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Profile: Krishna Boini

Krishna Boini
Krishna M. Boini, Ph.D.
Assistant Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
Physical Address: Science and Research Building 2, 3455 Cullen Blvd., Room 542A, Houston, TX 77204
Mailing Address: Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX 77204-5037

713-743-9630
kmboini@uh.edu

Education

Ph.D. in Pharmacology and Toxicology, University of Tuebingen, Tuebingen, Germany

Master of Pharmacy (Pharmacology), Andhra University, Visakhapatnam, India

Bachelor of Pharmacy, Andhra University, Visakhapatnam, India

Research Interests

Mechanisms of obesity-induced kidney diseases and hypertension

Current research focus: inflammatory machinery of podocytes in obesity-induced renal damage

Research Support

Title: Instigation of Glomerular Injury by Inflammasomes in Obesity: Beyond Inflammation
Source: NIH (5R01DK104031-02)
Role: Principal Investigator
Dates: 03/20/15–02/29/20
Total Costs: 1,71,562

Selected Publications (since 2010)

Boini KM, Koka S, Xia M, Gehr TB and Li PL. Sphingolipids in Obesity and its Complications. Frontiers in Bioscience (Land Mark edition), 22: 96-116, 2017.

Bao JX, Zhang QF, Wang M, Xia M, Boini KM, Gulbins E, Zhang Y, Li PL. Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary araterial myocytes. Frontiers in Bioscience, Land Mark, 22, 558-569, 2017.

Boini KM, Xia M, Koka S, Gehr TW, Li PL. Instigation of NLRP3 Inflammasome Activation and Glomerular Injury in Mice on the High Fat Diet: Role of Acid Sphingomyelinase Gene. Oncotarget 7:19031-19044, 2016

Li G, Xia M, Abais JM, Boini K, Li PL and Ritter JK. Protective action of Anandamide and its COX-2 Metabolite against L-Homocysteine-Induced NLRP3 inflammasome activation and Injury in Podocytes. J Pharmacol Exp Ther. 358: 61-70, 2016.

Conley SM, Abais JM, Boini KM and Li PL. Inflammasome activation in Chronic Glomerular Diseases. Current Drug Targets, 2016 (In Press).

Ritter JK, Li G, Xia M and Boini K. Anandamide and its metabolites: what are their roles in the kidney? Frontiers in Bioscience (Scholar edition), 8: 264-277, 2016

Xia M, Abais JM, Koka S, Meng N, Gehr TW, Boini KM and Li PL. Characterization and Activation of NLRP3 In flammasomes in the Renal Medulla in Mice. Kidney Blood Press Res. 41: 208-221, 2016.

Meng N, Xia M, Lu Y, Wang M, Boini KM, Li PL and Tang W. Activation of NLRP3 Inflammasomes in Mouse Hepatic Stellate Cells during Schistosoma J. Infection. Oncotarget Journal, 2016 (In Press).

Chen Y, LI X, Boini KM, Pitzer AL, Gulbins E, Zhang Y, Li PL. Endothelial NLRP3 inflammasome activation associated with lysosomal destabilization during coronary arteries. Biochem Biophys Acta 1853: 396-408, 2015

Abais JM#, Xia M, Zhang Y, Boini KM, Li PL. Redox regulation of NLRP3 inflammasomes: ROS as Trigger or Effector. Antioxid Redox Signal. 22: 1111-1129, 2015

Li G#, Li C, Xia M, Ritter JK, Gehr TW, Boini KM, Li PL. Enhanced epithelial –to-Mesenchymal transition associated with lysosome dysfunction in pododyctes. Cell Physiol and Biochem 35: 1773-1786, 2015

Abais JM#, Xia M, Li G, Chen Y, Conley SM, Gehr TW, Boini KM, Li PL: Nod-like receptor protein 3 (NLRP3) Inflammasome activation and podocytes injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia. J Bio Chem. 289: 27159-27168, 2014

Xia M, Conley SM, Li G, Li PL and Boini KM. Inhibition of hyperhomocysteinemia-induced Inflammasome activation and glomerular sclerosis by NLRP3 gene deletion. Cell Physiol and Biochem 34: 829-841, 2014

Xia M, Boini KM, Abais JM, Xu M, Zhang Y, Li PL. Endothelial NLRP3 Inflammasome Activation and Enhanced Neointima Formation in Mice by Adipokine Visfatin. Am J Pathol. 184: 1617-1628, 2014

