Many of the diseases typically associated with aging may not be related to aging per se, but rather an age-associated decrease in moderate/vigorous physical activity and an increase in sedentary time. These changes in physical activity patterns are further exacerbated by changes in body composition. Consequently, signaling pathways associated with inflammation and metabolism are affected. The modification of these signaling pathways can lead to an increased risk of chronic disease.
Dr. Markofski studies the acute and chronic effects of exercise and nutrition (specifically, dietary protein) on muscle function and biomarkers associated with disease risk. She has a specific interest in monocytes and inflammation and their impact on muscle and adipose tissue. Dr. Markofski uses molecular techniques and clinical and functional outcomes to develop evidence-based exercise and nutritional strategies for reducing the risk to develop chronic diseases and promote healthy aging.
Recent Publications and Research Activity
Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon-Jones D, Reidy PT, Sheffield-Moore M, Timmerman KL, Rasmussen, BB, and Volpi E. Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol. 2015 May;65:1-7. PMID: 25735236
Timmerman KL, Amonette WE, Markofski MM, Ansinelli HA, Gleason EA, Rasmussen BB, and Mossberg KA. Impaired IL-6 and IL-10 response to exercise in patients with traumatic brain injury. Eur J Appl Physiol. 2015 Jan;115(1):111-8.
Markofski MM, Flynn MG, Carrillo AE, Armstrong C, Campbell WW, and Sedlock, DA. Exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage with and without weight loss in overweight and obese adults. Eur J Appl Physiol. 2014 Aug;114(8):1737-48.
Markofski MM and Braun WA. Possible effects of menstrual cycle on contraction-induced muscle damage. J Strength Cond Res. 2014 Sep;28(9):2649.
Markofski MM, Carrillo AE, Timmerman KL, Jennings K, Coen PM, and Flynn MG. Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):675-81.
Drummond MJ, Timmerman KL, Markofski MM, Walker DK, Dickinson JM, Jamaluddin M, Brasier AR, Rasmussen BB, Volpi E. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R216-23.
Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013 Jun;32(3):375-81
Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22.
Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects. Eur J Appl Physiol. 2012 Aug;112(8):3045-52
Markofski MM and Volpi E. Protein metabolism in women and men: similarities and disparities. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):93-7.
Coen PM, Flynn MG, Markofski MM, Pence BD, Hannemann RE. Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population. Metabolism. 210 Dec;59(12):1775-83.
Coen, PM. Flynn, MG, Markofski, MM, Pence, BD, Hannemann, RE. Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage. Metabolism. 2009 Jul; 58(7):1030-8.
Timmerman KL, Flynn MG, Coen PM, Markofski MM, and Pence B. Influence of exercise training on CD14+CD16+ monocytes, toll-like receptor 4, and lipopolysaccharide-stimulated TNFα: production in elderly men and women. J Leukoc Biol. 2008 Nov; 84(5):1271-8.
Flynn MG, McFarlin BK, Markofski MM. The anti-inflammatory influence of exercise training. Am J Lifestyle Med. 2007 May-Jun; 1(3):220-35.
Braun WA, Hawthorne WE, Markofski MM. Acute EPOC response in women to circuit training and treadmill exercise of matched oxygen consumption. Eur J Appl PhysioI. 2005 94(5-6):500-.
von Duvillard SP, Braun WA, Markofski M, Beneke R, Leithauser R. Fluids and hydration in prolonged endurance performance. Nutrition. 2004 Jul-Aug;20(7-8):651-6.
B.S. in Kinesiology at California State Polytechnic University, Pomona, 2000
M.S. in Kinesiology at California State Polytechnic University, Pomona, 2004
Ph.D. in Health & Kinesiology at Purdue University, 2010