‘HEART MONTH’ TIP SHEET: UH
RESEARCHERS PUT A LOT OF HEART INTO THEIR WORK
HOUSTON, February 9, 2006 – Matters of the heart dominate
in February with Valentine’s Day and the American Heart Association’s
‘Heart Month’ topping the list. As you consider story
ideas about heart disease, stroke and heart attack prevention, keep
in mind these resources from the University of Houston. For more
information, or if you are unable to reach a professor, give us
a call at 713-743-8192.
DETECTING A HEART ATTACK TIME BOMB
A computational medicine breakthrough is helping pave the way to
uncover a ticking “time-bomb” in the heart. UH computer
science professor Ioannis Kakadiaris and doctoral student Sean O’Malley
are collaborating with Dr. Morteza Naghavi and other cardiologists
and engineers from the Association for Eradication of Heart Attack
in this research effort. This group has developed computer technology
with the potential to alert physicians to heart attack risk. For
the first time, Kakadiaris and his collaborators are enabling physicians
to detect microvessels linked to plaque inflammation that represent
regions of blood vessels prone to future rupture and sudden blockage.
Its early detection is essential in the practice of cardiology in
order to reduce the number of fatalities occurring every year due
to unpredicted heart attacks and strokes. Kakadiaris can be reached
at 713-743-1255 or ioannisk@uh.edu.
IMPROVING CEREBRAL ANEURYSM TREATMENT
Roughly 25,000 people in the United States suffer hemorrhage each
year from cerebral aneurysms, which are ballooning weak spots in
the wall of a blood vessel in the brain. Mechanical engineering
professor Ralph Metcalfe and his research students at UH are working
with physicians at The Methodist Hospital Research Institute on
new medical technology to identify brain aneurysms before they create
strokes. Metcalfe, who is working primarily with Dr. Charles Strother’s
research group, is attempting to develop methods to identify which
patients are most at risk. Metcalfe believes that the day is not
far off when a fully integrated computational-medical tool will
be commonly used in diagnostics and prevention, as well as remedial
treatment of this serious medical problem. Metcalfe can be reached
at 713-743-4503 or metcalfe@uh.edu.
PUMPING NEW LIFE INTO ARTIFICIAL HEARTS
Biomedical engineering student Hassan Khalil is conducting research
that pumps new life into artificial organs and fosters collaborations
between UH and the Texas Medical Center. His model of the human
vascular system allows for new experimentation in artificial organ
control that aims to maintain important physiological parameters,
such as total blood flow, and makes experiments more flexible, easier,
more predictable and less expensive. Collaborators on the project
include doctors at the Texas Heart Institute and UH biomedical engineering
professors Matt Franchek and Ralph Metcalfe. Khalil can be reached
at 832-355-7244 or hkhalil@uh.edu.
HEALTHY MIND, BODY AND SPIRIT
The University of Houston Spirit of Houston Marching Band is stepping
to the beat of a healthy drum. Members of the band, along with the
cheer squads and dance teams, are part of an ongoing study to assess
the risk factors for cardiovascular disease and obesity-related
conditions. The study is a project of the UH Department of Health
and Human Performance. Professor Jill Bush and her team assess students
twice a year and introduced them to a regular exercise program to
incorporate into their regular practice routine. She’ll present
her findings at the American College of Sports Medicine National
Conference in Denver this summer. Bush can be reached at 713-743-9869
or jbush@mail.uh.edu.
NEUROSCIENCE DISCOVERY COULD LEAD TO DRUGS FOR STROKE
Carrying out research with Dr. Bob Bryan at Baylor College of Medicine
on mechanisms that control dilation of blood vessels in the brain,
Stuart Dryer, UH professor of biology and biochemistry, says his
research may provide a new basis for developing drugs for stroke.
The discovery that activation of certain channels in cerebral smooth
muscle causes vessels to dilate, provides a possible pharmacological
strategy to develop drugs to selectively dilate blood vessels in
the brain that may be useful in certain kinds of stroke or pre-stroke
conditions. The work also could generate leads to develop drugs
for migraine. Dryer can be reached at 713-743-2697 or sdryer@uh.edu.
PREFERRED TREATMENT FOR HEART DISEASE NOW TURNED ON ASTHMA
Over the course of a 30-year period, tens of millions of heart patients
died prematurely before beta blockers were finally discovered to
decrease the mortality rate of congestive heart failure (CHF) patients,
says UH pharmacology professor Richard Bond. A proponent of paradoxical
pharmacology – the theory of using drugs that cause an initial
downturn in one’s condition before long-term improvements
occur – Bond has turned his attention to treating asthma this
same way. He found beta blockers ultimately allow air to flow more
freely in asthma sufferers by forcing the smooth muscle lining the
airways to relax and dilate. The work suggests that asthma and CHF
patients both exhibit the beneficial effect with long-term treatment.
Bond can be reached at 713-743-1210 or rabond@uh.edu.
PREVENTING ANEURYSMS FROM RUPTURING
In an effort to develop improved vascular prostheses, called stents,
to treat arteries damaged by aneurysm, UH math professor Suncica
Canic is collaborating with researchers at the Texas Medical Center,
using complex mathematical models to perfect stent design. Working
closely with doctors at the Texas Heart Institute and Baylor College
of Medicine, she has initiated interdisciplinary alliances to address
issues related to this type of medical treatment. The main goal
of her work is to help cardiologists gain deeper insight into the
problems related to the medical treatment of aortic abdominal aneurysm
and the treatment of coronary artery disease. Canic can be reached
at 713-743-3466 or scanic@uh.edu.
About the University of Houston
The University of Houston, Texas’ premier metropolitan research
and teaching institution, is home to more than 40 research centers
and institutes and sponsors more than 300 partnerships with corporate,
civic and governmental entities. UH, the most diverse research university
in the country, stands at the forefront of education, research and
service with more than 35,000 students.
About the Cullen College of Engineering
UH Cullen College of Engineering has produced five U.S. astronauts,
10 embers of the National Academy of Engineering, and degree programs
that have ranked in the top ten nationally. With more than 2,600
students, the college offers accredited undergraduate and graduate
degrees in biomedical, chemical, civil and environmental, electrical
and computer, industrial, and mechanical engineering. It also offers
specialized programs in aerospace, materials, petroleum engineering
and telecommunications.
To receive UH science news via e-mail, visit www.uh.edu/admin/media/sciencelist.html.
For more information about UH visit the university’s ‘Newsroom’ at www.uh.edu/admin/media/newsroom.
|
