Profile: Hua Chen

Hua Chen
Hua Chen, M.D., Ph.D.
Associate Professor of Pharmaceutical Health Outcomes and Policy

UH College of Pharmacy
Texas Medical Center Campus
1441 Moursund Street, Rm 331
Houston, TX 77030
832-842-8355
832-842-8383 (Fax)
hchen20@uh.edu

Education

Ph.D. in Pharmacy Care Administration, University of Georgia College of Pharmacy, Athens, GA

Master of Science in Pharmacology, Hunan Medical University, China

Medical Degree in General Medicine, Hunan Medical University, China

Awards and Honors

  • Best New Investigator Podium Presentation Award, ISPOR 11th Annual European Congress,  November 8-11, 2008. Athens, Greece.
  • Best Poster Presentation Award, ISPOR 13th Annual International Meeting, May 3-7, 2008. Toronto, ON, Canada.
  • First Place Poster Presentation Award, 8th Annual Health Services and Outcomes Research Conference (Kelsey Research Foundation), December 2007. Houston, TX.

Research Grants (External)

The impact of the FDA antidepressant black box warning on psychiatric practice.
Principal Investigator: Hua Chen
Coinvestigators: Rajender Aparasu, Michael Johnson
Funding Agency: Agency for Healthcare Research and Quality (AHRQ)
Amount of the grant: $70,200
Time period of the grant: March 2007 – June 2009
The impact of the FDA antidepressant black box warning on the utilization of psychotherapy, psychotropic medications, and antidepressant follow-up care among children and adolescents.
Principal Investigator: Hua Chen
Funding Agency: American Association of Colleges of Pharmacy (AACP)
Amount of the grant: $10,000
Time period of the grant: Dec. 2006 – Dec. 2007
Outcomes of Angiogenesis Receptor Blocker Use for Heart Failure in the Elderly
Principal Investigator: Michael Johnson
Coinvestigators: Hua Chen, Robert Morgan
Funding Agency: Agency for Healthcare Research and Quality (AHRQ)
Amount of the grant: $100,000
Time period of the grant: July 2008 – June 2010
Impact of Atypical Antipsychotic Use on Health Care Utilization in the Elderly
Principal Investigator: Rajender Aparasu
Coinvestigators: Hua Chen
Funding Agency: Agency for Healthcare Research and Quality (AHRQ)
Amount of the grant: $100,000
Time period of the grant: March 2008 – Aug. 2010

Research Grants (Internal)

Adverse drug events associated with the off-label uses of the second generation antipsychotic, antidepressant and anticonvulsant medications: An analysis of Food and Drug Administration MedWatch database.
Principal Investigator: Hua Chen
Funding Agency: University of Houston New Faculty Research Award
Amount of the grant: $6,000
Time period of the grant: Feb. 2006 – Aug. 2006

Selected Publications

Johnson ML, Parikh N, Kunik ME, Schulz PE, Patel JG, Chen H, Aparasu RR, Morgan RO. Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus. Alzheimers Dement. 2012 Sep;8(5):437-44.

Palli SR, Kamble PS, Chen H, Aparasu RR. Persistence of stimulants in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2012 Apr;22(2):139-48.

Chatterjee S, Chen H, Johnson ML, Aparasu RR. Risk of falls and fractures in older adults using atypical antipsychotic agents: a propensity score-adjusted, retrospective cohort study. Am J Geriatr Pharmacother. 2012 Apr;10(2):83-94. doi: 10.1016/j.amjopharm.2011.10.006.

Desai RJ, Ashton CM, Deswal A, Morgan RO, Mehta HB, Chen H, Aparasu RR, Johnson ML. Comparative effectiveness of individual angiotensin receptor blockers on risk of mortality in patients with chronic heart failure. Pharmacoepidemiol Drug Saf. 2012 Mar;21(3):233-40. doi: 10.1002/pds.2175.

Chitnis AS, Aparasu RR, Chen H, Johnson ML. Effect of certain angiotensin-converting enzyme inhibitors on mortality in heart failure: a multiple-propensity analysis. Res Social Adm Pharm. 2012 Mar;8(2):145-56.

