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Profile: Karim Alkadhi

Karim Alkadhi
Karim Alkadhi, Ph.D.
Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
Physical Address: Science and Research Building 2, 3455 Cullen Blvd., Room 521E, Houston, TX 77204
Mailing Address: Health and Biomedical Sciences Building 2, 4849 Calhoun Road, Room 3044, Houston, TX 77204-5037

713-743-1212 (Voice)
713-743-1229 (Fax)
KAlkadhi@uh.edu

Education

B.S. (Pharmacy) Baghdad University

M.S. (Pharmacology) College of Pharmacy, University of Connecticut

Ph.D. (Pharmacology/Physiology) College of Medicine, SUNY at Buffalo

Research Interests

  • Behavioral, neurophysiological and molecular effects of chronic stress in models of brain disorders including hypothyroidism, Alzheimer's disease and sleep deprivation
  • Beneficial effects of regular exercise on brain disorders

Courses

  • PHAR 4320 OSLS I (Physiology I)
  • PCOL 6450 Neurophysiology
  • PHAR 5322 Toxicology
  • PCOL 6370 Advanced Pharmacology I
  • PCOL 6361 Neuropharmacology
  • PhPS 3300 Human Physiology and Pathophysiology I

Selected Journal Articles

Alkadhi KA. Exercise as a Positive Modulator of Brain Function. Mol Neurobiol. 2017 May 2. doi: 10.1007/s12035-017-0516-4. [Epub ahead of print] Review. PMID: 28466271

Alkadhi KA and Alhaider IA. Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1. Mol Cell Neurosci. 2016 Mar;71:125-31. doi: 10.1016/j.mcn.2015.12.015. 

Dao AT, Zagaar MA, Levine AT, Alkadhi KA. Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer's Disease Model. Mol Neurobiol 2016 Dec;53(10):6859-6868.

Zagaar MA, Dao AT, Alhaider IA, Alkadhi KA. Prevention by Regular Exercise of Acute Sleep Deprivation-Induced Impairment of Late Phase LTP and Related Signaling Molecules in the Dentate Gyrus. Mol Neurobiol. 2016 Jul;53(5):2900-2910. doi: 10.1007/s12035-015-9176-4.

Dao AT, Zagaar MA, Alkadhi KA. Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer's disease. Mol Neurobiol. 2015 Dec;52(3):1067-1076. doi: 10.1007/s12035-014-8916-1

Alhaider IA and Alkadhi KA. Caffeine treatment prevents REM sleep deprivation induced impairment of late phase LTP in the dentate gyrus. Eur J Neurosci. 2015 Nov;42(10):2843-50. doi: 10.1111/ejn.13092.

Dao, An T; Zagaar, Munder A; Salim, Samina; Eriksen, Jason L; Alkadhi, Karim A. Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer’s disease. Int J Neuropsychopharmacol. 17(4):593-602. 2014

Alzoubi KH, and Alkadhi KA. Chronic nicotine treatment reverses hypothyroidism- induced impairment of L-LTP induction phase: critical role of CREB. Mol Neurobiol. 49(3):1245-55. 2014

Patki G, Li L, Allam F, Solanki N, Dao AT, Alkadhi K, Salim S. Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder. Physiol Behav. 130:47-53. 2014

Alzoubi KH, Alkadhi KA. Levothyroxin replacement therapy restores hypothyroidism induced impairment of L-LTP induction: critical role of CREB. Brain Res Bull. 100:29-37. 2014

Alkadhi KA, Tran TT. Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer's disease. Mol Neurobiol. 52:93-100, 2014

Alkadhi KA, Tran TT. Chronic psychosocial stress impairs early LTP but not late LTP in the dentate gyrus of at-risk rat model of Alzheimer׳s disease. Brain Res. 1588:150-158. 2014

