Profile: Douglas Eikenburg

Douglas Eikenburg
Douglas Eikenburg, Ph.D.
Chair, Department of Pharmacological and Pharmaceutical Sciences
Associate Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
521 G Science and Research Building 2
Houston, TX 77204-5037
713-743-1217
713-743-1884 (fax)
DEikenburg@uh.edu

Education

B.S. in Chemistry, St. Lawrence University, New York
Ph.D. in Pharmacology, Michigan State University

Research Interests

  • Local neuromodulatory mechanisms in cardiovascular tissues
  • Effect of stress on the cardiovascular system
  • Receptor regulation and desensitization
  • Cardiovascular and automatic pharmacology
  • Role of GRK3 in stress susceptibility regualation of GRK3 Expression

Courses

  • PHAR 5402/5403 Pharmacology of Hyperlipidemia and Arrhythmias Arrhythmia Skills Lab
  • PCOL 6370/6371 Introduction to Pharmacokinetics, Pharmacology of Adrenergic, Cholinergic and Nitric Oxide Neurotransmission in Advanced Pharmacology
  • PCOL 7333 Molecular Pharmacology
  • PCOL 7370 Scientific Writing

Awards and Honors

  • Selected Fellow, Academic Leadership Fellows Program, American Association of Colleges of Pharmacy, 2012-13
  • University of Houston Teaching Excellence Award, 2010
  • University of Houston College of Pharmacy Faculty Teaching Excellence Award, 2007
  • Paper “Role of Hsp90 and Protein Degradation in Regulating Neuronal Levels of GRK3” highlighted in “Nascent Transcripts” in Molecular Interventions, February 2007
  • Rho Chi Teaching Excellence Award - Honorable Mention, University of Houston College of Pharmacy, 2006
  • University of Houston Alumni Association, Outstanding Faculty Award, 2003
  • Elected President, University of Houston Chapter of Sigma Xi, 2000
  • Elected Fellow, American Heart Association High Blood Pressure Council, 1994
  • Rho Chi Teaching Excellence Award, University of Houston College of Pharmacy, 1992
  • American Heart Association, Established Investigator, 1987-1992

Selected Publications

Taneja M, Salim S, Saha K, Happe HK, Qutna N, Petty F, Bylund DB, Eikenburg DC. Differential effects of inescapable stress on locus coeruleus GRK3, alpha(2)-adrenoceptor and CRF(1) receptor levels in learned helpless and non-helpless rats: A potential link to stress resilience.  Behav Brain Res. (221) 25-33, 2011.

Salim, S., Desai, A. N., Taneja, M. and Eikenburg, D.C.: Chronic adrenaline treatment fails to down-regulate the Del301-303-Alpha2B-Adrenoceptor in neuronal cells. Br. J. Pharmacol. 2009 Sep;(158) 314-327, 2009.

Bawa-Khalfe, T., Altemimi, G.F., Mandyham, C.D., Schwarz, L.A., Eikenburg, D.C. and Standifer, K.S.: The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Phamacol. 2007 Dec 20, 7:16.

Salim, S., Hite, B, and Eikenburg, D.C.: Activation of CRF(1) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells. FEBS Letters Jul 10; (581) 3204-3210, 2007.

Salim, S., Standifer, K.M., and Eikenburg, D.C.: ERK1/2 Mediated Transcriptional Regulation of GRK3 Expression In Neuronal Cells. J. Phamacol. Exptl. Ther 2007 Apr;(321) 51-59, 2007.

Salim, S. and Eikenburg, D.C.: Role of Hsp90 and Protein Degradation in Regulating Neuronal Levels of GRK3. J. Phamacol. Exptl. Ther. 2007 Mar;(320) 1106-1112, 2007.

Desai, A., Salim, S., Standifer, K.M. and Eikenburg, D.C.: Involvement of GRK3 and GRK2 in Down-regulation of the alpha2B-Adrenoceptor. J. Phamacol. Exptl. Ther. 2006 Jun;(317) 1027-1035, 2006.

Desai, A., Standifer, K.M. and Eikenburg, D.C.: Cellular GRK levels regulate sensitivity of the alpha2B-adrenergic receptor to undergo agonist-induced down-regulation. J. Pharmacol. Exptl. Ther. 2005 Feb; (312) 767-775, 2005.

Abstracts

Saha K., Taneja M., Salim S., Bicol K., and Eikenburg, D.C.: Repeated Forced Swim Stress Induces Learned Helplessness in Rats. Experimental Biology, 2012.

Taneja, M., Saha, K., Patki, G., Lau, Y.S., and Eikenburg, D.C.: Sustained separation of rats into stress-susceptible and stress-resilient groups by repeated exposure to inescapable unpredictable stress. Experimental Biology, 2011.

Saha, K., Taneja, M., Salim, S., Ziburkus, J., and Eikenburg, D.C.:   Repeated Forced swim Stress-induced behavioral changes are associated with changes in GRK3 in rat Locus Coeruleus. Soc. Neuroscience, Abst. # 389.16, 2010.

Taneja, M., Saha, K., and Eikenburg, D.C.: Reduced GRK3 levels in Locus Coeruleus after unpredictable inescapable stress is associated with increased stress susceptibility. Soc. Neuroscience, Abst. # 389.16, 2010.