Boini KM, Xia M, Abais JM, Li G, Pitzer AL, Gehr TW, Zhang Y, Li PL: Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing. Biochim Biophys Acta. 1843: 836-845, 2014

Li X, Zhang Y, Xia M, Gulbins E, Boini KM, Li PL: Activation of nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. PLoS One. 9: e87552, 2014

Li X, Xu M, Pitzer AL, Xia M, Boini KM, Li PL, Zhang Y: Control of autophagy maturation by acid sphingomyelinase in mouse coronary arterial smooth muscle cells: protective role in atherosclerosis. J Mol Med (Berl). 92: 473-485, 2014

Zhang Y, Xu M, Xia M, Li X, Boini KM, Wang M, Gulbins E, Ratz PH, Li PL: Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 102: 68-78, 2014

Abais JM#, Xia M, Li G, Gehr TW, Boini KM, Li PL: Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia. Free Radic Biol Med. 67: 211-220, 2014

Xiong J, Xu M, Xi M, Li X, Abais JM, Li G, Riebling CR, Ritter JK, Boini KM*, Li PL*. Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes. J Cell Mol Med. 17: 1598-1607, 2013 (* Shared last authorship).

Xiong, J, Xia M, Yi F, Abais JM, Li N, Boini KM*, Li PL*. Regulation of Renin release via cyclic ADP-ribose-mediated signaling: evidence from mice lacking CD38 Gene. Cell Physiol Biochem 31: 44-55, 2013 (* Shared last authorship)

Abais JM#, Zhang C, Xia M, Liu Q, Gehr T, Boini KM, Li PL. NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli during Hyperhomocysteinemia. Antioxidant and Redox Signaling 18: 1537-1548, 2013

Wei YM, Li X, Xiong J, Abais JM, Xia M, Boini KM, Zhang Y and Li PL. Attenuation by Statins of membrane raft-redox signaling in coronary arterial endothelium. J Pharmacol Exp Ther. 345: 170-179 2013

Li CX#, Xia M, Abais JM, Liu X, Li N and Boini KM*, Li PL*. Protective Role of Growth Hormone Against Hyperhomocysteinemia-induced glomerular injury in Mice Naunyn Schmiedebergs Arch Pharmacol. 386: 551-561, 2013. (* Shared last authorship)

Wei Y, Li X, Xu M, Abais JM, Chen Y, Riebling CR, Boini KM, Li PL, Zhang Y. Enhancement of autophagy by simvastatin through inhibition of Rac-1-mTOR signaling pathway in coronary arterial myocytes. Cell Physiol Biochem 31: 925-937, 2013

Xu M, Li X, Walsh SW, Zhang Y, Abais JM, Boini KM, Li PL. Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol. 304: C458-466, 2013

Li X, Han WQ, Boini KM, Xia M, Zhang Y, Li PL. TRAIL-Death Receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice. J Mol Med 91: 25-36, 2013

Boini KM, Xia M, Abais JM, Li CX, Ming Xu, Li PL. Acid Sphingomyelinase Gene Deficiency Protects the Glomerular Injury in mice lacking CBS gene. PLOS One 7: e45020, 2012

Zhang C*, Boini KM*, Xia M, Abais JM, Li X, Liu Q, Li PL. Activation of nod-like receptor protein 3 Inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Hypertension 60: 154-162, 2012 (* Shared first authorship)

Boini KM, Xia M, Xiong J, Li C, Payne LP, Li PL. Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis. J Cell Mol Med. 16: 1674- 1685, 2012

Xu M, Xia M, Li XX, Han WQ, Boini KM, Zhang F, Zhang Y, Ritter JK, Li PL. Requirement of Translocated lysosomal H+-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells. Mol Biol Cell 23: 1546- 1557, 2012

Han WQ, Xia M, Xu M, Boini KM, Ritter JK, Li NJ, Li PL. Lysosome fusion to the cell membrane is mediated by the dysferlin C2A domain in coronary arterial endothelial cells. J Cell Science 125: 1225-1234, 2012

Boini KM, Xia M, Li C, Zhang C, Payne L, Abais JM, Poklis JL, Hylemon PB, Li PL. Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice. Am J Pathology 179: 2210-2219, 2011

Zhang C, Xia M, Boini KM, Li CX, Abais JM, Li XX, Laperle LA, Li PL. Epithelial-to- Mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia. Pflugers Arch. 462: 455-467, 2011

