Don Coltart - University of Houston
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Don Coltart

Don Coltart

Don  Coltart
Associate Professor
Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center
Ph.D.,  University of Alberta, 2000
M.Sc., University of Manitoba, 1995
B.Sc., University of Manibota, 1993

Department of Chemistry
University of Houston
Houston, Texas 77204-5003

Office: SERC 5008
Phone: 713.743.8762   
coltart @uh.edu

45)  Diastereoselective addition of Grignard reagents to a-epoxy N-sulfonyl hydrazones.  Uteuliyev, M. M.; Nguyen, T. T.; Coltart, D. M. Nature Chem. 2015, 7, 1024–1027.

44)  A Concise and Highly Enantioselective Total Synthesis of (+)-anti- and (–)-syn-Mefloquine Hydrochloride: Definitive Absolute Stereochemical Assignment of the Mefloquines.  Rastelli, E. J.; Coltart, D. M. Angew. Chemie. Int. Ed. 2015, 127, 14276–14280.

43)  The Apratoxin Marine Natural Products: Isolation, Structure Determination, and Asymmetric Total Synthesis. Tarsis, E. M.; Rastelli, E. J.; Wengryniuk, S. E.; Coltart, D. M. Tetrahedron 2015, 71, 5029–5044.

42)  A Formal Asymmetric Synthesis of Apratoxin D via Advanced-Stage Asymmetric ACC a,a-Bisalkylation of a Chiral Nonracemic Ketone. Dey, S.; Wengryniuk, S. E.; Tarsis, E. M.; Robertson, B. R.; Zhou, G.; Coltart, D. M. Tetrahedron Lett. 2015, 56, 2927–2929.

41)  Asymmetric Synthesis of Structural Analogues of (+)-Clusianone via Enantioselective ACC Alkylation.  Garnsey, M. R.; Uteuliyev, M.; Coltart, D. M. (Invited submission to Tetrahedron Lett. Harry Wasserman Memorial Issue) Tetrahedron Lett. 2015, 56, 3183–3185.

40)  Expanding the Scope of the Asymmetric Anti-Aldol Addition of Chiral N-Amino Cyclic Carbamate Hydrazones. Knight, J. D.; Coltart, D. M. Tetrahedron Lett. 2013, 54, 5470–5472.

39)  Asymmetric Anti-Aldol Addition of Achiral Ketones via Chiral N-Amino Cyclic Carbamate Hydrazones.  Knight, J. D.; Coltart, D. M. Chem. Commun. 2013, 49, 7495–7497.

38)  Asymmetric Total Synthesis of Apratoxin D.  Robertson, B. D.; Wengryniuk, S. E.; Coltart, D. M. Org. Lett. 2012, 14, 5192–5195.

37)  Catalytic Asymmetric Addition of Thiols to Nitrosoalkenes: An Umpolung Strategy for the Synthesis of Chiral Non-Racemic α-Sulfenyl Ketones.  Hatcher, J. M.; Kohler, M. C.; Coltart, D. M. Org. Lett. 2011, 13, 3810–3813.

36)  Asymmetric Total Synthesis of the Anti-Malarial Drug (+)-Mefloquine Hydrochloride via Chiral N-Amino Cyclic Carbamate Hydrazones.  Knight, J. D.; Sauer, S. J.; Coltart, D. M. Org. Lett. 2011, 13, 3118–3121.

35)   Regioselective Asymmetric a,α-Bisalkylation of Ketones via Complex Induced Syn-Deprotonation.  Wengryniuk, S. E.; Lim, D.; Coltart, D. M. J. Am. Chem Soc. 2011, 133, 8714–8720.

34)   Asymmetric Total Synthesis of (+)- and (–)-Clusianone and (+)- and (–)-Clusianone Methyl Enol Ether via ACC Alkylation and Evaluation of their Anti-HIV Activity.  Garnsey, M. R.; Matous, J. A.; Kwiek, J. J.; Coltart, D. M. Bioorg. Med. Chem. Lett.  2011, 21, 2406–2409. 

33)   Direct Carbon–Carbon Bond Formation via Soft Enolization: Aldol Addition of α-Halogenated Thioesters.  Yost, J. M.; Alfie, R.; Tarsis, E. T.; Coltart, D. M. Chem. Commun. 2011, 47, 571–572.

32)   The Origins of Stereoselectivity in the α-Alkylation of Chiral Hydrazones.  Krenske, E. H.; Houk, K. N.; Lim, D.; Wengryniuk, S. E.; Coltart, D. M. J. Org. Chem. 2010, 75, 8578–8584.

