Assistant Professor of Pharmaceutics
UH College of Pharmacy
Texas Medical Center Campus, Room 516
1441 Moursund St.
Houston, TX 77030
713-795-8317
713-795-8305 (fax)
mbikram@uh.edu
Education
Ph.D., Pharmaceutics & Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah
B.S., Biochemistry & Biological Sciences, University of Denver, Denver, Colo.
Research Interests
The development of polymeric prodrugs, biomimetic drug and gene delivery systems, and genetically engineered plasmids for the treatment and understanding of breast and ovarian cancer. Our focus is to understand the pathophysiology of a tumor environment with the goal of designing polymeric drug carriers that can be used to optimize the delivery of chemotherapeutic drugs and gene delivery systems. Additionally, combination therapies involving both chemotherapeutic drugs as well as gene delivery systems are promising treatments in the fight against cancer. Therefore, another area of our research will involve the development of therapeutic plasmids for the delivery of specific cytokine genes that are effective in eliciting strong immune responses against cancer cells in tandem with the administration of standard chemotherapeutic drugs.
Research Grants
U.S. Department of Defense: Bioresponsive Nanoparticles as Magnetic Resonance Molecular Probes.
Texas Higher Education Coordinating Board, Advanced Research Program: Stealth Targeted Magnetic Resonance Molecular Probes for Cancer Detection
Selected Publications
Gheorghe DE, Cui L, Karmonik C, Brazdeikis A, Penaloza JM, Young JK, Drezek RA, Bikram M. Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics. Nanoscale Res Lett. 2011 Oct 13;6:554.
Nounou MI, Emmanouil K, Chung S, Pham T, Lu Z, Bikram M. Novel reducible linear L-lysine-modified copolymers as efficient nonviral vectors. J Control Release. 2010 May 10;143(3):326-34.
Mody VV, Nounou MI, Bikram M. Novel nanomedicine-based MRI contrast agents for gynecological malignancies. Adv Drug Deliv Rev. 2009 Aug 10;61(10):795-807. Review.
Bikram M, West JL. Thermo-responsive systems for controlled drug delivery. Expert Opin Drug Deliv. 2008 Oct;5(10):1077-91. Review.
Bikram, M., Gobin, A.M., Whitmire, R.E. and West, J.L. (2007). Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery. J. Control. Release. 123:219-227.
Bikram, M., Fouletier-Dilling, C., Hipp, J.A., Gannon, F., Davis, A.R., Olmsted-Davis, E.A. and West, J.L. (2007). Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. Ann. Biomed. Eng. 35:796-807.
Janat-Amsbury, M.M., Yockman, J.W., Lee, M., Kern, S., Furgeson, D.Y., Bikram, M., and Kim, S.W. (2005). Local, non-viral IL-12 gene therapy using a water-soluble lipopolymer as carrier system combined with systemic paclitaxel for cancer treatment. J. Control. Release. 101: 273-285.
Bikram, M., Lee, M., Chang, C.W., Janat-Amsbury, M.M., Kern, S.E., and Kim, S.W. (2005). Long-circulating DNA-complexed biodegradable multiblock copolymers for gene delivery: degradation profiles and evidence of dysopsonization. J. Control. Release. 103: 221-233.
Lee, M., Bikram, M., Oh, S., Bull, D.A., and Kim, S.W. (2004). Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease. Pharm. Res. 21: 736-741.
Janat-Amsbury, M.M., Yockman, J.W., Lee, M., Kern, S., Furgeson, D.Y., Bikram, M., and Kim, S.W. (2004). Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. Mol. Ther. 9: 829-836.
Bikram, M., Ahn, C.-H., Chae, S.Y., Lee, M., Yockman, J.W., and Kim, S.W. (2004). Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g-histidine multiblock copolymers for nonviral gene delivery. Macromolecules. 37: 1903-1916.
Lee, M., Rentz, J., Bikram, M., Han, S., Bull, D.A., and Kim, S.W. (2003). Hypoxia-inducible VEGF gene delivery to ischemic myocardium using water-soluble lipopolymer. Gene Ther. 10: 1535-1542.
Carruthers, L.M., Closken, C.L., Link, K.L., Mahapatro, S.N., Bikram, M., Du, J.L., Eaton, S.S., and Eaton, G.R. (1999). Electron spin relaxation in chromium-nitrosyl complexes. Inorg. Chem. 38: 3529-3534.
