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Sunny
E. Ohia, Ph.D. |
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| Office of
the Dean |
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| 713-743-1252 |
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PCOL 6371 Advanced Pharmacology II |
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Research interests in the pharmacology
of receptors and signal transduction pathways for neurotransmitters
in the mammalian eye. Studies are directed toward identifying and
characterizing subtypes of prejunctional (autoreceptors and heteroreceptors)
and postjunctional receptors in the iris-ciliary body and retina.
Receptors of interest include those for norepinephrine, acetylcholine,
serotonin, prostaglandins, dopamine, histamine and neuropeptides.
Research techniques include in vitro assays of neurotransmitter
release, organ bath studies, receptor binding studies and radioimmunoassay
of hormones and second messengers, and in vivo measurement of intraocular
pressure in experimental animals. Extensive characterization of
mechanism of glutamate-induced excitotoxicity and neuroprotection
in mammalian retina. Other research interests include studies on
the regulation of uveal norepinephrine release by oxidative stress,
mechanism of intraocular lowering effect of bicyclic hexahydroaporphines.
The goal of this research is to identify potential target sites
that might be of importance in the therapy of ocular diseases such
as glaucoma, uveitis and retinal degenerations. |
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Omnicron Delta Kappa; Texas Pharmacy Association;
American Pharmaceutical Association; American Society for Health-System
Pharmacists; Texas Society of Health-System Pharmacists; Texas Pharmacy
Congress; Oxygen Society; Nitric Oxide Society; The Association
of African Biomedical Scientists; National Pharmaceutical Association;
Catecholamine Club; Association for Ocular Pharmacology and Therapeutics;
Western Pharmacological Society; British Pharmacological Society;
International Society for Eye Research; Sigma Xi; American Association
of Colleges of Pharmacy; The American Society for Pharmacology and
Experimental Therapeutics; The Association for Research in Vision
and Ophthalmology |
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LeDay, A.M., Awe, S.O., Kulkarni, K.H., Harris,
L.C., Opere, C., Dash, A. and Ohia, S.E.: Effect of Peroxides on
[3H]D-Aspartate Release from Bovine Isolated Retinae. Neurochemical
Research 29:811-818, 2004. LeDay, A.M., Kulkarni, K.H., Opere, C.A. and Ohia, S.E.: Arachidonic Acid Metabolites and Peroxide-Induced Inhibition of [3H]D-Aspartate Release from Bovine Isolated Retinae. Current Eye Research 28:367-372, 2004. Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D.: Safety Assessment of (-) - Hydroxycitric Acid and Super citriMax (R), a Novel Calcium/Potassium Salt. Food and Chemical Toxicology 42:1513-1529, 2004. Opere, C.A., WeiDong, Z., Huang, J., Adewale, A., Kruglet, M., Ohia, S.E.: Dual Effect of Isoprostanes on the Release of [3H]D-aspartate from Isolated Bovine Retinae: Role of Arachidonic Acid Metabolites. Neurochemical Research, 30:129-137, 2005.
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Bagchi, D., Shara, M., Ohia, S.E., Yasmin, T., Bagchi, M., Chatterjee, A., Stohs, S.J.: Safety Studies on a Novel, Natural Extract of (-)-Hydroxycitric Acid, a Supplement for Weight Management. Abstract presented to the Society of Toxicology 43rd Annual Meeting, Baltimore, MD, March 21-25, 2004. Shivers, K., Appiah, J., Kulkarni, K., Monjok, E., Opere, C.A., Ohia, S.E.: Inhibitory Adenosine Receptors in Isolated Porcine Irides. FASEB J. 18: Abstract No. 399.9, p. A585, 2004. McConnell, A., Williams, R., Shivers, K., Kulkarni, D., Monjok, E., Opere, C.A., Ohia, S.E.: Pharmacological Characterization of Prostanoid FP-Receptors in Isolated Porcine Irides. FASEB J. 18: Abstract No. 403.12, p. A598, 2004. Adewale, A., Opere, C.A., Kulkarni, K., Ohia, S.E.: Regulation of Potassium Induced [3H]D-Aspartate Release by Isoprostanes in Isolated Bovine Retinae. Abstract presented to the Experimental Biology Annual Meeting, Washington, D.C., April 17 – 21, 2004. Huang, J., Opere, C.A., Ohia, S.E.: Effect of Isoprostanes on Potassium-Induced [3H]GABA Release from Isolated Bovine Retinae. Abstract presented to the Experimental Biology Annual Meeting, Washington, D.C., April 17 – 21, 2004. Monjok, E., Shivers, K.L., Kulkarni, K.H., Opere, C.A., Ohia, S.E.: Atypical H1-Receptors Mediate Contractions of Porcine Isolated Irides to Histamine. Abstract presented to the Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL, April 25 – 29, 2004. Roche, V.F., Kulkarni, K.H., Shivers, K.L., Opere, C.A., Ohia, S.E.: Effect of a Bicyclic Hexahydroaporphine on Potassium Evoked [3H]D-Aspartate Release from Porcine Isolated Retinae. Abstract presented to the Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL, April 25 – 29, 2004. Opere, C.A., Adeniran, A.O., Huang, J., Zheng, W.D., Ohia, S.E.: Isoprostane-induced Inhibition of [3H]D-Aspartate Release from Bovine Isolated Reinae: Role of Prostanoids. Abstract presented to the Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL, April 25 – 29, 2004. Kulkarni, K.H., Shivers, K.L., Monjok, E.M., Opere, C.A., Ohia, S.E.: Regulation of 3H]D-Aspartate Release from Pig Isolated Retinae by Prostaglandins. Abstract presented to the Association for Research in Vision and Ophthalmology Annual Meeting, Fort Lauderdale, FL, April 25 – 29, 2004. |
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