Li CX #, Xia M, Han WQ, Li XX, Zhang C, Boini KM, Liu XC, Li PL. Reversal by growth hormone of homocysteine-induced epithelial-to-mesenchymal transition through membrane raft-redox signaling in podocytes. Cell Physiol Biochem 27: 691-702, 2011

Xia M, Zhang C, Boini KM, Thacker AM, Li PL. Membrane raft-lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin. Cardiovasc Res. 89: 401-409, 2011

Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Mol Endocrinol. 25:2106-2118, 2011

Ackermann TF*, Boini KM*, Beier N, Scholz W, Fuchss T, Lang F. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem 28:137-146, 2011 (* Shared first authorship)

Föller M, Kempe DS, Boini KM, Pathare G, Siraskar B, Capuano P, Alesutan I, Sopjani M, Stange G, Mohebbi N, Bhandaru M, Ackermann TF, Judenhofer MS, Pichler BJ, Biber J, Wagner CA, Lang F. PKB/SGK-Resistant GSK3 Enhances Phosphaturia and Calciuria. J Am Soc Nephrol. 22: 873-880, 2011

Lang PA, Graf D, Boini KM, Lang KS, Klingel K, Kandolf R, Lang F. Cell volume, the serum and glucocorticoid inducible kinase 1 and the liver. Z Gastroenterol. 49: 713-719, 2011

Fröhlich H*, Boini KM*, Seebohm G, Strutz-Seebohm N, Ureche ON, Föller M, Eichenmüller M, Shumilina E, Pathare G, Singh AK, Seidler U, Pfeifer KE, Lang F. Hypothyroidism of gene-targeted mice lacking Kcnq1. Pflugers Arch. 461: 45-52, 2011 (* Shared first authorship)

Boini KM, Zhang C, Xia M, Poklis JL, Li PL. Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet. J Pharmacol Exp Ther. 334: 839-846, 2010

Boini KM, Zhang C, Xia M, Han WQ, Brimson C, Poklis JL, Li PL. Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells. Biochim Biophys Acta. 1801: 1294-1304, 2010

Zhang C, Hu JJ, Xia M, Boini KM, Brimson C, Laperle LA, Li PL. Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91(phox) gene. Free Radic Biol Med. 48: 1109-1117, 2010

Zhang C, Hu JJ, Xia M, Boini KM, Brimson C, Li PL. Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes. Biochim Biophys Acta 1803: 482- 491, 2010

Zhang C, Yi F, Xia M, Boini KM, Zhu Q, Laperle LA, Abais JM, Brimson C, Li PL. NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. Antioxid Redox Signal. 13: 975-986, 2010

Föller M, Bobbala D, Koka S, Boini KM, Mahmud H, Kasinathan RS, Shumilina E, Amann K, Beranek G, Sausbier U, Ruth P, Sausbier M, Lang F, Huber SM. Functional significance of the intermediate conductance Ca2+-activated K+ channel for the short-term survival of injured erythrocytes. Pflugers Arch. 460:1029-1044, 2010

Fischer SS#, Kempe DS, Leibrock CB, Rexhepaj R, Siraskar B, Boini KM, Ackermann TF, Föller M, Hocher B, Rosenblatt KP, Kuro-O M, Lang F. Hyperaldosteronism in Klotho- deficient mice. Am J Physiol Renal Physiol. 299: F1171-1177, 2010

Zemtsova IM, Heise N, Fröhlich H, Qadri SM, Kucherenko Y, Boini KM, Pearce D, Shumilina E, Lang F. Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3. Am J Physiol Cell Physiol. 299: C1007- 1014, 2010

Huang DY, Gao H, Boini KM, Osswald H, Nuenberg B, Lang F. In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake. Pflugers Arch. 460: 187-196, 2010

Kempe DS, Ackermann TF#, Boini KM, Klaus F, Umbach AT, Dermaku-Sopjani M, Judenhofer MS, Pichler E, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F. Akt2/PKBß-sensitive regulation of renal phosphate transport. Acta Physiol (Oxf) 200: 75-85, 2010

Abstracts and Presentations (since 2010)

Koka S, Xia M, Chen Y, Li PL and Boini KM. Trimethylamine N-Oxide, an intestinal microbial metabolite instigates NLRP3 inflammasome activation and endothelial dysfunction. FASEB J 30: 2016.

