Robert Rodriguez	...	(Director)
Kyle Ward, Robert Rodriguez	...	(Writer)
Danny Trejo	...	Machete
Mel Gibson	...	Voz
Demián Bichir	...	Mendez (as Demian Bichir)
Amber Heard	...	Miss San Antonio
Michelle Rodriguez	...	Luz
Sofía Vergara	...	Desdemona
Charlie Sheen	...	Mr. President (as Carlos Estevez)
Lady Gaga	...	La Camaleón
Antonio Banderas	...	El Camaleón 4
Walton Goggins	...	El Cameleón 1 (as Walt Goggins)
Cuba Gooding Jr.	...	El Camaleón 2
Vanessa Hudgens	...	Cereza
Alexa PenaVega	...	KillJoy (as Alexa Vega)
Marko Zaror	...	Zaror
Tom Savini	...	Osiris Amanapur
Sofía Vergara	...	Madame Desdemona
Jessica Alba	...	Sartana
Alexa Vega	...	Killjoy
William Sadler	...	Sheriff Doakes
Mike Gassaway	...	Secret service agent
Demián Bichir	...	Mendez the Madman
Crystal Martinez	...	Wife of Mendez
Julio Oscar Mechoso	...	Chepo
Callie Hernandez	...	Space Babe
Billy Blair	...	Billy
Marci Madison	...	Nurse Fine
Samuel Davis	...	Clebourne
Alejandro Antonio	...	Boss of Mendez
Jason Christopher	...	Lieutenant Brass
David C. Heard	...	Doctor Villachez
Robert Rodriguez	...	Story
Carlos Rodríguez	...	Messenger
Marcel Rodriguez	...	Story
Carl Thiel	...	Original Music Composer
Juan Zuani	...	Radio Announcer
Rebecca Rodriguez	...	Editor
Emmy Robbin	...	Pris
Jimmy Gonzales	...	Man in Bondage
Steve Joyner	...	Production Design
Mary Vernieu	...	Casting
Pablo Bracho	...	Bartender Carlos
Ashley Wood	...	Male Tourist
Lindsey Graham	...	Casting
Patricia Vonne	...	Female Tourist (as Patricia Vonne Rodriguez)
Nina Proctor	...	Costume Design
Catherine Harper	...	foley
Vincent Fuentes	...	Cabrito Cook
Rick Delgado	...	Police Captain
Joe Rivera	...	Hairstylist
Mike McCutchen	...	art department coordinator
Daniel Arellano	...	Elderly Attendant (as Dan Arellano)
Meredith Johns	...	Makeup Effects
Elle LaMont	...	Dollface
Eduardo Renteria	...	Doctor Goodbar
Clark Crawford	...	Sound Designer
Pablo Esparza	...	Grasa
Paula Fairfield	...	Sound Designer
Angelo Palazzo	...	Sound Designer
Robert Tamayo	...	Stuttering Tito
Stuart Provine	...	Sound Effects Editor
Felix Sabates	...	Doc Felix
Brad Engleking	...	Sound Re-Recording Mixer
Jorge A. Jimenez	...	Dying Cartel GUy (as Jorge Jimenez)
Tim Rakoczy	...	Supervising Sound Editor
Sam Medina	...	Cartel Leader
Joe Montenegro	...	Special Effects Coordinator
Troy Brown	...	Stunt Coordinator
Jeffrey J. Dashnaw	...	Stunt Coordinator
Electra Avellan	...	Nurse Mona
Sean Maxwell	...	Second Unit Cinematographer
Elise Avellan	...	Nurse Lisa
P.K. Munson	...	Camera Operator
Matt Harshbarger	...	steadicam operator
Corey Burton	...	Trailer Voice Guy (voice)
Elon Musk	...	Himself
Rico Torres	...	Still Photographer
Tony Aaron II	...	additional photography
Stephany Baskin	...	Set Costumer
Beatrice Bellino	...	Script Supervisor
Mark Edward Wright	...	visual effects editor

Summary: During an operation of a Mexican Cartel, Machete Cortez and Sartana Rivera intercept the criminals alone, but another group arrives and a masked man kills Sartana. Machete is arrested, accused of killing his beloved Sartana and Sheriff Doakes hangs Machete. But the President of the USA Rathcock pardons and recruits Machete to kill the revolutionary Marcos Mendez that has threatened the USA with a missile with a bomb. Machete goes to San Antonio to meet the Miss San Antonio Blanca Vasquez that will be the liaison between Machete and President Rathcock. Then Machete goes to the brothel of Madame Desdemona to seek out the prostitute Cereza that is Mendez's mistress. Machete meets Mendez and learns that his heart is connected to the missile and only the arm dealer Luther Voz is capable to disarm the bomb. Now Machete needs to bring Mendez to the USA in less than twenty-four hours and save his new country in a dangerous journey with betrayals.