Profile: Mohammad Asghar
Assistant Professor of Pharmacology
444 Science & Research Bldg. 2
Houston, TX 77204-5037
B.S, Chemistry, A. M. University, Aligarh, India
M.S., Biochemistry, A. M. University, Aligarh, India
Ph.D., Biochemistry, A. M. University, Aligarh, India
Post-doctoral fellow, Department of Woman and Child Health, Astrid Lindgren Children Hospital, Karolinska Institute, Stockholm, Sweden
- National Institute of Health (News Release in 2001) recognizes that sodium (salt) is a risk factor for hypertension that increases the risk of heart attack, cardiovascular events, and even death in hypertensive individuals. The risk increases with age and is true for men and women.
- The kidney plays a pivotal role in the maintenance of sodium homeostasis and subsequently body fluid volume and blood pressure. There are several endogenous compounds present in the kidney, including angiotensin II and dopamine, that help maintain sodium homeostasis. Angiotensin II via AT1 receptor stimulates sodium transporters (Na,K-ATPase and Na,H-exchanger) and facilitates sodium re-absorption. While dopamine via D1 receptor inhibits these transporters and promotes sodium excretion. Appropriate functioning of these receptors is required for the maintenance of sodium homeostasis. An increase in AT1 receptor function and a decrease in D1 receptor function favor a positive sodium balance, increase in fluid volume and high blood pressure. The long-term goal of my research is to identify the role of kidney and the underlying mechanism(s) involved in causing high blood pressure in aging.
- PCOL 7350 Cellular Pharmacology
- PCOL 4131 Pharmacology II (Pharmacological and Pharmaceutical Research Awareness)
2011 - 2016
Title: Renal Dopmaine and Angiotension II Receptor Function in Age-Related Hypertension
2008 - 2010
NIA/NIH 1RO3 AG029904-01A2
Title: Exercise and kidney dopamine receptor function in aging.
2005 - 2010
NIA/NIH 1RO1 AG025056-01A1
Title: Age-related changes in dopamine D1 receptor function.
Salim S, Asghar M, Taneja M, Hovatta I, Chugh G, Vollert C, Vu A. Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Brain Res. 2011 Aug 2;1404:63-71.
Asghar M., Tayebati, S.K., Lokhandwala, M.F and Hussain, T.: Potential Dopamine-1 Receptor Stimulation in Hypertension Management. Curr. Hypertension Reports, 2011 Aug;13(4):294-302.
Sabuhi R, Ali Q, Asghar M, Al-Zamily NR, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol. 2011 Mar;300(3):F700-6.
Salim S, Asghar M, Taneja M, Hovatta I, Wu YL, Saha K, Sarraj N, Hite B. Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Lett. 2011 May 6;585(9):1375-81.
Chugh, G., Lokhandwala, M.F. and Asghar M.: Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats. Amer J Physiol: Renal Physiol, 300: F133-F138, 2011.
Salim S, Asghar M, Chugh G, Taneja M, Xia Z, Saha K. Oxidative stress: a potential recipe for anxiety, hypertension and insulin resistance. Brain Res. 2010 Nov 4;1359:178-85.
Sabuhi R, Asghar M, Hussain T. Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. Am J Physiol Renal Physiol. 2010 Oct;299(4):F815-20.
Asghar M, Chugh G, Lokhandwala MF. Inflammation compromises renal dopamine D1 receptor function in rats. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1543-9.
George L, Lokhandwala MF, Asghar M. Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1174-80.
Asghar M, Chillar A and Lokhandwala MF. Renal proximal tubules from old F344 rats grow into epithelial cells in primary cultures and exhibit increased oxidative stress and reduced D1 receptor function, Am J Cell-Physiol 295:C1326-C1331, 2008.
Asghar M, George L and Lokhandwala MF. Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. Am J Physiol, 293:F914-919, 2007
Salim S, Farooq N, Priyamvada S, Asghar M, , Khundmiri SJ, Khan F, Khan S and Yusufi ANK. Influence of Ramadan type fasting on carbohydrate metabolism, brush border membrane enzymes and phosphate transport in rat kidney used as a model. Brit J Nutr 98:984-990, 2007.
Asghar M, Monjok E, Kouamou G, Ohia S, Bagchi D and Lokhandwala M. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance and body weight in developing obese Zucker rats. Molecular Cellular Biol 304:93-99, 2007.
Riham Z. Fardoun, Asghar M, and Lokhandwala M: Role of NFkB in oxidative stress-induced defective renal dopamine D1 receptor signaling in the renal proximal tubules of Sprague-Dawley rats. Free Rad Biol Med 42:756-764, 2007
Fardoun R, Asghar M, and Lokhandwala M: Role of oxidative stress in defective renal dopamine D1 receptor- G-protein coupling and function in old Fischer 344 rats. Am J Physiol Renal Physiol 291:F945-951, 2006.
Asghar M, Banday A, Fardoun R, and Lokhandwala M: Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G-proteins via a mechanism involving protein kinase C and G-protein coupled receptor kinase 2. Free Rad Biol Med 40:13-20, 2006.
