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Profile: Mohammad Asghar

Mohammad Asghar
Mohammad Asghar, Ph.D.
Assistant Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
Physical Address: Science and Research Building 2, 3455 Cullen Blvd., Room 444, Houston, TX 77204
Mailing Address: Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX 77204-5037

Office: 713-743-1597
Fax: 713-743-1232
Email: masghar@uh.edu

Education

B.S, Chemistry, A. M. University, Aligarh, India

M.S., Biochemistry, A. M. University, Aligarh, India

Ph.D., Biochemistry, A. M. University, Aligarh, India

Post-doctoral fellow, Department of Woman and Child Health, Astrid Lindgren Children Hospital, Karolinska Institute, Stockholm, Sweden

Research Interests

  • National Institute of Health (News Release in 2001) recognizes that sodium (salt) is a risk factor for hypertension that increases the risk of heart attack, cardiovascular events, and even death in hypertensive individuals. The risk increases with age and is true for men and women.
  • The kidney plays a pivotal role in the maintenance of sodium homeostasis and subsequently body fluid volume and blood pressure. There are several endogenous compounds present in the kidney, including angiotensin II and dopamine, that help maintain sodium homeostasis. Angiotensin II via AT1 receptor stimulates sodium transporters (Na,K-ATPase and Na,H-exchanger) and facilitates sodium re-absorption. While dopamine via D1 receptor inhibits these transporters and promotes sodium excretion. Appropriate functioning of these receptors is required for the maintenance of sodium homeostasis. An increase in AT1 receptor function and a decrease in D1 receptor function favor a positive sodium balance, increase in fluid volume and high blood pressure. The long-term goal of my research is to identify the role of kidney and the underlying mechanism(s) involved in causing high blood pressure in aging.

Courses

  • PCOL 7350 Cellular Pharmacology
  • PCOL 4131 Pharmacology II (Pharmacological and Pharmaceutical Research Awareness)

Research Grants

2011 - 2016
NIA/NIH
Title: Renal Dopmaine and Angiotension II Receptor Function in Age-Related Hypertension
Role: PI

2008 - 2010
NIA/NIH 1RO3 AG029904-01A2
Title: Exercise and kidney dopamine receptor function in aging.
Role: PI

2005 - 2010
NIA/NIH 1RO1 AG025056-01A1
Title: Age-related changes in dopamine D1 receptor function.
Role: Co-Investigator

Selected Publications

Pokkunuri I, Chugh G, Rizvi I, Asghar M. Age-related hypertension and salt sensitivity are associated with unique cortico-medullary distribution of D1R, AT1R, and NADPH-oxidase in FBN rats. Clin Exp Hypertens. 2015;37(1):1-7. doi: 10.3109/10641963.2014.977489.

Chugh G, Pokkunuri I, Asghar M. Renal dopamine and angiotensin II receptor signaling in age-related hypertension. Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F1-7. doi: 10.1152/ajprenal.00441.2012. Review. PMID: 23097467

Chugh G, Lokhandwala MF, Asghar M. Altered functioning of both dopamine D1 and angiotensin II AT1 receptors causes hypertension in old rats. Hypertension 59:1029-1036, 2012.

George LE, Lokhandwala MF, Asghar M. Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells. Am J Physiol Renal Physiol 302:F1440-1446, 2012.

Salim S, Asghar M, Taneja M, Hovatta I, Chugh G, Vollert C, Vu A. Potential contribution of oxidative stress and inflammation to anxiety and hypertension. Brain Res. 2011 Aug 2;1404:63-71.

Asghar M., Tayebati, S.K., Lokhandwala, M.F and Hussain, T.: Potential Dopamine-1 Receptor Stimulation in Hypertension Management. Curr. Hypertension Reports, 2011 Aug;13(4):294-302.

Sabuhi R, Ali Q, Asghar M, Al-Zamily NR, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol. 2011 Mar;300(3):F700-6.

