Skip to main content

People


Dr. Austin Bigley

Research Assistant Professor

Office Number: 104 GAR
Phone: (713) 743-9840
Fax: 713-743-9860

Email: abbigley@Central.UH.EDU

Mailing Address:
3875 Holman St., Rm 104 Garrison
Houston, TX 77204-6015

Download Curriculum Vitae

Research Interests

I am a research assistant professor working in the laboratory of Dr. Richard Simpson at the University of Houston. I joined Dr. Simpson’s lab in 2009 and was funded my first two years as a teaching fellow and my last three years as a research assistant working on NASA grant NNX12AB48G. In September 2015, I won a NSBRI First Award Fellowship and I am currently PI on NSBRI Project #PF04307. I am interested in spaceflight immunology and cancer immunotherapy using NK-cells, especially how exercise, spaceflight, and Cytomegalovirus (CMV) infection modulate NK-cell activity against hematologic malignancies. My goal is to understand the mechanisms underlying the effects of exercise, spaceflight, and CMV infection on the phenotype, cytotoxicity, proliferative capacity, and persistence of NK-cells with an eye toward developing new NK-cell-based therapies for the treatment of cancer. Over the course of my academic career, I have acquired expertise in cell culture techniques, cytotoxicity assays, and flow cytometry methods that have led to multiple publications in prestigious peer-reviewed journals.

Recent Publications and Research Activity

Bigley, A.B., Spielmann, G., Agha, N., O’Connor, D.P., and Simpson, R.J. (2016). Dichotomous effects of latent CMV infection on the phenotype and functional properties of CD8+ T-cells and NK-cells. Cell Immunol 300, 26-32.

Bigley, A.B., Rezvani, K., Shah, N., Sekine, T., Balneger, N., Pistillo, M., Agha, N., Kunz, H., Bollard, C.M., and Simpson, R.J. (2016). Latent CMV infection enhances anti-tumor cytotoxicity through accumulation of NKG2C+ NK-cells in healthy humans. Clin Exp Immunol 185, 239-251.

Simpson, R.J., Bigley, A.B., Spielmann, G., LaVoy, E.C.P., Kunz, H., and Bollard, C.M. (2016). Human cytomegalovirus infection and the immune response to exercise. Exer Immunol Rev 22, 8-26.

Bigley, A.B. and Simpson, R.J. (2015). NK-cells and Exercise: Implications for cancer immunotherapy and survivorship. Discov Med 19(107), 433-445.

Bigley, A.B., Rezvani, K., Pistillo, M., Reed, J., Agha, N., Kunz, H., O’Connor, D.P., Sekine, T., Bollard, C.M., and Simpson, R.J. (2015) Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: Impact of latent cytomegalovirus infection and catecholamine sensitivity. Brain Behav Immun 49, 59-65.

Bigley, A.B., Spielmann, G., Agha, N., and Simpson, R.J. (2015). The effects of age and latent cytomegalovirus infection on NK-cell phenotype and exercise responsiveness in man. Oxid Med Cell Longev, Article ID 979645.

Brown, F.F., Bigley, A.B., Ross, J.C., LaVoy, E.C., Simpson, R.J., and Galloway, S.D. (2015). T-lymphocyte populations following a period of high volume training in female soccer players. Physiol Behav 152, 175-181.

Lavoy, E.C., Bigley, A.B., Spielmann, G., Rector, J.L., Morrison, M.R., O'Connor, D.P., and Simpson, R.J. (2014). CMV Amplifies T-cell Redeployment to Acute Exercise Independently of HSV-1 Serostatus. Med Sci Sports Exerc 46(2), 257-267.

Brown, F.F., Bigley, A.B., Sherry, C., Neal, C.M., Witard, O.C., Simpson, R.J., and Galloway, S.D. (2014). Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise. Brain Behav Immun 39, 152-159.

Spielmann, G., Bollard, C.M., Bigley, A.B., Hanley, P.J., Blaney, J.W., LaVoy, E.C., Pircher, H., and Simpson, R.J. (2014). The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behav Immun 39, 142-151.

Bigley, A.B., Rezvani, K., Chew, C., Sekine, T., Pistillo, M., Crucian, B., Bollard, C.M., and Simpson, R.J. (2014). Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain Behav Immun 39, 160-171.

Bigley, A.B., Spielmann, G., LaVoy, E.C., and Simpson, R.J. (2013). Can exercise-related improvements in immunity influence cancer prevention and prognosis in the elderly? Maturitas 76(1), 51-56.

Pistillo, M., Bigley, A.B., Spielmann, G., LaVoy, E.C., Morrison, M.R., Kunz, H., and Simpson, R.J. (2013). The effects of age and viral serology on gammadelta T-cell numbers and exercise responsiveness in humans. Cell Immunol 284(1-2), 91-97.

Bigley, A.B., Lowder, T.W., Spielmann, G., Rector, J.L., Pircher, H., Woods, J.A., and Simpson, R.J. (2012). NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection. Brain Behav Immun 26(1), 177-186.

Simpson, R.J., Lowder, T.W., Spielmann, G., Bigley, A.B., LaVoy, E.C., and Kunz, H. (2012). Exercise and the aging immune system. Ageing Res Rev 11(3), 404-420.

Education

B.S. in Biology at University of Houston, 2008

Ph.D. in Exercise Immunology at University of Houston, 2014