Profile: Mustafa Lokhandwala

Mustafa Lokhandwala
Mustafa F. Lokhandwala, Ph.D.
Executive Vice Dean for Research
Director, Heart and Kidney Institute
Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
453D Science and Research Bldg. 2
713-743-3777
713-743-1232 (Fax)
MLokhandwala@uh.edu

 

Education

B.Pharm, 1966, L.M. College of Pharmacy Ahmedabad, India

M.S. Pharmacology, 1968, Columbia University, New York, New York

Ph.D. Pharmacology, 1975, University of Houston, Houston, Texas

Positions Held

Executive Vice Dean for Research 2003-present

Dean, College of Pharmacy, 1992-2002, University of Houston

Interim Dean, College of Pharmacy 1991-1992, University of Houston

Professor, Department of Pharmacology, 1989-present, University of Houston

Chairman, Department of Pharmacology, 1980-1991, University of Houston

Associate Professor, Department of Pharmacology, 1981-1989, University of Houston

Assistant Professor Department of Pharmacology 1975-1981 University of Houston

Research Assistant Department of Pharmacology 1970-1971, Columbia University/Ciba-Geigy, New York and Tuckhoe, N.Y.

External Grants & Other Reviews

Member: Site Visit Committee, National Institute of General Medical Sciences, NIH, 1980, 1981.

Site Visit Committee, National Center for Research Resources, NIH, 1992.

Member: Special Review Committee, Pharmacological Sciences , NIGMS, March, 1987.

Special Review Group, Experimental Cardiovascular Science, NHLBI, October, 1992.

Member: Scientific Advisory Committee, RCMI Program Project, Texas Southern University, 1995-2000

Proposal Reviewer: National Science Foundation, 1980, 1984, 1985, 1992, 2000.

The National Kidney Foundation, 1997

Reviewer: Ph.D. Programs in Pharmacology, National Research Council, 1993.

Reviewer: Developmental Research Projects, RCMI Program for Texas Southern University 1993.

Evaluation Team Member: American Council on Pharmaceutical Education, 1994.

Reviewer: Italian Ministry for Education University and Research, 2001-present.

Member: Cardiovascular and Renal Study Section, CSR/NIH, July 1, 2002 – October 31, 2003.

Cellular and Molecular Biology of the Kidney Study Section, CSR/NIH, March 1, 2004-June 30, 2006.

Member: NHLBI Spring Hypertension Program Project Review Group, 2003.

Editorial Appointments

  • Editor-in-Chief, Clinical and Experimental Hypertension (1993-present)
  • Associate Editor, Clinical & Experimental Hypertension (1992-1993)
  • Editorial Board Member, Clinical & Experimental Hypertension (1985-1991)
  • Editorial Board Member, Drug Development Research (1986-1992)
  • Editorial Board Member, Journal of Cardiovascular Pharmacology (1987-1998))
  • Editorial Board Member, Hypertension Research (1999-present)
  • Editorial Board Member, Experimental Biology & Medicine (2000-2005)
  • Editorial Board Member, Journal of Epithelial Biology and Pharmacology (2008-present)

Research Interests

  • Cardiovascular and Autonomic Pharmacology
  • Hypertension and Antihypertensive Drug Mechanisms
  • Central and peripheral control of the cardiovascular and renal function
  • Role of oxidative stress in cardiovascular diseases
    • - receptor-G protein coupling
    • - drug responsiveness
    • - antioxidant supplementation
  • Dopamine, Dopamine Receptor Agonists and Cardiovascular Function
  • Dopamine receptor function in obesity, diabetes, hypertension and aging
  • Dopamine receptor mediated cellular signalling mechanisms in the proximal tubule
  • Role of kidney dopamine in fluid and electrolyte balance
  • Oxidative stress and D1 receptor signal transduction in the kidney

Courses

  • Pharmacology
  • Antiarrhythmic agents
  • Anticoagulant agents
  • Antianginal agents
  • Neuromuscular blocking agents
  • Narcotic and non-narcotic analgesics
  • Prostaglandins
  • Local anesthetic agents
  • Reproductive physiology and pharmacology

Graduate Courses

  • Cardiovascular pharmacology
  • Cardiovascular research techniques
  • Advances in renal pharmacology
  • Neuropharmacology
  • Significant discoveries in pharmacology

