Profile: Randall Prince

Randall Prince
Randall A. Prince, Pharm.D., Ph.D., FCCP, FCP, FIDSA 
Professor
Adjunct Professor of Medicine, UT-MD Anderson Cancer Center, Department of Medical Specialties, Section of Infectious Diseases
Department of Clinical Sciences and Administration
UH College of Pharmacy
Texas Medical Center Campus, Room 307
1441 Moursund
Houston, TX 77030
832-842-8389
832-842-8383 (Fax)
RPrince@uh.edu

Education

B.S., Philadelphia College of Pharmacy & Sciences
Pharm.D., Philadelphia College of Pharmacy & Sciences

Research Interests

  • Infectious Diseases
  • Pharmacokinetics

Patents

“Anti-infective Endotracheal Tube,” Rabih O. Dariouche and Randall A. Prince, Patent No. 7,452,345 (awarded November 18, 2008).

Awards & Honors

  • Distinguished Service Award, Society of Infectious Diseases Pharmacists, 2011
  • Fellow, American College of Clinical Pharmacology, 2008
  • Fellow, Infectious Diseases Society of America, 2008
  • UH College of Pharmacy Faculty Achievement Award, 1999
  • Outstanding Service Award, Society of Infectious Diseases Pharmacists, 1997
  • Fellow, American College of Clinical Pharmacy, 1994

Courses

  • Infectious Diseases Pharmacotherapy
  • Infectious Diseases Clerkship
  • Advanced Therapeutics I and II

Selected Journal Articles

Kassamali Z, Rotschafer JC, Jones RN, Prince RA, Danziger LH. Polymyxins: Wisdom Does Not Always Come With Age. Clin Infect Dis. 2013 Jul 12. [Epub ahead of print] PMID: 23728146

Rolston KV, Kapadia M, Tarrand J, Coyle E, Prince RA. Spectrum of gram-positive bacteraemia and in vitro activities of daptomycin, linezolid and vancomycin against organisms isolated from cancer patients. Int J Antimicrob Agents. 2013 Jun;41(6):516-20. doi: 10.1016/j.ijantimicag.2013.01.014. Epub 2013 Mar 6. PMID: 23481658

Lewis RE, Albert NP, Liao G, Wang W, Prince RA, Kontoyiannis DP. High-dose induction liposomal amphotericin B followed by de-escalation is effective in experimental Aspergillus terreus pneumonia. J Antimicrob Chemother. 2013 May;68(5):1148-51. doi: 10.1093/jac/dks521. Epub 2013 Jan 24.

Chaftari AM, Hachem RY, Ramos E, Kassis C, Campo M, Jiang Y, Prince RA, Wang W, Raad II. Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation. Transplantation. 2012 Aug 15;94(3):302-8.

Lewis RE, Liao G, Wang W, Prince RA, Kontoyiannis DP. Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection. Virulence. 2011 Jul-Aug;2(4):348-55.

Lewis RE, Liao G, Hou J, Prince RA, Kontoyiannis DP. Comparative in vivo dose-dependent activity of caspofungin and anidulafungin against echinocandin-susceptible and -resistant Aspergillus fumigatus. J Antimicrob Chemother. 2011 Jun;66(6):1324-31.

Mihu CN, Rhomberg PR, Jones RN, Coyle E, Prince RA, Rolston KV. Escherichia coli resistance to quinolones at a comprehensive cancer center. Diagn Microbiol Infect Dis. 2010 Jul;67(3):266-9.

Yuan Z, Ledesma KR, Singh R, Hou J, Prince RA, Tam VH. Quantitative assessment of combination antimicrobial therapy against multidrug-resistant bacteria in a murine pneumonia model. J Infect Dis. 2010 Mar 15;201(6):889-97.

Lewis RE, Albert ND, Liao G, Hou J, Prince RA, Kontoyiannis DP. Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of pulmonary mucormycosis. Antimicrob Agents Chemother. 2010 Mar;54(3):1298-304.