31)   Development of a Strategy for the Asymmetric Synthesis of Polycyclic Polyprenylated Acylphloroglucinols via N-Amino Cyclic Carbamate Hydrazones: Application to the Total Synthesis of (+)-Clusianone.  Garnsey, M. R.; Lim, D.; Yost, J. M.; Coltart, D. M. Org. Lett. 2010, 12, 5234-5237.

30)   Direct Carbon–Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled Syn-Aldol Addition of α-Halo Thioesters.  Sauer, S. J.; Garnsey, M. R.; Coltart, D. M. J. Am. Chem. Soc. 2010, 132, 13997–13999.

29)   Direct Carbon–Carbon Bond Formation via Soft Enolization: A Biomimetic Asymmetric Mannich Reaction of Phenylacetate Thioesters.  Kohler, M. C; Yost, J. M.; Garnsey, M. R.; Coltart, D. M. Org. Lett. 2010, 12, 3376–3379.  

28)   Copper-(I) Catalyzed Addition of Grignard Reagents to In Situ-Derived N-Sulfonyl Azoalkenes: An Alkylation Procedure Applicable to the Formation of up to Three Contiguous Quaternary Centers.  Hatcher, J. M.; Coltart, D. M. J. Am. Chem. Soc. 2010, 132, 4546–4547.   

27)   A Practical Synthesis of β-Keto Thioesters via Direct Crossed-Claisen Coupling of Thioesters and N-Acylbenzotriazoles.  Zhou, G.; Lim, D.; Coltart, D. M. Synthesis 2009, 3350–3352.

26)   Direct Carbon–Carbon Bond Formation via Soft Enolization of Thioesters: An Operationally Simple Mannich Addition Reaction.  Yost, J. M.; Garnsey, M. R.; Kohler, M. C.; Coltart, D. M. Synthesis, 2009, 56–58. 

25)   Overcoming the Limitations of the Baylis-Hillman Reaction: A Rapid and General Synthesis of α-Alkenyl β-Hydroxy Thioesters.  Tarsis, E. T.; Gromova, A.; Lim, D.; Zhou, G.; Coltart, D. M. Org. Lett. 2008, 10, 4819–4822. 

24)   Direct Carbon–Carbon Bond Formation via Chemoselective Soft Enolization of Thioesters: A Remarkably Simple and Versatile Crossed-Claisen Reaction Applied to the Synthesis of LY294002.  Zhou, G.; Lim, D.; Coltart, D. M. Org. Lett. 2008, 10, 3809–3812.

23)   Simple and Efficient Asymmetric α-Alkylation and a,α-Bisalkylation of Acyclic Ketones Using Chiral N-Amino Cyclic Carbamate Hydrazones.  Lim, D.; Coltart, D. M. Angew. Chem. Int. Ed. 2008, 47, 5207–5210.   

22)   MgBr2-OEt2 - Promoted Coupling of Ketones and Activated Acyl Donors via Soft Enolization: A Practical Synthesis of 1,3-Diketones.  Lim, D.; Zhou, G.; Livanos, A. E.; Fang, F.; Coltart, D. M. Synthesis, 2008, 2148–2152. 

21)   A Facile and Efficient Anti-Selective Four-Component Direct Aldol Addition via Chemoselective Thioester Enolate Formation.  Zhou, G.; Yost, J. M.; Sauer, S.; Coltart, D. M. Org. Lett. 2007, 9, 4663–4665. 

20)   Direct Carbon–Carbon Bond Formation via Soft Enolization: A Facile and Efficient Synthesis of 1,3-Diketones.  Lim, D.; Fang, F.; Zhou, G.; Coltart, D. M. Org. Lett. 2007, 9, 4139–4142. 

19)   A Direct Aldol Addition of Simple Thioesters Employing Soft Enolization.  Zhou, G.; Yost, J. M.; Coltart, D. M. Synthesis 2007, 478–482. 

18)   A Facile and Efficient Direct Aldol Addition of Simple Thioesters.  Yost, J. M.; Zhou, G.; Coltart, D. M. Org. Lett. 2006, 8, 1503–1506. 

Graduate and Postdoctoral

17)   Derivatized Amino Acids Relevant to Protein Synthesis by Native Chemical Ligation.  Clive, D. L. J.; Hisaindee, S.; Coltart, D. M. J. Org. Chem. 2003, 68, 9247–9254.

16)   A Novel Synthetic Approach to the 8,10-Dimethyl Anti-Syn-Anti Perhydrophenanthrene Skeleton.  Coltart, D. M.; Danishefsky, S. J. Org. Lett. 2003, 5, 1289–1292.

15)   Hydroxynorleucine as a Glycosyl Acceptor is an Efficient Means for Introducing Amino Acid Functionality into Complex Carbohydrates.  Keding, S. J.; Endo, A.; Biswas, K.; Zatorski, A.; Coltart, D. M.; Danishefsky, S. J. Tetrahedron Lett. 2003, 44, 3413–3416.  

