RIGOBERTO ADVINCULA
Associate Professor, Chemistry
Phone: 713.743.1760
E-mail: rcadvinc@uh.edu
Web site:http://www.nanostructure.uh.edu/
Rigoberto Advincula is an expert in the preparation of thin
films and surfaces using polymers and nanomaterials and molecular
and macromolecular assembly methods. His research has practical
applications in display devices, nanocoatings, and sensors.
Advincula’s projects and approaches are multidisciplinary,
combining elements of organic and polymer synthesis, engineering,
biorelated phenomena, and physical methods. He has the following
interests in the area of the biomedical field: 1) DNA adsorption
on polyelectolyte and dendrimer layers for DNA chips, 2) modification
of particle permeability for drug delivery, and 3) layer-by-layer
solgel and polyelectrolyte deposition methods for bioimplants.
In addition, Advincula recently received part of a $2 million
grant from the National Science Foundation to develop nanoscale
“Velcro” materials based on polymer brushes.
VEMURI BALAKOTAIAH
John and Rebecca Moores Professor of Chemical Engineering
Phone: 713.743.4318
E-mail: bala@uh.edu
Web site: http://www.chee.uh.edu/faculty/balakotaiah/
Vemuri Balakotaiah's research in the biomedical area, jointly
with Professor Akhil Bidani, involves the multiscale mathematical
modeling of physiological systems, both under normal and patho-physiological
conditions. One project involves modeling of Hepatopulmonary
Syndrome, characterized by the clinical triad of chronic liver
disease (generally, but not always, cirrhosis), hypoxemia
while breathing room air and pulmonary capillary dilatation,
believed to be due to local excess of intravascular nitric
oxide (NO) activity. The modeling efforts are tightly coupled
with experimental data from patients and nuclear medicine
scans obtained at UT Health Science Center. Other projects
in this area include detailed modeling of transport and binding
of reactive gases (oxygen, CO, and NO) in the red blood cell
and quantifying CO and NO poisoning in the blood.
STEVEN BALDELLI
Assistant Professor, Chemistry
Phone: 713.743.5107
E-mail: sbaldell@mail.uh.edu
Web site: http://www.chem.uh.edu/Faculty/Baldelli/web/index.html
Steven Baldelli is an expert in surface chemistry, optics,
and electrochemistry. His current projects include near-field
optical spectroscopy of metal, polymer, and composite nanoparticles
and investigation of organic monolayers that inhibit the corrosion
of metals. Baldelli’s research goals are to develop
spectroscopic imaging techniques for biological and materials
surface characterization and to obtain molecular-level information
on nanostructure and material surfaces. His research has applications
ranging from solar cells, photocatalysis, and environmental
remediation to biomaterials, corrosion, and energy conversion.
JAMES BRIGGS
Associate Professor, Biology and Biochemistry
Associate Professor, Chemical Engineering
Associate Professor, Chemistry
Phone: 713.743.8366
E-mail: jbriggs@uh.edu
Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=jbriggs
James Briggs studies the application and development of theoretical
methods for use on biological and organic molecular systems.
He developed the first computerized model consistent with
experimental data that predicts how the HIV integrase molecule
binds with viral DNA. Since HIV integrase is an enzyme essential
to the viral life cycle, Briggs' research is a breakthrough
that paves the way to develop drugs to combat AIDS.
CHENGZHI CAI
Assistant Professor of Chemistry
Phone: 713.743.2710
E-mail: ccai@mail.uh.edu
Chengzhi Cai's research focuses on positioning single biomolecules at surfaces for detection and studying single molecular interactions. His group has developed a robust, atomically flat, protein-resistant platform on silicon surfaces. They use conductive atomic force microscopy (AFM) to pattern the platform and covalently attach large molecules to the resulted nanospots. Other research includes synthesis of large, “sticky” dendron molecules that contain only one functional group for binding biomolecules and attachment of single functional molecules to the apex of AFM tips. This research contributes to the development of ultra-sensitive analytical tools for early diagnosis of disease.