Salim S, Asghar M, Taneja M, Hovatta I, Wu YL, Saha K, Sarraj N, Hite B. Novel role of RGS2 in regulation of antioxidant homeostasis in neuronal cells. FEBS Lett. 2011 May 6;585(9):1375-81.

Chugh, G., Lokhandwala, M.F. and Asghar M.: Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats. Amer J Physiol: Renal Physiol, 300: F133-F138, 2011.

Salim S, Asghar M, Chugh G, Taneja M, Xia Z, Saha K. Oxidative stress: a potential recipe for anxiety, hypertension and insulin resistance. Brain Res. 2010 Nov 4;1359:178-85.

Sabuhi R, Asghar M, Hussain T. Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. Am J Physiol Renal Physiol. 2010 Oct;299(4):F815-20.

Asghar M, Chugh G, Lokhandwala MF. Inflammation compromises renal dopamine D1 receptor function in rats. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1543-9.

George L, Lokhandwala MF, Asghar M. Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1174-80. 

Asghar M, Chillar A and Lokhandwala MF. Renal proximal tubules from old F344 rats grow into epithelial cells in primary cultures and exhibit increased oxidative stress and reduced D1 receptor function, Am J Cell-Physiol 295:C1326-C1331, 2008.

Asghar M, George L and Lokhandwala MF. Exercise decreases oxidative stress and inflammation and restores renal dopamine D1 receptor function in old rats. Am J Physiol, 293:F914-919, 2007

Salim S, Farooq N, Priyamvada S, Asghar M, , Khundmiri SJ, Khan F, Khan S and Yusufi ANK. Influence of Ramadan type fasting on carbohydrate metabolism, brush border membrane enzymes and phosphate transport in rat kidney used as a model. Brit J Nutr 98:984-990, 2007.

Asghar M, Monjok E, Kouamou G, Ohia S, Bagchi D and Lokhandwala M. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance and body weight in developing obese Zucker rats. Molecular Cellular Biol 304:93-99, 2007.

Riham Z. Fardoun, Asghar M, and Lokhandwala M: Role of NFkB in oxidative stress-induced defective renal dopamine D1 receptor signaling in the renal proximal tubules of Sprague-Dawley rats. Free Rad Biol Med 42:756-764, 2007

Fardoun R, Asghar M, and Lokhandwala M: Role of oxidative stress in defective renal dopamine D1 receptor- G-protein coupling and function in old Fischer 344 rats. Am J Physiol Renal Physiol 291:F945-951, 2006.

Asghar M, Banday A, Fardoun R, and Lokhandwala M: Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G-proteins via a mechanism involving protein kinase C and G-protein coupled receptor kinase 2. Free Rad Biol Med 40:13-20, 2006.

Asghar, M and Lokhandwala, MF. Antioxidant tempol decreases age-related increase in insulin resistance in Fischer 344 rats. Clin Exp Hyper 28:533-541, 2006.

Presentations & Abstracts

Salvi A, Patki G, Khan E*, Asghar M, Salim S. Protective Effect of Tempol on Buthionine Sulfoximine- Induced MitochondrialImpairment in Hippocampal Derived HT22 Cells. Oxid Med Cell Longev. 2016; 2016:5059043. doi: 10.1155/2016/5059043. Epub 2016 Mar.

Pokkunuri I, Chugh G, Rizvi I# and Asghar M. Age-related hypertension and salt-sensitivity are associated with unique cortico-medullary distribution of D1R, AT1R and NADPH-oxidase in FBN rats. Clin Exp Hypertens, 37:1-7, 2015.

Patki G, Allam FH*, Atrooz F, Dao AT, Solanki N, Chugh G,Asghar M, Jafri F*, Bohat R*, Alkadhi KA, Salim S. Grape powder intake prevents ovariectomy-induced anxiety-like behavior, memoryimpairment and high blood pressure in female Wistar rats. PLoS One, 2013

Chugh, G., Lokhandwala, M.F. and M. Asghar: Age-associated oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old Fischer 344 X Brown Norway F1 rats. Hypertension, 56: e164, 2010.