Affiliations

  • American Association for the Advancement of Science
  • American Society for Pharmacology and Experimental Therapeutics
  • Member, Committee on Public Affairs (1995-01)
  • Chair, Committee on Public Affairs (1996-01)
  • Member, Public Affairs Advisory Committee, FASEB (1996-99)
  • Member, Science Policy Committee, FASEB (1999-02)
  • Society for Experimental Biology and Medicine
  • International Society of Hypertension
  • Abstract Reviewer: Sixth Scientific Meeting, Heidelberg, Germany
  • Abstract Reviewer: Sixteenth Scientific Meeting, Glasgow, Scotland
  • Abstract Reviewer, Seventeenth Scientific Meeting, Amsterdam, The Netherlands
  • Fellow, Council for High Blood Pressure Research, American Heart Association
  • Council on Basic Science, American Heart Association
  • American Association of Colleges of Pharmacy
  • Member, Committee on Faculty Enterpreunership (1994-96)
  • Member, Finance Committee (1995-96)
  • Member, International Pharmaceutical Education Advisory Committee (2001-02)
  • Rho Chi
  • Fellow, American Society of Nephrology
  • Member, Program Committee, 2001 World Congress of Nephrology
  • Sigma Xi, The Scientific Research Society
  • Inter-American Society of Hypertension
  • Texas Pharmacy Association
  • Member, 1996 Pharmacist of the Year Selection Committee
  • Trustee, Texas Pharmacy Foundation (1996-97)
  • Texas Society of Health-Systems Pharmacists
  • The American Society of Hypertension
  • American Society of Health-Systems Pharmacists
  • Society for Free Radical Biology and Medicine
  • Abstract Reviewer (2003, 2004)

Awards & Honors

  • University of Houston chapter of Sigma Xi, The Scientific Research Society’s Research Excellence Award for 1993.
  • Individual Educational Excellence Award, Texas Pharmacy Association, 2000
  • Robert A. Boblitt Rho Chi Lecture, University of Houston College of Pharmacy, 2004

Selected Publications

A total of 10 books and journals, 24 book chapters, 27 review articles, 183 research papers and more than 200 abstracts. The following list includes publications from 2006 - present.

Journal Articles

George LE, Lokhandwala MF, Asghar M. Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells. Am J Physiol Renal Physiol. 2012 Jun;302(11):F1440-6.

Chugh G, Lokhandwala MF, Asghar M. Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats. Hypertension. 2012 May;59(5):1029-36.

Javkhedkar AA, Lokhandwala MF, Banday AA. Defective nitric oxide production impairs angiotensin II-induced Na-K-ATPase regulation in spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2012 Jan;302(1):F47-51.

Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol. 2011 Sep 30;667(1-3):258-64.

Banday AA, Lokhandwala MF. Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress. Am J Physiol Renal Physiol. 2011 Aug;301(2):F364-70.

Muhammad, A.B., Lokhandwala, M.F. and Banday, A.A.: Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese Zucker rats. Amer J Physiol: Renal Physiol, 300:F98-F104, 2011.

Chugh, G., Lokhandwala, M.F. and Asghar, M.: Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats. Amer J Physiol: Renal Physiol, 300: F133-F138, 2011.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation and hypertension. Hypertension, 57: 452-459, 2011.

Asghar, M., Chugh, G. and Lokhandwala, M.F.: Inflammation compromises renal dopamine D1 receptor function in rats. Amer J Physiol: Renal Physiol., 297: F1543-F1549, 2009.

George, L., Lokhandwala, M.F. and Asghar, M: Exercise activates redox sensitive transcription factors and restores renal D1 receptor function in old rats. Amer J Physiol: Renal Physiol., 297: F1174-1180, 2009.

Banday, A.A. and Lokhandwala, M.F.: Inhibition of natriuretic factors increases blood pressure in rats. Amer J Physiol: Renal Physiol., 297: F397-F402, 2009.

Banday, A. A. and Lokhandwala, M.F.: Loss of biphasic effect on Na/K-ATPase activity by angiotensin II involves defective angiotensin typr 1 receptor-nitric oxide signaling. Hypertension, 52: 1099-1105, 2008.

Asghar, M., Chillar, A. and Lokhandwala, M.F.: Renal proximal tubules from old Fischer 344 rats grow into epithelial cells in culture and exhibit inceresed oxidative stress and reduced D1 receptor function. Amer J Physiol: Cell Physiol. 295: C1326-C1331, 2008.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension. Amer J Physiol: Renal Physiol., 295: F698-F706, 2008.

Banday, A.A., Lau, Y-S. and Lokhandwala, M.F.: Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley Rats. Hypertension, 51: 367- 375, 2008.