ADAM CAPITANO
Assistant Professor, Chemical Engineering
Phone: 713.743.4319
E-mail: acapitano@uh.edu
Web site: http://www.chee.uh.edu/faculty/capitano/
Adam Capitano is using engineered biological tissues to solve
real-world problems. His research relies on the control of
cell-to-cell interactions to create tissue cultures designed
for purposes ranging from the sensing of chemical warfare
agents to organ repair. In addition to applications in sensing
technology, a second research thrust will involve the adaptation
of three-dimensional fabrication technologies to construct
tissues. This methodology will allow greater control over
the location of cells and key matrix components than has been
achieved with traditional technologies.
DAR-CHONE CHOW
Assistant Professor of Chemistry
Phone: 713.743.1798
E-mail: dchow@mail.uh.edu
Dar-Chone Chow researches the basis of conformational changes in the function of a protein. His group is studying two model systems that both have distinct conformational states during their functional processes. One of these systems is the assembly of cytokine/receptor complexes of the family of gp130 cytokines, also called IL-6 cytokines. Numerous cytokines and the corresponding receptors have been identified in the family. Based on recent progress that has elucidated some structural and biophysical features of the IL-6 signaling complex assembly, Chow is further studying the structural basis of the receptor-induced conformational changes within the IL-6 cytokine. He is expanding these studies to other cytokines to understand their signaling complex assemblies.
Another model system Chow is studying is the gastric H,K-ATPase. The goal is to characterize the thermodynamics and kinetics of substrate-bindings and substrate-induced conformational changes in the pumping cycle. In parallel, the laboratory will undertaking the structural studies of the H,K-ATPase. The long-term goal is to elucidate the structural and thermodynamics basis of the conformational changes during the pumping cycle, thus the pumping mechanism.
VINCENT M. DONNELLY
Professor, Chemical Engineering
Phone: 713.743.4313
E-mail: vmdonnelly@uh.edu
Web site: http://www.chee.uh.edu/faculty/donnelly/
Vincent M. Donnelly studies the use of gaseous plasmas for
nanometer-scale patterning of microelectronic materials. The
research ranges from very basic studies of plasma chemistry
and physics, such reactions on plasma-exposed surfaces and
studies of plasma-assisted carbon nanotube growth, to new
methods for fabricating nano-structures. One concept, dubbed
“nano-pantography,” is being explored as a novel
method for forming nano-patterned materials over large areas.
Any arbitrary pattern can be replicated simultaneously in
billions of selected regions on a substrate by focusing ions
to nanometer-sized spots and by rastering them along the bottoms
of orderly arrays of sub-micron sized ion-focusing lenses.
Materials can be deposited, as well as removed, making it
possible to obtain a wide range of nano-structured materials.
DEMETRE J. ECONOMOU
John and Rebecca Moores Professor of Chemical Engineering
Phone: 713.743.4320
E-mail: economou@uh.edu
Web site: http://www.chee.uh.edu/faculty/economou/
Demetre Economou studies the fundamentals and applications
of gaseous discharge plasmas for materials processing with
emphasis on nanomaterials and nanofabrication. His work in
nanopantography emphasizes a radically different approach
to high-throughput and versatile fabrication of nanometer
scale complex patterns over large areas (tens of cm2). He
also is studying neutral-bean etching, which involves patterning
of microelectronic materials in dimensions below 100 nm using
reactive neutral beams, without the adverse effects of charging
damage, associated with conventional reactive ion etching.
MATTHEW FRANCHEK
Professor, Mechanical Engineering
Chair, Department of Mechanical Engineering
Director, Biomedical Engineering Program
Phone: 713.743.4371
E-mail: mfranchek@uh.edu
Web site: http://www.egr.uh.edu/me/faculty/franchek/
Matthew Franchek’s nano-related research is directed
toward the dynamic modeling and control of interconnected
dynamical systems on the nano-scale. The nano-scale dynamic
modeling effort is focused on the development of analytical
tools linking nano-particle geometry/properties, surface properties,
and surround medium to adhesion forces (both short range and
long range forces). His biomedical research involves wellness
modeling and health prognosis for accurate bedside care using
information synthesis. Fast MRI scans will be used to validate
the resulting models. These results will lead to quality home
health monitoring thereby expanding health care to the underserved.