Conley SM, Chen Z, Xia M, Gehr TW, Boini KM, Li PL. Role of Vav2 in podocyte inflammasome activation and glomerular injury during hyperhomocysteinemia. FASEB J 30: 2016.

Conley SM, Li G, Xia M, Gehr TW, Boini KM, Li PL. NLRP3 Inflammasome as a Novel Target for Docosahexaenoic Acid and Its Metabolites to Abrogate Glomerular Injury during Hyperhomocysteinemia. FASEB J 30: 2016.

Hu J, Zhu Q, Li PL, Boini KM, Li N. Inhibition of hypoxia inducible factor-1α in the renal medulla contributes to fructose-induced salt-sensitive hypertension. FASEB J 30: 2016.

Xia M, Nguyen T, Bao JX, Meng N, Boini KM and Li PL. Microgravity-Induced Activation of Nlrp3 Inflammasomes in Mouse Vascular eEndothelial Cells. FASEB J 30: 2016.

Xia M, Li G, Conley SM, Meng N, Boini KM, Ritter JK and Li PL. Prostamide mediated protective action of anandamide on Nlrp3 inflammasome activation in glomeruli of mice with Hyperhomocysteinemia. FASEB J 30: 2016.

Boini KM, Xia M, Conley SM, Li G, Koka S, Gehr TW, Li PL. Contribution of High Mobility Group Box 1 to Hyperhomocysteinemia-induced Podocyte Injury and Glomerular Sclerosis. Hypertension 60: E107, 2015 (Received Kidney Council New Investigator Travel Award from American Heart Association, 2015)

Boini KM, Xia M, Conley SM, Li G, Gehr TW, Li PL. Prevention of High Fat-induced Podocyte Injury and Glomerular Sclerosis in Mice Lacking Nod-like Receptor Protein 3: Role of Inflammasome Extinction. FASEB J 29: 2015

Boini KM, Xia M, Conley SM, Gehr TW, Li PL. Podocyte Specific Deletion of Acid Ceramidase Predisposes Mice to Obesity-Induced Glomerular Injury. FASEB J 29: 2015 (Received Renal Research Recognition Award from American Physiological Society and Sudhir Gupta Young Scientist Award from ASIOA, 2015)

Chen Y, Xia M, Boini KM, Li PL. Ca2+-dependent and Ceramide-mediated Membrane Repair with Annexin V Recruitment and Aggregation in Mouse Endothelial Cells. FASEB J 29: 2015

Li G, Li C, Xia M, Abais JM, Boini KM, Ritter JK, Li PL. Enhanced Epithelial-to-Mesenchymal Transition Associated with Lysosome Dysfunction in Podocytes: Role of p62/Sequestosome 1 as a Signaling Hub. FASEB J 29: 2015

Xia M, Boini KM, Chen Y, Zhang Y, Li PL. Activation of Endothelial NLRP3 Inflammasomes associated with Acid Sphingomyelinase-dependent Formation of Membrane Raft Redox Signaling Platforms. FASEB J 29: 2015

Xia M, Abais JM, Boini KM, Li PL, Ritter JK. Protective Action of Prostamide E2 from Homocysteine-induced NLRP3 Inflammasome Activation and Podocyte Injury. FASEB J 29: 2015

Boini KM, Xia M, Li G, Abais JM and Li PL. Enhanced Dedifferentiation and Injury in Mouse Podocytes Lacking CD38 Gene. FASEB J 2014

Boini KM, Xia M, Abais JM and Li PL. Podocyte NLRP3 inflammasome Activation and Glomerular Injury by Adipokine Visfatin: In Vitro and In vivo Evidence. FASEB J 2014

Abais JM, Xia M, Boini KM and Li PL. Protective Effects of Docosahexaenoic Acid Metabolites against Homocysteine-induced Podocyte Injury by Inhibition of NLRP3 Inflammasomes. FASEB J 2014

Abais JM, Xia M, Boini KM and Li PL. Contribution of Guanine Nucleotide Exchange Factor Vav2 to Homocysteine-induced NLRP3 Inflammasome Activation in Mouse Podocytes. FASEB J 2014

Chen Y, Boini KM, Pitzer AL, Zhang Y, Li PL. Endothelial Nlrp3 Inflammasome Activation Associated with Lysosomal Destabilization During Coronary Arteritis. FASEB J 2014

Zhang Y, Xu M, Xia M, Li X, Boini KM, Li PL. Failure of Autophagy Maturation in CD38 Deficient Coronary Arterial Myocytes due to Inhibition of Dynein-mediated Autophagosome Trafficking. FASEB J 2014

Boini KM, Xia M, Abais JM, Zhang Y, Li PL: Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion. FASEB J, 27: 704.6, 2013.

