Profile: Douglas Eikenburg

Douglas Eikenburg
Douglas Eikenburg, Ph.D.
Chair, Department of Pharmacological and Pharmaceutical Sciences
Associate Professor of Pharmacology
Department of Pharmacological and Pharmaceutical Sciences
521 G Science and Research Building 2
Houston, TX 77204-5037
713-743-1217
713-743-1229 (fax)
DEikenburg@uh.edu

Education

B.S. in Chemistry, St. Lawrence University, New York
Ph.D. in Pharmacology, Michigan State University

Research Interests

  • Local neuromodulatory mechanisms in cardiovascular tissues
  • Effect of stress on the cardiovascular system
  • Receptor regulation and desensitization
  • Cardiovascular and automatic pharmacology
  • Role of GRK3 in stress susceptibility regualation of GRK3 Expression

Courses

  • PHAR 5402/5403 Pharmacology of Hyperlipidemia and Arrhythmias Arrhythmia Skills Lab
  • PCOL 6370/6371 Introduction to Pharmacokinetics, Pharmacology of Adrenergic, Cholinergic and Nitric Oxide Neurotransmission in Advanced Pharmacology
  • PCOL 7333 Molecular Pharmacology
  • PCOL 7370 Scientific Writing

Awards and Honors

  • Selected Fellow, Academic Leadership Fellows Program, American Association of Colleges of Pharmacy, 2012-13
  • University of Houston Teaching Excellence Award, 2010
  • University of Houston College of Pharmacy Faculty Teaching Excellence Award, 2007
  • Paper “Role of Hsp90 and Protein Degradation in Regulating Neuronal Levels of GRK3” highlighted in “Nascent Transcripts” in Molecular Interventions, February 2007
  • Rho Chi Teaching Excellence Award - Honorable Mention, University of Houston College of Pharmacy, 2006
  • University of Houston Alumni Association, Outstanding Faculty Award, 2003
  • Elected President, University of Houston Chapter of Sigma Xi, 2000
  • Elected Fellow, American Heart Association High Blood Pressure Council, 1994
  • Rho Chi Teaching Excellence Award, University of Houston College of Pharmacy, 1992
  • American Heart Association, Established Investigator, 1987-1992

Selected Publications

Taneja M, Salim S, Saha K, Happe HK, Qutna N, Petty F, Bylund DB, Eikenburg DC. Differential effects of inescapable stress on locus coeruleus GRK3, alpha(2)-adrenoceptor and CRF(1) receptor levels in learned helpless and non-helpless rats: A potential link to stress resilience.  Behav Brain Res. (221) 25-33, 2011.

Salim, S., Desai, A. N., Taneja, M. and Eikenburg, D.C.: Chronic adrenaline treatment fails to down-regulate the Del301-303-Alpha2B-Adrenoceptor in neuronal cells. Br. J. Pharmacol. 2009 Sep;(158) 314-327, 2009.

Bawa-Khalfe, T., Altemimi, G.F., Mandyham, C.D., Schwarz, L.A., Eikenburg, D.C. and Standifer, K.S.: The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Phamacol. 2007 Dec 20, 7:16.

Salim, S., Hite, B, and Eikenburg, D.C.: Activation of CRF(1) receptor causes ERK1/2 mediated increase in GRK3 expression in CATH.a cells. FEBS Letters Jul 10; (581) 3204-3210, 2007.

Salim, S., Standifer, K.M., and Eikenburg, D.C.: ERK1/2 Mediated Transcriptional Regulation of GRK3 Expression In Neuronal Cells. J. Phamacol. Exptl. Ther 2007 Apr;(321) 51-59, 2007.

Salim, S. and Eikenburg, D.C.: Role of Hsp90 and Protein Degradation in Regulating Neuronal Levels of GRK3. J. Phamacol. Exptl. Ther. 2007 Mar;(320) 1106-1112, 2007.

Desai, A., Salim, S., Standifer, K.M. and Eikenburg, D.C.: Involvement of GRK3 and GRK2 in Down-regulation of the alpha2B-Adrenoceptor. J. Phamacol. Exptl. Ther. 2006 Jun;(317) 1027-1035, 2006.

Desai, A., Standifer, K.M. and Eikenburg, D.C.: Cellular GRK levels regulate sensitivity of the alpha2B-adrenergic receptor to undergo agonist-induced down-regulation. J. Pharmacol. Exptl. Ther. 2005 Feb; (312) 767-775, 2005.

Abstracts

Saha K., Taneja M., Salim S., Bicol K., and Eikenburg, D.C.: Repeated Forced Swim Stress Induces Learned Helplessness in Rats. Experimental Biology, 2012.

Taneja, M., Saha, K., Patki, G., Lau, Y.S., and Eikenburg, D.C.: Sustained separation of rats into stress-susceptible and stress-resilient groups by repeated exposure to inescapable unpredictable stress. Experimental Biology, 2011.

Saha, K., Taneja, M., Salim, S., Ziburkus, J., and Eikenburg, D.C.:   Repeated Forced swim Stress-induced behavioral changes are associated with changes in GRK3 in rat Locus Coeruleus. Soc. Neuroscience, Abst. # 389.16, 2010.

Taneja, M., Saha, K., and Eikenburg, D.C.: Reduced GRK3 levels in Locus Coeruleus after unpredictable inescapable stress is associated with increased stress susceptibility. Soc. Neuroscience, Abst. # 389.16, 2010.