Allam Farida, An T Dao, Gaurav Chugh, Ritu Bohat, Faizan Jafri, Gaurav Patki, Christopher Mowrey, Mohammad Asghar, Karim A Alkadhi, and Samina Salim. Grape Powder Supplementation Prevents Oxidative Stress-Induced Anxiety-Like Behavior, Memory Impairment and High Blood Pressure in Rats. J. Nutrition 143(6):835-842, 2013 

Zagaar Munder, An Dao, Amber Levine, Ibrahim Alhaider, Samina Salim, Karim Alkadhi.  Regular treadmill exercise prevents sleep deprivation-induced disruption of synaptic plasticity and associated signaling cascade in the dentate gyrus. Mol. Cell. Neuroscience 56:375-383. 2013

Alzoubi KH, Khabour OF Alhaidar IA, Aleisa AM, Alkadhi KA Diabetes impairs synaptic plasticity in the superior cervical ganglion: Possible role for BDNF and oxidative stress. J. Mol Neuroscience 51(3):763-70. 2013

Chugh G, Asghar M, Patki G, Bohat R, Jafri F, Allam F, Dao AT, Mowrey C, Alkadhi K, Salim S. A high salt diet further impairs age-assiciated decline in cognitive, behavioral and cardiovascular functions in male Fischer brown Norway rats. J. Nutrition Sep;143(9):1406-1413, 2013

Patki G, Allam FH, Atrooz F, Dao AT, Solanki N, Chugh G, Asghar M, Jafri F, Bohat R, Alkadhi KA, Salim S. Grape powder intake prevents ovariectomy-induced anxiety-like behavior, memory impairment and high blood pressure in female Wistar rats. PLoS One. 2013 Sep 9;8(9):e74522. doi: 10.1371/journal.pone.0074522. PubMed

Alzoubi KH, Abdul-Razzak, KK, Khabour OF, Al-Tuweiq, GM, Alzubi MA, Alkadhi KA. Caffeine prevents chronic psychosocial stress and/or high fat diet induced cognitive impairment. Behav Br Res 237:7-14, 2013

Alzoubi KH., Srivareerat M., Aleisa AM., Alkadhi KA. Chronic caffeine treatment prevents stress-induced LTP impairment: the critical role of phosphorylated CaMKII and BDNF. J. Mol. Neurosci. 49:11-20, 2013

Zagaar, Munder, Ibrahim Alhaider An Dao, Amber Levine, Karim Alkadhi. Regular exercise prevents sleep deprivation associated impairment of long-term memory, synaptic plasticity and its signaling cascade in the CA1 area of the hippocampus. Sleep 36(5):751-761, 2013

Alzoubi K. H., M. Srivareerat, T. T. Tran, and K. A. Alkadhi. Role of a7- and a4b2-nAChRs in the Neuroprotective Effect of Nicotine in Stress-Induced Impairment of Hippocampus-Dependent Memory. Int J Neuropsychopharmacol 16:1105-1113,  2013

Dao, An T; Zagaar, Munder A; Levine Amber T; Salim, Samina; Eriksen, Jason L; Alkadhi, Karim A. Treadmill exercise prevents learning and memory impairment in Alzheimer’s disease-like pathology. Current Alzheimer Research Curr Alzheimer Res. 10(5):507-515. 2013

Alkadhi KA, Alzoubi KH, Srivareerat M, Tran TT. Elevation of BACE levels in Ab rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine: Int J Neuropsychopharmacol 15(2):223-233. 2012

Zoladz PR, Park CR., Halonen JD, Salim S, Alzoubi KH., Srivareerat M, Alkadhi KA, Diamond DM. Differential Expression of Molecular Markers of Synaptic Plasticity in the Hippocampus, Prefrontal Cortex and Amygdala in Response to Spatial Learning and Stress-Induced Amnesia. Hippocampus 22:577-589, 2012

Zagaar, Munder, Ibrahim Alhaider, An Dao, Amber Levine, Ahmed Alkarawi, Mariam Alzubaidy, Karim Alkadhi. The beneficial effects of regular exercise on cognition in REM sleep deprivation: Behavioral, electrophysiological and molecular evidence. Neurobiol. Dis 45:1153-1162, 2012

Alkadhi KA, Eriksen J. The Complex and multifactorial nature of Alzheimer’s disease. (Editorial). Current Neuropharmacol. 9: 586, 2011

Tran TT, Srivareerat M, Alhaider IA, Alkadhi KA. Chronic psychosocial stress enhances long-term depression in a subthreshold amyloid-beta rat model of Alzheimer's disease. J Neurochem. 2011 Oct;119(2):408-16. doi: 10.1111/j.1471-4159.2011.07437.x.

