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Faculty Profile

Anne DelcourAnne Delcour

Professor and NSM Associate Dean for Graduate Studies
Department of Biology and Biochemistry

Office: Science & Research 2, 221D
Contact: adelcour@uh.edu - (713) 743-2684

Education: Ph.D., Cornell University

Google Scholar Profile

Dr. Anne Delcour is interested in the molecular mechanisms of ion channel function and modulation. In particular, her lab is focused on the study of microbial pore-forming proteins with the use of electrophysiological techniques, such as patch-clamp and planar lipid bilayer electrophysiology. Much of the lab’s earlier work was devoted to the structure-function relationships and modulation of bacterial porins from Escherichia coli and Vibrio cholerae. In recent years, they have shifted their attention to the functional analysis of bacterial secretion systems, with collaborative studies on the chaperone-usher system of uropathogenic E. coli, the two-partner secretion system of Hemophilus influenzae and the translocon of the Type III secretion system of Pseudomonas aeruginosa. The use of electrophysiology has allowed the lab to make real-time observations in the millisecond time range of the dynamics of these complex molecular machines, and to peer into the mechanisms of their function and regulation. More recently, the lab has started to explore virally encoded channels (viroporins), in collaboration with Dr. Joseph Hyser at Baylor College of Medicine. These channels play fundamental roles in virus replication and few have been well characterized by electrophysiology.

Honors and Awards:

1982-1983 International Fellowship from the American Association of University Women
1987-1988 Muscular Dystrophy Association Fellowship
1989-1990 NIH Traineeship from the Department of Medical Genetics, University of Wisconsin-Madison
1990-1992 NIH Postdoctoral Fellowship (NRSA)
1994 Junior Faculty Enhancement Award, Oakridge Association of Universities
1996 Travel Award from the Biophysical Society
1997 Faculty Development Award, Natural Sciences and Mathematics Alumni Association, University of Houston
2001-2004 Member, the MBC-1 study section at NIH
2004-2005 Member , the PCMB study section at NIH
2006 Vice-Chair of the Gordon Conference on Bacterial Cell Surfaces.
2008 Chair of the Gordon Conference on Bacterial Cell Surfaces
2011 The John Butler Award for Teaching Excellence, College of Natural Sciences and Mathematics, University of Houston
2011-2014 Member, Review Editorial Board of Frontiers in Antimicrobials, Resistance and Chemotherapy, a specialty of Frontiers in Microbiology
2012 Member, NSF Membrane Transport and Biophysics study section
2013 Editor of "The Bacterial Cell Surface: Methods and Protocols," a volume of the “Methods in Molecular Biology” series (John Walker, series editor)
2015 Editor of “Electrophysiology of Unconventional Channels and Pores,” Springer Series in Biophysics (B. Martinac, Series Editor), Springer.
2015-present Member, Phi Kappa Phi honor society

Organizations, Outreach, Boards, Memberships:

Memberships: American Association for the Advancement of Science, Biophysical Society, American Society for Microbiology, American Society for Biochemistry and Molecular Biology, Phi Kappa Phi