XIAOLIAN GAO
Professor of Chemistry and Biology and Biochemistry
Phone: 713.743-2805
E-mail: xgao@uh.edu
Chemistry Web site: http://www.chem.uh.edu/Faculty/Gao/ResearchWebpages/index.html
NSM Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=gao
Xiaolian Gao is an expert in nucleic acid chemistry, nuclear
magnetic resonance (NMR) technology, structural biological
chemistry and combinatorial chemistry. Research in her lab
involves the interface of chemistry, and biological sciences.
She holds patents in biochip technologies. Her current focus
is to understand the relationships of function and structure
of complex genomes of human and other species.
DAN GRAUR
John and Rebecca Moores Professor of Biology and Biochemistry
Phone: 713.743.7236
E-mail: dgraur@uh.edu
Web site: http://nsm.uh.edu/~dgraur/
Dan Graur researches several theoretical, statistical, and
analytical topics in evolutionary bioinformatics. His research
ranges from physico-chemical characterization of deleterious
and neutral amino-acid replacements to development of methodologies
for the identification of contact points within the three-dimensional
structure of proteins, using evolutionary and phylogenetic
information. For his methodological research, Graur uses maximum-likelihood
and Bayesian approaches to reconstruct ancestral amino-acid
sequences. Currently, Graur’s research is focused on
the phrasing of the dynamic and static descriptions of the
compositional features of genomes. This research has applications
in human medical genetics and genetic engineering.
SUSAN HARDIN
Associate Professor, Biology and Biochemistry
Phone: 713.743.2686
E-mail: shardin@uh.edu
Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=shardin
Susan Hardin developed new technology for direct molecular
sensing that could be used to sequence an entire genome in
less than twenty-four hours. Her areas of expertise include
molecular genetics and biotechnology, especially with respect
to the mechanisms of enzymatic DNA synthesis and DNA replication.
The process that she and her colleagues pioneered could eliminate
many time-consuming intermediary steps as well as require
the use of only a single molecule of DNA to ïread.Í
ALEX IGNATIEV
Professor, Physics, Chemistry, and Electrical and Computer
Engineering
Director, Texas Center for Superconductivity and Advanced
Materials
Phone: 713.743.3621
E-mail: ignatiev@uh.edu
Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=aignatie
Alex Ignatiev's research interests include experimental solid-state
physics and chemistry, superconductivity and thin film and
superlattice processing and devices. He is developing a method
for capturing optical micro-detectors for improved surgical
handling during implantation into an eye. This project ultimately
improves handling of the optical
micro-detectors during transfer and implantation.
DONALD KOURI
Cullen Professor of Chemistry, Mathematics, and Physics
Phone: 713.743.3245
E-mail: kouri@uh.edu
Web site: http://www.chem.uh.edu/Faculty/Kouri/ResearchWebpages/Index.html
Donald Kouri's research originally dealt with theoretical and mathematical chemistry and physics. The current focus is on combining their recently developed time-independent wave packet formulation of reactive scattering with various approximations, in order to treat large molecular systems such as occur in biology. A second major area of research in mathematical chemistry and physics involves a new approach to functional approximation and discretization called the "distributed approximating functionals" (DAFs). They have been used to solve a variety of both linear and nonlinear partial differential equations important in the sciences and engineering. Growing out of the DAF-research, is work on the fundamentals of quantum theory and the connections to digital informatics. Of particular interest are new minimizers of the Heisenberg uncertainty principle, which has lead to new approaches to multi-resolution analysis in multi-dimensions. This has also made possible new advances in image analysis and 3-D visualization.