Aleisa AM, Helal G, Alhaider IA, Alzoubi KH, Srivareerat M, Tran TT, Al-Rejaie SS, Alkadhi KA. Acute nicotine treatment prevents REM sleep deprivation-induced learning and memory impairment in rat. Hippocampus. 2011 Aug;21(8):899-909. doi: 10.1002/hipo.20806.

Aleisa AM, Alzoubi KH, Alkadhi KA. Post-learning REM sleep deprivation impairs long-term memory: reversal by acute nicotine treatment. Neurosci Lett. 2011 Jul 15;499(1):28-31.

Tran TT, Srivareerat M, Alkadhi KA. Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease. Hippocampus. 2011 Jul;21(7):724-32. doi: 10.1002/hipo.20790.

Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA. Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease. Neurobiol Aging. 2011 May;32(5):834-44.

Zoladz PR, Park CR, Halonen JD, Salim S, Alzoubi KH, Srivareerat M, Fleshner M, Alkadhi KA, Diamond DM. Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesia. Hippocampus. 2011 May 2. doi: 10.1002/hipo.20922.

Alhaider IA, Aleisa AM, Tran TT, Alkadhi KA. Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. Mol Cell Neurosci. 2011 Apr;46(4):742-51.

Alkadhi KA, Alzoubi KH, Srivareerat M, Tran TT. Chronic Psychosocial Stress Exacerbates Impairment of Synaptic Plasticity in β-Amyloid Rat Model of Alzheimer's Disease: Prevention by Nicotine. Curr Alzheimer Res. 2011 Apr 1. [epub ahead of print]

Alkadhi KA, Alzoubi KH, Srivareerat M, Tran TT. Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine. Int J Neuropsychopharmacol. 2011 Feb 28:1-11. [epub ahead of print]

Alkadhi KA, Srivareerat M, Tran TT. Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease. Mol Cell Neurosci. 2010 Nov;45(3):289-96.

Alhaider IA, Aleisa AM, Tran TT, Alzoubi KH, Alkadhi KA. Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity. Sleep. 2010 Apr;33(4):437-44.

Alhaider IA, Aleisa AM, Tran TT, Alkadhi KA. Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus. Eur J Neurosci. 2010 Apr;31(8):1368-76.

Tran TT, Srivareerat M, Alkadhi KA. Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease. Neurobiol Dis. 2010 Mar;37(3):756-63.

Alzoubi KH, Abdul-Razzak KK, Khabour OF, Al-Tuweiq GM, Alzubi MA, Alkadhi KA. Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats. Behav Brain Res. 2009 Dec 1;204(1):117-23. 

Srivareerat M, Tran TT, Alzoubi KH, Alkadhi KA. Chronic psychosocial stress exacerbates impairment of cognition and long-term potentiation in beta-amyloid rat model of Alzheimer's disease. Biol Psychiatry. 2009 Jun 1;65(11):918-26.

Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA. Chronic nicotine restores normal Abeta levels and prevents short-term memory and E-LTP impairment in Abeta rat model of Alzheimer's disease. Neurobiol Aging. 2009 May 20.

Alzoubi KH, Alkadhi KA. Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats. Neurosci Res. 2009 Feb;63(2):95-9.

 

Alzoubi KH, Gerges NZ, Aleisa AM, Alkadhi KA. Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies. Hippocampus. 2009 Jan;19(1):66-78.