14)   On the Power of Chemical Synthesis: Immunological Evaluation of Models for Multiantigenic Carbohydrate-Based Cancer Vaccines.  Ragupathi, G.; Coltart, D. M.; Williams, L. J.; Koide, F.; Kagan, E.; Allen, J.; Harris, C.; Glunz, P. W.; Livingston, P. O.; Danishefsky, S. J. Proc. Natl. Acad. Sci. (U.S.A.) 2002, 99, 13699–13704.

13)   Construction of Carbohydrate-Based Antitumor Vaccines: Synthesis of Glycosyl Amino Acids by Olefin Cross-Metathesis.  Biswas, K.; Coltart, D. M.; Danishefsky, S. J. Tetrahedron Lett. 2002, 43, 6107–6110. 

12)   Principles of Mucin Architecture: Structural Studies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri- and Hexasaccharide Glycodomains.  Coltart, D. M.; A. K. Royyuru; Williams, W. J.; Glunz, P. W.; Sames, D.; Kuduk, S. D.; Schwarz, J. B.; Chen, X.-T.; Danishefsky, S. J.; Live, D. H. J. Am. Chem. Soc. 2002, 124, 9833–9844. 

11)   Constructing an Adenocarcinoma Vaccine: Immunization of Mice with Synthetic KH-1 Nonasaccharide Stimulates Anti-KH-1 and Anti-Ley Antibodies.  Ragupathi, G.; Deshpande, P. P.; Coltart, D. M.; Kim, H. J.; Williams, L. J.; Danishefsky, S. J.; Livingston, P. O. Intl. J. Cancer 2002, 99, 207–212. 

10)   Synthesis of the Naturally Occurring ACE Inhibitors (–)-A58365A and (–)-A58365B, and of an Unnatural but Biologically Active Analog.  Clive, D. L. J.; Coltart, D. M.; Zhou, Y.; de Lima, D. P.; Yang, H.; Lewanczuk, R. Z.  In Actualité de Chimie Thérapeutique, French Society of Medicinal Chemistry, 2002, 28th series, 21–50.   

9)     Peptide Segment Coupling by Prior Ligation and Proximity-Induced Intramolecular Acyl Transfer.  Coltart, D. M. Tetrahedron 2000, 56, 3449–3491. (Review) 

8)     Studies on the Preparation of 3,4-Disubstituted 2-Methoxypyridines.  Pelisson, M. M.; da Silva, G. V. J.; Clive, D. L. J.; Coltart, D. M.; Hof, F. A. J. of Heterocycl. Chem. 1999, 36, 653–658.

7)     Synthesis of the Angiotensin-Converting Enzyme Inhibitors (–)-A58365A and (–)-A58365B from a Common Intermediate.  Clive, D. L. J.; Coltart, D. M.; Zhou, Y. J. Org. Chem. 1999, 64, 1447–1454. 

6)     Synthesis of the Angiotensin-Converting Enzyme Inhibitor (±)-A58365A.  Clive, D. L. J.; Coltart, D. M. Tetrahedron Lett. 1998, 39, 2519–2522. 

5)     The Asymmetric Synthesis of Aryltetralin Lignans: (–)-Isolariciresinol Dimethyl Ether and (–)-Deoxysikkimotoxin.  Coltart, D. M.; Charlton, J. L. Can. J. Chem. 1996, 74, 88–94. 

Book Chapters and Encyclopedia Articles

4)    Asymmetric Alkylations in Stereoselective Synthesis.  Kohler, M. C.; Wengryniuk, S. E.; Coltart, D. M. in Stereoselective Synthesis of Drugs and Natural Products; Andrushko, V.; Andrushko, N. Eds. (submitted to Wiley-Blackwell) (Book chapter).

3)     Bis(phenylthio)methane.  Hatcher, J. M.; Coltart, D. M. in Encyclopedia of Reagents for Organic Synthesis; Fuchs, P. L. Ed.; John Wiley & Sons: 2011 (Encyclopedia Article).

2)     Tris(2-carboxyethyl)phosphine Hydrochloride.  Yost, J. M.; Knight, J. D.; Coltart, D. M. in Encyclopedia of Reagents for Organic Synthesis; Crich, D. Ed.; John Wiley & Sons: 2009 (Encyclopedia Article).

1)     Triphenylmethanethiol.  Garnsey, M. R.; Wengryniuk, S. E.; Coltart, D. M. in Encyclopedia of Reagents for Organic Synthesis; Crich, D. Ed.; John Wiley & Sons: 2009 (Encyclopedia Article).