M. Asghar, G. Chugh, D. Diz, M. Lokhandwala. High blood pressure in aging is associated with an up-regulation of AT1 and down-regulation of D1 receptors in the kidney. Journal of Nutrition, Health and Aging, Abs: S219: 13 (suppl. 1), 2009

Gaurav Chugh, Mustafa Lokhandwala, and Mohammad Asghar. High blood pressure in aged Fischer 344 X Brown Norway F1 rats is associated with increased oxidative stress, NFkB activation and exaggerated renal AT1 receptor response to Angiotensin II. FASEB J. 2009 23:1016.8.

Liza George, Mohammad Asghar, and Mustafa F. Lokhandwala. Exercise Stimulates Transcription Factors (Nrf2 & NFκB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008. Experimental Biology Meeting, 2008, April 5-9, San Diego, CA.

Mohammad Asghar and Mustafa F. Lokhandwala. Inflammation produced by lipopolysaccharide down-regulates renal Nrf2, compromises renal D1 receptor function and increases blood pressure during high-salt intake. J. Amer. Soc. Nephrol. 19: 140A, 2008. American Society of Nephrology Meeting, 2008, November 4-9, Philadelphia, PA.

Liza George, Mohammad Asghar, and Mustafa F. Lokhandwala. Role of NF-кB and Nrf-2 in Exercise Induced Restoration of Renal Dopamine D1 Receptor Function in Aging. American Society of Nephrology Meeting, 2008, November 4-9, Philadelphia, PA.

George, L., Asghar, M., and Lokhandwala, M.F. Exercise Stimulates Transcription Factors (Nrf2 & NF-κB), Increases Antioxidant Defenses, Decreases Oxidative Stress, and Restores Renal Dopamine D1 Receptor Function in Aging. FASEB J 22, 1159.6, 2008.

Liza, G., Asghar, M. and Lokhandwala, M.F.: Exercise reduces oxidative stress and inflammation and increases D1 receptor numbers and G-protein activation in renal proximal tubules of old rats. J Am Soc Nephrol 17: 603A, 2006.

Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: NF-kB contributes to oxidative stress-induced defective renal dopamine D1 receptor signaling in renal proximal tubules of Sprague Dawley rats. J Am Soc Nephrol 17: 603A, 2006.

Asghar, M., Fardoun, R. and Lokhandwala, M.F.: Oxidative stress and age-related decline in renal dopamine D1 receptor function. Free Radical Research, 40: S84, 2006.

Fardoun, R.Z., Asghar, M. and Lokhandwala, M.F.: Oxidative stress causes activation of NF-kB in renal proximal tubules of spargue dawley rats. FASEB J. 20: 709.8, 2006.

Asghar, M., Zeyssig, R., Monjok, E., Kouamou, G., Ohia, S.E., Lokhandwala, M.F. and Bagchi, D.: Effect of a novel hydroxycitric acid extract (HCA-SX) on oxidative stress, insulin resistance and brain serotonin levels in obese Zucker rats. FASEB J. 20: 655.4, 2006.

Memberships

  • Council on High Blood Pressure Research
  • American Society of Health-System Pharmacists
  • American Society of Nephrology
  • American Physiological Society
  • Society of Free Radical Research International

Professional Service

  • Abstract Reviewer: Annual Meeting of the Society for Free Radical Biology and Medicine, 2008 – present
  • Review Panel Member: Region III Peer Review Consortium, Committee 1A, American Heart Association, 2007-08
  • Journal Reviewer:
    • American Journal of Physiology
    • Circulation
    • Clinical and Experimental Hypertension
    • Journal of American Society of Nephrology
    • Journal of Clinical Investigation
    • Journal of Endocrinology
    • Journal of Sports Sciences
    • Kidney International
    • Regulatory Peptides
    • British Journal of Pharmacology