Profile: Karim Alkadhi

Karim Alkadhi
Karim Alkadhi, Ph.D.
Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
521 E Science and Research Building 2
Houston, TX 77204-5037

713-743-1212 (Voice)
713-743-1229 (Fax)
KAlkadhi@uh.edu

Education

B.S. (Pharmacy) Baghdad University

M.S. (Pharmacology) College of Pharmacy, University of Connecticut

Ph.D. (Pharmacology/Physiology) College of Medicine, SUNY at Buffalo

Research Interests

  • Behavioral, neurophysiological and molecular effects of chronic stress in models of brain disorders including hypothyroidism, Alzheimer's disease and sleep deprivation
  • Beneficial effects of regular exercise on brain disorders

Courses

  • PHAR 4320 OSLS I (Physiology I)
  • PCOL 6450 Neurophysiology
  • PHAR 5322 Toxicology
  • PCOL 6470 Advanced Pharmacology I
  • PCOL 6361 Neuropharmacology
  • PhPS 3300 Human Physiology and Pathophysiology I

Selected Journal Articles

Tran TT, Srivareerat M, Alhaider IA, Alkadhi KA. Chronic psychosocial stress enhances long-term depression in a subthreshold amyloid-beta rat model of Alzheimer's disease. J Neurochem. 2011 Oct;119(2):408-16. doi: 10.1111/j.1471-4159.2011.07437.x.

Aleisa AM, Helal G, Alhaider IA, Alzoubi KH, Srivareerat M, Tran TT, Al-Rejaie SS, Alkadhi KA. Acute nicotine treatment prevents REM sleep deprivation-induced learning and memory impairment in rat. Hippocampus. 2011 Aug;21(8):899-909. doi: 10.1002/hipo.20806.

Aleisa AM, Alzoubi KH, Alkadhi KA. Post-learning REM sleep deprivation impairs long-term memory: reversal by acute nicotine treatment. Neurosci Lett. 2011 Jul 15;499(1):28-31.

Tran TT, Srivareerat M, Alkadhi KA. Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease. Hippocampus. 2011 Jul;21(7):724-32. doi: 10.1002/hipo.20790.

Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA. Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease. Neurobiol Aging. 2011 May;32(5):834-44.

Zoladz PR, Park CR, Halonen JD, Salim S, Alzoubi KH, Srivareerat M, Fleshner M, Alkadhi KA, Diamond DM. Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia. Hippocampus. 2011 May 2. doi: 10.1002/hipo.20922.

Alhaider IA, Aleisa AM, Tran TT, Alkadhi KA. Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. Mol Cell Neurosci. 2011 Apr;46(4):742-51.

Alkadhi KA, Alzoubi KH, Srivareerat M, Tran TT. Chronic Psychosocial Stress Exacerbates Impairment of Synaptic Plasticity in β-Amyloid Rat Model of Alzheimer's Disease: Prevention by Nicotine. Curr Alzheimer Res. 2011 Apr 1. [epub ahead of print]

Alkadhi KA, Alzoubi KH, Srivareerat M, Tran TT. Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine. Int J Neuropsychopharmacol. 2011 Feb 28:1-11. [epub ahead of print]

Alkadhi KA, Srivareerat M, Tran TT. Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease. Mol Cell Neurosci. 2010 Nov;45(3):289-96.

Alhaider IA, Aleisa AM, Tran TT, Alzoubi KH, Alkadhi KA. Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity. Sleep. 2010 Apr;33(4):437-44.

Alhaider IA, Aleisa AM, Tran TT, Alkadhi KA. Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus. Eur J Neurosci. 2010 Apr;31(8):1368-76.

Tran TT, Srivareerat M, Alkadhi KA. Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease. Neurobiol Dis. 2010 Mar;37(3):756-63.

Alzoubi KH, Abdul-Razzak KK, Khabour OF, Al-Tuweiq GM, Alzubi MA, Alkadhi KA. Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats. Behav Brain Res. 2009 Dec 1;204(1):117-23. 

Srivareerat M, Tran TT, Alzoubi KH, Alkadhi KA. Chronic psychosocial stress exacerbates impairment of cognition and long-term potentiation in beta-amyloid rat model of Alzheimer's disease. Biol Psychiatry. 2009 Jun 1;65(11):918-26.

Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA. Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease. Neurobiol Aging. 2009 May 20.

Alzoubi KH, Alkadhi KA. Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats. Neurosci Res. 2009 Feb;63(2):95-9.

Alkadhi KA. Rhythmic discharge induced by temperature variation and drugs in isolated sympathetic ganglia. Clin Exp Hypertens. 2008 Oct;30(7):497-510.

Alkadhi KA, Al-Hijailan RS, Alzoubi KH. Long-term depression in the superior cervical ganglion of the rat. Brain Res. 2008 Oct 9;1234:25-31.

Alzoubi KH, Gerges NZ, Aleisa AM, Alkadhi KA. Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies. Hippocampus. 2009 Jan;19(1):66-78.

Alzoubi KH, Aleisa AM, Alkadhi KA. In vivo expression of ganglionic long-term potentiation in superior cervical ganglia from hypertensive aged rats. Neurobiol Aging. 2010 May;31(5):805-12.