Presentations & Abstracts
Bikram M., Nounou M.I., Cui L., Gheorghe D.E., Lorenz B., Karmonik C. Nanomaterials For Biomedical Applications. Podium presentation. Proceedings of ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology, NEMB2010, February 7-10, 2010 Houston, TX, USA.
Bikram M. Biocompatible Materials for Biomedical Applications. Podium presentation. Society for Biomaterials: Biomaterials Day at Texas A & M University. February 22, 2010, College Station, TX.
Nounou M.I., Emmanouil K., Chung S., Pham T., Lu Z., Bikram M. Novel Lysine-Based Bioreducible Nonviral Gene Delivery System. Podium presentation. AAPS National Biotechnology Conference. May 16-19, 2010. San Francisco, CA.
Nounou M.I., Emmanouil K., Chung S., Pham T., Lu Z., Bikram M. Novel Reducible L-Lysine Copolymers (LLCs) for Nonviral Gene Delivery. The 37th Annual Meeting and Exposition of the Controlled Release Society. July 10-14, 2010. Submitted. Portland, OR.
Cui L., Gheorghe D.E., Penaloza J.M., Pan Y., Bikram M. Development of Tumor-Targeting MRI Contrast Agent for Imaging. The 37th Annual Meeting and Exposition of the Controlled Release Society. July 10-14, 2010. Submitted. Portland. OR.
M. Bikram., Gheorghe D.E., Penaloza J.M., Lorenz B, Karmonik C. Metal-Alloy Nanoshells as New Nanotherapeutic and Diagnostic Agents. The 37th Annual Meeting and Exposition of the Controlled Release Society. July 10-14, 2010. Submitted. Portland, OR.
Nounou M.I., Emmanouil K., Chung S., Pham T., Lu Z., Bikram M. Efficient DNA Delivery Using Novel Bioreducible Linear L-Lysine Modified Copolymers (LLCs). Poster Presentation. Alliance for NanoHealth (ANH) Investigators Meeting, February 23, 2010. Houston, TX.
Cui L., Gheorghe D.E., Mogri E., Nguyen D., Yuli Pan, Bikram M. Novel Bioresponsive MRI Contrast Agent for Imaging. Poster Presentation. Alliance for NanoHealth (ANH) Investigators Meeting - February 23, 2010. Houston, TX.
Nounou M.I., Emmanouil K., Chung S., Pham T., Lu Z., Bikram M. Novel L-Lysine Reducible Copolymer For Efficient Nonviral Gene Delivery. Poster Presentation. The American Society of Gene & Cell Therapy 13th Annual Meeting. Accepted. San Diego, CA. May 17-22, 2010. Washington, D.C.
Lili Cui, Gheorghe D.E., Mody V.V., Karmonik C. Bikram M. Development of MMP-Specific MRI Contrast Agent for Ovarian Cancer. Poster Presentation. Meeting: 239th ACS National Meeting & Exposition - March 21-25, 2010, San Francisco, CA.
Gheorghe D.E., Penaloza J.M., Karmonik C., Drezek R.A., Bikram M. Gold-Silver Alloy Nanoshells: A New Candidate for Nanotherapeutics and Diagnostics. Poster Presentation. 239th ACS National Meeting & Exposition, March 21-25, 2010, San Francisco, CA.
Gheorghe D.E., Mody V.V., Penaloza J.M., Lorenz B., Karmonik C., Bikram M. Synthesis And Characterization Of Gold Alloy Nanoshells On Gd-Doped Iron Oxide Nanoparticles. Biomedical Engineering Society annual meeting. October 7-10, 2009, Pittsburgh, PA.
Nounou M.I., Mody V.V, Emmanouil K., Pham T., Lu Z., Bikram M. Design, Synthesis And Characterization Of Novel Lysine-Based Bioreducible Nonviral Gene Delivery System. Poster Presentation. Biomedical Engineering Society annual meeting. October 7-10, 2009, Pittsburgh, PA.
Mody V.V., Nounou M.I., Cui L., Karmonik C., Lorenz B., Bikram M. Development Of MMP-Specific MRI Contrast Agent For Ovarian Cancer. Poster Presentation. Biomedical Engineering Society annual meeting. October 7-10, 2009, Pittsburgh, PA.
Nounou M.I., Mody V.V, Emmanouil K., Pham T., Lu Z., Bikram M. Novel Lysine Based Bioreducible Non Viral Gene Carrier System: Synthesis, Characterization And In Vitro Evaluation. Poster Presentation. American Society of Gene Therapy 12th Annual Meeting. Accepted. San Diego, CA. May 27-30, 2009.