Boini KM, Xia M, Abais JM, Zhang Y, Li PL: High Fat Diet Failed to Induce NALP3 Inflammasome Activation and Glomerular Injury in Apoptosis-Associated Speck-like Protein (ASC) Knockout Mice. FASEB J, 27: 889.5, 2013

Abais JM#, Boini KM, Xia M, Li PL: Thioredoxin Interacting Protein Mediates Hcys-induced NLRP3 Inflammasome Activation in Mouse Podocytes. FASEB J, 27: 704.7, 2013

Abais JM#, Boini KM, Xia M, Li PL: Contribution of Reactive Oxygen Species to NLRP3 Inflammasome Activation in Glomeruli of Mice with Hyperhomocysteinemia. FASEB J, 27: 890.3, 2013

Li X, Zhang Y, Xia M, Boini KM, Li PL: Reversal of ATP-Induced NLRP3 Inflammasome Activation and Lipids Deposition in Macrophages from Mice Lacking Apoptosis-associated Speck-like Protein (ASC) Gene. FASEB J, 27: 686.11, 2013

Ritter JK, Li C, Xia M, Boini KM, Lichtman A, Li PL: The Anandamide Cyclooxygenase-2 Metabolite, Prostamide E2, as a Novel Diuretic and Natriuretic Lipid in the Mouse Renal Medulla. FASEB J, 27: 703.7, 2013

Xia M, Xiong J, Abais JM, Boini KM, Li PL: Regulation of Renal Sodium Excretion by Medullary NLRP3 Inflammasome Activation beyond Turning on Inflammation. FASEB J, 27: 1115.5, 2013

Xia M, Li CX, Li C, Abais JM, Zhang Y, Boini KM, Li PL: Epithelial-to-Mesenchymal Transition Induced by Accumulation of Autophagosomes in Podocytes. FASEB J, 27: 889.7, 2013

Boini KM, Xia M, Li C, Xiong J, Li PL. Acid Sphingomyelinase Gene Knockout Ameliorates Hyperhomocysteinemic Glomerular Injury in Mice Lacking Cystathionine β-synthase. FASEB J. 26: 691.6, 2012.

Boini KM, Xia M, Abais JM, Li PL. Instigation of NALP3 Inflammasome Activation and Glomerular Injury in Mice on the High Fat Diet: Role of Acid Sphingomyelinase Gene. FASEB J. 26: 690.7, 2012 (Received American Radiolabled Chemicals Junior Scientist Award, VCU Postdoctoral Travel Award and Finalist APS Amgen postdoctoral Excellence in Renal Research Award)

Xia M, Boini KM, Abais JM, Li XX , Mu X, Li PL. NALP3 Inflammasome Activation in the Coronary Arterial Wall of Obese Mice. FASEB J. 26: 877.7, 2012

Xia M, Xiong J, Boini KM, Abais JM#, Li PL. Characteristics and Hypertensive Actions of Renal Medullary NALP3 Inflammasomes in Mice. FASEB J. 26: 879.4, 2012

Abais JM#, Boini KM, Xia M, Li PL. Role of Different Reactive Oxygen Species in Homocysteine-induced NALP3 Inflammasome Activation in Mouse Podocytes. FASEB J. 26: 691.9, 2012

Abais JM#, Boini KM, Xia M, Li PL. Inhibition of NADPH Oxidase Attenuates Hyperhomocysteinemia-induced NALP3 Inflammasome Activation in Mouse Glomeruli. FASEB J. 26: 691.10, 2012

Xiong J, Xia M, Boini KM, Li PL. Renin Production and Release Associated with Cyclic ADP-Ribose-Mediated Signaling: Evidence from CD38 Gene Knockout Mice. FASEB J. 26: 690.21, 2012

Xiong J, Xia M, Xu M, Li XX, Abais JM, Boini KM, Li PL. Autophagy Maturation Controlled by CD38-Lysosome Signaling in Glomerular Podocytes of Mice. FASEB J. 26: 690.14, 2012