Stein GE, El-Mortada M, Smith C, Dybas L, Prince R, Havlichek D. Fungicidal activity of anidulafungin in serum from patients does not correlate to its susceptible breakpoint against Candida spp. J Antimicrob Chemother. 2010 Feb; 65 (2):374-6.

Singh R, Ledesma KR, Chang KT, Hou JG, Prince RA, Tam VH. Pharmacodynamics of moxifloxacin against a high inoculum of Escherichia coli in an in vitro infection model. J Antimicrob Chemother. 2009 Sep;64(3):556-62.

Andes D, Diekema DJ, Pfaller MA, Prince RA, Marchillo K, Ashbeck J, Hou J. In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model. Antimicrob Agents Chemother. 2008 52:539-50.17

Vemulakonda GA, Hariprasad SM, Mieler WF, Prince RA, Shah GK, VanGelder RN. Aqueous and vitreous concentrations following topical administration of 1% voriconazole in humans. Arch Opthalmol 2008 126:18-22

Lim TP, Ledesma KR, Chang KT, Hou JG, Kwa AL, Nikolaou M, Quinn JP, Prince RA, Tam VH. Quantitative assessment of combination antimicrobial therapy against multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2008 Aug;52 (8):2898-904.

Kwa AL, Lim TP, Low JG, Hou J, Kurup A, Prince RA, Tam VH. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008 60:163-7.

Lewis RE, Chamilos G, Prince RA, Kontoyiannis DP. Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice. Antimicrob Agents Chemother. 2007 51(3):1078-81.

Lewis RE, Liao G, Hou J, Chamilos G, Prince RA, Kontoyiannis DP. Comparative analysis of amphotericin B lipid complex and liposomal amphotericin B kinetics of lung accumulation and fungal clearance in a murine model of acute invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2007 Apr;51 (4):1253-8.

Hariprasad SM, Shah GK, Mieler WF, Feiner L, Blinder KJ, Holekamp NM, Gao H, Prince RA. Vitreous and aqueous penetration of orally administered moxifloxacin in humans. Arch Ophthalmol. 2006 Feb;124 (2):178-82.

Wiederhold NP, Tam VH, Chi J, Prince RA, Kontoyiannis DP, Lewis RE. Pharmacodynamic activity of amphotericin B deoxycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2006 Feb;50 (2):469-73.

Lewis RE, Wiederhold NP, Prince RA, Kontoyiannis DP. In vitro pharmacodynamics of rapid versus continuous infusion of amphotericin B deoxycholate against Candida species in the presence of human serum albumin. J Antimicrob Chemother. 2006 Feb;57(2):288-93.

Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways. Antimicrob Agents Chemother. 2005 Dec;49 (12):5146-8.

Walker P, Neuhauser MN, Tam VH, Willey JS, Palmer JL, Bruera E, Prince RA. Subcutaneous administration of cefepime. J Pain Symptom Manage. 2005 Aug;30(2):170-4.

Gauthier GM, Nork TM, Prince R, Andes D. Subtherapeutic ocular penetration of caspofungin and associated treatment failure in Candida albicans endophthalmitis. Clin Infect Dis. 2005 Aug 1;41(3):e27-8.

Hariprasad SM, Blinder KJ, Shah GK, Apte RS, Rosenblatt B, Holecamp NM, Thomas MA, Mieler WF, Chi J, Prince RA. Penetration pharmacokinetics of topically administered 0.5% Moxifloxacin ophthalmic solution in human aqueous and vitreous. Arch Opthalmol 2005;123:39-44.

Wiederhold NP, Coyle EA, Raad II, Prince RA, Lewis RE. Antibacterial activity of linezolid and vancomycin in an in vitro pharmacodynamic model of gram-positive catheter-related bacteraemia. J Antimicrob Chemother. 2005 May;55(5):792-5.

Hariprasad SM, Shah GK, Chi J, Prince RA. Determination of aqueous and vitreous concentration of moxifloxacin 0.5% after delivery via a dissolvable corneal collagen shield device. J Cataract Refract Surg. 2005 Nov;31(11):2142-6.

