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Profile: Bin Guo

Bin Guo
Bin Guo, Ph.D.
Associate Professor of Pharmaceutics
Department of Pharmacological and Pharmaceutical Sciences
1441 Moursund, Room 529
Houston, TX 77030

832-842-8301
bguo3@uh.edu

Education

Ph.D. in Molecular Pharmacology, Roswell Park Cancer Institute, Department of Molecular Pharmacology and Cancer Therapeutics, Graduate Division of State University of New York (SUNY) at Buffalo, Buffalo, NY

B.S. in Cell Biology, Department of Biology, The University of Science and Technology of China, Hefei, P.R. China

Research Interests

Understanding the epigenetic mechanisms that regulate cancer progression and the development of new cancer therapeutic agents

Patents

"Methods for Identifying Modulators of Apoptosis". United States patent number: 435/7.2; 424/9.2. International patent number G01N 033/53; G01N 033/567; G01N 033/574; A61K 049/00.

"Conversion of Apoptotic Proteins". United States patent number 514/12; 424/155.1; 530/350; 530/388.8. International patent number A61K 039/395; A61K 038/17.

Memberships, Editorial Appointments and Service Activities

Memberships

  • Kappa Chapter, The Rho Chi Society (Pharmaceutical Honor Society)
  • American Association of Colleges of Pharmacy (AACP)
  • American Association for Cancer research (AACR)
  • American Association for the Advancement of Science (AAAS)

Editorial Appointments

  • Associate Editor, American Journal of Cancer Research
  • Editor, Journal of Cancer Therapeutics and Research
  • Editor, Clinical Pharmacology & Biopharmaceutics
  • Manuscript Reviewer: Journal of Biological Chemistry; Cancer Research; Molecular Biology of the Cell; Cancer Prevention Research; Oncogene; Journal of Gastroenterology; Cancer Letter; Clinical Biochemistry; British Journal of Cancer; PLOS ONE; Journal of Molecular Medicine; Experimental Cell Research

Service Activities

  • Member of NIH ZRG1 OBT-A (55) R study section, November 2016
  • Member of NIH F09B_2016_05 CSR Fellowship Panel, March 2016
  • Member of NIH GDD (gene and drug delivery) study section, October, 2015
  • Department of Veterans Affairs, VA Oncology Merit Review Panel (ONCA), 2015
  • Department of Veterans Affairs, VA Oncology Merit Review Panel (ONCA), 2014
  • Department of Veterans Affairs, VA Oncology Merit Review Panel (ONCA), 2013
  • National Institute of Health, R15 study section, Internet Assisted Review, 2012
  • National Medical Research Council, Singapore, 2011
  • Member of study section for Concept Award - Cell Biology, DOD BCRP, 2010
  • Mail Reviewer, NIH/NCI study section (CAMP), 2009
  • Member of Cell Biology study section CBY#1, Department of Defense Breast Cancer Research Program, 2006, 2009
  • Israel Science Foundation, 2005

Research Support

Active Grants

Title: RNA Therapeutics for Targeted Treatment of Colon Cancer (R01 CA186100-01A1)
Source: National Institutes of Health/National Cancer Institute
Role: Principal Investigator
Dates: 5/19/2015–4/30/2019
Total Costs: $1,351,550

Title: Echogenic Polymersomes for Triggered Contents Release (R01 GM114080-01)
Source: National Institutes of Health/National Institute of General Medical Sciences
Role: Multi-Principal Investigator
Dates: 9/5/15–8/31/19
Total Costs: $1,161,750

Completed Research Support

Title: Center for Protease Research (P30 GM103332)
Source: National Institutes of Health/National Institute of General Medical Sciences
Role: Project Principal Investigator
Dates: 7/1/14–6/30/16

Title: New Strategies for Targeting Protease in Disease (P20 RR015566)
Source: NIH/NCRR
Role: Project Principal Investigator
Dates: 7/01/07–6/30/13

Title: Mechanism of Bax activation in apoptosis (R21 CA111765)
Source: National Institutes of Health/National Cancer Institute
Role: Principal Investigator
Dates: 9/01/05–8/31/08

Title: A Novel Membrane-Permeable, Breast-Targeting, Pro-Apoptotic Peptide for Treatment of Breast Cancer
Source: Department of Defense BCRP (W81XWH-04-1-0705)
Role: Principal Investigator
Dates: 9/30/04–9/30/06

Title:Chemoprevention of Familial Adenomatous Polyposis by a Combination of 3,3’-Diindolylmethane and Butyrate in APCmin/+ Mice (R03 CA130062)
Source: National Institutes of Health/National Cancer Institute
Role: Principal Investigator
Dates: 7/01/08–6/30/11

Selected Publications (since 2005)

Zhang Q., Sun M., Zhou S., and Guo B. 2016 Class I HDAC inhibitor mocetinostat induces apoptosis by activation of miR-31 expression and suppression of E2F6 Cell Death Discovery (2) 16036; doi:10.1038/cddiscovery.2016.36.