 

 

Book Chapters & Reviews

Book Chapters

Karim A. Alkadhi, Ibrahim Alhaider, Munder Zagaar, Karem Alzoubi. “Food and Nutritional Components in Focus: caffeine: chemistry, analysis, function and effects.”  Victor R. Preedy  (ed.) in press (2012). The Royal Society of Chemistry (RSC Publishing), King’s College, London.

Karim A. Alkadhi, Karem H. Alzoubi. "Synaptic Plasticity of Autonomic Ganglia." (Ch. 26) in Sudden Death in Epilepsy: Forensic and Clinical Issues, Claire Lathers et al. (eds)., CRC Press 2011.

Invited Reviews

Alkadhi KA. Chronic stress accelerates and intensifies Ab-induced Alzheimer’s disease-like pathogenesis in rat models. US Psychiatry (in press), 2011.

Alkadhi K, Alzoubi K. Role of long-term potentiation of sympathetic ganglia (gLTP) in hypertension. Clin Exp Hypertens. 2007 Jul;29(5):267-86. Review.

Alkadhi KA and Alzoubi KH: Role of Long Term Potentiation of Sympathetic Ganglia (gLTP) in Hypertension. Clinical and Experimental Hypertension 29:267-286, 2007.

Alkadhi KA, Alzoubi KH and Aleisa AM: Plasticity of synaptic transmission in autonomic ganglia. Progress in Neurobiol 75:83-108, 2005.

Presentations & Abstracts

Tran TT, Srivareerat, M, Alhaider, IA, Alkadhi, KA. Chronic psychosocial stress accelerates cognitive impairment in an at risk rat model of Alzheimer’s disease: Molecular studies. Soc. Neuroscience 35: 2009.

Alkadhi KA, Alzoubi KH, Alhaider IA, Aleisa AM. Streptozotocin-induced diabetes impairs ganglionic transmission and synaptic plasticity in the superior cervical ganglion. Soc. Neuroscience 35: 2009.

Alhaider IA, TT Tran, AM Aleisa, KH Alzoubi, KA Alkadhi. Effects of caffeine on cognitive deficit in acutely sleep deprived rats: electrophysiological and molecular evidence. Soc. Neuroscience 35: 2009.

Alzoubi  KH, KK Abdul-Razzaq, OF Khabour, GM Al-Tuweiq, Alzubi MA, Alkadhi KA. Chronic caffeine administration prevents high fat diet-induced impairment of hippocampus-dependent learning and memory. Soc. Neuroscience 35: 2009.

Zagaar, MA., Srivareerat M, Tran TT., and Alkadhi KA. Elevation of BACE levels in A-beta rat model of Alzheimer’s disease: exacerbation by chronic stress and prevention by nicotine- Further validation of the model. Soc. Neuroscience 35: 2009.

Tran TT, Srivareerat M, Aleisa AM, Alhaider IA, Alkadhi KA. Stress impairs long-term potentiation in the dentate gyrus in an early-stage Alzheimer’s disease rat model. Soc. Neuroscience 34: 2008.

Srivareerat. M., Alzoubi K.H., Alkadhi K.A., Zoladz P.R., Park C.R., Halonen J.D, D.M. Diamond. Differential expression OF CaMKII BDNF and calcineurin in the hippocampus and amygdala in response to spatial learning and predator stress-induced amnesia. Soc. Neuroscience 34: 2008.

Alzoubi KH, Abdul-Razzaq KK, Khabour OF, Al-Tuweiq GM, Alkadhi KA. Chronic caffeine administration prevents stress-induced impairment of hippocampus-dependent memory. Soc. Neuroscience 34: 2008.

Alhaider I A, Aleisa A. M., Tran T T, Srivareerat M, Alzoubi KH, Alkadhi K A. Caffeine prevents the impairment of the spatial learning and memory induced by sleep deprivation. Soc. Neuroscience 34: 2008.