KURT L. KRAUSE
Associate Professor, Biology and Biochemistry, and Chemistry
Phone: 713.743.8370
E-mail: kkrause@uh.edu
Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=klkrause
Kurt L. Krause is an expert on protein structure and proteomics.
He has a long-standing interest in BioNano Technology as represented
in the fields of drug discovery, diagnosis and drug delivery.
The main focus of his lab is on the structure and function
of drug targets, virulence factors and redox proteins, especially
those from highly pathogenic organisms.
RAMANAN KRISHNAMOORTI
Associate Professor, Chemical Engineering
Phone: 713.743.4312
E-mail: ramanan@mail.uh.edu
Web site: http://www.chee.uh.edu/faculty/krishnamoorti/
Ramanan Krishnamoorti's research focuses on understanding
and controlling the structure—processing—properties
of polymer-based nanocomposite materials for mutli-functional
applications. Materials prepared with dispersed carbon nanotubes
and nanometer thick-layered silicates have shown dramatic
increases in mechanical properties while demonstrating unique
electrical, optical or barrier properties. He also is collaborating
with Professors Lee and Rigoberto Advincula toward preparing
electroluminiscent polymer nanocomposites as organic light-emitting
diodes.
T. RANDALL LEE
Professor, Chemical Engineering
Professor, Chemistry
Phone: 713.743.2724
E-mail: trlee@uh.edu
Chemistry Web site: http://www.chem.uh.edu/Faculty/Lee/Web/index.htm
NSM Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=trlee
T. Randall Lee uses nanotechnology to synthesize new materials
for technological and biological applications. This use of
synthesis helps to prepare new materials for technological
applications. His groupÍs latest research efforts include
using self-assembled monolayers (SAMs) to create ultrathin
surface coatings for miniature electronic devices, and using
SAMS that are biologically active to enhance the growth of
protein crystals for applications of tissue engineering.
HAN LE
Professor, Electrical and Computer Engineering
Phone: 713.743.4465
E-mail: hqle@uh.edu
Han Le’s research focuses on optical sensing in the
infrared region ranging from specialized devices to enabling
components and system architecture. His current research includes
tunable lasers, waveguide Bragg gratings, micro/nano photonics,
microscopic biomedical IR imaging, multi-spectral CDMA optical
sensor architecture, and laser-based stand-off sensing for
chemical/biological agents.
GLEN B. LEGGE
Assistant Professor, Biology and Biochemistry
Phone: 713.743.8380
E-mail: glegge@uh.edu
Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=glegge
Glen B. Legge uses structural biology to link the fields of
biology and chemistry by understanding the molecular mechanisms
of biological processes. He is currently researching how tissue
factor, which initiates blood coagulation, is activated. When
tissue factor is improperly regulated, thrombosis, atherosclerosis,
septic shock, and cancer can result. A concurrent project
on bacterial biofilms seeks to understand how bacterial colonization
can be inhibited during long-term space flight.
DMITRI LITVINOV
Associate Professor, Electrical and Computer Engineering
Phone: 713.743.4168
E-mail: dlitvinov@uh.edu
Web site: http://www2.egr.uh.edu/%7Edlitvino/
Dmitri Litvinov’s research covers a broad range of applications
of nanomagnetic systems including biosensors with biodetection
capabilities at a single-molecule level, next-generation computing
systems based on magnetic quantum cellular automata, ultra-fast/ultra-high
density nonvolatile random access memory, and chip-size terabyte
data storage systems. The unifying theme behind the research
is nanomagnetic, which promises effective control of magnetic
states at the single domain level and scalability all the
way down to the superparamagnetic limit near 2-3 nm. It is
this scalability that can provide a long-term, evolutionary
path for industrial development and power the information
age far beyond the roadmaps of the semiconductor and data
storage industries.
JOHN H. MILLER, JR.
