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Original Articles

Kosten TA, Zhang XY, Kehoe P. Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups. Developmental Brain Research, 141:109-116, 2003.

Miserendino MJD, Haile CN, Kosten TA. Strain differences in response to escapable and inescapable novel environments and their ability to predict amphetamine-induced locomotor activity. Psychopharmacology, 167:281-290, 2003.

Haile CN, During MJ, Jatlow PI, Kosten TR, Kosten TA. Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats. Biological Psychiatry, 54:915-921, 2003.

Kosten TA, Sanchez H, Zhang XY, Kehoe P. Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats. Behavioural Brain Research, 151:137-149, 2004

Kosten TA, Zhang X-Y, Kehoe P. Infant rats with chronic neonatal isolation experience show decreased extracellular serotonin levels in ventral striatum at baseline and in response to cocaine. Developmental Brain Research, 152:19-24, 2004.

Kosten TR, Kosten TA. New medication strategies for comorbid substance use and major psychiatric disorders. Biological Psychiatry, 56:771-777, 2004

Zhang XY, Sanchez H, Kehoe P, Kosten TA. Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats. Psychopharmacology, 177:391-399, 2005.

Kosten TA, Miserendino MJD, Bombace JC, Lee HJ, Kim JJ. Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivity. Behavioural Brain Research, 157: 235-244, 2005.

Zhang XY, Kosten TA. Prazosin, an a-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking. Biological Psychiatry, 57:1202-1204, 2005.

Kosten TA, Sanchez H, Jatlow PI, Kehoe P. Neonatal isolation alters estrous cycle interaction on acute behavioral effects of cocaine. Psychoneuroendocrinology, 30:753-761, 2005.

Kosten TA, Zhang X-Y, Kehoe P. Neurochemical and behavioral responses to cocaine in adult male rats with neonatal isolation experience. Journal of Pharmacology and Experimental Therapeutics, 314:661-667, 2005.

Karanian DA, Brown QB, Makriyannis, A, Kosten TA, Bahr BA. Dual modulation of endocannabinoid transport and fatty-acid amide hydrolase protects against excitotoxicity. Journal of Neuroscience, 25:7813-7820, 2005.

Haile CN, Zhang X-Y, Carroll FI, Kosten TA. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Research, 1055:186-195, 2005.

Kosten TA, Kehoe P. Neonatal isolation is a relevant model for studying the contributions of early life stress to vulnerability to drug abuse: response to Marmendal et al 2004. Developmental Psychobiology, 47:108-110, 2005.

Kosten TA, Zhang X-Y, Kehoe P. Heightened cocaine and food self-administration in female rats with neonatal isolation experience. Neuropsychopharmacology, 31, 70-76, 2006.

Kim JJ, Song EY, Kosten TA. Stress effects in the hippocampus: synaptic plasticity and memory. Stress, 9:1-11, 2006.

Zhang X-Y, Kehoe P, Kosten TA. Neonatal isolation alters estrous cycle effects on ventral striatal extracellular monoamine levels. Progress in Neuropsychopharmacology & Biological Psychiatry, 30:504-511, 2006.

Kosten TA, Lee HJ, Kim JJ. Early life stress impairs fear conditioning in adult male and female rats. Brain Research, 1087:142-150, 2006.

Haile CN, Kosten TR, Kosten TA. Genetics of dopamine and its contribution to cocaine addiction. Behavioral Genetics, 37:119-145, 2007.

Zhang X-Y, Kosten TA. Previous exposure to cocaine enhances cocaine self-administration in an alpha-1 adrenergic receptor dependent manner. Neuropsychopharmacology. 32:638-645, 2007.

Kosten TA, Zhang XY, Haile CN. Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses. Behavioral Neuroscience, 121:380-388, 2007.

Kosten TA, Lee HJ, Kim JJ. Neonatal handling alters learning in adult male and female rats in a task-specific manner. Brain Research, 1154:144-53, 2007.

Kosten TA, Karanian DA, Yeh J, Haile CN, Kim JJ, Kehoe P, Bahr BA. Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience. Neurobiology of Learning and Memory, 88:167-176, 2007.

Kosten TA, Zhang XY. Sex differences in non-reinforced responding for cocaine. American Journal on Drug and Alcohol Abuse. 34:473-88, 2008.

Haile CN, Kosten TA, Kosten TR. Pharmacogenetic treatments for drug addiction: alcohol and opiates. American Journal of Drug and Alcohol Abuse. 34:355-81, 2008.

