Instructional Associate Professor
Director, Faculty Development
542G Science and Research Building 2
Houston, TX 77204-5037
Ph.D. in Microbiology, University of Texas Medical Branch, Galveston, Texas
Medical Technology, U.S. Public Health Service Hospital, Baltimore, Md.
B.S. in Microbiology, University of Maryland, College Park, Md.
Our laboratory has been using pharmacological agents to improve the cellular uptake, retention and expression of genes for the purposes of effective non-viral gene therapy. We have determined that cytoskeletal dynamics may be critical to the success of gene delivery and expression. Using glucocorticoids and anti-mitotics to alter cytoskeletal dynamics, we can improve expression of the transgene 20-50 fold. The molecular mechanisms by which these drug agents improve transfected gene expression is currently under investigation.
- PHAR 4330 Pharmaceutics I
- PHAR 4331 Pharmaceutics II
- 2011: Teaching Excellence Award, University of Houston
- 2009: University of Houston, College of Pharmacy Teaching Excellence Award (selected by college faculty)
- 2009: Certificate of Recognition for Teaching Excellence, Rho Chi Honorary Society, Beta Omicron Chapter
- 2007: Certificate of Recognition for Teaching Excellence, Rho Chi Honorary Society, Beta Omicron Chapter
- 2006: University of Houston, College of Pharmacy Teaching Excellence Award (selected by college faculty)
- 2002: Travel Award to attend the American Society of Gene Therapy Meeting in Boston, MA.
- 2001: Induction into Rho Chi, the National Pharmacy Honorary Society
Peer-reviewed Journal Articles
Bawa-Khalfe T, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. Br. J. Pharmacol. 2007, 7:16-21.
Nair, R.R., D.M. Sherry and L.A. Schwarz. Colchicine-mediated focal adhesion formation promotes transient, lipoplex-mediated transfection of A549 cells, Gene Therapy and Molecular Biology, 2007, 11: 1-14.
N. Gerges, A. Aleisa, L. Schwarz, K. Alkadhi. Reduced basal CaMKII levels in hippocampal CA1 region: Possible cause of stress-induced impairment of LTP in chronically stressed Rats. Hippocampus, 2004, 14: 402-410.
Gerges, NZ, A.M. Aleisa, L.A. Schwarz, K.A. Alkadhi. Chronic psychosocial stress decreases calcineurin in the dentate gyrus: a possible mechanism for preservation of early LTP. Neuroscience. 117: 869-874. 2003.
Nair, R.R., J.R. Rodgers and Schwarz, L.A., "Enhancement of transgene expression by combining glucocorticoids and anti-mitotic agents during transient transfection using DNA-cationic liposomes". 2002. Molecular Therapy, 5:1-8.
Aggarwal, B.B., Schwarz, L.A., Hogan, M.E. and Rando, R. (1996). Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibits TNF production and blocks the TNF-dependent growth of human glioblastoma tumor cells. Can. Res. 56: 5156-5164.
Schwarz, L.A., Cheng, S.H., Hogan, M.E., Johnson, J.L., Black, M. and Waldrep, J.C. (1996). Delivery of DNA-liposome complexes by small particle aerosol. Hum. Gene Therapy 7:731-7.
Hammer D, Soltis R, Pittinger A, Bouldin A, Schwarz L, Piacek P, Medina M, Creekmore F, Rose R, Scott S. White paper on the recognition of teaching excellence, part 2: evidence, assessment and reward. Am. Journal Pharmaceut. Ed. 74(9) Article 164, Nov, 2010.
Liu, Y., Mauthner, S. & Schwarz, L. (2009). Using CPS to promote active learning. In Song, H. & Kidd, T. (Eds.), Handbook of Research on Human Performance and Instructional Technology. IGI Global. Hershey, PA.
Yu-Lee, L.-y., A.M. Stevens, J.A. Hrachovy and L.A. Schwarz. 1990. Prolactinmediated regulation of transcription in lymphocytes. In: Neuropeptides and Immunopeptides: Messengers in a Neuroimmune Axis., M.S. O'Dorisio and A. Paneri, eds. Annals N.Y. Acad. Sci. 564: 146-155.
Schwarz, L.A. and W.R. Fleischmann, Jr. Potentiation of interferon action. In: Texas Reports of Biology and Medicine. Volume 41. Interferons: A review to 1982. S. Baron, F. Dianzani and G. John Stanton, eds. Galveston, TX, 1982.
Fleischmann, W.R., Jr. and L.A. Schwarz. Potentiation of the antiviral and antitumor actions of interferons In: Methods in Enzymology. Vol. 78: 432-440, Interferons, S. Pestka, ed. Academic Press, New York, 1981.
Facilitating Scholarly Interchange Via Electronic Media. Julianna Szilagyi, Lindsay Schwarz, Shari Mauthner. University of Houston, College of Pharmacy, Houston, TX. Presented, AACP annual meeting, July, 2010.
Schwarz, L and S. Mauthner. Use of student response systems in a rigorous professional pharmacy basic science curriculum. 2009. ICER 2009 meeting, Nov. 16-18, 2009
Schwarz, L and R. Nair. The combination of glucocorticoids with inhibitors of histone deacetylase enhance expression of genes delivered by lipid-mediated gene transfer. 2001. Mol therapy 3, Part 2: s555.
Nair, R. and L. Schwarz. Enhancement of transgene expression during transient transfection using DNA-cationic liposomes by combining glucocorticoids and colchicine. 2001. Mol. Therapy, 3, Part 2: s571.
Tate, C., J. Carroll, L. Schwarz, Gudicote, J. 1998. SERCA2a and Na+/Ca++exchanger expression is increased in the hearts of rabbits with experimental obesity. FASEB Journal.
Real-time classroom assessment and peer-teaching in a rigorous, professional pharmacy curriculum. Lindsay A. Schwarz and Shari M. Mauthner. 10th Annual Texas A&M Assessment Conference.
Click or clock: teaching the benefits of participation rather than “clocking” for attendance. Lindsay A. Schwarz and Shari M. Mauthner, Presented at the University of Houston Faculty Showcase, April 22, 2010.
“Click or clock: teaching the benefits of participation rather than “clocking” for attendance.” Lindsay A. Schwarz and Shari M. Mauthner, Presented at the Turning Technologies conference at Harvard University, Cambridge MA, Nov. 11 2010.
Schwarz, L.A., J.L. Johnson and V. Knight, September 9, 1995. “Glucocorticoid enhancement of gene transfection and expression”. U.S. Patent Application, D5806B. Awarded: in South Africa (#96/7590), Australia (#712208), New Zealand (#318272) and the European Union (0848616). U.S. patent, approved July 10, 2003, #08/709,554
- American Association for the Advancement of Science
- American Association of Colleges of Pharmacy
- Sigma Xi
- American Society of Gene Therapy
- American Heart Association
- Rho Chi, National Pharmacy Honorary Society