Alzoubi KH, Aleisa AM, Alkadhi KA. Effect of chronic stress or nicotine on hypothyroidism-induced enhancement of LTD: electrophysiological and molecular studies. Neurobiol Dis. 2008 Oct;32(1):81-7.

Alzoubi KH, Aleisa AM, Alkadhi KA. Expression of gLTP in Sympathetic Ganglia of Obese Zucker Rats In Vivo: Molecular Evidence. J Mol Neurosci. 2008 Jul;35(3):297-306

Alzoubi KH, Aleisa AM, Alkadhi KA. Expression of gLTP in sympathetic ganglia from stress-hypertensive rats: molecular evidence. J Mol Neurosci. 2008 Jun;35(2):201-9.

Alzoubi K. H. and Alkadhi K. A. A critical role of CREB in the impairment of late phase LTP by hypothyroidism. Experimental Neurology 203(1):63-71, 2007

Alzoubi, K.H., A.M. Aleisa, and Alkadhi K.A. Adult-onset hypothyroidism facilitates and enhances LTD: Reversal by nicotine treatment. Neurobiol. Dis 26:264-272, 2007

Alzoubi, K.H., A.M. Aleisa, and Alkadhi KA. Nicotine prevents disruption of the late phase LTP-related molecular cascade in adult-onset hypothyroidism Hippocampus 17:654-664, 2007

Aleisa A.M., K.H. Alzoubi and K.A. Alkadhi. Nicotine prevents stress-induced enhancement of LTD: electrophysiological and molecular studies. J. Neuroscience Res 83(2):309-317, 2006

Aleisa A.M., K.H. Alzoubi, N.Z. Gerges, and K.A. Alkadhi. Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF. Neurobiol. Dis 22:453-462, 2006

Aleisa A. M., K. H. Alzoubi, N. Z. Gerges, and K. A. Alkadhi. Nicotine blocks stress-induced impairment of spatial memory and LTP of the CA1 region. Int. J Neuropsychopharmacol 9: 417-426, 2006

Alkadhi KA, Karem H. Alzoubi, Abdulaziz M. Aleisa, Felicia L. Tanner and Ayad S. Nimer. Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in sympathetic ganglia. Neurobiol. Dis. 20:849-857, 2005

Book Chapters & Reviews

Book Chapters

Karim A. Alkadhi, Ibrahim Alhaider, Munder Zagaar, Karem Alzoubi. “Food and Nutritional Components in Focus: caffeine: chemistry, analysis, function and effects.”  Victor R. Preedy  (ed.) in press (2012). The Royal Society of Chemistry (RSC Publishing), King’s College, London.

Karim A. Alkadhi, Karem H. Alzoubi. "Synaptic Plasticity of Autonomic Ganglia." (Ch. 26) in Sudden Death in Epilepsy: Forensic and Clinical Issues, Claire Lathers et al. (eds)., CRC Press 2011.

Invited Reviews

Alkadhi KA. Chronic stress accelerates and intensifies Ab-induced Alzheimer’s disease-like pathogenesis in rat models. US Psychiatry (in press), 2011.

Alkadhi K, Alzoubi K. Role of long-term potentiation of sympathetic ganglia (gLTP) in hypertension. Clin Exp Hypertens. 2007 Jul;29(5):267-86. Review.

Alkadhi KA and Alzoubi KH: Role of Long Term Potentiation of Sympathetic Ganglia (gLTP) in Hypertension. Clinical and Experimental Hypertension 29:267-286, 2007.

Alkadhi KA, Alzoubi KH and Aleisa AM: Plasticity of synaptic transmission in autonomic ganglia. Progress in Neurobiol 75:83-108, 2005.

Presentations & Abstracts

Tran TT, Srivareerat, M, Alhaider, IA, Alkadhi, KA. Chronic psychosocial stress accelerates cognitive impairment in an at risk rat model of Alzheimer’s disease: Molecular studies. Soc. Neuroscience 35: 2009.

Alkadhi KA, Alzoubi KH, Alhaider IA, Aleisa AM. Streptozotocin-induced diabetes impairs ganglionic transmission and synaptic plasticity in the superior cervical ganglion. Soc. Neuroscience 35: 2009.

Alhaider IA, TT Tran, AM Aleisa, KH Alzoubi, KA Alkadhi. Effects of caffeine on cognitive deficit in acutely sleep deprived rats: electrophysiological and molecular evidence. Soc. Neuroscience 35: 2009.

Alzoubi  KH, KK Abdul-Razzaq, OF Khabour, GM Al-Tuweiq, Alzubi MA, Alkadhi KA. Chronic caffeine administration prevents high fat diet-induced impairment of hippocampus-dependent learning and memory. Soc. Neuroscience 35: 2009.

Zagaar, MA., Srivareerat M, Tran TT., and Alkadhi KA. Elevation of BACE levels in A-beta rat model of Alzheimer’s disease: exacerbation by chronic stress and prevention by nicotine- Further validation of the model. Soc. Neuroscience 35: 2009.