Asghar, M., George, L. and Lokhandwala, M.F.: Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. Amer J Physiol: Renal Physiol. 293: F914-F919., 2007.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Insulin Causes Renal Dopamine D1 Receptor  Desensitization via GRK2-mediated Receptor Phosphorylation Involving Phosphatidylinositol3-Kinase and Protein kinase C. Amer J Physiol: Renal, 293: F877-F884, 2007.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress reduces renal dopamine D1 receptor-Gq/11α G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2. Amer J Physiol: Renal, 293: F306-F315, 2007.

Asghar, M., Monjok, E., Kouamou, G., Ohia, S.E., Bagchi, D. and Lokhandwala, M.F.: Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance and body weight in developing obese Zucker rats. Mol. Cell. Biochem. 304: 93-99, 2007.

Banday, A. A., Fazili, F. R. and Lokhandwala, M. F.: Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms involving nuclear factor-kB and protein kinase C. J Amer Soc Nephrol, 18: 1446-1457, 2007.

Banday, A. A., Muhammad, A.B., Fazili, F.R. and Lokhandwala, M.F.: Mechanism of oxidative stress induced increase in salt sensitivity and development of hypertension in Sprague Dawley rats, Hypertension, 49[part 2]: 664-667, 2007.

Fardoun, R. Z., Asghar, M. and Lokhandwala, M.F.: Role of NFkB in oxidative stress-induced defective dopamine D1 receptor signaling in renal proximal tubules of Sprague Dawley rats. Free Radical Biol. & Med. 42: 756-764, 2007.

Banday, A.A., Fazili, F.R., Marwaha, A.A. and Lokhandwala, M.F.: Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats. Kidney International, 71: 397-406, 2007.

Banday, A.A. and Lokhandwala, M.F.: Defective renal dopamine D1 receptor function contributes to hyperinsulinemia mediated hypertension. Clin Exp Hypertension, 28: 695-705, 2006.

Fardoun, R. Z., Asghar, M. and Lokhandwala, M.F.: Role of Oxidative Stress in Defective Renal Dopamine D1 Receptor- G-Protein Coupling and Function in Old Fischer 344 Rats. Amer J Physiol: Renal Physiol. 291: F945-F951, 2006.

Asghar, M. and Lokhandwala, M.F.: Antioxidant tempol decreases age-related increase in insulin resistance in old Fischer 344 rats. Clin Exp Hypertension, 28: 533-541, 2006.

Marwaha, A. and Lokhandwala, M. F.: Tempol reduces oxidative stress and restores renal dopamine D1-like receptor G-protein coupling and function in hyperglycemic rats. Amer J Physiol: Renal Physiol. 291: F58-F66, 2006.

Asghar, M. Banday, A. A., Fardoun, R. and Lokhandwala, M.F.: Hydrogen peroxide causes uncoupling of dopamine D1 receptors from G-proteins via a mechanism involving PKC and GRK2. Free Radical Biol. & Med. 40: 13-20, 2006. 

Reviews

Tayebati SK, Lokhandwala MF, Amenta F. Dopamine and vascular dynamics control: present status and future perspectives. Curr Neurovasc Res. 2011 Aug 1;8(3):246-57.

Asghar M, Tayebati SK, Lokhandwala MF, Hussain T.  Potential dopamine-1 receptor stimulation in hypertension management. Curr Hypertens Rep. 2011 Aug;13(4):294-302.

Banday, A. A. and Lokhandwala, M. F.: Dopamine receptors and hypertension. Curr. Hypertension Reports 10: 268-275, 2008.

Books and Book Chapters

Lokhandwala, M.F.: Acido tioctio: farmacologia ed applicazioni terapeutiche di un antiossidante particolare. In: R(+) Dalla Ricerca Di Base Alle Applicazioni Cliniche Dell’enantiomero Naturale Di Un Antiossidante Multifunzione, Eds. A. Amenta, V. Costigliola and M.F. Lokhandwala. Pacine Editore S.p.A., Pisa, Italy, 2010.

R(+) Dalla Ricerca Di Base Alle Applicazioni Cliniche Dell’enantiomero Naturale Di Un Antiossidante Multifunzione, Eds. A. Amenta, V. Costigliola and M.F. Lokhandwala. Pacine Editore S.p.A., Pisa, Italy, 2010.

Abstracts

Chugh, G., Lokhandwala, M.F. and Asghar, M.: Age-associated oxidative stress alters renal D1 and AT1 receptor functions and increases blodd pressure in old Fischer 344 X Brown Norway F1 rats. Hypertension, 56: e164, 2010.

Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Oxidative stress via nuclear factor kappa B causes vascular angiotensin type 1 receptor upregulation and contributes to development of hypertension in SHR. Hypertension, 56: e154, 2010.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress causes renal AT1 receptor upregulation, NHE3 overstimulation and hypertension. Hypertension, 56: e117, 2010.

Javkhedkar, A., Lokhandwala, M.F. and Banday, A.A.: Oxidative stress impairs renal nitric oxide signaling and ang II mediated biphasic Na/K-ATPase regulation in spontaneously hypertensive rats. Hypertension, 52: e164, 2010.

Javkhedkar, A., Lokhandwala, M.F. and Banday, A.A.: Higher renal AT1 receptor affinity exaggerates Ang II induced Na/K-ATPase stimulation in spontaneously hypertensive rats. FASEB J. 24: LB707, 2010.

Amenta, F., Bhatt, S., Nwankwo, I.E., Muhammad, A.B., Ricci, A., Tayebati, S.K., Tomassoni, D. and Lokhandwala, M.F.: Microanatomical Changes In The Brain Of Obese Zucker Rats: A Model Of Metabolic Syndrome 6th International Meeting on Vascular Dementia, Spain, 2009. (#327)

Bhatt, S., Banday, A.A. and Lokhandwala M.F.: Vascular oxidative stress, NFκB activation and AT1 Receptor upregulation precede the development of hypertension in Spontaneously Hypertensive Rats (SHR) FASEB J. 2009 23:LB53 (Experimental Biology 2009)

Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Early Chronic Resveratrol Treatment Reduces Blood Pressure and Vasoconstriction and Improves Endothelium-Dependent Vasorelaxations by Lowering Oxidative Stress in Spontaneously Hypertensive Rats. 63rd Annual High Blood Pressure Research Conference 2009 Hypertension. 2009; 54: e26-e127 (P268)

Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Vascular and Not Systemic Oxidative Stress Precedes Development of Hypertension and Is Associated with NFκB Activation and AT1 Receptor Upregulation. 63rd Annual High Blood Pressure Research Conference 2009 Hypertension. 2009; 54: e26-e127 (P261)

Banday, A. A. and Lokhandwla, M. F.: Antioxidant-mediated Nrf2 activation prevents AT1 receptor upregulation, endothelial dysfunction and hypertension by abolishing NFκB activation during oxidative stress, J. Clin. Hypertension, 11:A2, 2009.

George, L., Asghar, M., and Lokhandwala, M.F. Exercise Stimulates Transcription Factors (Nrf2 & NF-κB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008.

Banday, A. A. and Lokhandwala, M. F.: Loss of biphasic effect on renal Na/K-ATPase by angiotensin II involves defective regulation of AT1 receptor-NO-cGMP signaling during oxidative stress. J. Amer. Soc. Nephrol. 19: 377A, 2008.

Asghar, M. and Lokhandwala, M.F.: Inflammation produced by lipopolysaccharide downregulates renal Nrf2, compromises renal D1 receptor function and increases blood pressure during high salt intake. J. Amer. Soc. Nephrol. 19: 140A, 2008.

George, L., Lokhandwala, M.F. and Asghar, M.: Role of NFkB and Nrf2 in exercise-induced restoration of renal dopamine D1 receptor function in aging. J. Amer. Soc. Nephrol. 19: 139A, 2008.

Banday, A.A. and Lokhandwala, M.F.: Role of Nrf2 in prevention of renal angiotensin AT1 receptor upregulation and hypertension during oxidative stress. J. Amer. Soc. Nephrol. 19: 67A, 2008.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters in hypertension. Hypertension, 52: e59, 2008.

Banday, A.A. and Lokhandwala, M.F.: Antioxidant mediated Nrf2 activation blocks NFkB stimulation and prevents angiotensin AT1 receptor upregulation and hypertension during oxidative stress. Hypertension, 52: e58, 2008.

Lokhandwala, M.F., Banday, A.A., Bhatt, S. and Javkhedkar, A.: Oxidative stress and transcriptional regulation of angiotensin AT1 receptors in hypertension. Physiol. Res. 57:54P, 2008.

Lokhandwala, M.F., Marwaha, A., Trivedi, M. and Banday, A.A.: Oxidative Stress and renal dopamine D1 receptor function in experimental diabetes. Clin Exp Hypertension, 29:223, 2007.

