Steven J. Bark
Department of Biology and Biochemistry
Office: Science & Engineering Research Center, 4022
Contact: firstname.lastname@example.org - (713) 743-9638
Education: Ph.D., The Scripps Research Institute
Google Scholar Profile
Pathogenic bacteria adapt to external stresses such as starvation, the immune system, and antibiotics in a manner to enhance bacterial pathogenesis, infectivity, and survival. The focus of Dr. Steven Bark’s research is to understand the molecular mechanisms regulating these stress-adaptive responses in Micrococcus luteus, a gram-positive bacterial relative of the pathogenic bacteria M. tuberculosis (tuberculosis) and M. leprae (leprosy). Bark’s lab is using mass spectrometry, analytical protein chemistry, and molecular and cell biology approaches to dissect the protein signaling and interaction networks that define these diverse stress responses at the molecular level. This knowledge will provide critical insight into how pathogenic bacteria adapt to external stresses, contribute understanding of host-pathogen relationships, and identify novel molecular approaches to therapeutically target bacteria exploiting these stress responses for survival.