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College of Pharmacy Faculty
Department of Phamacological and Pharmceutical Sciences

Richard A. Bond, Ph.D.
Associate Professor

Selected Recent Publications

Edwards, S., Hoyler, S.L., Bond, R.A., Wilcox, R.E.: Sensitization of ß2-adrenoceptor mediated cAMP generation after exposure to inverse agonists. In preparation.

Xiao, R-P., Zhu, W., Zheng, M., Chakir, K., Bond, R.A., Lakatta, E.G. and Cheng, H.: Subtype-specific ß-adrenergic signaling pathways in the heart and their potential clinical implications. Trends Pharmacol. Sci. 25: 358-365, 2004.

Callaerts-Végh Zs, Evans KLJ, Dudekula N, Cuba D, Knoll BJ, Callaerts P, Giles H, Shardonofsky FR, Bond RA.: Effects of acute and chronic administration of ß-adrenoceptor ligands on airway function in a murine model of asthma. Proc. Nat. Acad. Sci. 101: 4948-4953, 2004.

Callaerts-Vegh, Zs., Evans, K.J., Shipley, G.L., Davies, P.J.A., Cuba, D.L., Gurji, H.A., Giles, H. and Bond, R.A.: Effects of different beta-adrenoceptor ligands in mice with permanent occlusion of a coronary artery. Br. J Pharmacol.;138: 1505-16, 2003.

Xiao, R-P., Zhang, S-J., Chakir, K., Avdonin, P., Weizhong, Z., Bond, R.A., Balke, W.C., Lakatta, E.G. and Cheng, H.: Enhanced Gi signaling selectively negates ß2-AR, but not ß1-AR, mediated positive inotropic effect in myocytes from failing rat hearts. Circulation, 108:1633-1639, 2003.

Flesch, M., Hoper, A., Evans, K.J., Bond, R.A., Peshock, R., Diwan, A., Brinsa, T.A.,n Wei, C-C., Sivasubramanian, N., Spinale, F.G. and Mann, D.: Activation and functional significance of the renin angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor. Circulation. 108: 598-604, 2003.

Evans, K.J., Bond, R.A., Corry, D., and Shardonofsky, F.: Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma. J. Applied Physiol. 94: 245-252, 2003.

Bond, R.A.: Can intellectualism stifle scientific discovery? Nature Rev. Drug Discovery. 10: 825-829, 2002.

Liu, X., Callaerts-Vegh, Zs., Evans, K. and Bond, R.A.: Chronic Infusions of Antagonists and Inverse Agonists Produces Heterologous Sensitization in Transgenic Mice with Cardiac-Specific Overexpression of the Human ß2-adrenoceptor J. Cardiovasc. Pharmacol. 40: 448-455, 2002.

Bond, R.A.: Is Paradoxical Pharmacology a strategy worth pursuing? Trends Pharmacol. Sci 22: 273-276, 2001.

Franceshini, D., Orr-Urtreger, A., Yu, W. Mackey, L.Y., Bond, R.A., Armstrong, D., Patrick, J.W., Beaudet, A.L., and De Bisai, M.: Altered baroreceptor reflex in a7 deficient mice. Behav. Brain Res. 113: 3-10, 2000.

Bylund, D.B., Bond, R.A., Bouvier, M., Clarke, D.E., Eikenburg, D.C., Hieble, J.P., Kobilka, B.K., Langer, S.Z., Lefkowitz, R.J., Minneman, K.P., and Ruffolo, R.R.: Adrenoceptors. The IUPHAR compendium of receptor characterization and classification, 88-103, 2000.

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