Banday, A.A., Muhammad, A.B. and Lokhandwala, M.F.: Mechanisms of oxidative stress induced increase in salt sensitivity and development of hypertension in Sprague-dawley rats. Hypertension, 48: e56, 2006.

Liza, G., Asghar, M. and Lokhandwala, M.F.: Exercise reduces oxidative stress and inflammation and increases D1 receptor numbers and G-protein activation in renal proximal tubules of old rats. J Am Soc Nephrol 17: 603A, 2006.

Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: NF-kB contributes to oxidative stress-induced defective renal dopamine D1 receptor signaling in renal proximal tubules of Sprague Dawley rats. J Am Soc Nephrol 17: 603A, 2006.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: ERK1/2 and G-protein coupled receptor kinase 2 are required for insulin induced heterologous dopamine D1 receptor desensitization in renal epithelial cells. J Am Soc Nephrol 17: 594A, 2006.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Oxidative stress induced renal dopamine D1 receptor dysfunction involves NF-kB and protein kinase C activation. J Am Soc Nephrol 17: 450A, 2006.

Banday, A.A., Fasili, F.R. and Lokhandwala, M.F.: G-protein coupled receptor kinase 2 mediates high glucose induced renal dopamine D1 receptor desensitization by interacting with G>άq/11. J Am Soc Nephrol 17: 365A, 2006.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Chronic insulin treatment phosphorylates ά1 Na, K-ATPase subunit at serine 11/18 and reduces its activity involving phophotidylinositol-3-kinase dependent atypical Protein Kinase C ξ/λ activation. J Am Soc Nephrol 17: 296A, 2006.

Banday, A.A. and Lokhandwala, M.F.: Impaired renal dopamine D1 receptor function contributes to oxidative stress mediated hypertension. Free Radical Research, 40:S152, 2006.

Asghar, M., Fardoun, R. and Lokhandwala, M.F.: Oxidative stress and age-related decline in renal dopamine D1 receptor function. Free Radical Research, 40: S84, 2006.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress induced renal D1 receptor dysfunction causes salt sensitive hypertension in spague dawley rats. FASEB J. 20: 743.11, 2006.

Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: Oxidative stress causes activation of NF-kB in renal proximal tubules of spargue dawley rats. FASEB J. 20: 709.8, 2006.

Asghar, M., Zeyssig, R., Monjok, E., Kouamou, G., Ohia, S.E., Lokhandwala, M.F. and Bagchi, D.: Effect of a novel hydroxycitric acid extract (HCA-SX) on oxidative stress, insulin resistance and brain serotonin levels in obese Zucker rats. FASEB J. 20: 655.4, 2006.

Invited Meeting Lectures

Dr. Lokhandwala has been invited to several national and international scientific meetings over the last 35 years. The following is only a partial list, representing presentations at symposia and seminars since 2002:

Symposium on R alpha lipoic acid, Rome, Italy, September, 2010.

The 13th Innternational SHR Symposium, Prague, the Czec Republic, June, 2008

The 12th International SHR Symposium, Kyoto, Japan, October, 2006

The Biology of Aging, Gordon Research Conference, Ventura, CA, February, 2006.

Seventh Annual Diabetes Conference, The SMi Group, London, England, October, 2005

Biology of the Aging Kidney Workshop, National Institute on Aging, Bethesda, MD, January, 2003.

Fourth Annual John H. Laragh Conference on Advances in Hypertension Research, The American Society of Hypertension, Coral Gables, FL., January, 2003.

8th International Conference on Peripheral Dopamine, Stockholm, Sweden, June, 2002.

Partnership in Pharmacy Focus 2002 Conference, Palm Harbor, FL. April, 2002.

Invited Seminar Presentations

Dr. Lokhandwala has been invited to present seminars and lectures at medical, research and higher education institutions around the world. Following is a partial list, representing seminars and lectures delivered since 2006:

Faculty of Pharmacy, University of Camerino, Camerino, Italy, October, 2008.

Departmant of Pharmacology, University of Medicine and Dentistry of New Jersey, Newark, NJ. April, 2008.

Department of Pharmacology and Neuroscience, University of North Texas Health Sciences Center, Forth Worth, TX. March, 2008

Deprtmant of Cardiology, The Third Military Medical University, Chogqing, P.R. China, March, 2007

Department of Pharmacology, The Third Military Medical University, Chogqing, P.R. China, March, 2007

School of Pharmacy, Texas Tech University Health Sciences Center Amarillo, Tx. January, 2007

Department of Health and Kinesiology, Texas A&M University, College Station, Tx. November, 2006.