Chen H, Patel A, Sherer J, Aparasu R. The definition and prevalence of pediatric psychotropic polypharmacy. Psychiatr Serv. 2011 Dec;62(12):1450-5.

Parikh N, Johnson ML, Kunik ME, Chen H, Yadav R, Schulz PE, Mehta H. (2011) Risk factors for dementia in patients over 65 with diabetes. Int J of Geriatr Psychiatry 26(7):749-57.

Mehta S, Chen H, Johnson M, Aparasu RR. (2011) Risk of serious cardiac events in older adults using antipsychotic agents. Am J Geriatr Pharmacother 9 (2): 120-32.

Nagar S, Chen H, Sherer J,  Aparasu RR. (2010) Functional impairment in children and adolescents with depression. CMRO 26 (9): 2057-64.

Mehta S, Chen H, Johnson M, Aparasu RR (2010). Risk of Falls and Fractures in Older Adults Using Antipsychotic Agents: A Propensity-Matched Retrospective Cohort Study. Drugs & Aging 27 (10): 815-29.

Mehta S, Johnson JM, Chen H, Aparasu RR. (2010) Risk of cerebrovascular adverse events in older adults using antipsychotic agents: a propensity-matched retrospective cohort study. J of Clin Psychiatry, 71(6), 689-698.

Essien EJ, Monjok E, Chen H, Abugosh S, Ekong E, Peters RJ, Holmes L, Holstad MM, Mgbere O.(2010) Correlates of HIV knowleges and sexual risk behaviors among female military personnel. AIDS Behav 14 (6): 1401-14.

Kamble P, Chen H, Sherer J, and Aparasu RR. (2010) Off-label use of second-generation antipsychotic agents among elderly nursing home residents. Psychiatric Services 61, 130 -136.

Lal L, Raju A, Miller LA, Chen H, Arbuckle R, Sansgiry S. (2010) Impact of changes in reimbursement policies and institutional practice algorithm for utilization of erythropoietic-stimulating agents on treatment patterns and costs in anemic lymphoma patients. Supportive Care in Cancer 19 (2): 251-9.

Kamble P, Sherer J, Chen H, and Aparasu RR. (2009) Antipsychotic use among elderly nursing home residents with dementia in the United States: An analysis on national survey data. Drugs & Aging, 26 (6), 1- 10.

Aparasu RR, Jano E, Johnson ML, Chen H. (2008) Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients. American Journal of Geriatric Pharmacotherapy, 6 (4), 198- 204.

Kamble P, Chen H, Sherer J, Aparasu RR. (2008) Antipsychotic drug use among elderly nursing home residents in the United States. American Journal of Geriatric Pharmacotherapy, 6 (4), 187-197.

Chen H, Nwangwu A, Aparasu RR, Essien EJ, Sun S, Lee KY. (2008) The impact of Medicare new drug benefit (Part D) on the utilization of psychotropic medications and consequent out of pocket expenditure for community based elderly. Psychiatric Services, 59: 1191-1197.

Jano E, Johnson M, Chen H and Aparasu RR. (2008) Determinants of atypical antipsychotic use among antipsychotic users in community-dwelling elderly, 1996–2004. Current Medical Research and Opinions, 24: 709-716.

Jano E, Chen H, Johnson ML, Aparasu RR. (2007) Antipsychotic utilization and expenditure trends among elderly persons. Psychiatric Services, 58:1400.

Chen H, Kennedy WK, Dorfman JH, Fincham JE, Reeves J, Martin BC. (2007) The effect of adjunctive mood stabilizers on antipsychotic utilization pattern and health resource utilization for Medicaid enrollees with schizophrenia. Current Medical Research and Opinions, 23: 1351-1365.

Chen H, Suda KJ, Turpin RS, Pai MP, Bearden DT, Gary KW. (2007) High- versus low-dose fluconazole therapy for empiric treatment of suspected invasive candidiasis among high-risk patients in the intensive care unit: a cost-effectiveness analysis. Current Medical Research and Opinions, 23: 1057-1065.