Lewis RE, Wiederhold NP, Lionakis MS, Prince RA, Kontoyiannis DP. Frequency and species distribution of gliotoxin-producing Aspergillus isolates recovered from patients at a tertiary-care cancer center. J Clin Microbiol. 2005 Dec;43(12):6120-2.

Lewis RE, Wiederhold NP, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA. Detection of gliotoxin in experimental and human aspergillosis. Infection and Immunity 2005;73:635-7.

Book Chapters

Coyle E and Prince RA. Urinary tract Infections and Prostatitis. DiPiro J (ed). Pharmacotherapy: A Pathophysiologic Approach, 8th ed, 2011.

Coyle E and Prince RA. Urinary Tract Infections. Linn, W (ed.) Pharmacotherapy in Primary Care, 2009.

Coyle E and Prince RA. Urinary Tract Infections and Prostatitis. DiPiro (ed). Pharmacotherapy: A Pathophysiologic Approach, 7th ed., 2008.

Coyle E and Prince RA. Urinary Tract Infections and Prostatitis. DiPiro (ed). Pharmacotherapy: A Pathophysiologic Approach, 6th ed., 2005.

Editorials/Letters to the Editor

Comment on: Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma. Tam VH, Hou J, Kwa AL, Prince RA. J Antimicrob Chemother. 2009;63: 627-8.

Hsue G, Napier JT, Prince RA, Chi J, Hospenthal DR. Treatment of meningeal coccidioidomycosis with caspofungin. J Antimicrob Chemother 2004;54:292-294.

Presentations & Abstracts

Z. Kassamali*, W. Wang, R. Jones, J. Rotschafer, L. Danziger, R. Prince. Is what you see what you get? Product variation in clinical and reference formulations of polymyxin B. Abstract Nr. 1119, ECCMID meeting, 23rd European Congress of Clinical Microbiology and Infectious Diseases, Berlin, Germany, April 2013.

Singh R, Ledesma KR, Chang KT, Hou JG, Prince RA, Tam VH. Pharmacodynamics of moxifloxacin against a high inoculum of E. coli. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Ullman MA, Mitropoulos IF, Hovde LB, Prince RA, Rotschafer JC. In vitro Pharmacodynamic evaluation of meropenem and colistin against multidrug-resistant A. baumannii. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Lewis RE, Liaio G, Hou J, Prince RA, Kontoyiannis DP. Comparison of caspofungin and anidulafungin activity against echinocandin-susceptible and -resistant A. fumigatus in a neutropenic murine model of invasive pulmonary aspergillosis. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Lewis RE, Albert ND., Hou J, Prince RA, Kontoyiannis DP. Comparative pharmacodynamics of amphotericin B lipid complex and liposomal amphotericin B in a murine model of acute invasive pulmonary zygomycosis. 48th Annual ICAAC/IDSA 46th Annual Meeting, Washington, D.C., Oct. 25-28, 2008.

Kwa A., Lim T., Low J., Hou J., Kurup A, Prince R., and Tam V., Pharmacokinetics of Polymyxin B in Patients with Multi-Drug Resistant Gram-Negative Bacterial Infections, Abstract #A-10, Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, September 2007.

Editorial Appointments

  • Editorial Board Member, Journal of Infectious Disease Pharmacotherapy
  • Journal Reviewer: Journal of Chromatography B; Antimicrobial Agents Chemotherapy; Journal of Applied and Environmental Microbiology
  • Fellowship Reviewer, American College of Clinical Pharmacy

Memberships

  • American Association of Pharmaceutical Scientists, 1999-present
  • American College of Clinical Pharmacy, 1998-present
  • Infectious Diseases Society of America, 2001-present
  • International Immunocompromised Host Society, 2001-present
  • The Society of Infectious Diseases Pharmacists, 1989-present
  • Rho Chi Honor Society, 1973-present