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Profile: Xiang Li

Xiang Li
Xiang Li, M.D., Ph.D.
Research Assistant Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
Physical Address: Science and Research Building 2, 3455 Cullen Blvd., Room 453, Houston, TX 77204
Mailing Address: Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX 77204-5037

713-743-7978
xli59@uh.edu

Education

M.D. in Clinical Medicine, Peking University, Beijing, China
M.S., Department of Pharmacology & Toxicology, Medical College of Wisconsin
Ph.D., Department of Molecular Biology, School of Medicine, University of Duisburg-Essen, Germany

Research Interests

Mechanisms of cardivoascular diseases and hypertension associated with aging, chronic kidney disease, autoimmune disease and infectious diseases. Current projects focus on the roles of exosome, microparticles, and non-coding RNA in these diseases.

Postdoctoral Training & Professional Experience

Research Assistant Professor, Department of Pharmacological & Pharmaceutical Sciences, University of Houston College of Pharmacy, 2015-present

Postdoctoral fellow, Department of Pharmacology & Toxicology, Virginia Commonwealth University, 2011-2015

Postdoctoral fellow, Department of Molecular Biology, School of Medicine, University of Duisburg-Essen, Germany, 2010-2011

Research Scientist, Nanning Hospital, Guangxi, China, 2001-2003

Publications

Chen Y, Li X, Boini KM, Pitzer AL, Gulbins E, Zhang Y, Li PL. Endothelial Nlrp3 Inflammasome Activation with Lysosomal Destabilization during Coronary Arteritis. Biochim Biophys Acta.–Mol Cell Res. 2015 Feb;1853(2):396-408. doi: 10.1016/j.bbamcr.2014.11.012. Epub 2014 Nov 15. PMID: 25450976

Li X, Zhang Y, Xia M, Gulbins E, Boini KM, Li PL. Activation of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition and Migration: Implication of a Novel Role of Inflammasome in Atherogenesis. PLoS One. 2014 9(1):e87552.

Li X, Xu M, Pitzer AL, Xia M, Boini KM, Li PL, Zhang Y. Control of Autophagy Maturation by Acid Sphingomyelinase in Mouse Coronary Arterial Smooth Muscle Cells: Protective Role in Atherosclerosis. J Mol Med 2014; 92: 473-485. PMCID in process. (Commented by Friedrich C. Luft in "Acid sphingomyelinase, autophagy, and atherosclerosis". J Mol Med. 2014; 92: 429-431)

Zhang Y, Xu M, Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014; 102:68-78. PMCID: PMC395862

Li X, Han WQ, Boini KM, Xia M, Zhang Y, Li PL. TRAIL-Death Receptor 4 Signaling via Lysosome Fusion and Membrane Raft Clustering In Coronary Arterial Endothelial Cells: Evidence from ASM Knockout Mice. J Mol Med. 2013; 91:25-36. PMCID: PMC3537912 (Commented in Lang F. The trail to deadly membrane rafts. J Mol Med. 2013:91:1-3)

Wei YM, Li X, Abais JM, Xia M, Boini KM, Zhang Y, Li PL. Attenuation by Statins of Membrane Raft-Redox Signaling in Coronary Arterial Endothelium. J Pharmacol Exp Ther. 2013; 345(2):170-9. PMCID: PMC3629800

Wei YM, Li X, Xu M, Abais JM, Chen Y, Riebling CR, Boini KM, Li PL, Zhang Y. Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes. Cell Physiol Biochem. 2013; 31:925-937. PMCID: PMC3753088

Li X, Gulbins E, Zhang Y. Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury. Cell Physiol Biochem. 2012; 30: 905-914. PMCID: PMC3758749

Li X, Gulbins E, Zhang Y. Oxidative stress triggers Ca2+-dependent lysosome trafficking and activation of acid sphingomyelinase. Cell Physiol Biochem. 2012; 30: 815-826. PMID:22890197

Zhang C, Boini KM, Xia M, Abais JM, Li X, Liu QL, Li PL. Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia. Hypertension 2012; 60:154-162. PMCID: PMC3753400

Li X, Hong S, Li PL, Zhang Y. Docosahexanoic acid-induced coronary arterial dilation: Actions of 17S-hydroxy docosahexanoic acid on K+ channel activity. J Pharmacol Exp Ther. 2011; 336: 891-899.

Zhang Y, Li X, Carpinteiro A, Soddman M, Gulbins E. Kinase suppressor of ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nat Med. 2011; 17: 341-346.

Li X, Becker KA, Zhang Y. Ceramide in redox signaling and cardiovascular diseases. Cell Physiol Biochem. 2010; 26: 41-48

Zhang Y, Li X, Grassmé H, Döring G, Gulbins E. Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages upon infection. J Immunol. 2010; 184: 5104-5111.

Li X, Zhang Y, Gulbins E. Lipid rafts and Pseudomonas aeruginosa infections. 2009; Handbook of Hydrocarbon and Lipid Microbiology Vol 3_00062. 

Zhang Y, Li X, Becker KA, Gulbins E. Ceramide-enriched membrane domains-structure and function. Biochim Biophys Acta 2009; 1788: 178-183. 

Zhang Y, Li X, Carpinteiro A, Gulbins E. Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa–induced macrophage apoptosis. J Immunol. 2008 181:4247-4254.

Dumitru CA, Zhang Y, Li X, Gulbins E. Ceramide: a novel player in reactive oxygen species-induced signaling. Antioxid Redox Signal. 2007;9:1535-1540.

 Yi XY, Li X, Zhang F, Yi F, Matson DR, Jiang MT, Li P. Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle. Am J Physiol Heart Circ Physiol. 2006 290: H1136-44.