Chen H, Reeves J, Fincham JE, Kennedy WK, Dorfman JH, Martin BC. (2006) Prevalence and factors associated with the off-label use of antipsychotic, antidepressant and anticonvulsant medications among Georgia Medicaid eligibles in 2001. Journal of Clinical Psychiatry, 67:972- 982.

Chen H, Cantrell CR. (2006) Prevalence and factors associated with self-reported vaccination rates among US adults at higher risk of vaccine-preventable hepatitis. Current Medical Research and Opinions, 22: 2489- 2496.

Garey KW, Dao T, Chen H, etc., (2006) Timing of Vancomycin Prophylaxis for patients undergoing cardiac surgery and the risk of surgical site infections, Journal of Antimicrobial Chemotherapy, 58(3):645- 650.

Amrutkar PP, Rege MD, Chen H, LaRocco MT, Gentry LO, Gary KW. (2006) Comparison of risk factors for candidemia vs. bacteremia in hospitalized patients: distinguishing candidemia from bacteremia. Infection, 2006 34(6):322- 327.

Presentations & Abstracts

Podium Presentations

Mehta, S, Patel, A, Aparasu, RR, Perez, MO, Chen H. Comparative Effectiveness of Monotherapy with Mood Stabilizers versus Atypical Antipsychotics for the Treatment of Bipolar Disorder in Children and Adolescents: A Retrospective-Claims Data Study. Value in Health 15(4): A5, 2012. ISPOR 17th Annual International Meeting, Washington, D.C., USA, June 2-6, 2012.

Aparasu RR, Chatterjee S, Mehta S, Chen H. Antipsychotic Use and Risk of All-Cause Mortality in Elderly Dual Eligible Beneficiaries. Value in Health 15(4): A3- A4, 2012. ISPOR 17th Annual International Meeting, Washington, D.C., USA, June 2-6, 2012.

Sudharshan L, Chen H. The long term utilization of stimulants in children and adolescents: A Medicaid study. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Bhattacharjee S, Chen H, Bhatara V, Aparasu RR. Comparative Safety of stimulant and atomoxetine associated with the risk of substance use disorder among adolescents with attention-deficit /hyperactive disorder. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Mehta S, Aparasu RR, Chen H, Johnson M. Risk of falls and fractures in older adults using antipsychotic agents- a propensity matched prospective cohort study. Value in Health, 13 (3), A4. ISPOR 15th Annual International Meeting, Atlanta, GA, USA, May 15-19, 2010.

Chitnis AS, Aparasu RR, Chen H, Johnson ML. Comparing binary propensity score analysis with multiple propensity score approach among patients with chronic heart failure. Value in Health, 13 (3), A7. ISPOR 15th Annual International Meeting, Atlanta, GA, USA, May 15-19, 2010.

Mehta S, Chen H, Aparasu RR, Johnson M. Comparison of different propensity score matching methods in elderly antipsychotic users. Value in Health, 13 (3), A8. ISPOR 15th Annual International Meeting, Atlanta, GA, USA, May 15-19, 2010.

Chen H, Obajuluwa T, Johnson M, Aparasu R. The effect of Medicare Part D on inappropriate psychotropic medication use in the elderly. Value in Health, 12 (3), A12. ISPOR 14 Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Chen H, Chaudhari S, Aparasu R, Johnson M. Out of pocket psychotropic prescription burden on elderly Medicare beneficiaries before and after the implementation of Medicare Part D: A Medicaid study. Value in Health, 12 (3), A16. ISPOR 14 Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Nagar SP, Mehta S, Zweifel P, Chen H. Risk of diabetes associated with the use of atypical antipsychotics in children and adolescents- A Texas Medicaid study. Value in Health, 12 (3), A18.  ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Johnson ML, Parikh NM, Kunik M, Schulz P, Chen H, Aparasu R, Yadav R, Morgan R. Anti-hypertensive drug use and risk of dementia in patients with diabetes mellitus. Value in Health, 12 (3), A10. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Chen H, Sudharshan L. The Sustained diagnosis of attention-deficit hyperactivity disorder from childhood to adulthood: A Medicaid study. Value in Health, 11 (6), A339. ISPOR 11th Annual European Congress, Athens, Greece, November 8-11, 2008. Podium Presentation Award

Chen H, Nwangwu A, Aparasu RR, Sun SX, Lee KY. The impact of Medicare new drug benefit (Part D) on the utilization of psychotropic medications and consequent out of pocket expenditure for the elderly. Value in Health. 11(3):A13, 2008. ISPOR 13th Annual International Meeting, May 3-7, 2008 Toronto, ON, Canada.