Binzel DW, Shu Y., Li, H., Sun M., Zhang Q., Shu D., Guo B., and Guo P. 2016 Specific delivery of miRNA for high efficient inhibition of prostate cancer by RNA nanotechnology. Molecular Therapy 24 (7), 1267–1277 doi: 10.1038/mt.2016.85.

Xu Y., Yang X., Zhao P., Yang Z., Yan C., Guo B., Qian SY 2016 Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2. Free Radical Biology and Medicine, 96: 67-77.

Raza S., Meyer M., Schommer J., Hammer K., Guo B., and Ghribi O. 2016 27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. Medical Oncology 33:12

Singh RK, Cho K, Padi SK, Yu J, Haldar M, Mandal T, Yan C, Cook G, Guo B, Mallik S, Srivastava DK. Mechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels. J Biol Chem. 2015 Mar 6;290(10):6607-19. doi: 10.1074/jbc.M114.600627. Epub 2015 Jan 20. PMID: 25605725

Zhang Q., Padi KR S., Tindall DJ, and Guo B. 2014 Polycomb protein EZH2 suppresses apoptosis by silencing the pro-apoptotic miR-31. Cell Death and Disease, 5, e1486; doi:10.1038/cddis.2014.454.

Kulkarni PS, Haldar MK, Nahire RR, Katti P, Ambre AH, Muhonen WW, Shabb JB, Padi SK, Singh RK, Borowicz PP, Shrivastava DK, Katti KS, Reindl K, Guo B, Mallik S. Mmp-9 responsive PEG cleavable nanovesicles for efficient delivery of chemotherapeutics to pancreatic cancer. Mol Pharm. 2014 Jul 7;11(7):2390-9. doi: 10.1021/mp500108p. Epub 2014 May 23. PMID: 24827725

Padi KR S., Zhang Q., Rustum YM, Morrison C., and Guo B. 2013 MicroRNA-627 mediates the epigenetic mechanism of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. Gastroenterology, 145(2): 437-46. Impact Factor: 16.716

Guo B., Binzel D.W. 2013 MicroRNAs: Biology and Role in RNA Nanotechnolgy. In P. Guo & F. Haque (Eds.), RNA Nanotechnology and Therapeutics (pp. 533-41). Boca Raton, FL: CRC Press.

Scott M.D., Dutta R., Haldar M.K., Guo B., Friesner D.L., and Mallik S. 2012 Differentiation of prostate cancer cells using flexible fluorescent polymers. Analytical Chemistry, 84, 17-20.

Bhatnagar N., Li X., Padi KR S., Zhang Q., Tang M., and Guo B. 2010 Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. Cell Death and Disease, 1, e105; doi:10.1038/cddis.2010.85. Cited by 104 articles

Li Y., Li X., and Guo B. 2010 Chemopreventive agent 3,3’-Diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Cancer Research, 70(2): 646-54. Cited by 57 articles

Bhatnagar N., Li X., Chen Y., Zhou X., Garrett SH, and Guo B. 2009 3,3’-Diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. Cancer Prevention Research, 2(6): 581-589. Cited by 62 articles

Shan Z., Yu Q., Purwaha P., Guo B., Qian S.Y. 2009 A combination study of spin-trapping, LC/ESR and LC/MS on carbon-centred radicals formed from lipoxygenase-catalysed peroxidation of eicosapentaenoic acid. Free Radical Research 43(1):13-27.

Huang X., Li X., and Guo B. 2008 KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. Journal of Biological Chemistry, 283(44):29795-801. Cited by 97 articles

Huang X. and Guo B. 2006 Adenomatous polyposis coli Determines Sensitivity to Histone Deacetylase Inhibitor-Induced Apoptosis in Colon Cancer Cells. Cancer Research, 66(18):9245-51.

Zhai D., Luciano F., Zhu X., Guo B., Satterthwait AC, and Reed JC. 2005 Humanin Binds and Nullifies Bid Activity by Blocking Its Activation of Bax and Bak. Journal of Biological Chemistry 280(16): 15815-15824.

Invited Lectures

  • "miR-627 and Vitamin D in Colon Cancer Suppression." Epigenetics and Epigenomics Symposium, University of North Dakota, Grand Forks, ND, Oct. 2, 2014.
  • "Epigenetic Regulation of Apoptosis in Cancer Treatment and Prevention." Mayo Clinic, Rochester, MN, Aug 9, 2010.
  • "Epigenetic Regulation of Apoptosis." New York University School of Medicine, New York, NY, Nov 11, 2009.

Awards and Honors

  • The Dean's Award for Excellence in Research, NDSU College of Pharmacy, 2016
  • The Dean’s Award for Excellence in Research, NDSU College of Pharmacy, 2010
  • Who’s Who in America, 2009 Edition.