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Faculty Profile

Amy K. SaterMaria Bondesson

Research Assistant Professor
Department of Biology and Biochemistry

Office: SERC 3028
Contact: - (832) 842-8805

Molecular Toxicology

Consumers are constantly exposed to thousands of industrial chemicals and a major exposure route is through different food items. Many of these chemicals interact with the fine tuned hormone system in the human body and are therefore referred to as endocrine disrupting chemicals. Research indicates that endocrine disrupting chemicals contribute to a wide range of human diseases such as obesity, atherosclerosis, type 2 diabetes, osteoporosis, breast-, prostate- and colon cancer and reproductive disturbances. These diseases are becoming increasingly common and are a considerable burden on society and the economy at a global level. My research interest is to study how environmental pollutants affect human health. We are currently running several research projects on environmental pollutants. In the first project we study how the enodcrine disrupting chemical bisphenol A in combination with phytoestrogens affect signaling of the estrogen receptors. The second project uses zebrafish as a model system to detect chemical pollutants that perturb embryonic development. For more information on this project see http// In a third project we develop zebrafish screening methods for detection of chemicals that cause obesity and diabetes.

  • Pinto CL, Kalasekar SM, McCollum CW, Riu A, Jonsson P, Lopez J, Swindell EC, Bouhlatouf A, Balaguer P, Bondesson M, Gustafsson JÅ. Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Mol Cell Endocrinol. 2016 419:29-43
  • Gorelick DA, Pinto CL, Hao R, Bondesson M. Use of Reporter Genes to Analyze Estrogen Response: The Transgenic Zebrafish Model. Methods Mol Biol. 2016;1366:315-25
  • Ducharme NA, Reif DM, Gustafsson J-Å, Bondesson M. Comparison of toxicity values across zebrafish and mammalian studies: implications for chemical testing. Reproductive Toxicology 2015 55:3-10
  • Kalasekar SM, Zacharia E, Kessler N, Ducharme NA, Gustafsson JA, Kakadiaris IA and Bondesson M. Identification of environmental chemicals that induce yolk malabsorption in zebrafish through automated image segmentation. Reproductive Toxicology 2015 55:20-29
  • Bondesson M, Hao R, Lin C-Y, Williams C and Gustafsson J-Å. Estrogen receptor signaling during vertebrate development. Biochim Biophys Acta Gene Regulatory Mechanisms 2015 1849(2):142-151
  • Tal TL, McCollum CW, Harris PS, Olin J, Kleinstreuer N, Wood, CM, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TK, Padilla S, Hemmer MJ. Immediate and long term consequences of vascular toxicity during development using a quantitative vascular disruption assay in zebrafish. Reproductive Toxicology 2014 48:51-61
  • Pinto C, Grimaldi M, Boulahtouf A, Pakdel F, Brion F, Aït-Aïssa S, Cavaillès V, Bourguet W, Gustafsson J-Å, Bondesson M, Balaguer P. Characterization of zebrafish estrogen receptors subtype selectivity of natural, pharmaceutical and environmental estrogens. Toxicology and Applied Pharmacology 2014 280(1):60-69
  • McCollum CW, Hans C, Shah S, Merchant FA, Gustafsson J-Å and Bondesson M. Embryonic exposure to sodium arsenite perturbs vascular development in zebrafish. Aquatic Toxicology 2014 152C:152-163
  • Hans C, McCollum C, Bondesson M, Gustafsson J-Å, Shah S, Merchant F. Automated analysis of zebrafish images for screening toxicants. Conference Proceedings IEEE Engineering in Medicine and Biology Society 2013 30043007
  • Le YH, Ducharme NA, Bondesson M, Kakadiaris IA. A framework for building multi-tissue atlas of zebrafish embryo. In Proc. IEEE 11th International Symposium on Biomedical Imaging. 2014 Biomedical Imaging (ISBI), 750-753
  • Williams C, Bondesson M, Krementsov DN, Teusher C. Gestational bisphenol A exposure and testis development. Endocrine Disruptors 2014 2: e29088
  • Riu A, McCollum CW, Pinto C, Grimaldi M, Hillenweck A, Perdu E, Zalko D, Bernard L, Laudet V, Balaguer P, Bondesson M, Gustafsson J-Å. Halogenated Bisphenol A analogs act as obesogens in zebrafish larvae (Danio rerio). Toxicological Sciences 2014 139(1):48-58
  • Katchy A, Pinto C, Jonsson P, Vu T, Pandelova M, Schramm K-W, Gustafsson J-Å, Bondesson M, Williams C. Co-exposure to phytoestrogens and bisphenol A mimic estrogenic effects in a additive manner. Toxicol Sci. 2014 138(1):21-35
  • Hao R, Bondesson M, Singh AV, Riu A, McCollum CW, Knudsen TB, Gorelick DA, Gustafsson JÅ. Identification of Estrogen Target Genes during Zebrafish Embryonic Development through Transcriptomic Analysis. PLoS One. 2013 8(11):e79020
  • Ducharme NA, Peterson LE, Reif D, Benfenati E, McCollum CW, Gustafsson JA and Bondesson M. Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies. Reproductive Toxicology 2013 41:98108