Kosten TA, Galloway MP, Duman RS, Russell DS, D'Sa C. Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures. Neuropsychopharmacology. 33:1545-58, 2008.

Haile CN, Kosten TR, Kosten TA. Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. American Journal of Drug and Alcohol Abuse, 35:161-177, 2009.

Kosten TA, Kehoe P. Immediate and enduring effects of neonatal isolation on maternal behavior in rats. International Journal of Developmental Neuroscience, 28: 53-61, 2010.

Kosten TA. Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats. Pharmacology Biochemistry and Behavior, 98: 533–538. 2011.

Xiang, X, Huang, W, Haile, CN, Kosten TA. Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences. Behavioural Brain Research, 222: 326-331, 2011.

Kosten TA, Miserendino MJD. Stress alters the discriminative stimulus and response rate effects of cocaine differentially in Lewis and Fischer inbred rats. Behavioral Sciences, 2:23-37, 2012.

Haile CN, Hao, Y, O’Malley PW, Newton TF, Kosten TA. The α1 antagonist doxazosin alters the behavioral effects of cocaine in rats. Brain Sciences, 2: 619-633, 2012.

Shen XY*, Kosten TA*, Lopez AY, Kinsey BM, Kosten TR, Orson, FM. A vaccine against methampehtamine attenuates its behavioral effects in mice. Drug and Alcohol Dependence, 129:41– 48, 2013. *co-1st authors.

Hao Y, Huang W, Nielsen DA, Kosten TA. Litter gender composition and sex affect maternal behavior and DNA methylation levels of the Oprm1 gene in rat offspring. Frontiers in Child and Neurodevelopmental Psychiatry, 2:21, 2011.

Kosten TA, Kim JJ, Lee HJ. Early life manipulations alter learning and memory in rats. Neuroscience and Biobehavioral Reviews, 36:1985-2006, 2012.

Kosten TA, Meisch RA. Predicting extinction and reinstatement of alcohol and sucrose self-administration in outbred rats. Experimental and Clinical Psychopharmacology, 21:245-251, 2013.

Kosten TA, Shen XY, O’Malley PW, Kinsey BM, Lykissa ED, Orson FM, Kosten TR. A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 45:223-229, 2013.

Kosten TA, Huang W, Nielsen DA. Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats. Developmental Psychobiology, 56: 392–406, 2014.

Kosten TA, Nielsen DA. Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon17 promoter gene in hippocampus and cerebellum. International Journal of Developmental Neuroscience, 36:5-12, 2014.

Kosten TA, Shen XY, Kinsey BM, Kosten TR, Orson FM. Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization. American Journal of Addictions, 23(6):604-607, 2014.

Gomez, JL, Cunningham CL, Finn DA, Young EA, Helpenstell LK, Schuette LM, Fidler TL, Kosten TA, Ryabinin AE. Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence. Neuropharmacology, 97:182-93, 2015.

Haile CN, Kosten TA, Shen XY, O’Malley PW, Winoske KJ, Kinsey BM, Wu Y, Huang Z, Lykissa ED, Naidu N, Cox JA, Arora R, Kosten TR, Orson FM. Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine. American Journal on Addictions, Dec;24(8):748-55, 2015.

Ohia-Nwoko O, Kosten TA, Haile CN. Animal models and the development of vaccines to treat substance use disorders. International Review of Neurobiology, 126:263-291, 2016. (TAK Invited review).

Nieto SJ, Patriquin MA, Nielsen DA, Kosten TA. Don’t worry; be informed about the epigenetics of anxiety. Pharmacology Biochemistry & Behavior, 146-147:60-72, 2016. (TAK Invited review).


Kosten TA, Kehoe P. Early life stress and vulnerability to addiction. In: M al’Absi, Ed., Stress and Addiction: Biological and Psychological Mechanisms, Elsevier Press, San Diego, pp. 105-126, 2007.

Kosten TA, Nielsen DA. Maternal epigenetic inheritance and stress during gestation: focus on brain and behavioral disorders. In: TO Trygve, Ed., Transgenerational Epigenetics: evidence and Debate, Elsevier Press, San Diego, pp.197-219, 2014.

Kosten TA, Haile CN, Lijffijt M, Swann, AC. Alcohol use disorders: adaptations and progression to disordered drinking. In: Lijffijt M, Swann, AC, Moeller G Eds., Neurobiology of Addictions: Susceptibility, Progression, and Resilience, Oxford University Press, London, in press.

Kosten TR, Kosten TA. Vaccines for methamphetamine use disorder. In: Montoya I Ed., Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes,Springer, in press.