Aleisa A. M., Alzoubi K. H., Alhaider I A, Srivareerat M., Tran T T, Alkadhi K A. Nicotine treatment reverses sleep deprivation-induced impairment of LTP in anesthetized rats. Soc. Neuroscience 34: 2008.

Alkadhi KA, Alzoubi KH, Alhaidar I, Aleisa AM, Srivareerat M. Chronic i.c.v infusion of β-amyloid impairs ganglionic transmission and synaptic plasticity in the superior cervical ganglion. Soc. Neuroscience 34: 2008.

Tran TT, Srivareerat M, Alkadhi KA. Stress accelerates the onset of Alzheimer’s disease:  electrophysiological studies. Soc. Neuroscience 33: 2007

Srivareerat M, Tran TT, Alzoubi KH, Alkadhi KA. Nicotine antagonizes stress and beta-amyloid-induced impairment of synaptic plasticity. Soc. Neuroscience 33: 2007

Aleisa, AM, Helal, Attia S, Alhoshani A, Alhosaini K, Alkadhi KA, Alzoubi KH, Alrejaie S, Al-Shabanah O, Alhaider A. Nicotine reverses sleep deprivation induced cognitive impairment. Soc. Neuroscience 33: 2007

Alzoubi KH, Aleisa AM, Alkadhi KA. Levothyroxin restores Hypothyroidism-Induced Impairment of Hippocampus-dependent Learning and Memory. Soc. Neuroscience 33: 2007

Tran TT, Srivareerat MM and Alkadhi KA. Chronic psychosocial stress hastens the onset of Alzheimer’s disease. Soc. Neuroscience 32: 2006

Srivareerat MM, Tran, TT, Alkadhi KA. Nicotine blocks stress and Alzheimer’s-induced impairment of spatial memory in a beta-amyloid-induced rat model of Alzheimer’s disease. Soc. Neuroscience 32: 2006

K.H. Alzoubi, A.M. Aleisa, and Alkadhi KA. Hypothyroidism-induced enhancement of LTD: reversal by nicotine and possible role of NMDA receptors. Soc. Neuroscience 32: 2006

Memberships

  • Society for Neuroscience
  • American Society for Pharmacology and Experimental Therapeutics (ASPET)
  • Society for Experimental Biology and Medicine
  • British Pharmacological Society
  • International Brain Research Organization (IBRO)
  • Rho Chi, Pharmaceutical Honor Society
  • International Society for Myochemistry

Editorial Appointments

  • Editorial Board Member, Clinical and Experimental Hypertension
  • Editorial Board Member, Journal of Pharmacology and Toxicology
  • Editorial Board Member, Current Neuropharmacology
  • Editorial Board Member, Advances in Pharmacological Sciences
  • Editorial Board Member, Clinical Pharmacology-Current Research
  • Editorial Board Member, Pharmacie Globale
  • Journal Reviewer (ad hoc): Am J Physiology, Behavioral Brain Research, Brain Research Bulletin, Brain Research, Biological Psychiatry, Clin Exp Hypertension, Clin Exp Pharmacol and Physiol, Epilepsia, European Journal of Pharmacology, Euro J Neuroscience, Experimental Neurology, Hippocampus, Hypertension, J. Neurosci Res, J. Gerontology, Molecular Psychiatry, Neurotoxicology, Molecular Pharmacology, Neuropharmacology, Neuropsychopharmacology, Neuroreport, Neuroscience, Neuroscience Letters, Neurotox Res, Toxicology & Applied Pharmacology

Professional Service (Study Sections & Review Panels)

  • NSF graduate Research Fellowship Program (GRFP), 1996-present
  • American Heart Association, 2005-present
  • Alzheimer Association, 2003-present
  • The Health Research Board in Ireland, 2006-present
  • The National Defense Science and Engineering Graduate (NDSEG) Fellowship Program, 2006-present
  • The Qatar National Research Fund (QNRF), 2007-present
  • Philip Morris External Research Program, 2003-2007
  • AACP New Investigators Program/Pharmacology and Toxicology Panel, 2006-2007