Associate Professor of Physics
Phone: 713.743.8257
E-mail: jhmiller@uh.edu
Dr. Miller's research interests include the electromagnetic properties of live cells and complex biological macromolecules, including proteins. A live cell in an electrolyte or other extracellular medium has a finite membrane potential due to a net negative charge in the interior, and can thus be polarized by an applied electric field. In addition, most proteins in their native (folded) state are either electrically charged (eg. actin, which self assembles into 8-nm diameter filaments) or have a net electrical dipole moment (eg. the 5-nm wide a-b tubulin heterodimer). These properties lead to enormous dielectric responses at low frequencies, which can be probed non-invasively at various length scales.His research group has observed changes with time in the dielectric properties of a-b tubulin dimers as they self assemble to form 25-nm diameter microtubules, a major component of the cellular cytoskeleton and substantial reductions in the dielectric response of eucaryotic cells when exposed to respiratory inhibitors, such as cyanide, that attack the mitochondria. This is significant, because it shows we can non-invasively probe the metabolic states of these internal organelles. More recently, our group has found evidence for novel phase transitions in biological systems, such as a dramatic change with temperature in the dielectric response of E. coli .
KISHORE K. MOHANTY
Professor of Chemical Engineering
Phone: 713.743.4331
E-mail: mohanty@uh.edu
Dr. Mohanty's research focuses on transport of simple and complex fluids in complex microstructured materials for applications in energy, environment and biotechnology. Many naturally occurring materials such as sandstones, carbonates, aquifers, human bones and tissues are microstructured. Many fluids used in these systems are nanostructured. This research is aimed at imaging these structures, understanding the physics of transport, relating the microstructures to transport coefficients and developing new materials for enhanced targeted transport. Surfactants are being developed to control the adhesion of oil molecules to calcite surfaces and thus enhance oil recovery. Delivery materials are being developed for controlled and targeted drug and gene delivery. The relation between the molecular interaction, material nanostructure and transport/interfacial properties are being probed. Nanomaterials are being developed to image transport in many different scales.
SHIN-SHEM (STEVEN) PEI
Professor, Electrical and Computer Engineering, and Physics
Deputy Director, Texas Center for Superconducting and Advanced
Materials
Associate Dean for Research, Cullen College of Engineering
Phone: 713.743.4433
E-mail: spei@uh.edu
Web site: http://www.egr.uh.edu/ece/faculty/pei/
Steven Pei’s research interests are in the quantum wells,
quantum dots, and carbon nanotubes for infrared and high-speed
electronic applications, in particular, the mid-infrared lasers
and far-infrared detectors. His research helped to pioneer
the development of semiconductor mid-infrared lasers operating
at the 3-5 micron wavelength transmission window in the atmosphere
for space exploration, environmental monitoring, trace gas
detection, medical diagnostics, and biodefense applications.
He achieved the first semiconductor mid-infrared laser operating
at near room temperature in 1995 and demonstrated the first
type-II quantum cascade laser in 1996. Later, he also realized
the first very long wavelength infrared photodetector operating
at 15-21 micron wavelength for space surveillance and far-infrared
imaging and spectroscopy applications.
SCOTT S. PERRY
Professor, Chemistry
Professor, Chemical Engineering
Phone: 713.743.2715
E-mail: perry@uh.edu
Web site: http://www.chem.uh.edu/Faculty/Perry/Index.html
Scott Perry researches biomimetic polymer lubricants and properties
of supported, nanometer-sized metal clusters, using microscopies
to map out the interfacial properties on a nanometer scale
and surface analysis probes to assess the chemical and structural
nature of these materials. Perry’s studies of biomimetic
polymers are aimed at understanding water-based lubrication,
and his investigations of metallic nanoparticles seek to establish
methods of stabilizing particle size at elevated temperatures,
an important characteristic in catalytic applications. This
research will allow greater insight into the design of artificial
human joints and the methods of stabilizing nanoscale catalysts.