Taneja, M., Salim, S., Happe, H.K., Petty, F., Bylund, D.B., and Eikenburg, D.C.: Differential changes in CRF1 receptors and alpha2-adrenceptors are associated with changes in GRK3 in brains of learned helpless and non-helpless rats. Soc. Neuroscience, Abst. #776.9, 2009.

Eikenburg, D.C., Taneja, M. and Salim, S.: An SNP in the Human GRK3 Gene Promoter-Luciferase Construct Eliminates Hormone-Induced Activation of GRK3Transcription. Experimental Biology, Abst. #944.2, 2009.

Taneja, M., Salim, S., Happe, H.K., Petty, F., Bylund, D.B., and Eikenburg, D.C.: Changes in GRK3/2 levels in brain regions of learned helpless and non-helpless rats. Experimental Biology, Abst. #LB613, 2008.

Standifer, K.M. and Ramirez, V.I., Eikenburg, D.C. and Bawa-Khalfe, T.: ERK-mediated GRK3 upreulation via EGFR transactivation and co-activation of alpha2- and beta2-AR by epinephrine in a human neuronal cell line. Experimental Biology, Abst. # LB630, 2008.

Salim, S., Eikenburg, D.C., Dessauer, C.W. and Hite, B.: Oxidative stress increased GRK2 expression which suppresses increased cAMP accumulation in response to CRF activation in CATH.a cells. Experimental Biology, Abst. # 909.1, 2008.

Eikenburg, D.C., Salim, S., Gokhale, A. and Taneja, M.: Chronic EPI treatment fails to down-regulate Del(301-303) alpha2B-AR in normal and GRK3 over-expressing neuronal cells. Experimental Biology, Abst. # 725.1, 2008.

Salim, S., Hite, B., Zagaar, M. and Eikenburg, D.C.: CRF Treatment results in ERK1/2 Mediated Increase in GRK3 expression in CATH.a Cells. Experimental Biology, Abst. # 4230, 2007.

Eikenburg, D.C. Salim, S., Gokhale, A. and Taneja, M.: Del301-303 Alpha2B-AR Does not down-regulate in response to chronic epinephrine treatment. Gordon Research Conference, Phosphorylation and G-Protein Mediated Signaling Networks. University of New England, June 10-15, 2007.

Eikenburg, D.C., Salim, S., Hite, B. and Zagaar, M.: CRF treatment results in ERK1/2-mediated increase in GRK3 expression in CATH.a cells. Experimental Biology, Abst. # 4230, 2007.

Salim, S, Standifer, K.M..and Eikenburg, D.C.: Simlutaneous activation of alpha2- and beta2-adrenoceptors by EPI is required for the ERK1/2-dependent increase in GRK3 transcription in neuronal cells. Experimental Biology, Abst. # 4158, 2007.

Salim, S.and Eikenburg, D.C.: Regulation of GRK3 expression via ERK 1/2-Mediated Transcription and Hsp90-Mediated Protein Stabilization. Experimental Biology, Abst. # 6661, 2006.

Eikenburg, D.C. and Salm, S.: Regulation of GRK3 expression via ERK1/2-mediated transcriptional regulaton and Hsp-90-mediated protein stabilization, Keystone Symposium on G-Protein Coupled Receptors, February 2006.

Eikenburg, D.C.. Gokhale (Desai), A.A., and Standifer, K.M.: Evidence for a role of endogenous GRK3 and GRK2 in agonist-induced down-regulation of alpha2B-AR. Experimental Biology, 2005.

Invited Presentations

"Plagiarism - Don't Do It!", New Graduate Student Orientation, Department of Clinical Sciences & Administration, University of Houston College of Pharmacy, August 2011, August 2009, August 2008

“Role of GRK3 in the Regulation of Alpha2-Adrenoceptor Signaling in Neurons,” University of Porto, Institute for Pharmacology Porto, Portugal, (invited research seminar) September 17, 2008.

"GRK3: A Regulator of Stress Hormone/Neurotransmitter Signaling in Neurons." University of Texas Health Science Center-Houston, Department of Integrative Biology and Pharmacology, (invited research seminar) March 31, 2008.

“Grant Proposal Writing: Do You Really Understand What Peer-Review Means?”, University of Oklahoma Health Sciences Center, Graduate College and the Oklahoma, Center for Neuroscience (invited presentation) October 2, 2007.

Appointments, Memberships and Service

Memberships

  • Phi Beta Kappa
  • Sigma Xi
  • American Association of Colleges of Pharmacy
  • American Society for Pharmacology and Experimental Therapeutics
  • British Pharmacolgical Society
  • Society for Neuroscience
  • Fellow, American Heart Association High Blood Pressure Council

Editorial Board Appointments

  • Journal Editorial Board, Clinical and Experimental Hypertension, 1991 - present
  • Editor, British Journal of Pharmacology, 2007 - present
  • New Editor Mentor, British Journal of Pharmacology, 2009 - present

Service Activities

  • Member, American Heart Association, Molecular Signaling 3 Review Panel, 2010 - present
  • Member, Review Committee #1, American Heart Association, Western Affiliate, 1999-2003
  • Member, American Association of Colleges of Pharmacy, New Faculty Research Grants Review Committee, 1998-2005
  • Member, American Society for Pharmacology and Experimental Therapeutics, Short Course/Continuing Education Committee, 1999-2002
  • Member, American Society for Pharmacology and Experimental Therapeutics, Committee for the Care and Use of Research Animals, 1997-2001
  • Member and Secretary, IUPHAR Sub-Committee For Nomenclature and Receptor Classification of the Adrenoceptors, 1990-present