Wei YM, Zhang Y, Boini KM, Li PL. Enhanced Membrane Raft-Redox Signaling Associated with NADPH Oxidase in Coronary Arterial Endothelium during Hypercholesterolemia FASEB J 26: 681.4, 2012

Boini KM, Xia M, Zhang C, Abais JM, Li X and Li PL. Activation of Inflammasomes as a Triggering Mechanism of Glomerular Injury in Mice on the High Fat Diet. FASEB J 25: 1028.6, 2011

Boini KM, Xia M and Li PL. Implication of CD38 Gene in Podocytes Epithelial to Mesenchymal Transition and Glomerular Sclerosis. FASEB J 25: 665.12, 2011

Abais JM#, Zhang C, Xia M, Boini KM, Li X, Laperle L, Thacker A, Li PL. NADPH Oxidase- Mediated Activation of Inflammasomes by Increased Homocysteine in Mouse Podocytes and Glomeruli. FASEB J 25: 1030.5, 2011

Xia M, Boini KM, Abais JM, Li PL. Silencing of Acid Sphingomyelinase Gene Prevented Glomerular Oxidative Stress and Sclerosis in Hyperhomocysteinemic Mice. FASEB J 25: 667.12, 2011

Han WQ, Xia M, Xu M, Boini KM, Li PL. Dysferlin-Mediated Lysosome Fusion to Cell Membrane in Endothelial Dysfunction Associated with Membrane Raft Clustering in Coronary Arteries. FASEB J 25: 820.18, 2011

Han WQ, Boini KM, Xia M, Li PL. Death Receptor-4 Signaling via Lysosome Fusion and Membrane Raft Clustering In Mouse Coronary Arterial Endothelial Cells. FASEB J, 820.29, 2011

Xu M, Zhang F, Xia M, Li XX, Abais JM, Boini KM, Li PL. Lysosomal Regulation of Autophagy Efflux via CD38-Mediated Signaling in Mouse Coronary Arterial Myocytes. Hypertension 58: E178, 2011

Boini KM, Zhang C, Xia M, Li PL. Protection of Glomeruli from Hyperhomocysteinemia- Induced Injury in Acid Sphingomyelinase Gene Knockout Mice. FASEB J 24: 1059.13, 2010

Boini KM, Zhang C, Xia M, Li PL. Visfatin-Induced Lipid Raft Redox Signaling Platforms and Hyperpermeability in Glomerular Endothelial Cells. FASEB J 24: 996.3, 2010

Zhang C, Boini KM, Xia M, Hu J, Li PL. Homocysteine Induces Epithelial-to-Mesenchymal Transition of Podocytes through the Activation of NADPH Oxidase. FASEB J 24: 1059.5, 2010

Zhang C, Xia M, Boini KM, Hu J, Li PL. Amelioration of Glomerulosclerosis by NMDA Receptor Blockade in Hyperhomocysteinemic rats. FASEB J 24: 1059.6, 2010

Zhang C, Xia M, Wang Z, Hu J, Boini KM, Li N, Li PL. Turning on Inflammatory Response to Homocysteine through Activation of Inflammasomes in Podocytes. FASEB J 24: 590.14, 2010

Zhang F, Xu M, Boini KM, Xia M, Li PL. Enhanced Lipid Deposition and Foam Cell Formation in Coronary Artery Wall by Deletion of CD38 Gene. Hypertension 56: E57, 2010

Invited Seminars

Podocyte Inflammasomes as a Trigger of Glomerular Sclerosis in Obesity. Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Science Center, Amarillo, TX, March 16-18, 2016.

Role of Inflammasomes in Obesity-Induced Glomerular Sclerosis. Department of Nephrology, School of Medicine, Virginia Commonwealth University, Richmond, VA, February 25, 2016.

Podocyte Inflammasomes as a Perpetual Trigger of Glomerular Sclerosis in Obesity. Department of Pharmacology and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX, January 26-28, 2016.