B. MONTGOMERY PETTITT
Hugh Roy and Lillie Cranz Cullen Distinguished Professor of
Chemistry
Professor, Physics, Computer Science, and Biology and Biochemistry
Director, Institute for Molecular Design
Phone: 713.743.3263
E-mail: pettitt@uh.edu
Web site: http://www.chem.uh.edu/Faculty/Pettitt/ResearchWebpages/INDEX.HTML
B. Montgomery Pettitt's work is applicable to many areas,
including rational drug design. He works to bridge the gap
between theoretical and experimental approaches to biomolecular
structure and function—an area of increasing importance
to medicine and industry because advances in computing make
it possible to do accurate theoretical and experimental studies
of enzymes, nucleic acids, and biomolecular assemblies. His
research ranges from physical chemistry governing polar molecules
in the liquid state to work aimed at elucidating the fundamental
aspects of biomolecular conformational structure and dynamics
in solution.
J. WAYNE RABALAIS
Hugh Roy and Lillie Cranz Cullen Professor of Chemistry
Chair, Department of Chemistry
Phone: 713.743.3282
E-mail: rabalais@uh.edu
Web site: http://vnet.nsm.uh.edu/webpages/nsm/homepage/homepage.lasso?155622-961-5=rabalais
J. Wayne Rabalais developed a method of creating ñnanodots,î
nanometer size metallic structures, also known as ñquantum
dots.î The method involves irradiation by low-energy ions
for subplantation into the surface layer of a solid. This
breakthrough in nanotechnology opens the door to develop biological
nanodots, which are linked to biomolecules to form sensitive
probes for identification of specific compounds and to track
biological events.
MICHAEL A. REA
Professor, Biology and Biochemistry
Phone: 713.743.2682
E-mail: mrea@uh.edu
Web site: http://vnet.uh.edu/webpages/bio/homepage_bio.lasso?155622-961-5=mrea
Michael Rea studies the neurobiology of behavior, with an
emphasis on the mechanism through which the brain’s
biological clock organizes behavior into daily rhythms of
activity and sleep. Through collaborative research, Rea has
developed a method for the construction of ordered networks
of defined neurons on modified gold surfaces. This research
will be used to understand how individual oscillatory neurons
interact to form an integrated biological clock and how this
clock communicates with the rest of the brain to coordinate
rhythms in physiology and behavior. Dr Rea is also co-founder
of VisiGen Biotechnologies, Inc., where he oversees development
of a patented, fluorescence-based, single molecule DNA sequencing
system.
DEBBIE ROBERTS
Associate Professor, Civil and Environmental Engineering
Phone: 713.743.4281
E-mail: djroberts@uh.edu
Web site: http://www.egr.uh.edu/cive/faculty/roberts/
Debbie Roberts principally studies the anaerobic metabolism
of contaminants in soil and water. Her current studies include
the development of a biological process for the removal of
perchlorate from ion exchange regenerant brines and directly
in groundwater. The studies include engineering as well as
microbial ecology research. She also is investigating and
developing a model that can predict the fate of synthetic
drilling mud base fluids (SBF) in deep Gulf of Mexico sediments.
This study, funded by MMS, invesitgates the microbial ecology
rates and pathways of anaerobic degradation of SBF using deep
Gulf sediments incubated at 4C and under pressure.
PAUL RUCHHOEFT
Assistant Professor, Electrical and Computer Engineering
Phone: 713.743.4485
E-mail: pruchhoeft@uh.edu
Web site: http://www.egr.uh.edu/ece/faculty/ruchhoeft/
Paul Ruchhoeft's research is focused on the development of
a manufacturing system for fabricating large-area periodic
nanostructures using ion beam proximity lithography. His current
projects include fabricating large-area water filtration membranes
with well-defined pore structure and geometry and infrared
filters for thermophotovoltaic energy conversion. He is also
collaborating with Professors Vincent Donnelly and Demetre
Ecomonou by fabricating orderly arrays of sub-micron sized
ion-focusing lenses used in “nano-pantography.”