Nounou M.I., Mody V.V, Emmanouil K., Pham T., Lu Z., Bikram M. Efficient DNA Delivery Using Novel Bioreducible Linear L-Lysine-Modified Copolymers (LLC). Poster Presentation. Recent Advances in Drug Delivery Systems 14th International Symposium. Salt Lake City, UT. February 15-18, 2009.
Mody V.V., Nounou M., Karmonik C., Bikram M. Synthesis Of Dual Bioresponsive Ultrasmall Superparamagnetic Iron Oxide Nanoparticles As MR Contrast Agents And Evaluation Of Its Cytotoxicity In Vitro. Poster Presentation. The Houston Society for Engineering in Medicine and Biology. Houston, TX. March 19-20, 2009.
Gheorghe D.E., Mody V.V., Bikram M. Synthesis And Characterization Of Gold Alloy Nanoshells On Gd-Doped Iron Oxide Nanoparticles. Poster Presentation. The Houston Society for Engineering in Medicine and Biology. Houston, TX. March 19-20, 2009.
Nounou M.I., Mody V.V, Emmanouil K., Pham T., Lu Z., Bikram M. Synthesis and Characterization Of Novel Bioreducible Linear Disulfide Copolymers (LDC) For Non-Viral Gene Delivery. Oral Presentation. The Houston Society for Engineering in Medicine and Biology. Houston, TX. March 19-20, 2009.
Mody V.V., Nounou M., Karmonik C., Bikram M. Development of Tumor-Targeted MRI Contrast Agents for the Early Detection of Ovarian Cancer. Poster Presentation. Controlled Release Society. New York, NY. July 12-16, 2008.
Bikram M, Mody V.V., Nounou M., Karmonik C. Tumor-specific MRI Contrast Agents for Ovarian Cancer. Poster Presentation. Gordon Research Conference. Big Sky, MT. August 24-29, 2008.
Mody V.V., Nounou M., Karmonik C., Bikram M. Development of Tumor-Targeted MRI Contrast Agents for the Early Detection of Ovarian Cancer. Poster Presentation. Controlled Release Society. New York, NY. July 12-16, 2008.
Mody V.V., Abdelraouf K., Nounou M., Karmonik C., Bikram M. Synthesis and Characterization of Bioresponsive Ultrasmall Paramagnetic Iron Oxide Nanoparticles as MR Contrast Agents. Oral Presentation. The Houston Society for Engineering in Medicine and Biology. Houston, TX. February 7-8, 2008.
Bikram M., Fouletier-Dilling C., Shafer J.A., Hipp J.A., Davis A.R., Olmsted-Davis E.A., West J.L. Bone Formation from Hydrogel Carriers Loaded with Adenovirus Transduced Cells Expressing BMP-2. Poster Presentation. Recent Advances in Drug Delivery Systems 13th International Symposium. Salt Lake City, UT. February 26-28, 2007.
Bikram M., Gobin A., Whitmire R.E., West J.L. Modulated Protein Release from Hydrogel Drug Reservoirs. Oral Presentation. American Chemical Society 62nd Southwest Regional Meeting. Houston, TX. October 20, 2006.
Bikram M., Fouletier-Dilling C., Shafer J.A., Hipp J.A., Davis A.R., Olmsted-Davis E.A., West J.L. Ectopic Bone Formation from Hydrogel Carriers Loaded with BMP-transduced Cells. Oral Presentation. Society For Biomaterials 2006 Annual Meeting and Exposition. Pittsburgh, PA.
Bikram M., Gobin A.M., Whitmire R.E., Sershen S.R., West J.L. Temperature-sensitive Hydrogels with SiO2-Au Nanoshells for Controlled Protein Delivery. Oral Presentation. Society For Biomaterials 2006 Annual Meeting and Exposition. Pittsburgh, PA.
Bikram M., Fouletier-Dilling C., Davis A.R., Olmsted-Davis E.A., West J.L. Ectopic Osteoinduction from Hydrogels containing Adenovirus-transduced Cells Expressing BMP2. Poster Presentation. American Society of Gene Therapy 8th Annual Meeting. St. Louis, MO. June 1-5, 2005.
Dilling C.M., Bosh P., Davis A.R., Shafer J.A., Stice S., Bikram M., West J.L., Olmsted-Davis E.A. GeneJammer® Enhances Cellular Transduction with Recombinant Adenovirus. Poster Presentation. American Society of Gene Therapy 8th Annual Meeting. St. Louis, MO. June 1-5, 2005.