Instigation of Glomerular Injury by Inflammasomes in Obesity. Virginia Commonwealth University, May 21, 2015

Podocyte Inflammasomes as a Trigger of Glomerular Sclerosis in Hyperhomocysteinemia. Kakatiya University, October 16, 2014

Turning on Inflammatory Response to Homocysteine through Activation of Inflammasomes in Podocytes, VCU Pharmacology and Toxicology, October, 2013

Instigation of NALP3 Inflammasome Activation and Glomerular Injury in Mice on the High Fat Diet: Role of Acid Sphingomyelinase Gene, Invited speaker at FASEB meeting, April at San Diego, 2012

Instigation of NALP3 Inflammasome Activation and Glomerular Injury in Mice on the High Fat Diet: Role of Acid Sphingomyelinase Gene. Invited speaker from ASIOA meeting, April at San Diego, 2012

Protection of Glomeruli from Hyperhomocysteinemia-Induced Injury in Acid Sphingomyelinase Gene Knockout Mice, Invited speaker at FASEB meeting, April at Anaheim, 2010

Increased plasma ceramide contributes to obesity and renal injury in mice on high fat diet, VCU Pharmacology and Toxicology, May, 2009

Role of serum and glucocorticoid inducible kinase 1 in glucose metabolism. University of Tuebingen, July, 2007

Awards and Honors

  • Kidney Council New Investigator Travel Award from American Heart Associations, 2015
  • Renal Research Recognition Award from American Physiological Society, 2015
  • Sudhir Gupta Young Scientist Award from Association of Scientists of Indian Origin in America (ASIOA), 2015
  • VCU Postdoctoral Spring Travel Award 2012, Virginia Commonwealth University, Richmond, VA
  • American Radiolabled Chemicals Junior Scientist Award in Pharmacology by Association of Scientists of Indian Origin in America, 2012
  • Finalist, Amgen Postdoctoral Excellence in Renal Research Award, American Physiological Society, 2012
  • Outstanding Poster Award at German Physiological Meeting, Cologne, Germany, 2008
  • Travel grant award, International Society of Nephrology, Forefronts Symposium, Ittingen, Switzerland, 2005
  • Special Appreciation Prize at National Seminar on Pharmaceutical Millenium, Andhra University, Visakhapatnam, 2002

Editorial Appointments

Editorial Boards
  • Nephron Physiology, Associate editor, 2014-Present Phcog Magazine, Associate editor, 2011-Present
  • Pharmacognosy Reviews Journal, Associate editor, 2012-Present
  • Journal of Physiology and Pharmaceutical Sciences, Editor-in-Chief, 2015-Present
  • Journal of Clinical and Experimental Hypertension, Member, 2016-Present
  • Free Radicals and Antioxidants Journal, Member, 2010-Present
  • Journal of Diabetes and Endocrinology, Editor-in-Chief, 2010-Present
  • Austin Journal of Endocrinology and Diabetes, Member, 2014-Present

Journal Reviewer

  • Proceedings of National Academy of Sciences, 2016-Present
  • Journal of Biological Chemistry, 2015-Present
  • American Journal of Physiology-Renal Physiology, 2014-present
  • American Journal of Physiology-Cell Physiology, 2014-present
  • British Journal of Pharmacology, 2010-present
  • PLoS One, 2012-present
  • Cellular Physiology and Biochemistry, 2013-present
  • Antioxidant and Redox signalling, 2012-present
  • Kidney and Blood Pressure Research, 2013-present
  • Journal of Diabetes and its complications, 2010-present
  • Indian Journal of Pharmacology, 2006-present
  • Molecular and Cellular Biochemistry, 2006-present
  • Journal of Membrane Biology, 2013-present
  • Journal of Molecurlar Membrnae Biology, 2013-present
  • Journal of Experimental Pharmacology, 2009-present
  • Journal of Young Pharmacist, 2009-present
  • Journal of Diabetology and Metabolic syndrome, 2009-present
  • Journal of Experimental and Clinical Endocrinology and Diabetes, 2010-present
  • Journal of Vascular Research, 2012-present
  • Journal of Diabetes, 2011-present
  • Journal of Cell Biochemistry and Function, 2012-present
  • Journal of Molecular Biology Reports, 2011-present
  • Journal of Cellular Physiology and Biochemistry, 2012-present
  • Journal of Molecular Neurobiology, 2014-present
  • Pharmacology Reports journal, 2015-present

Memberships & Affiliations

  • American Association of Colleges of Pharmacy, 2016-present
  • American Society of Nephrology, 2014-present
  • American Heart Association, 2009–present
  • American Society of Experimental Pharmacology and Therapeutics, 2009–present
  • American Physiological Society, 2009–present
  • American Association of Pharmaceutical Scientists, 2009–present
  • Andhra Pradesh State Pharmacy Council, 1994–present