  • Shirinifard A, McCollum CW, Bondesson M, Gustafsson JA, Glazier JA, Clendenon SG. 3D quantitative analyses of angiogenic sprout growth dynamics. Dev Dyn. 2013 242(5):518-26
  • Thomas C, Rajapaksa G, Nikolos F, Hao R, Katchy A, McCollum C, Bondesson M, Quinlan P, Thompson A, Krishnamurthy S, Esteva F, Gustafsson J-A. ERbeta represses basal breast cancer EMT by destabilizing EGFR. Breast Cancer Res. 2012 14(6):R148
  • Zacharia E, Bondesson M, Gustafsson J-Å and Kakadiaris I. Segmentation of Zebrafish Embryonic Images using a Geometric Atlas Deformation. Conference Proceedings IEEE Engineering in Medicine and Biology Society 2012 39984001
  • Chatonnet F, Guyot R, Picou F, Bondesson M, Flamant F. Genome-Wide Search Reveals the Existence of a Limited Number of Thyroid Hormone Receptor Alpha Target Genes in Cerebellar Neurons. PLoS ONE 2012 7(5): e30703.
  • McCollum CW, Ducharme NA, Bondesson M and Gustafsson J-A. Developmental toxicity screening in zebrafish. Birth Defects Research (Part C) 2011 93:67114
  • Zacharia E, Bondesson M, Riu A, Ducharme NA, Gustafsson JA, Kakadiaris IA. Automatic segmentation of time-lapse microscopy images depicting a live Dharma embryo. Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:8082-5.
  • Hans C, Shete A, Shah SK, McCollum CW, Bondesson M, Merchant FA. 3D imaging for quantitative assessment of toxicity on vascular development in zebrafish. Conf Proc IEEE Eng Med Biol Soc. 2011 Aug;2011:5969-72.
  • Bondesson M and Gustafsson J-A. Does consuming isoflavones reduce or increase breast cancer risk? Genome Medicine 2010 2(12):90
  • Bondesson M, Jonsson J, Pongratz I, Olea N, Cravedi J-P, Zalko D, Hakansson H, Halldin K, Di Lorenzo D, Behl C, Manthey D, Balaguer P, Demeneix B, Fini JB, Laudet V, Gustafsson J-A. A CASCADE of Effects of Bisphenol A, Reproductive Toxicology, 2009 28(4):563-7
  • Turowska O, Nauman A, Pietrzak M, Poplawski P, Master A, Nygard M, Bondesson M, Tanski Z and Puzianowska-Kuznicka M. Overexpression of E2F1 in clear cell Renal Cell Carcinoma: a potential impact of erroneous regulation by thyroid hormone nuclear receptors. Thyroid 2007 17(11):1039-48
  • Nygård M, Becker N, Demeneix B, Pettersson K and Bondesson M (2006). Thyroid hormone-mediated negative transcriptional regulation of necdin expression. Journal of Molecular Endocrinology 36(3), 517-30
  • Bondesson M and Gustafsson JÅ (2006) Chemical Contaminants in food: The CASCADE Network of Excellence. Food Science and Technology 20; 34-36
  • Demeneix B, Gustafsson JÅ, Bondesson M et al. (2005) Vote REACH for the safer management of chemicals in EU. Financial Times Nov 7
  • Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist L, Ruas JL, Poellinger L, Lendahl U and Bondesson M (2005). Hypoxia requires notch signaling to maintain the undifferentiated cell state. Developmental Cell 9, 617-628
  • Nygård M., Wahlström G.M., Tokumoto Y.M., Gustafsson M.V. and Bondesson M. (2003) Hormone-dependent repression of the E2F-1 gene by thyroid hormone receptors. Molecular Endocrinology 17, 79-92
  • Ichimura K., Bondesson M., Goike H., Schmidt E., Moshref A. and Collins VP. Deregulation of the p14 ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1/S transition control gene abnormalities. Cancer Research 2000 60, 417-424
  • Wahlström G., Vennström B. and Bondesson M. The adenovirus E1A oncoprotein is a potent coactivator for thyroid hormone receptors. Molecular Endocrinology 1999 13:1119-1129
  • Castro D., Arvidsson M., Bondesson M. and Perlmann T. Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2. The Journal of Biological Chemistry 1999 274:37483-37490
  • Bondesson M., Öhman K., Mannervik M., Fan S. and Akusjärvi G. Adenovirus E4 Open Reading Frame 4 Protein Autoregulates E4 Transcription by Inhibiting E1A Transactivation of the E4 Promoter. Journal of Virology 70:3844-3851, 1996
  • Bondesson M., Mannervik M., Akusjärvi G. and Svensson C. An Adenovirus E1A Transcriptional Repressor Domain Functions as an Activator when Tethered to a Promoter. Nucleic Acids Research 22:3053-3060, 1994
  • Linder S., Popowics P., Svensson S., Marshall H., Bondesson M. and Akusjärvi G. Enhanced Invasive Properties of Rat Embryo Fibroblasts Transformed by Adenovirus E1A Mutants with Deletions in the Carboxy-terminal Exon. Oncogene 7:439-443, 1992
  • Bondesson M., Svensson C., Linder S. and Akusjärvi G. The Carboxy-terminal Exon of the Adenovirus E1A protein is Required for E4F-dependent Transcription Activation. The EMBO Journal 11:3347-3354, 1992
  • Svensson C., Bondesson M., Nyberg E., Linder S., Jones N. and Akusjärvi G. Independent Transformation Activity by Adenovirus-5 E1A-Conserved Regions 1 or 2 Mutants. Virology 182:553-561, 1991