Shah D, Parikh NM, Kamble PS, Chen H, Johnson M. Can Two A’s Result in a Failure?: Effect of Asiprin on the Risk of Heart Failure Hospitalizations in CHF Patients on ACE Inhibitors. Value in Health. 2008; 11(3), A17. ISPOR 13th Annual International Meeting, May 3-7, 2008 Toronto, ON, Canada.

Jano E, Chen H, Johnson M, Aparasu R. Determinants of atypical antipsychotic use in community-dewelling elderly patients. The Journal of the American Pharmacists Association 2008; 48(2): 237. American Pharmacists Association annual conference, March 14-17, 2008, San Diego, CA.

Obajuluwa T, Raju A, Pandey G, Donga P, Chen H, Aparasu R. Drug utilization patterns among children with otitismedia from 2003 to 2004 in the United States. Research in Social and Administrative Pharmacy, 2007; Vol 3 (3): e12.  Southern Pharmacy Administration Conference, June, 2007, Little Rock, AR.


Poster Presentations

Patel AR, Chen H, Aparasu RR, Sherer JT. The definition and prevalence of psychotropic polypharmacy in Medicaid children and adolescents. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Chatterjee S, Chen H, Johnson ML, Aparasu RR. Risk of falls and fractures in older adults using atypical antipsychotics: a multiple propensity score adjusted retrospective cohort study. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Aparasu RR, Mehta S, Chen H. Risk of death in dual eligible nursing home residents using antipsychotic agents. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Karkare S, Aparasu RR, Chen H, Rajan SS. Antidepressant persistence and associated health care expenditures in children with depression. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Palli SR, Aparasu RR, Chen H, Sherer JT. Persistence of stimulant treatment in children and adolescents with attention deficit hyperactive disorder. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Palli SR, Aparasu RR, Chen H, Sherer JT.  Psychotropic polypharmacy in children and adolescents with attention deficit hyperactive disorder. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Mehta S, Patel A, Chen H. Utilization pattern and treatment adherence with mood stabilizers and atypical antipsychotics among pediatric patients with bipolar disorder: a restropective claims based study. ISPOR 16th Annual International Meeting, Baltimore, MD, USA, May 21-25, 2011.

Aparasu RR, Mehta S, Chen H. Performance of two instrumental variables to examine the risk of death in dual eligible elderly nursing home residents using antipsychotic agents.

Nagar S, Aparasu RR, Chen H, Sherer J. Functional impairment in children and adolescents with depression. Value in Health, 13 (3), A120. ISPOR 15th Annual International Meeting, Atlanta, GA, USA, May 15-19, 2010.

Nagar S, Aparasu RR, Chen H, Sherer J. Health care expenditures in pediatric population with depression in the United States. Value in Health, 13 (3), A118. ISPOR 15th Annual International Meeting, Atlanta, GA, USA, May 15-19, 2010.

Bhowmik D, Chen H, Aparasu RR, Bhatara V. Risk of weight gain with the use of selective serotonin reuptake inhibitors (SSRI) and atypical antipsychotics (SGA) combination treatment in children and adolescents. Value in Health, 13 (3), A180. ISPOR 15th Annual International Meeting, Atlanta, GA, USA, May 15-19, 2010.

Johnson M, Desai R, Morgan R, Ashton CM, Deswal A, Chen H, Aparasu R. A marginal structural model to compare the effectiveness of individual angiotensin receptor blockers in veterans with chronic heart failure. Value in Health, 2009 Oct;12(7):A313. ISPOR 12th European Congress, Paris, France, Oct 24-27, 2009.