Asghar, M and Lokhandwala, MF. Antioxidant tempol decreases age-related increase in insulin resistance in Fischer 344 rats. Clin Exp Hyper 28:533-541, 2006.
Khudmiri, S.J., Asghar M., Banday, A.A. Khan, F., Salim, S., Levi, M. and Yusufi, A.N. Effect of ischemia reperfusion on sodium-dependent phosphate transport in renal brush border membranes. Biochim Biophys Acta. 1716:19-28, 2005.
Asghar, M., and Lokahndwala, M.F: Antioxidant supplementation normalizes elevated protein kinase C activity in the proximal tubules of old rats. Exp Biol Med 229: 270-275, 2004.
Khudmiri, S.J., Asghar M., Khan F., Salim, S., and Yusufi, A.N.: Effect of ischemia and reperfusion on enzymes of carbohydrate metabolism in rat kidney. J Nephrol 17(3):377-832004, 2004.
Chugh, G., Lokhandwala, M.F. and M. Asghar: Age-associated oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old Fischer 344 X Brown Norway F1 rats. Hypertension, 56: e164, 2010.
M. Asghar, G. Chugh, D. Diz, M. Lokhandwala. High blood pressure in aging is associated with an up-regulation of AT1 and down-regulation of D1 receptors in the kidney. Journal of Nutrition, Health and Aging, Abs: S219: 13 (suppl. 1), 2009
Gaurav Chugh, Mustafa Lokhandwala, and Mohammad Asghar. High blood pressure in aged Fischer 344 X Brown Norway F1 rats is associated with increased oxidative stress, NFkB activation and exaggerated renal AT1 receptor response to Angiotensin II. FASEB J. 2009 23:1016.8.
Liza George, Mohammad Asghar, and Mustafa F. Lokhandwala. Exercise Stimulates Transcription Factors (Nrf2 & NFκB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008. Experimental Biology Meeting, 2008, April 5-9, San Diego, CA.
Mohammad Asghar and Mustafa F. Lokhandwala. Inflammation produced by lipopolysaccharide down-regulates renal Nrf2, compromises renal D1 receptor function and increases blood pressure during high-salt intake. J. Amer. Soc. Nephrol. 19: 140A, 2008. American Society of Nephrology Meeting, 2008, November 4-9, Philadelphia, PA.
Liza George, Mohammad Asghar, and Mustafa F. Lokhandwala. Role of NF-кB and Nrf-2 in Exercise Induced Restoration of Renal Dopamine D1 Receptor Function in Aging. American Society of Nephrology Meeting, 2008, November 4-9, Philadelphia, PA.
George, L., Asghar, M., and Lokhandwala, M.F. Exercise Stimulates Transcription Factors (Nrf2 & NF-κB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008.
Liza, G., Asghar, M. and Lokhandwala, M.F.: Exercise reduces oxidative stress and inflammation and increases D1 receptor numbers and G-protein activation in renal proximal tubules of old rats. J Am Soc Nephrol 17: 603A, 2006.
Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: NF-kB contributes to oxidative stress-induced defective renal dopamine D1 receptor signaling in renal proximal tubules of Sprague Dawley rats. J Am Soc Nephrol 17: 603A, 2006.
Asghar, M., Fardoun, R. and Lokhandwala, M.F.: Oxidative stress and age-related decline in renal dopamine D1 receptor function. Free Radical Research, 40: S84, 2006.
Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: Oxidative stress causes activation of NF-kB in renal proximal tubules of spargue dawley rats. FASEB J. 20: 709.8, 2006.
Asghar, M., Zeyssig, R., Monjok, E., Kouamou, G., Ohia, S.E., Lokhandwala, M.F. and Bagchi, D.: Effect of a novel hydroxycitric acid extract (HCA-SX) on oxidative stress, insulin resistance and brain serotonin levels in obese Zucker rats. FASEB J. 20: 655.4, 2006.
Asghar, M., Fardoun, R.Z., Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced activation of nuclear transcription facter NFkB and G-protein coupled receptor kinase 2 causes dopamine D1 receptor G-protein uncoupling in renal proximal tubules of old rats. J. Amer. Soc. Nephrol. 16, 374A, 2005.
Asghar, M. and Lokhandwala, M. F.: Lowering of oxidative stress by tempol leads to a decrease in age-associated increase in insulin resistance in Fischer 344 rats. Free Rad. Biol. Med. 39: S30, 2005.
- American Society of Health-System Pharmacists
- American Society of Nephrology
- Society of Free Radical Research International
- Abstract Reviewer: Annual Meeting of the Society for Free Radical Biology and Medicine, 2008 – present
- Review Panel Member: Region III Peer Review Consortium, Committee 1A, American Heart Association, 2007-08
- Journal Reviewer:
- Clinical and Experimental Hypertension
- Journal of American Society of Nephrology
- Journal of Endocrinology
- Journal of Sports Sciences
- Regulatory Peptides
- British Journal of Pharmacology