Profile: Anees Banday

Anees Ahmad Banday
Anees Ahmad Banday, Ph.D.
Research Assistant Professor of Pharmacology
University of Houston College of Pharmacy
Department of Pharmacological & Pharmaceutical Sciences
Science & Research Bldg. 2, Room 453B
Houston, TX 77204-5037

abanday@uh.edu

713-743-1230 (office), 713-743-3666 (lab)
713-742-1229 (office), 713-743-3667 (lab)

Education

Ph.D. Biochemistry
M.Sc. Biochemistry
B.SC. (Honours) Biochemistry

Research Interests

Mechanisms and role of oxidative stress in renal dopamine receptor dysfunction and hypertension

Awards and Honors

  • Young Investigator Award, American Society of Nephology

Research Grants

“Oxidative Stress and Transcriptional Regulation of Renal AT1 Receptors in Hypertension,” American Heart Association, 07/01/08-06/30/09, $308,000

Selected Publications

Javkhedkar AA, Lokhandwala MF, Banday AA. Defective Nitric Oxide Production Impairs Angiotensin II-Induced Na/K-ATPase Regulation in Spontaneously Hypertensive Rats. Am J Physiol Renal Physiol. 2012 Jan;302(1):F47-51. PMID: 21900450

Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol. 2011 Sep 30;667(1-3):258-64.

Banday AA, Lokhandwala MF. Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress. Am J Physiol Renal Physiol. 2011 Aug;301(2):F364-70.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation and hypertension. Hypertension, 57: 452-459, 2011.

Muhammad, A.B., Lokhandwala, M.F. and Banday, A.A.: Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese Zucker rats. Amer J Physiol: Renal Physiol, 300:F98-F104, 2011.

Banday AA, Lokhandwala MF. Inhibition of natriuretic factors increases blood pressure in rats. Am J Physiol Renal Physiol. 2009 Aug;297(2):F397-402. 

Banday AA, Lokhandwala MF. Loss of biphasic effect on Na/K-ATPase activity by angiotensin II involves defective angiotensin type 1 receptor-nitric oxide signaling. Hypertension. 2008 Dec;52(6):1099-105.

Banday AA, Lokhandwala MF. Dopamine receptors and hypertension. Curr Hypertens Rep. 2008 Aug;10(4):268-75.

Banday AA, Lokhandwala MF. Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension. Am J Physiol Renal Physiol. 2008 Sep;295(3):F698-706.

Banday AA, Priyamvada S, Farooq N, Yusufi AN, Khan F. Effect of uranyl nitrate on enzymes of carbohydrate metabolism and brush border membrane in different kidney tissues. Food Chem Toxicol. 2008 Jun;46(6):2080-8.

Banday AA, Farooq N, Priyamvada S, Yusufi AN, Khan F. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci. 2008 Feb 27;82(9-10):450-9.

Banday AA, Lau YS, Lokhandwala MF. Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats. Hypertension. 2008 Feb;51(2):367-75.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F. Insulin Causes Renal Dopamine D1 Receptor Desensitization via GRK2-mediated Receptor Phosphorylation Involving Phosphatidylinositol3-Kinase and Protein kinase C, Amer J Physiol: Renal Physiol., 293: F877–F884, 2007.

Banday, A.A. and Lokhandwala, M.F. Oxidative Stress Reduces Renal Dopamine D1 Receptor-Gq/11a G Protein-Phospholipase C Signaling Involving G Protein-Coupled Receptor Kinase 2, Amer J Physiol: Renal Physiol., 293: F306–F315, 2007.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F. Oxidative Stress Causes Renal Dopamine D1 Receptor Dysfunction and Hypertension via Mechanisms Involving Nuclear Factor-kB and Protein Kinase C, J Amer Soc Nephrol, 18: 1446–1457, 2007.

Banday, A.A., Muhammad, A.B., Fazili, F.R., and Lokhandwala, M.F. Mechanism of Oxidative Stress Induced Increase in Salt Sensitivity and Development of Hypertension in Sprague Dawley Rats, Hypertension, 49[part 2]: 664–667, 2007.

Banday, A.A., Fazili, F.R., Marwaha, A.A., and Lokhandwala, M.F. Mitogen-Activated Protein Kinase Upregulation Reduces Renal D1 Receptor Affinity and G-protein Coupling in Obese Rats, Kidney International, 71: 397–406, 2007.

Banday, A.A. and Lokhandwala, M.F., Defective Renal Dopamine D1 Receptor Function Contributes to Hyperinsulinemia Mediated Hypertension, Clin Exp Hypertension, 28: 695–705, 2006.

Asghar, M., Banday, A.A., Fardoun, R. and Lokhandwala, M.F. Hydrogen Peroxide Causes Uncoupling of Dopamine D1 Receptors from G-Proteins via a Mechanism Involving PKC and GRK2, Free Radical Biol. & Med., 40: 13–20, 2006.

Fatima S, Arivarasu NA, Banday Anees Ahmad, Yusufi AN, Mahmood R. Effect of potassium dichromate on renal brush border membrane enzymes and phosphate transport in rats. Hum Exp Toxicol. 2005 Dec; 24(12):631-8.

Khundmiri S.J., Asghar M., Banday Anees Ahmad, Khan F., Salim S. and Yusufi A.N.K. Effects of ischemia reperfusion injury on sodium dependent phosphate transport in rat renal proximal tubular membranes. Biochemica et Biophysica Acta. 1716(1):19-28; 2005.

Banday Anees Ahmad, Marwaha A, Tallam LS, Lokhandwalal MF. Tempol reduces oxidate stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes 54(7):2219-26, 2005.