Yadav R, Agarwal SJ, Desai R, Chitnis A, Morgan R, Johnson M, Chen H. Effect of ACE inhibitors and ARBs on incidence of renal disease in elderly patients with diabetes. Value in Health, 12 (3), A98. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Parikh NM, Morgan R, Kunik M, Schulz P, Chen H, Aparasu R, Yadav R, Johnson M.  Risk factors for dementia in elderly patients with diabetes mellitus. Value in Health, 12 (3), A99. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Chitnis A, Sharma M, Yadav R, Chen H, Aparasu R, Johnson ML. Comparative effectiveness of individual angiotensin converting enzyme inhibitors in patients with chronic heart failure. Value in Health, 12 (3), A142. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Parikh NM, Shah DH, Deswal A, Ashton CM, Agarwal SJ, Chen H, Johnson M.  The association of asprin use on risk of hospitalization in CHF patients taking ACE inhibitors: A retrospective analysis of a national cohort of veterans. Value in Health, 12 (3), A146. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Pawar DS, Saundankar V, Akinwunmi P, Tseng F, Chen H. The impact of the FDA antidepressant black box warning on the continuity of antidepressant treatment in children with depression. Value in Health, 12 (3), A183. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Bhowmik D, Dwibedi N, Goyal R, Chen H. Effect of black box warning on time to switch from antidepressants to antipsychotics among children suffering from depressive disorders in Texas. Value in Health,12 (3), A184. ISPOR 14th Annual International Meeting, Orlando, FL, USA, May 16-20, 2009.

Chaudhari S, Chen H. Out of Pocket Spending By Elderly Medicare Beneficiaries Before and After Implementation of Medicare Part D. Drug Information Association (DIA) 44th Annual Meeting in Boston, MA, June 22-26, 2008.

Sudharshan L, Chen H. The Sustained Diagnosis Of Attention-Deficit Hyperactivity Disorder rom Childhood To Adulthood: A Medicaid Study. Drug Information Association (DIA) 44th Annual Meeting in Boston, Massachusetts June 22-26, 2008.

Donga PZ, Pandey GS, Chen H. Differential effects of Olanzapine and Clozapine on Type 2 Diabetes: Findings from a Claims Database. Value in Health. 2008; 11(3), A113. ISPOR 13th Annual International Meeting, May 3-7, 2008 Toronto, ON, Canada.

Sudharshan L, Sharma M, Obajuluwa T, Chen H. Risk of Hospitalization Associated with Beta Blocker Therapy in Patients of Chronic Heart Failure and Diabetes: A Medicaid Study. Value in Health. 2008; 11(3), A187. ISPOR 13th Annual International Meeting, May 3-7, 2008 Toronto, ON, Canada.

Sudharshan L, Chen H. "Adverse events associated with the utilization of selective serotonin reuptake inhibitors (SSRIs) antidepressant medications among children: a review of the FDA adverse event reporting system (AERS). The Journal of the American Pharmacists Association 2008; 48(2): 268. Presented at the 8th Annual Health Services and Outcomes Research Conference conducted by Kelsey Research Foundation, Houston, November 6, 2007, Houston, TX, and the American Pharmacists Association annual conference, March 14-17, 2008, San Diego, CA.

Chaudhari  SL., Dasgupta A, Reddy LR, Wattal R, Aparasu R, Chen H. National pattern of prescribing stimulants and antidepressants for adult patients suffering  from attention-deficit disorders in the United States. Research in Social and Administrative Pharmacy, 2007; Vol 3 (3): e11-e12.  Southern Pharmacy Administration Conference, June, 2007, Little Rock, AR.

Abbass I, Chen H. “Adverse event profile associated with off-label use of antipsychotic medications.” Value in Health. 2007; 10(3), A72. ISPOR 12th Annual International Meeting, May 19-23, 2007, Arlington, VA, USA.

Chen H, Martin BC.The impact of prescribing off-label mood stabilizers for patients with schizophrenia. Value in Health 2006; 9(3):A72. 11th International Society for Pharmacoeconomics and Outcomes Research (ISPOR) annual meeting. Philadelphia, PA, May 21, 2006.