Prince RA. Urinary tract Infections and Prostatitis. DiPiro j (ed). Pharmacotherapy: A Pathophysiologic Approach, 9th ed, 2014.

Coyle E and Prince RA. Urinary tract Infections and Prostatitis. DiPiro J (ed). Pharmacotherapy: A Pathophysiologic Approach, 8th ed, 2011.

Coyle E and Prince RA. Urinary Tract Infections. Linn, W (ed.) Pharmacotherapy in Primary Care, 2009.

Coyle E and Prince RA. Urinary Tract Infections and Prostatitis. DiPiro (ed). Pharmacotherapy: A Pathophysiologic Approach, 7th ed., 2008.

Coyle E and Prince RA. Urinary Tract Infections and Prostatitis. DiPiro (ed). Pharmacotherapy: A Pathophysiologic Approach, 6th ed., 2005.

Editorials/Letters to the Editor

Comment on: Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma. Tam VH, Hou J, Kwa AL, Prince RA. J Antimicrob Chemother. 2009;63: 627-8.

Hsue G, Napier JT, Prince RA, Chi J, Hospenthal DR. Treatment of meningeal coccidioidomycosis with caspofungin. J Antimicrob Chemother 2004;54:292-294.

Presentations & Abstracts

Z. Kassamali*, W. Wang, R. Jones, J. Rotschafer, L. Danziger, R. Prince. Is what you see what you get? Product variation in clinical and reference formulations of polymyxin B. Abstract Nr. 1119, ECCMID meeting, 23rd European Congress of Clinical Microbiology and Infectious Diseases, Berlin, Germany, April 2013.

Singh R, Ledesma KR, Chang KT, Hou JG, Prince RA, Tam VH. Pharmacodynamics of moxifloxacin against a high inoculum of E. coli. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Ullman MA, Mitropoulos IF, Hovde LB, Prince RA, Rotschafer JC. In vitro Pharmacodynamic evaluation of meropenem and colistin against multidrug-resistant A. baumannii. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Lewis RE, Liaio G, Hou J, Prince RA, Kontoyiannis DP. Comparison of caspofungin and anidulafungin activity against echinocandin-susceptible and -resistant A. fumigatus in a neutropenic murine model of invasive pulmonary aspergillosis. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Lewis RE, Albert ND., Hou J, Prince RA, Kontoyiannis DP. Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of acute invasive pulmonary zygomycosis. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Kwa A., Lim T., Low J., Hou J., Kurup A, Prince R., and Tam V., Pharmacokinetics of Polymyxin B in Patients with Multi-Drug Resistant Gram-Negative Bacterial Infections, Abstract #A-10, Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, September 2007.

Editorial Appointments

  • Editorial Board Member, Journal of Infectious Disease Pharmacotherapy
  • Journal Reviewer: Journal of Chromatography B; Antimicrobial Agents Chemotherapy; Journal of Applied and Environmental Microbiology
  • Fellowship Reviewer, American College of Clinical Pharmacy

Memberships

  • American College of Clinical Pharmacy, 1982-present
  • American College of Clinical Pharmacology, 1998-present
  • Infectious Diseases Society of America, 2001-present
  • International Immunocompromised Host Society, 2001-present
  • The Society of Infectious Diseases Pharmacists, 1989-present