Banday Anees Ahmad, Siddiqui AH, Menezes M.M. and Hussain T. Insulin treatment enhances AT1 receptor function in OK cells. American Journal of Physiology-Renal Physiology 288(6):F1213-9, 2005.

Presentations and Abstracts

Javkhedkar, A., Lokhandwala, M.F. and Banday, A.A.: Oxidative stress impairs renal nitric oxide signaling and ang II mediated biphasic Na/K-ATPase regulation in spontaneously hypertensive rats. Hypertension, 52: e164, 2010.

Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Oxidative stress via nuclear factor kappa B causes vascular angiotensin type 1 receptor upregulation and contributes to development of hypertension in SHR. Hypertension, 56: e154, 2010.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress causes renal AT1 receptor upregulation, NHE3 overstimulation and hypertension. Hypertension, 56: e117, 2010.

Javkhedkar, A., Lokhandwala, M.F. and Banday, A.A.: Higher renal AT1 receptor affinity exaggerates Ang II induced Na/K-ATPase stimulation in spontaneously hypertensive rats. FASEB J. 24: LB707, 2010.

Bhatt, S., Banday, A.A. and Lokhandwala M.F.: Vascular oxidative stress, NF?B activation and AT1 Receptor upregulation precede the development of hypertension in Spontaneously Hypertensive Rats (SHR)  FASEB J. 2009 23:LB53  (Experimental Biology 2009)

Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Early Chronic Resveratrol Treatment Reduces Blood Pressure and Vasoconstriction and Improves Endothelium-Dependent Vasorelaxations by Lowering Oxidative Stress in Spontaneously Hypertensive Rats. 63rd Annual High Blood Pressure Research Conference 2009 Hypertension. 2009; 54: e26-e127 (P268)

Bhatt, S., Lokhandwala, M.F. and Banday, A.A.: Vascular and Not Systemic Oxidative Stress Precedes Development of Hypertension and Is Associated with NFkB Activation and AT1 Receptor Upregulation. 63rd Annual High Blood Pressure Research Conference 2009 Hypertension. 2009; 54: e26-e127 (P261)

Banday, A. A. and Lokhandwla, M. F.: Antioxidant-mediated Nrf2 activation prevents AT1 receptor upregulation, endothelial dysfunction and hypertension by abolishing NFkB activation during oxidative stress, J. Clin. Hypertension, 11:A2, 2009.

Banday, A. A. and Lokhandwala, M. F.: Loss of biphasic effect on renal Na/K-ATPase by angiotensin II involves defective regulation of AT1 receptor-NO-cGMP signaling during oxidative stress. J. Amer. Soc. Nephrol. 19: 377A, 2008.

Banday, A.A. and Lokhandwala, M.F.: Role of Nrf2 in prevention of renal angiotensin AT1 receptor upregulation and hypertension during oxidative stress. J. Amer. Soc. Nephrol. 19: 67A, 2008.

Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters in hypertension. Hypertension, 52: e59, 2008.

Banday, A.A. and Lokhandwala, M.F.: Antioxidant mediated Nrf2 activation blocks NFkB stimulation and prevents angiotensin AT1 receptor upregulation and hypertension during oxidative stress. Hypertension, 52: e58, 2008.

Lokhandwala, M.F., Banday, A.A., Bhatt, S. and Javkhedkar, A.: Oxidative stress and transcriptional regulation of angiotensin AT1 receptors in hypertension. Physiol. Res. 57:54P, 2008.

Lokhandwala, M.F., Marwaha, A., Trivedi, M. and Banday, A.A.: Oxidative Stress and renal dopamine D1 receptor function in experimental diabetes. Clin Exp Hypertension, 29:223, 2007.

Banday, A.A., Muhammad, A.B. and Lokhandwala, M.F.: Mechanisms of oxidative stress induced increase in salt sensitivity and development of hypertension in Sprague-dawley rats. Hypertension, 48: e56, 2006.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: ERK1/2 and G-protein coupled receptor kinase 2 are required for insulin induced heterologous dopamine D1 receptor desensitization in renal epithelial cells. J Am Soc Nephrol 17: 594A, 2006.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Oxidative stress induced renal dopamine D1 receptor dysfunction involves NF-kB and protein kinase C activation. J Am Soc Nephrol 17: 450A, 2006.

Banday, A.A., Fasili, F.R. and Lokhandwala, M.F.: G-protein coupled receptor kinase 2 mediates high glucose induced renal dopamine D1 receptor desensitization by interacting with Gάq/11. J Am Soc Nephrol 17: 365A, 2006.

Banday, A.A., Fazili, F.R. and Lokhandwala, M.F.: Chronic insulin treatment phosphorylates ά1 Na, K-ATPase subunit at serine 11/18 and reduces its activity involving phophotidylinositol-3-kinase dependent atypical Protein Kinase C ξ/λ activation. J Am Soc Nephrol 17: 296A, 2006.

Banday, A.A. and Lokhandwala, M.F.: Impaired renal dopamine D1 receptor function contributes to oxidative stress mediated hypertension. Free Radical Research, 40:S152, 2006.

Asghar, M., Fardoun, R.Z., Banday, A.A. and Lokhandwala, M.F.: Oxidative stress-induced activation of nuclear transcription facter NFkB and G-protein coupled receptor kinase 2 causes dopamine D1 receptor G-protein uncoupling in renal proximal tubules of old rats. J. Amer. Soc. Nephrol. 16, 374A, 2005.

Professional Service & Affiliations

  • Council for High Blood Pressure Research, American Heart Association
  • American Society of Nephrology
  • Qualified CSIR-UGC-NET-97 conducted jointly by Council of Scientific and Industrial Research (C.S.I.R) and University Grants Commission (U.G.C.), Government of India