DONNA STOKES
Assistant Professor, Physics
Phone: 713.743.3588
E-mail: dstokes@uh.edu
Donna Stokes studies materials properties of semiconductors
for development of novel infrared detectors and lasers. Her
current research includes structural, optical, and electrical
analysis of self-assembled nanostructures in type-II semiconducting
detectors for chemical and biological sensing in the infrared
region; isoelectronic co-doping of GaP for white light sources;
iron disilicide for light-emitting diodes for communications
applications; and molecular beam epitaxial-grown nanomagnetic
materials for information and data storage applications.
PETER G. VEKILOV
Associate Professor, Chemical Engineering
Phone: 713.743.4315
E-mail: peter.vekilov@mail.uh.edu
Web site: http://www.chee.uh.edu/faculty/vekilov/
Peter G. Vekilov studies phase transitions in protein solutions,
and has recently disproved some long-standing theories about
the basic principles that drive nucleation. His work, which
includes the formation of liquid and solid, ordered, and disordered
phases of native or of partially misfolded protein molecules.
This work has important significance to the proper understanding
of several major diseases, such as sickle cell anemia and
Alzheimer’s disease.
RICHARD WILLSON
Associate Professor of Chemical Engineering
Phone: 713.743.4308
E-mail: willson@uh.edu
Dr. Willson's research focuses on nanostructured adsorbents for protein and DNA separation and analysis. Ordinary adsorbents (e.g., ion exchangers) are randomly derivitized with functional groups (e.g., charges), sprinkled over their surface area. This produces extensive heterogeneity, in that there are some places where several charges are close together, and many where a smaller number are clustered. So the binding properties are heterogeneous, and the selectivity for purification (e.g., of protein pharmaceuticals) or analysis (e.g., proteomics) is inherently limited. This group is controlling the distribution of charges on a nm scale by immobilizing groups of charges all at once as nanoclusters. This reduces the heterogeneity of adsorption, and confers interesting new specificity for proteins displaying clusters of charges on their surfaces. We are now also exploring nanocluster metal-chelates for DNA/RNA separations.
This group is also studying nanoscale optical labels for DNA, antibodies and cellular structures. They are making detectable, high-information content physical labels for use in diagnostics, DNA chips, and parallel, high-information content drug screening. These labels are synthesized in a collaborative project with the Prof. Paul Ruchhoeft of the UH Department of Electrical Engineering, using massively-parallel helium ion beams patterned using stencil masks, with characteristic feature sizes near 100 nm.
JOHN C. WOLFE
Professor, Electrical and Computer Engineering
Phone: 713.743.4481
E-mail: wolfe@uh.edu
Web site: http://www.egr.uh.edu/ece/faculty/wolfe/
John C. Wolfe is the director of the Nanosystem Manufacturing
Center that combines core strengths in nanofabrication and
charged particle systems to address the manufacturing needs
of the emerging applications of nanotechnology in energy conversion,
water purification, and nanomagnetic systems (see below).
We are developing, in this context, a novel printing technology
that uses atoms, like ink, to transfer a stencil pattern to
a surface. It has the very high throughput needed for manufacturing
and an ultimate resolution near 2nm. About fifty times smaller
than the finest feature in integrated circuits today, these
tiny features are needed at the interface between integrated
circuits and the molecular world.
DAVID ZIMMERMAN
Professor, Mechanical Engineering
Phone: 713.743.4520
E-mail: dzimmerman@uh.edu
Web site: http://www.egr.uh.edu/me/faculty/zimmerman/
David Zimmerman studies modeling and measurement of dynamic
response of microelectromechanical systems (MEMS), an emerging
technology having potential application in military, environmental,
medical, and industrial applications. Though the MEMS concept
has been known for more than twenty years, the commercialization
of MEMS technology has not progressed as fast as IC chip technology.
He is particularly interested in evaluating the quality of
manufacturing of the MEMS device using its' dynamic response.
He also studies the mechanical characterization of carbon
nanotube composite materials. |