Tran TT, Srivareerat M, Aleisa AM, Alhaider IA, Alkadhi KA. Stress impairs long-term potentiation in the dentate gyrus in an early-stage Alzheimer’s disease rat model. Soc. Neuroscience 34: 2008.

Srivareerat. M., Alzoubi K.H., Alkadhi K.A., Zoladz P.R., Park C.R., Halonen J.D, D.M. Diamond. Differential expression OF CaMKII BDNF and calcineurin in the hippocampus and amygdala in response to spatial learning and predator stress-induced amnesia. Soc. Neuroscience 34: 2008.

Alzoubi KH, Abdul-Razzaq KK, Khabour OF, Al-Tuweiq GM, Alkadhi KA. Chronic caffeine administration prevents stress-induced impairment of hippocampus-dependent memory. Soc. Neuroscience 34: 2008.

Alhaider I A, Aleisa A. M., Tran T T, Srivareerat M, Alzoubi KH, Alkadhi K A. Caffeine prevents the impairment of the spatial learning and memory induced by sleep deprivation. Soc. Neuroscience 34: 2008.

Aleisa A. M., Alzoubi K. H., Alhaider I A, Srivareerat M., Tran T T, Alkadhi K A. Nicotine treatment reverses sleep deprivation-induced impairment of LTP in anesthetized rats. Soc. Neuroscience 34: 2008.

Alkadhi KA, Alzoubi KH, Alhaidar I, Aleisa AM, Srivareerat M. Chronic i.c.v infusion of β-amyloid impairs ganglionic transmission and synaptic plasticity in the superior cervical ganglion. Soc. Neuroscience 34: 2008.

Tran TT, Srivareerat M, Alkadhi KA. Stress accelerates the onset of Alzheimer’s disease:  electrophysiological studies. Soc. Neuroscience 33: 2007

Srivareerat M, Tran TT, Alzoubi KH, Alkadhi KA. Nicotine antagonizes stress and beta-amyloid-induced impairment of synaptic plasticity. Soc. Neuroscience 33: 2007

Aleisa, AM, Helal, Attia S, Alhoshani A, Alhosaini K, Alkadhi KA, Alzoubi KH, Alrejaie S, Al-Shabanah O, Alhaider A. Nicotine reverses sleep deprivation induced cognitive impairment. Soc. Neuroscience 33: 2007

Alzoubi KH, Aleisa AM, Alkadhi KA. Levothyroxin restores Hypothyroidism-Induced Impairment of Hippocampus-dependent Learning and Memory. Soc. Neuroscience 33: 2007

Tran TT, Srivareerat MM and Alkadhi KA. Chronic psychosocial stress hastens the onset of Alzheimer’s disease. Soc. Neuroscience 32: 2006

Srivareerat MM, Tran, TT, Alkadhi KA. Nicotine blocks stress and Alzheimer’s-induced impairment of spatial memory in a beta-amyloid-induced rat model of Alzheimer’s disease. Soc. Neuroscience 32: 2006

K.H. Alzoubi, A.M. Aleisa, and Alkadhi KA. Hypothyroidism-induced enhancement of LTD: reversal by nicotine and possible role of NMDA receptors. Soc. Neuroscience 32: 2006

Memberships

  • Society for Neuroscience
  • American Society for Pharmacology and Experimental Therapeutics (ASPET)
  • Society for Experimental Biology and Medicine
  • British Pharmacological Society
  • International Brain Research Organization (IBRO)
  • Rho Chi, Pharmaceutical Honor Society
  • International Society for Myochemistry

Editorial Appointments

  • Editorial Board Member, Clinical and Experimental Hypertension
  • Editorial Board Member, Journal of Pharmacology and Toxicology
  • Editorial Board Member, Current Neuropharmacology
  • Editorial Board Member, Advances in Pharmacological Sciences
  • Editorial Board Member, Clinical Pharmacology-Current Research
  • Editorial Board Member, Pharmacie Globale
  • Journal Reviewer (ad hoc): Am J Physiology, Behavioral Brain Research, Brain Research Bulletin, Brain Research, Biological Psychiatry, Clin Exp Hypertension, Clin Exp Pharmacol and Physiol, Epilepsia, European Journal of Pharmacology, Euro J Neuroscience, Experimental Neurology, Hippocampus, Hypertension, J. Neurosci Res, J. Gerontology, Molecular Psychiatry, Neurotoxicology, Molecular Pharmacology, Neuropharmacology, Neuropsychopharmacology, Neuroreport, Neuroscience, Neuroscience Letters, Neurotox Res, Toxicology & Applied Pharmacology

Professional Service (Study Sections & Review Panels)

  • NSF graduate Research Fellowship Program (GRFP), 1996-present
  • American Heart Association, 2005-present
  • Alzheimer Association, 2003-present
  • The Health Research Board in Ireland, 2006-present
  • The National Defense Science and Engineering Graduate (NDSEG) Fellowship Program, 2006-present
  • The Qatar National Research Fund (QNRF), 2007-present
  • Philip Morris External Research Program, 2003-2007
  • AACP New Investigators Program/Pharmacology and Toxicology Panel, 2006-2007