Taneja, M., Salim, S., Happe, H.K., Petty, F., Bylund, D.B., and Eikenburg, D.C.: Differential changes in CRF1 receptors and alpha2-adrenceptors are associated with changes in GRK3 in brains of learned helpless and non-helpless rats. Soc. Neuroscience, Abst. #776.9, 2009.

Eikenburg, D.C., Taneja, M. and Salim, S.: An SNP in the Human GRK3 Gene Promoter-Luciferase Construct Eliminates Hormone-Induced Activation of GRK3Transcription. Experimental Biology, Abst. #944.2, 2009.

Taneja, M., Salim, S., Happe, H.K., Petty, F., Bylund, D.B., and Eikenburg, D.C.: Changes in GRK3/2 levels in brain regions of learned helpless and non-helpless rats. Experimental Biology, Abst. #LB613, 2008.

Standifer, K.M. and Ramirez, V.I., Eikenburg, D.C. and Bawa-Khalfe, T.: ERK-mediated GRK3 upreulation via EGFR transactivation and co-activation of alpha2- and beta2-AR by epinephrine in a human neuronal cell line. Experimental Biology, Abst. # LB630, 2008.

Salim, S., Eikenburg, D.C., Dessauer, C.W. and Hite, B.: Oxidative stress increased GRK2 expression which suppresses increased cAMP accumulation in response to CRF activation in CATH.a cells. Experimental Biology, Abst. # 909.1, 2008.

Eikenburg, D.C., Salim, S., Gokhale, A. and Taneja, M.: Chronic EPI treatment fails to down-regulate Del(301-303) alpha2B-AR in normal and GRK3 over-expressing neuronal cells. Experimental Biology, Abst. # 725.1, 2008.

Salim, S., Hite, B., Zagaar, M. and Eikenburg, D.C.: CRF Treatment results in ERK1/2 Mediated Increase in GRK3 expression in CATH.a Cells. Experimental Biology, Abst. # 4230, 2007.

Eikenburg, D.C. Salim, S., Gokhale, A. and Taneja, M.: Del301-303 Alpha2B-AR Does not down-regulate in response to chronic epinephrine treatment. Gordon Research Conference, Phosphorylation and G-Protein Mediated Signaling Networks. University of New England, June 10-15, 2007.

Eikenburg, D.C., Salim, S., Hite, B. and Zagaar, M.: CRF treatment results in ERK1/2-mediated increase in GRK3 expression in CATH.a cells. Experimental Biology, Abst. # 4230, 2007.

Salim, S, Standifer, K.M..and Eikenburg, D.C.: Simlutaneous activation of alpha2- and beta2-adrenoceptors by EPI is required for the ERK1/2-dependent increase in GRK3 transcription in neuronal cells. Experimental Biology, Abst. # 4158, 2007.

Salim, S.and Eikenburg, D.C.: Regulation of GRK3 expression via ERK 1/2-Mediated Transcription and Hsp90-Mediated Protein Stabilization. Experimental Biology, Abst. # 6661, 2006.

Eikenburg, D.C. and Salm, S.: Regulation of GRK3 expression via ERK1/2-mediated transcriptional regulaton and Hsp-90-mediated protein stabilization, Keystone Symposium on G-Protein Coupled Receptors, February 2006.

Eikenburg, D.C.. Gokhale (Desai), A.A., and Standifer, K.M.: Evidence for a role of endogenous GRK3 and GRK2 in agonist-induced down-regulation of alpha2B-AR. Experimental Biology, 2005.

Invited Presentations

"Plagiarism - Don't Do It!", New Graduate Student Orientation, Department of Clinical Sciences & Administration, University of Houston College of Pharmacy, August 2011, August 2009, August 2008

“Role of GRK3 in the Regulation of Alpha2-Adrenoceptor Signaling in Neurons,” University of Porto, Institute for Pharmacology Porto, Portugal, (invited research seminar) September 17, 2008.

"GRK3: A Regulator of Stress Hormone/Neurotransmitter Signaling in Neurons." University of Texas Health Science Center-Houston, Department of Integrative Biology and Pharmacology, (invited research seminar) March 31, 2008.

“Grant Proposal Writing: Do You Really Understand What Peer-Review Means?”, University of Oklahoma Health Sciences Center, Graduate College and the Oklahoma, Center for Neuroscience (invited presentation) October 2, 2007.

Appointments, Memberships and Service

Memberships

Phi Beta Kappa
Sigma Xi
American Association of Colleges of Pharmacy
American Society for Pharmacology and Experimental Therapeutics
British Pharmacolgical Society
Society for Neuroscience
Fellow, American Heart Association High Blood Pressure Council

Editorial Board Appointments

Journal Editorial Board, Clinical and Experimental Hypertension, 1991 - present
Editor, British Journal of Pharmacology, 2007 - present
New Editor Mentor, British Journal of Pharmacology, 2009 - present

Service Activities

Member, American Heart Association, Molecular Signaling 3 Review Panel, 2010 - present
Member, Review Committee #1, American Heart Association, Western Affiliate, 1999-2003
Member, American Association of Colleges of Pharmacy, New Faculty Research Grants Review Committee, 1998-2005
Member, American Society for Pharmacology and Experimental Therapeutics, Short Course/Continuing Education Committee, 1999-2002
Member, American Society for Pharmacology and Experimental Therapeutics, Committee for the Care and Use of Research Animals, 1997-2001
Member and Secretary, IUPHAR Sub-Committee For Nomenclature and Receptor Classification of the Adrenoceptors, 1990-present